Research graph
References from 3D-Printed and Biofabricated Scaffolds for Osteoporotic Bone Defect Repair: Mechanical Adaptation, Redox Control, Senescence Modulation and Osteoimmunomodulation. Local targets link to admitted publications; unresolved targets remain external evidence.
The global burden of fractures and its underlying etiologies: Results from and further analysis of the Global Burden of Disease Study 2021
10.1007/s11657-025-01596-3 · 2025 · External reference
Global epidemiology of hip fractures: Secular trends in incidence rate, post-fracture treatment, and all-cause mortality
10.1002/jbmr.4821 · 2023 · External reference
10.3389/fbioe.2025.1541746
10.3389/fbioe.2025.1541746 · External reference
Intramembranous ossification and endochondral ossification are impaired differently between glucocorticoid-induced osteoporosis and estrogen deficiency-induced osteoporosis
10.1038/s41598-018-22095-1 · 2018 · External reference
Autograft, allograft, and bone graft substitutes: Clinical evidence and indications for use in the setting of orthopaedic trauma surgery
10.1097/bot.0000000000001420 · 2019 · External reference
Fully porous 3D printed titanium femoral stem to reduce stress-shielding following total hip arthroplasty
10.1002/jor.23445 · 2017 · External reference
Amniotic membrane attenuates heterotopic ossification following high dose bone morphogenetic protein-2 treatment of segmental bone defects
10.1002/jor.25324 · 2023 · External reference
Subsidence rates associated with porous 3D-printed versus solid titanium cages in transforaminal lumbar interbody fusion
10.1177/21925682231157762 · 2024 · External reference
10.3389/fbioe.2021.754205
10.3389/fbioe.2021.754205 · External reference
10.3389/fbioe.2025.1557203
10.3389/fbioe.2025.1557203 · External reference
Cellular senescence and other age-related mechanisms in skeletal diseases
10.1038/s41413-025-00448-7 · 2025 · External reference
The redox-senescence axis and its therapeutic targeting
10.1016/j.redox.2021.102032 · 2021 · External reference
Osteogenesis and ageing: Lessons from mesenchymal stem cells
10.1186/s13287-018-0995-x · 2018 · External reference
Targeting cellular senescence prevents age-related bone loss in mice
10.1038/nm.4385 · 2017 · External reference
Independent roles of estrogen deficiency and cellular senescence in the pathogenesis of osteoporosis: Evidence in young adult mice and older humans
10.1002/jbmr.3729 · 2019 · External reference
Deconstructing cellular senescence in bone and beyond
10.1172/jci169069 · 2023 · External reference
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: A phase 2 randomized controlled trial
10.1038/s41591-024-03096-2 · 2024 · External reference
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
10.1038/nature13145 · 2014 · External reference
Human type H vessels are a sensitive biomarker of bone mass
10.1038/cddis.2017.36 · 2017 · External reference
Optimizing type H vessels formation via short fibers 3D scaffolds with maintaining redox homeostasis for osteoporotic bone remodeling
2025 · External reference
Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration
2023 · External reference
Immunosenescence and inflammageing: Mechanisms and role in diseases
10.1016/j.arr.2024.102540 · 2024 · External reference
A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation
2022 · External reference
Ageing, osteocytes, and mechanotransduction
10.1007/s11914-017-0402-z · 2017 · External reference
Pathogenic mechanisms of glucocorticoid-induced osteoporosis
10.1016/j.cytogfr.2023.03.002 · 2023 · External reference
10.3389/fendo.2018.00006
10.3389/fendo.2018.00006 · External reference
Effect of agents affecting bone homeostasis on short- and long-term implant failure
10.1111/clr.14144 · 2023 · External reference
Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal ageing and bone diseases
10.1007/s00774-015-0656-4 · 2015 · External reference
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast–osteoclast crosstalk
10.1038/s41467-019-14146-6 · 2020 · External reference
10.3390/bioengineering10060672
10.3390/bioengineering10060672 · External reference
10.3390/polym14061153
10.3390/polym14061153 · External reference
Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review
10.1016/j.mtbio.2024.101341 · 2024 · External reference
A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects
10.7150/thno.40103 · 2020 · External reference
Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats
10.1177/0885328218765847 · 2018 · External reference
Sequential therapy for bone regeneration by cerium oxide-reinforced 3D-printed bioactive glass scaffolds
10.1021/acsnano.2c09855 · 2023 · External reference
Cerium-containing mesoporous bioactive glass nanoparticles reinforced 3D-printed bioceramic scaffolds toward enhanced mechanical, antioxidant, and osteogenic activities for bone regeneration
10.1002/adhm.202404346 · 2025 · External reference
Repurpose dasatinib and quercetin: Targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration
2023 · External reference
Bioactive multifunctional hydrogel scaffolds remodel the inflammatory microenvironment and osteogenic–osteoclastic homeostasis to advance osteoporotic bone defect repair
10.1021/acsnano.5c15635 · 2025 · External reference
10.3390/polym13132115
10.3390/polym13132115 · External reference
Current state of fabrication technologies and materials for bone tissue engineering
10.1016/j.actbio.2018.09.031 · 2018 · External reference
10.3390/jfb16120463
10.3390/jfb16120463 · External reference
Advancements in tissue and organ 3D bioprinting: Current techniques, applications, and future perspectives
10.1016/j.matdes.2024.112853 · 2024 · External reference
10.3389/fbioe.2022.896719
10.3389/fbioe.2022.896719 · External reference
4D printing of smart scaffolds for bone regeneration: A systematic review
10.1088/1748-605x/ad8f80 · 2025 · External reference
NIR-responsive deployable and self-fitting 4D-printed bone tissue scaffold
10.1021/acsami.4c10385 · 2024 · External reference
A review of computational optimization of bone scaffold architecture: Methods, challenges, and perspectives
10.1088/2516-1091/ad879a · 2025 · External reference
A mechanical-assisted post-bioprinting strategy for challenging bone defects repair
10.1038/s41467-024-48023-8 · 2024 · External reference
Effects of pore size and porosity on cytocompatibility and osteogenic differentiation of porous titanium
10.1007/s10856-021-06548-0 · 2021 · External reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · 2018 · External reference
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
10.1038/nm.4324 · 2017 · External reference
10.3389/fbioe.2022.928799
10.3389/fbioe.2022.928799 · External reference
Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis
2022 · External reference
Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives
2025 · External reference
Osteoimmunology: Evolving concepts in bone–immune interactions in health and disease
10.1038/s41577-019-0178-8 · 2019 · External reference
10.3389/fbioe.2025.1640560
10.3389/fbioe.2025.1640560 · External reference
3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair
10.1016/j.mtbio.2026.102879 · 2026 · External reference
10.3389/fbioe.2024.1385365
10.3389/fbioe.2024.1385365 · External reference
Repair of critical diaphyseal defects of lower limbs by 3D printed porous Ti6Al4V scaffolds without additional bone grafting: A prospective clinical study
10.1007/s10856-022-06685-0 · 2022 · External reference
Three-dimensional printed bioresorbable scaffold for maxillofacial bone reconstruction: A scoping review
10.1590/0103-6440202406112 · 2024 · External reference
10.3390/bioengineering10070857
10.3390/bioengineering10070857 · External reference
10.3389/fphar.2024.1486812
10.3389/fphar.2024.1486812 · External reference
Patient-specific implants made of 3D printed bioresorbable polymers at the point-of-care: Material, technology, and scope of surgical application
10.1186/s41205-024-00207-0 · 2024 · External reference
Cerium-containing mesoporous bioactive glass nanoparticles reinforced 3D-printed bioceramic scaffolds toward enhanced mechanical, antioxidant, and osteogenic activities for bone regeneration
10.1002/adhm.202404346 · ExternalCitation · doi-reference
Independent roles of estrogen deficiency and cellular senescence in the pathogenesis of osteoporosis: Evidence in young adult mice and older humans
10.1002/jbmr.3729 · ExternalCitation · doi-reference
Global epidemiology of hip fractures: Secular trends in incidence rate, post-fracture treatment, and all-cause mortality
10.1002/jbmr.4821 · ExternalCitation · doi-reference
Fully porous 3D printed titanium femoral stem to reduce stress-shielding following total hip arthroplasty
10.1002/jor.23445 · ExternalCitation · doi-reference
Amniotic membrane attenuates heterotopic ossification following high dose bone morphogenetic protein-2 treatment of segmental bone defects
10.1002/jor.25324 · ExternalCitation · doi-reference
Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal ageing and bone diseases
10.1007/s00774-015-0656-4 · ExternalCitation · doi-reference
Effects of pore size and porosity on cytocompatibility and osteogenic differentiation of porous titanium
10.1007/s10856-021-06548-0 · ExternalCitation · doi-reference
Repair of critical diaphyseal defects of lower limbs by 3D printed porous Ti6Al4V scaffolds without additional bone grafting: A prospective clinical study
10.1007/s10856-022-06685-0 · ExternalCitation · doi-reference
The global burden of fractures and its underlying etiologies: Results from and further analysis of the Global Burden of Disease Study 2021
10.1007/s11657-025-01596-3 · ExternalCitation · doi-reference
Ageing, osteocytes, and mechanotransduction
10.1007/s11914-017-0402-z · ExternalCitation · doi-reference
Current state of fabrication technologies and materials for bone tissue engineering
10.1016/j.actbio.2018.09.031 · ExternalCitation · doi-reference
Immunosenescence and inflammageing: Mechanisms and role in diseases
10.1016/j.arr.2024.102540 · ExternalCitation · doi-reference
Pathogenic mechanisms of glucocorticoid-induced osteoporosis
10.1016/j.cytogfr.2023.03.002 · ExternalCitation · doi-reference
Advancements in tissue and organ 3D bioprinting: Current techniques, applications, and future perspectives
10.1016/j.matdes.2024.112853 · ExternalCitation · doi-reference
Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review
10.1016/j.mtbio.2024.101341 · ExternalCitation · doi-reference
3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair
10.1016/j.mtbio.2026.102879 · ExternalCitation · doi-reference
The redox-senescence axis and its therapeutic targeting
10.1016/j.redox.2021.102032 · ExternalCitation · doi-reference
NIR-responsive deployable and self-fitting 4D-printed bone tissue scaffold
10.1021/acsami.4c10385 · ExternalCitation · doi-reference
Sequential therapy for bone regeneration by cerium oxide-reinforced 3D-printed bioactive glass scaffolds
10.1021/acsnano.2c09855 · ExternalCitation · doi-reference
Bioactive multifunctional hydrogel scaffolds remodel the inflammatory microenvironment and osteogenic–osteoclastic homeostasis to advance osteoporotic bone defect repair
10.1021/acsnano.5c15635 · ExternalCitation · doi-reference
Human type H vessels are a sensitive biomarker of bone mass
10.1038/cddis.2017.36 · ExternalCitation · doi-reference
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
10.1038/nature13145 · ExternalCitation · doi-reference
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
10.1038/nm.4324 · ExternalCitation · doi-reference
Targeting cellular senescence prevents age-related bone loss in mice
10.1038/nm.4385 · ExternalCitation · doi-reference
Cellular senescence and other age-related mechanisms in skeletal diseases
10.1038/s41413-025-00448-7 · ExternalCitation · doi-reference
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast–osteoclast crosstalk
10.1038/s41467-019-14146-6 · ExternalCitation · doi-reference
A mechanical-assisted post-bioprinting strategy for challenging bone defects repair
10.1038/s41467-024-48023-8 · ExternalCitation · doi-reference
Osteoimmunology: Evolving concepts in bone–immune interactions in health and disease
10.1038/s41577-019-0178-8 · ExternalCitation · doi-reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · ExternalCitation · doi-reference
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: A phase 2 randomized controlled trial
10.1038/s41591-024-03096-2 · ExternalCitation · doi-reference
Intramembranous ossification and endochondral ossification are impaired differently between glucocorticoid-induced osteoporosis and estrogen deficiency-induced osteoporosis
10.1038/s41598-018-22095-1 · ExternalCitation · doi-reference
4D printing of smart scaffolds for bone regeneration: A systematic review
10.1088/1748-605x/ad8f80 · ExternalCitation · doi-reference
A review of computational optimization of bone scaffold architecture: Methods, challenges, and perspectives
10.1088/2516-1091/ad879a · ExternalCitation · doi-reference
Autograft, allograft, and bone graft substitutes: Clinical evidence and indications for use in the setting of orthopaedic trauma surgery
10.1097/bot.0000000000001420 · ExternalCitation · doi-reference
Effect of agents affecting bone homeostasis on short- and long-term implant failure
10.1111/clr.14144 · ExternalCitation · doi-reference
Deconstructing cellular senescence in bone and beyond
10.1172/jci169069 · ExternalCitation · doi-reference
Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats
10.1177/0885328218765847 · ExternalCitation · doi-reference
Subsidence rates associated with porous 3D-printed versus solid titanium cages in transforaminal lumbar interbody fusion
10.1177/21925682231157762 · ExternalCitation · doi-reference
Osteogenesis and ageing: Lessons from mesenchymal stem cells
10.1186/s13287-018-0995-x · ExternalCitation · doi-reference
Patient-specific implants made of 3D printed bioresorbable polymers at the point-of-care: Material, technology, and scope of surgical application
10.1186/s41205-024-00207-0 · ExternalCitation · doi-reference
Three-dimensional printed bioresorbable scaffold for maxillofacial bone reconstruction: A scoping review
10.1590/0103-6440202406112 · ExternalCitation · doi-reference
10.3389/fbioe.2021.754205
10.3389/fbioe.2021.754205 · ExternalCitation · doi-reference
10.3389/fbioe.2022.896719
10.3389/fbioe.2022.896719 · ExternalCitation · doi-reference
10.3389/fbioe.2022.928799
10.3389/fbioe.2022.928799 · ExternalCitation · doi-reference
10.3389/fbioe.2024.1385365
10.3389/fbioe.2024.1385365 · ExternalCitation · doi-reference
10.3389/fbioe.2025.1541746
10.3389/fbioe.2025.1541746 · ExternalCitation · doi-reference
10.3389/fbioe.2025.1557203
10.3389/fbioe.2025.1557203 · ExternalCitation · doi-reference
10.3389/fbioe.2025.1640560
10.3389/fbioe.2025.1640560 · ExternalCitation · doi-reference
10.3389/fendo.2018.00006
10.3389/fendo.2018.00006 · ExternalCitation · doi-reference
10.3389/fphar.2024.1486812
10.3389/fphar.2024.1486812 · ExternalCitation · doi-reference
10.3390/bioengineering10060672
10.3390/bioengineering10060672 · ExternalCitation · doi-reference
10.3390/bioengineering10070857
10.3390/bioengineering10070857 · ExternalCitation · doi-reference
10.3390/jfb16120463
10.3390/jfb16120463 · ExternalCitation · doi-reference
10.3390/polym13132115
10.3390/polym13132115 · ExternalCitation · doi-reference
10.3390/polym14061153
10.3390/polym14061153 · ExternalCitation · doi-reference
A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects
10.7150/thno.40103 · ExternalCitation · doi-reference
