Research graph
References from PU.1 as a Master Regulator of Immune Cell Development and Function: Structural Basis, Gene Regulatory Networks, Disease Roles, and Therapeutic Targeting. Local targets link to admitted publications; unresolved targets remain external evidence.
Transcription factors in myeloid development: Balancing differentiation with transformation
10.1038/nri2024 · 2007 · External reference
Hematopoiesis: An evolving paradigm for stem cell biology
10.1016/j.cell.2008.01.025 · 2008 · External reference
From haematopoietic stem cells to complex differentiation landscapes
10.1038/nature25022 · 2018 · External reference
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
10.1002/j.1460-2075.1996.tb00949.x · 1996 · External reference
10.31083/j.fbs1602010
10.31083/j.fbs1602010 · External reference
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
10.1126/science.8079170 · 1994 · External reference
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
10.1084/jem.20041535 · 2005 · External reference
Transcription factor PU.1 and immune cell differentiation
10.3892/ijmm.2020.4763 · 2020 · External reference
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia
10.1038/nm.3936 · 2015 · External reference
Regulation of B lymphocyte and macrophage development by graded expression of PU.1
10.1126/science.288.5470.1439 · 2000 · External reference
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages
10.1186/s13072-024-00556-4 · 2024 · External reference
Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1
10.1038/s41467-019-13960-2 · 2020 · External reference
A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling
10.1038/s41594-022-00886-5 · 2023 · External reference
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
10.1016/j.molcel.2010.05.004 · 2010 · External reference
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages
10.1016/j.immuni.2010.02.008 · 2010 · External reference
PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers
10.1073/pnas.1017214108 · 2011 · External reference
PU.1-Activated Genomic Regions Define Low-risk MDS Subsets Characterized by Immune Dysregulation and Disease Progression
10.1182/blood.2025030760 · 2026 · External reference
Alzheimer’s-associated PU.1 expression levels regulate microglial inflammatory response
10.1016/j.nbd.2020.105217 · 2021 · External reference
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
10.1038/ng1361 · 2004 · External reference
PU.1 expression in microglia
10.1016/s0165-5728(99)00262-3 · 2000 · External reference
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
10.1038/nn.3318 · 2013 · External reference
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease
10.1038/nn.4587 · 2017 · External reference
A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex
10.1038/380456a0 · 1996 · External reference
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo
10.1038/emboj.2010.106 · 2010 · External reference
Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1
10.1093/nar/gkt355 · 2013 · External reference
Co-crystallization of an ETS domain (PU.1) in complex with DNA. Engineering the length of both protein and oligonucleotide
10.1074/jbc.270.41.24258 · 1995 · External reference
DNA selection by the master transcription factor PU.1
10.1016/j.celrep.2023.112671 · 2023 · External reference
Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)
10.1101/gr.231423.117 · 2018 · External reference
DNA binding regulates the self-association of the ETS domain of PU.1 in a sequence-dependent manner
10.1021/bi300331v · 2012 · External reference
A Recurrent Activating Missense Mutation in Waldenstrom Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation
10.1158/2159-8290.cd-18-0873 · 2019 · External reference
C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
10.1074/jbc.274.8.4939 · 1999 · External reference
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
10.1073/pnas.96.15.8705 · 1999 · External reference
RUNX1 regulates corepressor interactions of PU.1
10.1182/blood-2010-10-312512 · 2011 · External reference
Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: Possible role in lineage commitment decisions
10.1182/blood.v100.2.483 · 2002 · External reference
Conserved ETS domain arginines mediate DNA binding, nuclear localization, and a novel mode of bZIP interaction
10.1074/jbc.m509143200 · 2005 · External reference
Crystal structure of PU.1/IRF-4/DNA ternary complex
10.1016/s1097-2765(02)00703-7 · 2002 · External reference
Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP
10.1038/sj.onc.1202427 · 1999 · External reference
The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
10.1073/pnas.90.4.1580 · 1993 · External reference
The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1beta eRNA and mRNA transcription in mouse melanoma and macrophage cell lines
10.1074/jbc.ra119.010149 · 2019 · External reference
Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation
10.1126/science.8456286 · 1993 · External reference
Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II
10.4049/jimmunol.158.4.1848 · 1997 · External reference
The transcription factor PU.1 is involved in macrophage proliferation
10.1084/jem.184.1.61 · 1996 · External reference
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor
1994 · External reference
Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
10.1126/science.2876518 · 1986 · External reference
FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1
10.1158/1541-7786.mcr-20-0268 · 2021 · External reference
PU.1 is degraded in differentiation of erythrocytes through a proteasome-dependent pathway
10.1089/dna.2006.25.340 · 2006 · External reference
USP7 sustains hematopoietic stem cell homeostasis partially via PU.1 stabilization
10.7150/ijbs.123712 · 2026 · External reference
Assembly requirements of PU.1-Pip (IRF-4) activator complexes: Inhibiting function in vivo using fused dimers
10.1093/emboj/18.4.977 · 1999 · External reference
Functional analysis of PU.1 domains in monocyte-specific gene regulation
10.1016/s0014-5793(04)00116-4 · 2004 · External reference
MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)
10.1074/jbc.m109.011601 · 2009 · External reference
The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation
10.1084/jem.20140338 · 2014 · External reference
An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling
10.1016/j.cell.2007.02.048 · 2007 · External reference
Coordination of Myeloid Differentiation with Reduced Cell Cycle Progression by PU.1 Induction of MicroRNAs Targeting Cell Cycle Regulators and Lipid Anabolism
10.1128/mcb.00013-17 · 2017 · External reference
MIR-23A microRNA cluster inhibits B-cell development
10.1016/j.exphem.2010.04.004 · 2010 · External reference
Super-enhancer-associated long noncoding RNA lnc-SPI1U mediates SPI1 feedback regulation by interacting with HNRNPH1 and HNRNPF
10.1038/s41388-025-03612-9 · 2025 · External reference
The conserved 5′-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo
10.1093/nar/25.14.2869 · 1997 · External reference
AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain
10.1074/jbc.m007482200 · 2001 · External reference
Protein acetylation regulates both PU.1 transactivation and Ig kappa 3’ enhancer activity
10.4049/jimmunol.175.8.5160 · 2005 · External reference
Impaired repressor activity and biological functions of PU.1 in MEL cells induced by mutations in the acetylation motifs within the ETS domain
10.1016/j.bbrc.2005.07.098 · 2005 · External reference
Macrophage development from HSCs requires PU.1-coordinated microRNA expression
10.1182/blood-2011-02-335141 · 2011 · External reference
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells
10.1182/blood-2010-08-302976 · 2011 · External reference
The C/EBPalpha-(PU.1-LOUP) regulatory circuit regulates monocyte/macrophage development and immune functions
10.1182/blood.2025030667 · 2026 · External reference
PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
10.1182/blood.v94.7.2310.419k34_2310_2318 · 1999 · External reference
PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
10.1128/mcb.15.10.5830 · 1995 · External reference
PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
10.1182/blood.v88.4.1234.bloodjournal8841234 · 1996 · External reference
Potential autoregulation of transcription factor PU.1 by an upstream regulatory element
10.1128/mcb.25.7.2832-2845.2005 · 2005 · External reference
Temporal autoregulation during human PU.1 locus SubTAD formation
10.1182/blood-2018-02-834721 · 2018 · External reference
Positive feedback between PU.1 and the cell cycle controls myeloid differentiation
10.1126/science.1240831 · 2013 · External reference
The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation
10.1073/pnas.0706963104 · 2007 · External reference
Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML
10.1182/blood.2020007920 · 2021 · External reference
CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling
10.1073/pnas.2322524121 · 2024 · External reference
Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages
10.1152/ajplung.90320.2008 · 2009 · External reference
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity
10.1016/j.immuni.2020.07.018 · 2020 · External reference
PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment
10.1016/j.celrep.2013.04.007 · 2013 · External reference
Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPalpha
10.1038/s41594-023-01189-z · 2024 · External reference
SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
10.1158/0008-5472.can-22-2129 · 2023 · External reference
The Lineage-Specific Transcription Factor PU.1 Prevents Polycomb-Mediated Heterochromatin Formation at Macrophage-Specific Genes
10.1128/mcb.00027-15 · 2015 · External reference
Cohesin complex cooperates with PU.1 at super-enhancers to regulate the differentiation and identity of conventional dendritic cells
10.1016/j.celrep.2026.117331 · 2026 · External reference
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
10.1038/s41467-021-22548-8 · 2021 · External reference
PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
10.1093/emboj/17.15.4456 · 1998 · External reference
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
10.1182/blood-2005-03-0860 · 2005 · External reference
Functional PU.1 in macrophages has a pivotal role in NF-kappaB activation and neutrophilic lung inflammation during endotoxemia
10.1182/blood-2011-03-341123 · 2011 · External reference
Normal myeloid development requires both the glutamine-rich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain
10.1128/mcb.18.7.4347 · 1998 · External reference
Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment
10.1128/mcb.22.24.8681-8694.2002 · 2002 · External reference
Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses
10.1073/pnas.1901258116 · 2019 · External reference
Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation
10.1074/jbc.m110.165431 · 2011 · External reference
IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: Characterization of a new subtype of IFN-stimulated response element
10.4049/jimmunol.168.12.6224 · 2002 · External reference
TopBP1 orchestrates PU.1-IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunity
10.1038/s12276-026-01715-1 · 2026 · External reference
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
10.1101/gad.9.11.1377 · 1995 · External reference
The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
10.1084/jem.20140425 · 2014 · External reference
Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation
10.1073/pnas.1901122116 · 2019 · External reference
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
10.1038/ng.2007.7 · 2008 · External reference
Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy
10.1074/jbc.m114.562447 · 2014 · External reference
Truncated RUNX1 protein generated by a novel t(1;21)(p32;q22) chromosomal translocation impairs the proliferation and differentiation of human hematopoietic progenitors
10.1038/onc.2015.70 · 2016 · External reference
A critical role of the Erk1/2 downstream targets c-Fos, Egr-1, and Egr-2 in PU.1-driven monocyte development
10.1093/jleuko/qiaf159 · 2025 · External reference
GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription
10.1182/blood.v95.8.2543 · 2000 · External reference
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
10.1182/blood.v96.8.2641 · 2000 · External reference
10.1371/journal.pone.0152234
10.1371/journal.pone.0152234 · External reference
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate
10.1182/blood-2009-03-207944 · 2009 · External reference
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
10.1101/gad.12.15.2403 · 1998 · External reference
Stepwise reprogramming of B cells into macrophages
10.1016/s0092-8674(04)00419-2 · 2004 · External reference
Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors
10.1016/j.immuni.2006.09.011 · 2006 · External reference
Inflammatory signals directly instruct PU.1 in HSCs via TNF
10.1182/blood-2018-02-832998 · 2019 · External reference
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
10.1084/jem.20201750 · 2021 · External reference
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
10.1016/j.stem.2007.07.004 · 2007 · External reference
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
10.1038/leu.2010.104 · 2010 · External reference
Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage
10.1016/s1074-7613(02)00277-7 · 2002 · External reference
PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
10.1084/jem.20050075 · 2005 · External reference
10.3389/fimmu.2018.01264
10.3389/fimmu.2018.01264 · External reference
Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response
10.1038/s41467-026-69718-0 · 2026 · External reference
Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor
10.1038/ni973 · 2003 · External reference
PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells
10.1073/pnas.0711961105 · 2008 · External reference
Bcl-XL expression correlates with primary macrophage differentiation, activation of functional competence, and survival and results from synergistic transcriptional activation by Ets2 and PU.1
10.1074/jbc.m008270200 · 2001 · External reference
Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1
10.4049/jimmunol.169.11.6332 · 2002 · External reference
Epigenetic program and transcription factor circuitry of dendritic cell development
2015 · External reference
Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells
10.1016/j.jaci.2011.10.019 · 2012 · External reference
Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells
10.1182/blood-2010-06-291898 · 2011 · External reference
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT
10.1016/j.immuni.2018.11.010 · 2019 · External reference
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils
10.1038/s41590-019-0343-z · 2019 · External reference
Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent
10.1182/blood.v92.5.1576 · 1998 · External reference
C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
10.1128/mcb.16.9.4717 · 1996 · External reference
Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification
10.1073/pnas.93.20.10838 · 1996 · External reference
The development of functional B lymphocytes in conditional PU.1 knock-out mice
10.1182/blood-2005-01-0283 · 2005 · External reference
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells
10.1084/jem.20202648 · 2021 · External reference
Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1
10.1101/gad.259879.115 · 2015 · External reference
10.3389/fnagi.2025.1537388
10.3389/fnagi.2025.1537388 · External reference
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
10.1038/s41467-022-28043-y · 2022 · External reference
The transcription factor PU.1 is critical for viability and function of human brain microglia
10.1002/glia.22486 · 2013 · External reference
PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
10.1186/s13024-018-0277-1 · 2018 · External reference
One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them
10.1182/blood.2024026683 · 2025 · External reference
PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
10.1182/blood-2004-06-2234 · 2004 · External reference
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
10.1038/leu.2013.384 · 2014 · External reference
Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells
10.1111/cas.12593 · 2015 · External reference
Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia
10.1038/leu.2015.172 · 2016 · External reference
Lentiviral PU.1 overexpression restores differentiation in myeloid leukemic blasts
10.1038/sj.leu.2404645 · 2007 · External reference
Heterozygous PU.1 mutations are associated with acute myeloid leukemia
10.1182/blood.v100.3.998 · 2002 · External reference
Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia
10.1038/sj.onc.1208422 · 2005 · External reference
10.1056/nejmoa1301689
10.1056/nejmoa1301689 · External reference
Genomic Classification and Prognosis in Acute Myeloid Leukemia
10.1056/nejmoa1516192 · 2016 · External reference
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
10.1182/blood-2002-04-1288 · 2003 · External reference
PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia
10.1016/j.ccr.2009.12.045 · 2010 · External reference
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
10.1016/j.stem.2025.01.010 · 2025 · External reference
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
10.1182/blood-2014-01-550855 · 2014 · External reference
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
10.1172/jci30525 · 2007 · External reference
Heterozygous deletion of the PU.1 locus in human AML
10.1182/blood-2009-03-212225 · 2010 · External reference
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
10.1038/ng1679 · 2006 · External reference
NF-kappaB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia
10.1038/leu.2014.231 · 2015 · External reference
Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice
10.1038/onc.2013.414 · 2014 · External reference
C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment
10.1182/blood-2007-03-080291 · 2007 · External reference
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
10.1182/blood-2010-11-317909 · 2011 · External reference
5-azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity
10.1038/leu.2012.47 · 2012 · External reference
Genome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome
10.1038/leu.2013.45 · 2013 · External reference
Decreased PU.1 expression in mature B cells induces lymphomagenesis
10.1111/cas.16344 · 2024 · External reference
Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia
10.1182/blood-2011-02-335539 · 2011 · External reference
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth
10.1158/0008-5472.can-06-4265 · 2007 · External reference
Oncogenic microRNA-155 and its target PU.1: An integrative gene expression study in six of the most prevalent lymphomas
10.1007/s12185-015-1847-4 · 2015 · External reference
PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells
10.1182/blood-2012-05-431429 · 2013 · External reference
10.1371/journal.pone.0087448
10.1371/journal.pone.0087448 · External reference
Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer
10.1038/s41392-026-02669-6 · 2026 · External reference
10.3389/fonc.2022.820568
10.3389/fonc.2022.820568 · External reference
SPI1 involvement in malignant melanoma pathogenesis by regulation of HK2 through the AKT1/mTOR pathway
10.1111/jcmm.17844 · 2023 · External reference
SPI1 mediates CST2 transcription to promote the proliferation, metastasis, and angiogenesis of esophageal cancer
10.1016/j.abb.2026.110832 · 2026 · External reference
SPI1 mediates transcriptional activation of TPX2 and RNF2 to regulate the radiosensitivity of lung squamous cell carcinoma
10.1016/j.abb.2022.109425 · 2022 · External reference
High expression of PU.1 is associated with Her-2 and shorter survival in patients with breast cancer
2017 · External reference
PU.1 is a mediator of the reactive stromal response associated with castration-resistant prostate cancer
10.1038/s42003-026-10297-7 · 2026 · External reference
10.3389/fimmu.2025.1590953
10.3389/fimmu.2025.1590953 · External reference
SIRT1 inhibits differentiation of monocytes to macrophages: Amelioration of synovial inflammation in rheumatoid arthritis
10.1007/s00109-016-1402-7 · 2016 · External reference
PU.1 serves a critical role in the innate defense against Aspergillus fumigatus via dendritic cell-associated C-type lectin receptor-1 and toll-like receptors-2 and 4 in THP-1-derived macrophages
10.3892/mmr.2017.6504 · 2017 · External reference
The ETS-family transcription factor PU.1 is a critical regulator of the inhibitory Fcgamma receptor IIB expression in humans
10.1093/jimmun/vkaf109 · 2025 · External reference
Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions
10.1073/pnas.92.12.5391 · 1995 · External reference
Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: A mechanism for phenotypic change to phagocytic cells
10.1128/mcb.16.5.2264 · 1996 · External reference
Overexpression of IRF8 and Pu.1 in B cells of systemic lupus erythematosus patients
10.1177/09612033251366400 · 2025 · External reference
MicroRNA-150 targets PU.1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis
10.1016/j.jneuroim.2018.06.010 · 2018 · External reference
PU.1 drives psoriasis pathogenesis by promoting intermediate monocytes-to-M1 macrophage differentiation through Dectin-1 signaling
10.1016/j.jaut.2026.103610 · 2026 · External reference
10.55563/clinexprheumatol/kd33az
10.55563/clinexprheumatol/kd33az · External reference
10.3389/fcell.2023.1204160
10.3389/fcell.2023.1204160 · External reference
PU.1 controls fibroblast polarization and tissue fibrosis
10.1038/s41586-019-0896-x · 2019 · External reference
Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis
10.1016/j.jhep.2020.02.025 · 2020 · External reference
PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II by reducing TGF-beta1/Smads pathway activation
10.1111/jcmm.16678 · 2021 · External reference
Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models
10.1016/j.neuron.2026.03.011 · 2026 · External reference
Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
10.7554/elife.105788 · 2025 · External reference
Lymphoid gene expression supports neuroprotective microglia function
10.1038/s41586-025-09662-z · 2025 · External reference
Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition
10.1007/s13238-018-0599-3 · 2019 · External reference
LncRNA Glelr modulates microglia inflammatory programs in association with PU.1
10.1016/j.nbd.2026.107366 · 2026 · External reference
PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids
10.1093/brain/awaf340 · 2026 · External reference
C9orf72 hexanucleotide repeat expansions impair microglial response in ALS
10.1038/s41593-025-02075-1 · 2025 · External reference
Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation
10.1002/adma.202309225 · 2024 · External reference
Pharmacological inhibition of the transcription factor PU.1 in leukemia
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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
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Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
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Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
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Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice
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Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
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PU.1 controls fibroblast polarization and tissue fibrosis
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C9orf72 hexanucleotide repeat expansions impair microglial response in ALS
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A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling
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Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPalpha
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PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells
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PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers
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Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation
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Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses
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CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling
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The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
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Scavenger receptor A gene regulatory elements target gene expression to macrophages and to foam cells of atherosclerotic lesions
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Co-crystallization of an ETS domain (PU.1) in complex with DNA. Engineering the length of both protein and oligonucleotide
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C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
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AKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domain
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Conserved ETS domain arginines mediate DNA binding, nuclear localization, and a novel mode of bZIP interaction
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The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1beta eRNA and mRNA transcription in mouse melanoma and macrophage cell lines
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The transcription factor PU.1 is involved in macrophage proliferation
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PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
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The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
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Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
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Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells
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PU.1 is degraded in differentiation of erythrocytes through a proteasome-dependent pathway
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PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids
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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
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Assembly requirements of PU.1-Pip (IRF-4) activator complexes: Inhibiting function in vivo using fused dimers
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The ETS-family transcription factor PU.1 is a critical regulator of the inhibitory Fcgamma receptor IIB expression in humans
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A critical role of the Erk1/2 downstream targets c-Fos, Egr-1, and Egr-2 in PU.1-driven monocyte development
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The conserved 5′-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo
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Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1
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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
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Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1
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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
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Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)
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Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells
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Decreased PU.1 expression in mature B cells induces lymphomagenesis
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PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II by reducing TGF-beta1/Smads pathway activation
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SPI1 involvement in malignant melanoma pathogenesis by regulation of HK2 through the AKT1/mTOR pathway
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Positive feedback between PU.1 and the cell cycle controls myeloid differentiation
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Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
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Regulation of B lymphocyte and macrophage development by graded expression of PU.1
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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
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Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation
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Coordination of Myeloid Differentiation with Reduced Cell Cycle Progression by PU.1 Induction of MicroRNAs Targeting Cell Cycle Regulators and Lipid Anabolism
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The Lineage-Specific Transcription Factor PU.1 Prevents Polycomb-Mediated Heterochromatin Formation at Macrophage-Specific Genes
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PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene
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Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: A mechanism for phenotypic change to phagocytic cells
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C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
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Normal myeloid development requires both the glutamine-rich transactivation domain and the PEST region of transcription factor PU.1 but not the potent acidic transactivation domain
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Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment
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Potential autoregulation of transcription factor PU.1 by an upstream regulatory element
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Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages
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Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth
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SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
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FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1
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A Recurrent Activating Missense Mutation in Waldenstrom Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation
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A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
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Pharmacological inhibition of the transcription factor PU.1 in leukemia
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Overexpression of IRF8 and Pu.1 in B cells of systemic lupus erythematosus patients
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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
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PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
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The development of functional B lymphocytes in conditional PU.1 knock-out mice
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Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
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C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment
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Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate
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Heterozygous deletion of the PU.1 locus in human AML
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Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells
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Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells
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RUNX1 regulates corepressor interactions of PU.1
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The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
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Macrophage development from HSCs requires PU.1-coordinated microRNA expression
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Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia
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Functional PU.1 in macrophages has a pivotal role in NF-kappaB activation and neutrophilic lung inflammation during endotoxemia
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PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells
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The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
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LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPalpha-dependent enhancers in AML
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