Research graph
References from Hypoxia Triggers BNIP3/BNIP3L-Associated Mitophagy in HT22 Immortalized Hippocampal Neurons: A Temporal Descriptive Study. Local targets link to admitted publications; unresolved targets remain external evidence.
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
10.1038/s41467-021-23508-y · 2021 · External reference
10.3389/fncel.2023.1277375
10.3389/fncel.2023.1277375 · External reference
Hypoxia causes mitochondrial dysfunction and brain memory disorder in a manner mediated by the reduction of Cirbp
10.1016/j.scitotenv.2021.151228 · 2022 · External reference
Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats
10.1155/2017/3214918 · 2017 · External reference
Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits
10.1186/s13041-021-00827-1 · 2021 · External reference
Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult
10.1038/s41418-024-01265-x · 2024 · External reference
CIRBP regulates mitochondrial respiratory function and modulates neuronal developmental abnormalities induced by perinatal hypoxia
10.1016/j.freeradbiomed.2025.05.412 · 2025 · External reference
High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α-astrocyte-SLC1A2 pathway
10.1186/s12974-026-03744-z · 2026 · External reference
10.3390/ijms232214094
10.3390/ijms232214094 · External reference
Mitochondrial Damage due to Hypoxia and Its Forensic Significance
2020 · External reference
Na(+) controls hypoxic signalling by the mitochondrial respiratory chain
10.1038/s41586-020-2551-y · 2020 · External reference
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions
2020 · External reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · 2012 · External reference
Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery
10.1080/15548627.2020.1755120 · 2021 · External reference
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
10.1038/s41598-022-26775-x · 2023 · External reference
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
10.1038/s41401-024-01292-x · 2024 · External reference
Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway
10.1016/j.brainres.2018.06.028 · 2018 · External reference
PINK1 overexpression protects against cerebral ischemia through Parkin regulation
10.1002/tox.22855 · 2020 · External reference
Intermittent Hypoxia Impairs Cognitive Function and Promotes Mitophagy and Lysophagy in Obstructive Sleep Apnea-Hypopnea Syndrome Rat Model
10.1007/s12033-024-01319-y · 2025 · External reference
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains
10.1080/15548627.2020.1802089 · 2021 · External reference
The mitophagy pathway and its implications in human diseases
10.1038/s41392-023-01503-7 · 2023 · External reference
Role of mitophagy in neonatal rats with hypoxic-ischemic brain damage
2017 · External reference
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
10.1093/hmg/ddr048 · 2011 · External reference
Mitochondrial function at extreme high altitude
10.1113/jp270079 · 2016 · External reference
AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia
2018 · External reference
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells
10.1016/j.bbadis.2017.07.018 · 2017 · External reference
Propofol via Antioxidant Property Attenuated Hypoxia-Mediated Mitochondrial Dynamic Imbalance and Malfunction in Primary Rat Hippocampal Neurons
10.1155/2022/6298786 · 2022 · External reference
10.3389/fimmu.2021.628168
10.3389/fimmu.2021.628168 · External reference
Methods in mammalian autophagy research
10.1016/j.cell.2010.01.028 · 2010 · External reference
Acetylcholine Attenuates Hypoxia/Reoxygenation Injury by Inducing Mitophagy Through PINK1/Parkin Signal Pathway in H9c2 Cells
10.1002/jcp.25215 · 2016 · External reference
Protective effect of resveratrol on rat cardiomyocyte H9C2 cells injured by hypoxia/reoxygenation by regulating mitochondrial autophagy PTEN-induced putative kinase protein 1/Parkinson disease protein 2 signaling pathway
2022 · External reference
Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia
10.1016/j.redox.2021.102047 · 2021 · External reference
10.3390/cells11071193
10.3390/cells11071193 · External reference
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy
10.1083/jcb.202204021 · 2023 · External reference
Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX
10.1016/j.bbamcr.2015.02.022 · 2015 · External reference
10.3389/fcell.2021.631016
10.3389/fcell.2021.631016 · External reference
The role of HIF-1α/BNIP3/mitophagy in acrylonitrile-induced neuronal death in HT22?cells and mice: A potential neuroprotection target
10.1016/j.cbi.2024.111327 · 2025 · External reference
MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy
10.1080/15548627.2017.1310789 · 2017 · External reference
ATG5: A central autophagy regulator implicated in various human diseases
10.1002/cbf.3740 · 2022 · External reference
The role of CK2 in the regulation of mitochondrial autophagy induced by rotenone
10.1016/j.toxlet.2023.05.002 · 2023 · External reference
Dental pulp stem cell secretome inhibits mitophagy-induced hippocampal neural injury during hypoxia
10.1016/j.freeradbiomed.2025.06.021 · 2025 · External reference
Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors
10.1038/s41420-025-02341-y · 2025 · External reference
Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation
10.1038/s41420-025-02933-8 · 2026 · External reference
PRKAA2-mediated mitophagy regulates oxygen consumption in yak renal tubular epithelial cells under chronic hypoxia
10.1016/j.cellsig.2024.111450 · 2024 · External reference
Effects of hypoxia combined with LPS on the expression of pro- inflammatory cytokines and BNIP3 in primary cultured astrocyte
2021 · External reference
ATG5: A central autophagy regulator implicated in various human diseases
10.1002/cbf.3740 · ExternalCitation · doi-reference
Acetylcholine Attenuates Hypoxia/Reoxygenation Injury by Inducing Mitophagy Through PINK1/Parkin Signal Pathway in H9c2 Cells
10.1002/jcp.25215 · ExternalCitation · doi-reference
PINK1 overexpression protects against cerebral ischemia through Parkin regulation
10.1002/tox.22855 · ExternalCitation · doi-reference
Intermittent Hypoxia Impairs Cognitive Function and Promotes Mitophagy and Lysophagy in Obstructive Sleep Apnea-Hypopnea Syndrome Rat Model
10.1007/s12033-024-01319-y · ExternalCitation · doi-reference
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells
10.1016/j.bbadis.2017.07.018 · ExternalCitation · doi-reference
Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX
10.1016/j.bbamcr.2015.02.022 · ExternalCitation · doi-reference
Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway
10.1016/j.brainres.2018.06.028 · ExternalCitation · doi-reference
The role of HIF-1α/BNIP3/mitophagy in acrylonitrile-induced neuronal death in HT22?cells and mice: A potential neuroprotection target
10.1016/j.cbi.2024.111327 · ExternalCitation · doi-reference
Methods in mammalian autophagy research
10.1016/j.cell.2010.01.028 · ExternalCitation · doi-reference
PRKAA2-mediated mitophagy regulates oxygen consumption in yak renal tubular epithelial cells under chronic hypoxia
10.1016/j.cellsig.2024.111450 · ExternalCitation · doi-reference
CIRBP regulates mitochondrial respiratory function and modulates neuronal developmental abnormalities induced by perinatal hypoxia
10.1016/j.freeradbiomed.2025.05.412 · ExternalCitation · doi-reference
Dental pulp stem cell secretome inhibits mitophagy-induced hippocampal neural injury during hypoxia
10.1016/j.freeradbiomed.2025.06.021 · ExternalCitation · doi-reference
Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia
10.1016/j.redox.2021.102047 · ExternalCitation · doi-reference
Hypoxia causes mitochondrial dysfunction and brain memory disorder in a manner mediated by the reduction of Cirbp
10.1016/j.scitotenv.2021.151228 · ExternalCitation · doi-reference
The role of CK2 in the regulation of mitochondrial autophagy induced by rotenone
10.1016/j.toxlet.2023.05.002 · ExternalCitation · doi-reference
The mitophagy pathway and its implications in human diseases
10.1038/s41392-023-01503-7 · ExternalCitation · doi-reference
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
10.1038/s41401-024-01292-x · ExternalCitation · doi-reference
Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult
10.1038/s41418-024-01265-x · ExternalCitation · doi-reference
Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors
10.1038/s41420-025-02341-y · ExternalCitation · doi-reference
Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation
10.1038/s41420-025-02933-8 · ExternalCitation · doi-reference
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
10.1038/s41467-021-23508-y · ExternalCitation · doi-reference
Na(+) controls hypoxic signalling by the mitochondrial respiratory chain
10.1038/s41586-020-2551-y · ExternalCitation · doi-reference
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
10.1038/s41598-022-26775-x · ExternalCitation · doi-reference
MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy
10.1080/15548627.2017.1310789 · ExternalCitation · doi-reference
Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery
10.1080/15548627.2020.1755120 · ExternalCitation · doi-reference
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains
10.1080/15548627.2020.1802089 · ExternalCitation · doi-reference
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy
10.1083/jcb.202204021 · ExternalCitation · doi-reference
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
10.1093/hmg/ddr048 · ExternalCitation · doi-reference
Mitochondrial function at extreme high altitude
10.1113/jp270079 · ExternalCitation · doi-reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · ExternalCitation · doi-reference
Effect of Endogenous Arginine-Vasopressin Arising from the Paraventricular Nucleus on Learning and Memory Functions in Vascular Dementia Model Rats
10.1155/2017/3214918 · ExternalCitation · doi-reference
Propofol via Antioxidant Property Attenuated Hypoxia-Mediated Mitochondrial Dynamic Imbalance and Malfunction in Primary Rat Hippocampal Neurons
10.1155/2022/6298786 · ExternalCitation · doi-reference
High-altitude hypoxia drives dentate gyrus neuronal vulnerability through an IL1α-astrocyte-SLC1A2 pathway
10.1186/s12974-026-03744-z · ExternalCitation · doi-reference
Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits
10.1186/s13041-021-00827-1 · ExternalCitation · doi-reference
10.3389/fcell.2021.631016
10.3389/fcell.2021.631016 · ExternalCitation · doi-reference
10.3389/fimmu.2021.628168
10.3389/fimmu.2021.628168 · ExternalCitation · doi-reference
10.3389/fncel.2023.1277375
10.3389/fncel.2023.1277375 · ExternalCitation · doi-reference
10.3390/cells11071193
10.3390/cells11071193 · ExternalCitation · doi-reference
10.3390/ijms232214094
10.3390/ijms232214094 · ExternalCitation · doi-reference
