Research graph
References from Outside-In Signaling as a Detonator-like Stimulus of Integrin Activation by Promoting Both Affinity and Avidity. Local targets link to admitted publications; unresolved targets remain external evidence.
Embryonic mesodermal defects in alpha 5 integrin-deficient mice
10.1242/dev.119.4.1093 · 1993 · External reference
Mystery solved: Discovery of a novel integrin ligand in the developing kidney
10.1083/jcb.200106124 · 2001 · External reference
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
10.1083/jcb.134.2.559 · 1996 · External reference
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
10.1083/jcb.137.3.729 · 1997 · External reference
Integrin signalling regulates YAP and TAZ to control skin homeostasis
2016 · External reference
Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure
10.1161/hh0402.105790 · 2002 · External reference
Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle
10.1016/s0022-510x(99)00012-x · 1999 · External reference
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy
10.1093/hmg/ddl018 · 2006 · External reference
Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling
10.1055/s-0037-1616222 · 2001 · External reference
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin “outside-in” signaling
10.1126/science.1174779 · 2010 · External reference
A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes
10.1073/pnas.93.20.11019 · 1996 · External reference
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
10.1016/0092-8674(93)90305-a · 1993 · External reference
10.3390/ijms24076331
10.3390/ijms24076331 · External reference
Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
10.1083/jcb.131.3.791 · 1995 · External reference
Beta1-integrin orients epithelial polarity via Rac1 and laminin
10.1091/mbc.e04-05-0435 · 2005 · External reference
Disruption of epithelial cell-matrix interactions induces apoptosis
10.1083/jcb.124.4.619 · 1994 · External reference
A dual role for talin in NK cell cytotoxicity: Activation of LFA-1-mediated cell adhesion and polarization of NK cells
10.4049/jimmunol.182.2.948 · 2009 · External reference
10.3390/cells11111751
10.3390/cells11111751 · External reference
Integrins: Bidirectional, allosteric signalling machines
10.1016/s0092-8674(02)00971-6 · 2002 · External reference
Structural basis of integrin regulation and signaling
10.1146/annurev.immunol.25.022106.141618 · 2007 · External reference
Conformational equilibria and intrinsic affinities define integrin activation
10.15252/embj.201695803 · 2017 · External reference
Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS
10.1091/mbc.e21-11-0536 · 2022 · External reference
Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
10.1182/blood-2011-08-373118 · 2012 · External reference
NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization
10.1128/mcb.00424-16 · 2017 · External reference
Ligand binding initiates single-molecule integrin conformational activation
10.1016/j.cell.2024.04.049 · 2024 · External reference
Ligands “activate” integrin alpha IIb beta 3 (platelet GPIIb-IIIa)
10.1016/0092-8674(91)90458-b · 1991 · External reference
Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state
10.4049/jimmunol.1002246 · 2010 · External reference
Measuring integrin conformational change on the cell surface with super-resolution microscopy
10.1016/j.celrep.2018.01.062 · 2018 · External reference
The nonconserved integrin cytoplasmic region determines integrin subtype-specific characteristics by modulating talin1 binding kinetics
10.1016/j.jbc.2025.110793 · 2025 · External reference
Integrin avidity regulation: Are changes in affinity and conformation underemphasized?
10.1016/j.ceb.2003.08.003 · 2003 · External reference
Regulation of integrin activity and signalling
10.1016/j.bbagen.2009.03.007 · 2009 · External reference
Mechanism of integrin activation by talin and its cooperation with kindlin
10.1038/s41467-022-30117-w · 2022 · External reference
Talin and kindlin cooperate to control the density of integrin clusters
10.1242/jcs.260746 · 2023 · External reference
Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion
10.1073/pnas.1116425109 · 2012 · External reference
Affinity, lateral mobility, and clustering contribute independently to beta 2-integrin-mediated adhesion
10.1152/ajpcell.00039.2009 · 2010 · External reference
Intracellular signalling controlling integrin activation in lymphocytes
10.1038/nri1646 · 2005 · External reference
Integrin regulation
10.1016/j.ceb.2005.08.010 · 2005 · External reference
Integrin inside-out signaling and the immunological synapse
10.1016/j.ceb.2011.10.004 · 2012 · External reference
Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1
10.1126/scisignal.abf2184 · 2021 · External reference
Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
10.1038/s41467-017-01822-8 · 2017 · External reference
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences
10.1074/jbc.m807117200 · 2009 · External reference
Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion
10.1038/ncomms6880 · 2014 · External reference
The tail of integrins, talin, and kindlins
10.1126/science.1163865 · 2009 · External reference
Integrin activation by talin, kindlin and mechanical forces
10.1038/s41556-018-0234-9 · 2019 · External reference
Talin and kindlin use integrin tail allostery and direct binding to activate integrins
10.1038/s41594-023-01139-9 · 2023 · External reference
Genetic and cell biological analysis of integrin outside-in signaling
10.1101/gad.1758709 · 2009 · External reference
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration
10.4161/sgtp.27958 · 2014 · External reference
Integrin signaling to the actin cytoskeleton
10.1016/s0955-0674(03)00109-1 · 2003 · External reference
Adhesion signaling—Crosstalk between integrins, Src and Rho
10.1242/jcs.039446 · 2009 · External reference
Functional atlas of the integrin adhesome
10.1038/ncb0807-858 · 2007 · External reference
Nanoscale architecture of integrin-based cell adhesions
10.1038/nature09621 · 2010 · External reference
Integrin signalling at a glance
10.1242/jcs.018093 · 2009 · External reference
New perspectives on integrin-dependent adhesions
10.1016/j.ceb.2019.12.008 · 2020 · External reference
Focal adhesion kinase in integrin signaling
10.1016/s0945-053x(97)90008-1 · 1997 · External reference
Focal adhesions are sites of integrin extension
10.1083/jcb.200907174 · 2010 · External reference
Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
10.1083/jcb.201707075 · 2018 · External reference
Vinculin controls focal adhesion formation by direct interactions with talin and actin
10.1083/jcb.200703036 · 2007 · External reference
Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond
10.1073/pnas.2218116120 · 2023 · External reference
Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
10.1038/s41467-021-23372-w · 2021 · External reference
Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion
10.1038/s41467-021-21142-2 · 2021 · External reference
Cas phosphorylation regulates focal adhesion assembly
10.7554/elife.90234 · 2023 · External reference
Integrins in immunity
10.1242/jcs.019117 · 2009 · External reference
Integrins: Dynamic scaffolds for adhesion and signaling in platelets
10.1182/blood-2004-04-1257 · 2004 · External reference
CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion
10.1002/(sici)1521-4141(199808)28:08<2331::aid-immu2331>3.0.co;2-c · 1998 · External reference
T-cell integrins: More than just sticking points
10.1242/jcs.00876 · 2003 · External reference
Three-dimensional segregation of supramolecular activation clusters in T cells
10.1038/25764 · 1998 · External reference
The immunological synapse: A molecular machine controlling T cell activation
10.1126/science.285.5425.221 · 1999 · External reference
Low-affinity LFA1-dependent outside-in signaling mediates avidity modulation via the Rabin8-Rab8 axis
10.1093/pnasnexus/pgae332 · 2024 · External reference
The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling
10.1038/s41467-025-56631-1 · 2025 · External reference
Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling
10.1073/pnas.2032886100 · 2003 · External reference
Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling
10.1074/jbc.m111.239608 · 2011 · External reference
A mechanism of platelet integrin αIIbβ3 outside-in signaling through a novel integrin αIIb subunit-filamin-actin linkage
2023 · External reference
Shear and integrin outside-in signaling activate NADPH-oxidase 2 to promote platelet activation
10.1161/atvbaha.120.315773 · 2021 · External reference
Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking
10.1126/scisignal.2005199 · 2014 · External reference
A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation
10.1083/jcb.201609072 · 2017 · External reference
Distinct recycling of active and inactive β1 integrins
10.1111/j.1600-0854.2012.01327.x · 2012 · External reference
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
10.1016/j.devcel.2025.06.025 · 2025 · External reference
PDGF-regulated Rab4-dependent recycling of αVβ3 integrin from early endosomes is necessary for cell adhesion and spreading
10.1016/s0960-9822(01)00442-0 · 2001 · External reference
Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
10.1186/s12964-024-02024-8 · 2025 · External reference
Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6
10.1002/advs.202501078 · 2025 · External reference
Vitronectin-αvβ3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells
10.1158/0008-5472.can-13-0218 · 2013 · External reference
Ligand-occupied integrin internalization links nutrient signaling to invasive migration
10.1016/j.celrep.2014.12.037 · 2015 · External reference
Starved epithelial cells uptake extracellular matrix for survival
10.1038/ncomms13989 · 2017 · External reference
10.3390/ijms242216062
10.3390/ijms242216062 · External reference
Demonstration of catch bonds between an integrin and its ligand
10.1083/jcb.200810002 · 2009 · External reference
Forcing switch from short- to intermediate- and long-lived states of the αA domain generates LFA-1/ICAM-1 catch bonds
10.1074/jbc.m110.155770 · 2010 · External reference
Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3
10.1021/acsnano.3c06253 · 2024 · External reference
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αVβ6-dependent physical force
10.1016/j.yexcr.2012.01.020 · 2012 · External reference
Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β
10.1016/j.cell.2019.12.030 · 2020 · External reference
Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation
10.1083/jcb.201710022 · 2018 · External reference
Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interaction
10.1038/s41598-019-42002-6 · 2019 · External reference
General structural features that regulate integrin affinity revealed by atypical αVβ8
10.1038/s41467-019-13248-5 · 2019 · External reference
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
10.1084/jem.192.4.495 · 2000 · External reference
RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes
10.1126/scisignal.aai8629 · 2017 · External reference
Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration
2013 · External reference
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
10.1038/emboj.2010.74 · 2010 · External reference
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation
10.1083/jcb.201607039 · 2016 · External reference
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes
10.15252/embj.201797840 · 2018 · External reference
Beyond autophagy: LC3-associated phagocytosis and endocytosis
10.1126/sciadv.abn1702 · 2022 · External reference
LC3-associated endocytosis and the functions of Rubicon and ATG16L1
10.1126/sciadv.abo5600 · 2022 · External reference
Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism
10.1126/sciadv.abo1274 · 2022 · External reference
A guide to membrane atg8ylation and autophagy with reflections on immunity
10.1083/jcb.202203083 · 2022 · External reference
Caveolae couple mechanical stress to integrin recycling and activation
10.7554/elife.82348 · 2022 · External reference
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
10.1038/ncb2152 · 2011 · External reference
MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway
10.1016/j.bbrc.2008.02.093 · 2008 · External reference
AMPK negatively regulates tensin-dependent integrin activity
10.1083/jcb.201609066 · 2017 · External reference
AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration
10.1038/s41467-023-38292-0 · 2023 · External reference
10.3390/ijms23031825
10.3390/ijms23031825 · External reference
Cargo-selective regulation of clathrin-mediated endocytosis by AMP-activated protein kinase
10.1016/j.isci.2025.113131 · 2025 · External reference
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
10.1083/jcb.201406121 · 2015 · External reference
Coordinated integrin activation by actin-dependent force during T-cell migration
10.1038/ncomms13119 · 2016 · External reference
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
10.1038/356063a0 · 1992 · External reference
Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes
10.4049/jimmunol.149.4.1424 · 1992 · External reference
A novel targeted T-cell modulator, efalizumab, for plaque psoriasis
10.1056/nejmoa030002 · 2003 · External reference
Vedolizumab as induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa1215734 · 2013 · External reference
Vedolizumab as induction and maintenance therapy for Crohn’s disease
10.1056/nejmoa1215739 · 2013 · External reference
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
10.1056/nejmoa044397 · 2006 · External reference
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
10.1056/nejmoa051782 · 2005 · External reference
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease
10.1056/nejmoa051586 · 2005 · External reference
Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients
10.1016/j.jaad.2010.05.033 · 2011 · External reference
A mechanism for antibody-mediated outside-in activation of LFA-1
10.1074/jbc.m704699200 · 2008 · External reference
10.1371/journal.pone.0052208
10.1371/journal.pone.0052208 · External reference
CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion
10.1002/(sici)1521-4141(199808)28:08<2331::aid-immu2331>3.0.co;2-c · ExternalCitation · doi-reference
Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6
10.1002/advs.202501078 · ExternalCitation · doi-reference
Ligands “activate” integrin alpha IIb beta 3 (platelet GPIIb-IIIa)
10.1016/0092-8674(91)90458-b · ExternalCitation · doi-reference
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
10.1016/0092-8674(93)90305-a · ExternalCitation · doi-reference
Regulation of integrin activity and signalling
10.1016/j.bbagen.2009.03.007 · ExternalCitation · doi-reference
MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway
10.1016/j.bbrc.2008.02.093 · ExternalCitation · doi-reference
Integrin avidity regulation: Are changes in affinity and conformation underemphasized?
10.1016/j.ceb.2003.08.003 · ExternalCitation · doi-reference
Integrin regulation
10.1016/j.ceb.2005.08.010 · ExternalCitation · doi-reference
Integrin inside-out signaling and the immunological synapse
10.1016/j.ceb.2011.10.004 · ExternalCitation · doi-reference
New perspectives on integrin-dependent adhesions
10.1016/j.ceb.2019.12.008 · ExternalCitation · doi-reference
Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β
10.1016/j.cell.2019.12.030 · ExternalCitation · doi-reference
Ligand binding initiates single-molecule integrin conformational activation
10.1016/j.cell.2024.04.049 · ExternalCitation · doi-reference
Ligand-occupied integrin internalization links nutrient signaling to invasive migration
10.1016/j.celrep.2014.12.037 · ExternalCitation · doi-reference
Measuring integrin conformational change on the cell surface with super-resolution microscopy
10.1016/j.celrep.2018.01.062 · ExternalCitation · doi-reference
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
10.1016/j.devcel.2025.06.025 · ExternalCitation · doi-reference
Cargo-selective regulation of clathrin-mediated endocytosis by AMP-activated protein kinase
10.1016/j.isci.2025.113131 · ExternalCitation · doi-reference
Progressive multifocal leukoencephalopathy associated with efalizumab use in psoriasis patients
10.1016/j.jaad.2010.05.033 · ExternalCitation · doi-reference
The nonconserved integrin cytoplasmic region determines integrin subtype-specific characteristics by modulating talin1 binding kinetics
10.1016/j.jbc.2025.110793 · ExternalCitation · doi-reference
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αVβ6-dependent physical force
10.1016/j.yexcr.2012.01.020 · ExternalCitation · doi-reference
Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle
10.1016/s0022-510x(99)00012-x · ExternalCitation · doi-reference
Integrins: Bidirectional, allosteric signalling machines
10.1016/s0092-8674(02)00971-6 · ExternalCitation · doi-reference
Focal adhesion kinase in integrin signaling
10.1016/s0945-053x(97)90008-1 · ExternalCitation · doi-reference
Integrin signaling to the actin cytoskeleton
10.1016/s0955-0674(03)00109-1 · ExternalCitation · doi-reference
PDGF-regulated Rab4-dependent recycling of αVβ3 integrin from early endosomes is necessary for cell adhesion and spreading
10.1016/s0960-9822(01)00442-0 · ExternalCitation · doi-reference
Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3
10.1021/acsnano.3c06253 · ExternalCitation · doi-reference
Three-dimensional segregation of supramolecular activation clusters in T cells
10.1038/25764 · ExternalCitation · doi-reference
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
10.1038/356063a0 · ExternalCitation · doi-reference
LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis
10.1038/emboj.2010.74 · ExternalCitation · doi-reference
Nanoscale architecture of integrin-based cell adhesions
10.1038/nature09621 · ExternalCitation · doi-reference
Functional atlas of the integrin adhesome
10.1038/ncb0807-858 · ExternalCitation · doi-reference
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
10.1038/ncb2152 · ExternalCitation · doi-reference
Coordinated integrin activation by actin-dependent force during T-cell migration
10.1038/ncomms13119 · ExternalCitation · doi-reference
Starved epithelial cells uptake extracellular matrix for survival
10.1038/ncomms13989 · ExternalCitation · doi-reference
Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion
10.1038/ncomms6880 · ExternalCitation · doi-reference
Intracellular signalling controlling integrin activation in lymphocytes
10.1038/nri1646 · ExternalCitation · doi-reference
Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
10.1038/s41467-017-01822-8 · ExternalCitation · doi-reference
General structural features that regulate integrin affinity revealed by atypical αVβ8
10.1038/s41467-019-13248-5 · ExternalCitation · doi-reference
Quantitative single-protein imaging reveals molecular complex formation of integrin, talin, and kindlin during cell adhesion
10.1038/s41467-021-21142-2 · ExternalCitation · doi-reference
Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions
10.1038/s41467-021-23372-w · ExternalCitation · doi-reference
Mechanism of integrin activation by talin and its cooperation with kindlin
10.1038/s41467-022-30117-w · ExternalCitation · doi-reference
AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration
10.1038/s41467-023-38292-0 · ExternalCitation · doi-reference
The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling
10.1038/s41467-025-56631-1 · ExternalCitation · doi-reference
Integrin activation by talin, kindlin and mechanical forces
10.1038/s41556-018-0234-9 · ExternalCitation · doi-reference
Talin and kindlin use integrin tail allostery and direct binding to activate integrins
10.1038/s41594-023-01139-9 · ExternalCitation · doi-reference
Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interaction
10.1038/s41598-019-42002-6 · ExternalCitation · doi-reference
Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling
10.1055/s-0037-1616222 · ExternalCitation · doi-reference
A novel targeted T-cell modulator, efalizumab, for plaque psoriasis
10.1056/nejmoa030002 · ExternalCitation · doi-reference
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
10.1056/nejmoa044397 · ExternalCitation · doi-reference
Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn’s disease
10.1056/nejmoa051586 · ExternalCitation · doi-reference
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
10.1056/nejmoa051782 · ExternalCitation · doi-reference
Vedolizumab as induction and maintenance therapy for ulcerative colitis
10.1056/nejmoa1215734 · ExternalCitation · doi-reference
Vedolizumab as induction and maintenance therapy for Crohn’s disease
10.1056/nejmoa1215739 · ExternalCitation · doi-reference
Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion
10.1073/pnas.1116425109 · ExternalCitation · doi-reference
Soluble CD40 ligand induces beta3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling
10.1073/pnas.2032886100 · ExternalCitation · doi-reference
Kindlin stabilizes the talin·integrin bond under mechanical load by generating an ideal bond
10.1073/pnas.2218116120 · ExternalCitation · doi-reference
A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes
10.1073/pnas.93.20.11019 · ExternalCitation · doi-reference
Forcing switch from short- to intermediate- and long-lived states of the αA domain generates LFA-1/ICAM-1 catch bonds
10.1074/jbc.m110.155770 · ExternalCitation · doi-reference
Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling
10.1074/jbc.m111.239608 · ExternalCitation · doi-reference
A mechanism for antibody-mediated outside-in activation of LFA-1
10.1074/jbc.m704699200 · ExternalCitation · doi-reference
RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences
10.1074/jbc.m807117200 · ExternalCitation · doi-reference
Disruption of epithelial cell-matrix interactions induces apoptosis
10.1083/jcb.124.4.619 · ExternalCitation · doi-reference
Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
10.1083/jcb.131.3.791 · ExternalCitation · doi-reference
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
10.1083/jcb.134.2.559 · ExternalCitation · doi-reference
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
10.1083/jcb.137.3.729 · ExternalCitation · doi-reference
Mystery solved: Discovery of a novel integrin ligand in the developing kidney
10.1083/jcb.200106124 · ExternalCitation · doi-reference
Vinculin controls focal adhesion formation by direct interactions with talin and actin
10.1083/jcb.200703036 · ExternalCitation · doi-reference
Demonstration of catch bonds between an integrin and its ligand
10.1083/jcb.200810002 · ExternalCitation · doi-reference
Focal adhesions are sites of integrin extension
10.1083/jcb.200907174 · ExternalCitation · doi-reference
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
10.1083/jcb.201406121 · ExternalCitation · doi-reference
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation
10.1083/jcb.201607039 · ExternalCitation · doi-reference
AMPK negatively regulates tensin-dependent integrin activity
10.1083/jcb.201609066 · ExternalCitation · doi-reference
A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation
10.1083/jcb.201609072 · ExternalCitation · doi-reference
Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
10.1083/jcb.201707075 · ExternalCitation · doi-reference
Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation
10.1083/jcb.201710022 · ExternalCitation · doi-reference
A guide to membrane atg8ylation and autophagy with reflections on immunity
10.1083/jcb.202203083 · ExternalCitation · doi-reference
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
10.1084/jem.192.4.495 · ExternalCitation · doi-reference
Beta1-integrin orients epithelial polarity via Rac1 and laminin
10.1091/mbc.e04-05-0435 · ExternalCitation · doi-reference
Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS
10.1091/mbc.e21-11-0536 · ExternalCitation · doi-reference
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy
10.1093/hmg/ddl018 · ExternalCitation · doi-reference
Low-affinity LFA1-dependent outside-in signaling mediates avidity modulation via the Rabin8-Rab8 axis
10.1093/pnasnexus/pgae332 · ExternalCitation · doi-reference
Genetic and cell biological analysis of integrin outside-in signaling
10.1101/gad.1758709 · ExternalCitation · doi-reference
Distinct recycling of active and inactive β1 integrins
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