Research graph
References from Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules. Local targets link to admitted publications; unresolved targets remain external evidence.
DHA Laden Liposome Incorporated HA-Menthol-CD Host-Guest Hydrogels as Delivery System for Osteoarthritis Treatment
10.1016/j.ijbiomac.2025.147650 · 2025 · External reference
Models of Osteoarthritis: Relevance and New Insights
10.1007/s00223-020-00670-x · 2021 · External reference
Yiqi Xugu HeJi Restores Cartilage Metabolic Homeostasis via AKT1-Thr473 Activation in Osteoarthritis
10.1016/j.phymed.2025.157228 · 2025 · External reference
10.3389/fcell.2022.1092776
10.3389/fcell.2022.1092776 · External reference
SUMO-Modified Bone Marrow Mesenchymal Stem Cells Promoted the Repair of Articular Cartilage in Rats
10.1002/cbin.11256 · 2020 · External reference
Expression of MiR-204 in Patients with Osteoarthritis and Its Damage to Chondrocytes
2020 · External reference
Association of Osteoarthritis With Increased Risk of Cardiovascular Diseases in the Elderly: Findings From the Progetto Veneto Anziano Study Cohort
10.1002/art.39564 · 2016 · External reference
Association between Osteoarthritis and Cardiovascular Disease: Systematic Review and Meta-Analysis
10.1177/2047487315610663 · 2016 · External reference
10.1186/s12891-022-05712-z
10.1186/s12891-022-05712-z · External reference
Epidemiological Study on the Prevalence and Severity of Knee Osteoarthritis in Geriatric Patients With Fragility Fractures of the Hip
2025 · External reference
High Prevalence of Symptomatic Knee Osteoarthritis Among Patients Who Have Fragility Hip Fractures
10.1016/j.arth.2025.01.016 · 2025 · External reference
Osteoarthritis Year in Review 2024: Epidemiology and Therapy
10.1016/j.joca.2024.07.014 · 2024 · External reference
10.3389/fimmu.2024.1331934
10.3389/fimmu.2024.1331934 · External reference
10.3389/fmed.2024.1476853
10.3389/fmed.2024.1476853 · External reference
Differences in Ankle and Knee Muscle Architecture and Plantar Pressure Distribution among Women with Knee Osteoarthritis
10.1002/jfa2.12028 · 2024 · External reference
Identification of CaMK4 as a Sex-Difference-Related Gene in Knee Osteoarthritis
10.21037/atm-22-4284 · 2023 · External reference
Osteoarthritis in 2020 and beyond: A Lancet Commission
10.1016/s0140-6736(20)32230-3 · 2020 · External reference
Clinical and Radiographic Features of Knee Osteoarthritis of Elderly Patients
10.2174/1573397113666170425150133 · 2018 · External reference
The GSK-3β/Β-catenin Signaling Pathway Is Involved in HMGB1-induced Chondrocyte Apoptosis and Cartilage Matrix Degradation
2020 · External reference
Uncovering Causal Genetic Mediators Linking Redefined Obesity to Osteoarthritis: Multidimensional Analysis from Population to Genetic Mechanisms
10.1016/j.joca.2025.11.003 · 2025 · External reference
Global Burden of Early-Onset Osteoarthritis, 1990–2019: Results from the Global Burden of Disease Study 2019
10.1136/ard-2023-225324 · 2024 · External reference
10.1186/s12889-018-5381-1
10.1186/s12889-018-5381-1 · External reference
Intersectional Racial, Ethnic, and Sex-Based Disparities in Length of Stay after Total Hip and Knee Arthroplasty: An Analysis of National Data
10.1016/j.joca.2025.10.016 · 2025 · External reference
The Burden of OA-Health Services and Economics
10.1016/j.joca.2021.05.007 · 2022 · External reference
Advances in Osteoarthritis Research: From Diagnosis, Treatment to Mechanism Studies
2024 · External reference
10.3390/biom13040580
10.3390/biom13040580 · External reference
Changes of Type II Collagenase Biomarkers on IL-1β-Induced Rat Articular Chondrocytes
10.3892/etm.2021.10014 · 2021 · External reference
Chinese guidelines for diagnosis and treatment of osteoarthritis (2024 edition)
2024 · External reference
A Comprehensive Review on the Advancements of Dual COX-2/5-LOX Inhibitors as Anti-Inflammatory Drugs
10.1111/cbdd.70114 · 2025 · External reference
Long-Term Effects of Infrapatellar Fat Pad SVF Infiltration in Knee Osteoarthritis Management: A Prospective Cohort Study
10.1016/j.bonr.2025.101827 · 2025 · External reference
10.3389/fendo.2025.1593658
10.3389/fendo.2025.1593658 · External reference
Hip Osteoarthritis: A Novel Network Analysis of Subchondral Trabecular Bone Structures
10.1093/pnasnexus/pgac258 · 2022 · External reference
Advantages of Pure Platelet-Rich Plasma Compared with Leukocyte- and Platelet-Rich Plasma in Treating Rabbit Knee Osteoarthritis
10.12659/msm.898218 · 2016 · External reference
Molecular Pathogenesis of OA Pain: Past, Present, and Future
10.1016/j.joca.2024.01.005 · 2024 · External reference
Exercise Interventions and Patient Beliefs for People with Hip, Knee or Hip and Knee Osteoarthritis: A Mixed Methods Review
2018 · External reference
Exercise for Osteoarthritis of the Knee
2015 · External reference
Self-Management Education Programmes for Osteoarthritis
2014 · External reference
Kinematic and Dynamic Analysis of an Anatomically Based Knee Joint
10.1016/j.jbiomech.2010.02.001 · 2010 · External reference
Lower Limb Joint Loading during High-Impact Activities: Implication for Bone Health
10.1093/jbmrpl/ziae119 · 2024 · External reference
What Are the Prognostic Factors for Radiographic Progression of Knee Osteoarthritis? A Meta-Analysis
10.1007/s11999-015-4349-z · 2015 · External reference
Prioritization of Patient-Centered Comparative Effectiveness Research for Osteoarthritis
10.7326/m14-0318 · 2014 · External reference
Expressing Pain and Fatigue: A New Method of Analysis to Explore Differences in Osteoarthritis Experience
10.1002/art.24273 · 2009 · External reference
Pain Distribution in Primary Care Patients with Hip Osteoarthritis
10.1093/fampra/cmw071 · 2016 · External reference
10.3389/fonc.2021.745808
10.3389/fonc.2021.745808 · External reference
Advances in Multi-Omics and Therapeutic Studies of Henoch-Schönlein Purpura
10.1186/s13052-025-02174-6 · 2025 · External reference
10.3390/microorganisms12071380
10.3390/microorganisms12071380 · External reference
Transcriptomics in the RNA-Seq Era
10.1016/j.cbpa.2012.12.008 · 2013 · External reference
10.1371/journal.pcbi.1005457
10.1371/journal.pcbi.1005457 · External reference
Transcriptomics: Advances and Approaches
10.1007/s11427-013-4557-2 · 2013 · External reference
A Review of DNA Sequencing Techniques
10.1017/s0033583502003797 · 2002 · External reference
Long Walk to Genomics: History and Current Approaches to Genome Sequencing and Assembly
10.1016/j.csbj.2019.11.002 · 2020 · External reference
K-Mer Spectrum-Based Error Correction Algorithm for Next-Generation Sequencing Data
10.1155/2022/8077664 · 2022 · External reference
RNA-Seq: A Revolutionary Tool for Transcriptomics
10.1038/nrg2484 · 2009 · External reference
Unresolved reference
External reference
Slide-Seq: A Scalable Technology for Measuring Genome-Wide Expression at High Spatial Resolution
10.1126/science.aaw1219 · 2019 · External reference
High-Definition Spatial Transcriptomic Profiling of Immune Cell Populations in Colorectal Cancer
10.1038/s41588-025-02193-3 · 2025 · External reference
Open-ST: High-Resolution Spatial Transcriptomics in 3D
10.1016/j.cell.2024.05.055 · 2024 · External reference
Evolution of Comparative Transcriptomics: Biological Scales, Phylogenetic Spans, and Modeling Frameworks
10.1016/j.gde.2025.102387 · 2025 · External reference
Proteomics: Technologies and Their Applications
10.1093/chromsci/bmw167 · 2017 · External reference
10.3389/fpls.2023.1305381
10.3389/fpls.2023.1305381 · External reference
10.3390/ijns9010015
10.3390/ijns9010015 · External reference
Proteomics to Study Genes and Genomes
10.1038/35015709 · 2000 · External reference
Comparative Proteomics of CcRCC Cell Lines to Identify Kidney Cancer Progression Factors
10.21873/cgp.20480 · 2024 · External reference
Lung Cancer Proteomics: Recent Advances in Biomarker Discovery
10.1155/2011/726869 · 2011 · External reference
10.3389/fonc.2023.1166207
10.3389/fonc.2023.1166207 · External reference
10.3390/biomedicines12010001
10.3390/biomedicines12010001 · External reference
Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review
10.1111/jre.13357 · 2025 · External reference
Current Two-dimensional Electrophoresis Technology for Proteomics
10.1002/pmic.200401031 · 2004 · External reference
The Evolution of Two-Dimensional Gel Electrophoresis—From Proteomics to Emerging Alternative Applications
10.1016/j.chroma.2019.460763 · 2020 · External reference
Unveiling Molecular Mechanisms of Pepper Resistance to Phytophthora Capsici through Grafting Using ITRAQ-Based Proteomic Analysis
10.1038/s41598-024-55596-3 · 2024 · External reference
Comparing SILAC and Two-Dimensional Gel Electrophoresis Image Analysis for Profiling Urokinase Plasminogen Activator Signaling in Ovarian Cancer Cells
10.1021/pr060638v · 2007 · External reference
Temporal Proteomic Profiling via 4D-DIA Reveals Early Defense Mechanisms and Core Resistance Determinants in Soybean against Phakopsora Pachyrhizi
10.1007/s44154-025-00268-z · 2025 · External reference
The Use of a Quantitative Cysteinyl-Peptide Enrichment Technology for High-Throughput Quantitative Proteomics
10.1007/978-1-59745-255-7_7 · 2007 · External reference
Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules
10.1089/nsm.2020.0009 · 2020 · External reference
LC-MS/MS-Based Targeted Proteomics Quantitatively Detects the Interaction between P53 and MDM2 in Breast Cancer
10.1016/j.jprot.2016.11.002 · 2017 · External reference
Targeted Liquid Chromatography-tandem Mass Spectrometry Analysis of Proteins: Basic Principles, Applications, and Perspectives
10.1002/pmic.202100153 · 2021 · External reference
Synthetic Peptide Arrays for Pathway-Level Protein Monitoring by Liquid Chromatography-Tandem Mass Spectrometry
10.1074/mcp.m900456-mcp200 · 2010 · External reference
Mass Spectrometric Analysis of Protein Mixtures at Low Levels Using Cleavable 13C-Isotope-Coded Affinity Tag and Multidimensional Chromatography
10.1074/mcp.m300021-mcp200 · 2003 · External reference
Toward a Human Blood Serum Proteome
10.1074/mcp.m200066-mcp200 · 2002 · External reference
10.3389/fcell.2021.751371
10.3389/fcell.2021.751371 · External reference
Genome-Wide Analysis of Protein and MRNA Copy Numbers in Single Escherichia Coli Cells with Single-Molecule Sensitivity
10.1007/978-1-4939-2987-0_5 · 2015 · External reference
Mass Spectrometry Imaging-Based Single-Cell Lipidomics Profiles Metabolic Signatures of Heart Failure
10.34133/research.0019 · 2023 · External reference
Functional Single-Cell Proteomics: Technology and Biological Applications
10.1007/978-1-0716-4402-7_9 · 2025 · External reference
Mass-Spectrometry-Based Proteomics: From Single Cells to Clinical Applications
10.1038/s41586-025-08584-0 · 2025 · External reference
Advances and Challenges in Liquid Chromatography-Mass Spectrometry-Based Proteomics Profiling for Clinical Applications
10.1074/mcp.m600162-mcp200 · 2006 · External reference
Identification of the Pathogenic Pathways in Osteoarthritic Hip Cartilage: Commonality and Discord between Hip and Knee OA
10.1016/j.joca.2012.05.006 · 2012 · External reference
Knee and Hip Articular Cartilage Have Distinct Epigenomic Landscapes: Implications for Future Cartilage Regeneration Approaches
10.1136/annrheumdis-2014-205980 · 2014 · External reference
Identification of Long Non-Coding RNAs Expressed in Knee and Hip Osteoarthritic Cartilage
10.1016/j.joca.2018.12.015 · 2019 · External reference
Elucidating the Molecular Composition of Cartilage by Proteomics
10.1021/acs.jproteome.5b00946 · 2016 · External reference
A Novel Variant in GLIS3 Is Associated with Osteoarthritis
10.1136/annrheumdis-2017-211848 · 2018 · External reference
ANGPTL2 Aggravates LPS-Induced Septic Cardiomyopathy via NLRP3-Mediated Inflammasome in a DUSP1-Dependent Pathway
10.1016/j.intimp.2023.110701 · 2023 · External reference
Tumor Cell–Derived Angiopoietin-like Protein ANGPTL2 Is a Critical Driver of Metastasis
10.1158/0008-5472.can-11-3878 · 2012 · External reference
Angiopoietin-like 2 Upregulation Promotes Human Chondrocyte Injury via NF-ΚB and P38/MAPK Signaling Pathway
10.1007/s00774-019-01016-w · 2019 · External reference
CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype
10.1002/advs.202502108 · 2025 · External reference
10.1186/s12885-024-12451-y
10.1186/s12885-024-12451-y · External reference
Tumor Suppressor Role of the CL2/DRO1/CCDC80 Gene in Thyroid Carcinogenesis
10.1210/jc.2012-2926 · 2013 · External reference
Plasma Asprosin, CCDC80 and ANGPTL4 Levels Are Associated with Metabolic and Cardiovascular Risk in Patients with Inflammatory Bowel Disease
10.33549/physiolres.934547 · 2021 · External reference
Thyroid Hormone Induces Ossification and Terminal Maturation in a Preserved OA Cartilage Biomimetic Model
10.1186/s13075-024-03326-5 · 2024 · External reference
Human HtrA1 in the Archived Eyes with Age-Related Macular Degeneration
2007 · External reference
Human Photoreceptor Cells from Different Macular Subregions Have Distinct Transcriptional Profiles
10.1093/hmg/ddab140 · 2021 · External reference
Distribution of the Serine Protease HtrA1 in Normal Human Tissues
10.1177/002215540305101004 · 2003 · External reference
Identification and Cloning of Two Isoforms of Human High-Temperature Requirement Factor A3 (HtrA3), Characterization of Its Genomic Structure and Comparison of Its Tissue Distribution with HtrA1 and HtrA2
10.1042/bj20021569 · 2003 · External reference
Overexpression of HTRA1 Increases the Proliferation and Migration of Retinal Pigment Epithelium
10.17219/acem/135939 · 2021 · External reference
HTRA1-Driven Detachment of Type I Collagen from Endoplasmic Reticulum Contributes to Myocardial Fibrosis in Dilated Cardiomyopathy
10.1186/s12967-024-05098-7 · 2024 · External reference
Expression of Mouse HtrA1 Serine Protease in Normal Bone and Cartilage and Its Upregulation in Joint Cartilage Damaged by Experimental Arthritis
10.1016/j.bone.2005.03.015 · 2005 · External reference
The Serine Proteinase HtrA1 Is Ubiquitous and Abundant in Osteoarthritic Joints, but What Is It Doing?
10.1016/j.joca.2022.03.010 · 2022 · External reference
HtrA1 Serine Protease Inhibits Signaling Mediated by Tgfβ Family Proteins
10.1242/dev.00999 · 2004 · External reference
Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
10.1016/j.joca.2008.07.010 · 2009 · External reference
A Microarray Study of Articular Cartilage in Relation to Obesity and Severity of Knee Osteoarthritis
10.1177/1947603518796122 · 2020 · External reference
PH-Sensing G Protein-Coupled Orphan Receptor GPR68 Is Expressed in Human Cartilage and Correlates with Degradation of Extracellular Matrix during OA Progression
10.7717/peerj.16553 · 2023 · External reference
Cartilage Tissue from Sites of Weight Bearing in Patients with Osteoarthritis Exhibits a Differential Phenotype with Distinct Chondrocytes Subests
10.1136/rmdopen-2023-003255 · 2023 · External reference
Free Glutaraldehyde Gelatin Microsphere Loaded Mesenchymal Stem Cells Alleviate Osteoarthritis by Promoting Ext1 Expression
10.7150/thno.109468 · 2025 · External reference
10.3390/ijms24076611
10.3390/ijms24076611 · External reference
A Molecular Map of Long Non-Coding RNA Expression, Isoform Switching and Alternative Splicing in Osteoarthritis
10.1093/hmg/ddac017 · 2022 · External reference
10.3390/ijms25084348
10.3390/ijms25084348 · External reference
Identification of Candidate Genes and Chemicals Associated with Osteoarthritis by Transcriptome-Wide Association Study and Chemical-Gene Interaction Analysis
10.1186/s13075-023-03164-x · 2023 · External reference
Elucidating the Role of LGALS3BP in Coronary Atherosclerosis: Integrating Bioinformatics and Machine Learning for Advanced Insights
10.1186/s13019-025-03462-2 · 2025 · External reference
10.3389/fphar.2020.566129
10.3389/fphar.2020.566129 · External reference
10.3389/fgene.2022.974936
10.3389/fgene.2022.974936 · External reference
Study on the Mechanism of Shenmai Injection in the Treatment of Sepsis
10.1111/jcmm.70201 · 2024 · External reference
10.3390/ijms22020569
10.3390/ijms22020569 · External reference
10.3390/ijms22157876
10.3390/ijms22157876 · External reference
Bioinformatics Analysis and Experimental Validation of Mitochondrial Autophagy Genes in Knee Osteoarthritis
10.2147/ijgm.s444847 · 2024 · External reference
Genetic, Clinical and Radiographic Signs in Knee Osteoarthritis Susceptibility
10.1186/ar4535 · 2014 · External reference
Chloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis
10.2147/jir.s350432 · 2022 · External reference
10.3390/v11090797
10.3390/v11090797 · External reference
10.3390/jcm7120535
10.3390/jcm7120535 · External reference
Integrative Epigenomics, Transcriptomics and Proteomics of Patient Chondrocytes Reveal Genes and Pathways Involved in Osteoarthritis
10.1038/s41598-017-09335-6 · 2017 · External reference
Dysregulated Energy Metabolism Impairs Chondrocyte Function in Osteoarthritis
10.1016/j.joca.2022.11.004 · 2023 · External reference
Single-Cell RNA Sequencing Reveals Transcriptional Changes in the Cartilage of Subchondral Insufficiency Fracture of the Knee
10.2147/jir.s385648 · 2022 · External reference
Unveiling Inflammatory and Prehypertrophic Cell Populations as Key Contributors to Knee Cartilage Degeneration in Osteoarthritis Using Multi-Omics Data Integration
10.1136/ard-2023-224420 · 2024 · External reference
10.3389/fimmu.2024.1407679
10.3389/fimmu.2024.1407679 · External reference
10.3390/ijms21010364
10.3390/ijms21010364 · External reference
10.3390/cells10061462
10.3390/cells10061462 · External reference
Unveiling the Mechanisms of Mechanical Loading-Induced Knee Osteoarthritis through Transcriptomics
10.1016/j.intimp.2025.114785 · 2025 · External reference
Analysis of Molecular Changes and Features in Rat Knee Osteoarthritis Cartilage: Progress From Cellular Changes to Structural Damage
10.1177/19476035231213174 · 2025 · External reference
Transcriptomic Analyses of Joint Tissues during Osteoarthritis Development in a Rat Model Reveal Dysregulated Mechanotransduction and Extracellular Matrix Pathways
10.1016/j.joca.2022.10.003 · 2023 · External reference
Proteomic Analysis of Articular Cartilage Shows Increased Type II Collagen Synthesis in Osteoarthritis and Expression of Inhibin ΒA (Activin A), a Regulatory Molecule for Chondrocytes
10.1074/jbc.m407041200 · 2004 · External reference
Proteomic Analysis of Human Articular Cartilage: Identification of Differentially Expressed Proteins in Knee Osteoarthritis
10.1016/j.jbspin.2007.12.003 · 2008 · External reference
Protein Profile of Osteoarthritic Human Articular Cartilage Using Tandem Mass Spectrometry
10.1002/rcm.2692 · 2006 · External reference
10.1186/s12891-025-08738-1
10.1186/s12891-025-08738-1 · External reference
Proteomic Characterization of Regenerated Cartilage Following Knee Joint Distraction; a Human Case-Study
10.1080/03008207.2024.2440716 · 2024 · External reference
The Deterioration of Calcified Cartilage Integrity Reflects the Severity of Osteoarthritis—A Structural, Molecular, and Biochemical Analysis
10.1096/fj.202101449r · 2022 · External reference
A Proteomics Investigation of Primary Human Articular Chondrocyte Isolation
10.1016/j.ocarto.2025.100664 · 2025 · External reference
Differential Proteome Analysis of Normal and Osteoarthritic Chondrocytes Reveals Distortion of Vimentin Network in Osteoarthritis
10.1016/j.joca.2007.06.005 · 2008 · External reference
Proteomic Analysis of Osteoarthritic Chondrocyte Reveals the Hyaluronic Acid-Regulated Proteins Involved in Chondroprotective Effect under Oxidative Stress
10.1016/j.jprot.2014.01.016 · 2014 · External reference
Comparative Proteomic Analysis of Hypertrophic Chondrocytes in Osteoarthritis
10.1186/s12014-015-9085-6 · 2015 · External reference
10.3390/biomedicines11041189
10.3390/biomedicines11041189 · External reference
Chondrocyte Protein Co-Synthesis Network Analysis Links ECM Mechanosensing to Metabolic Adaptation in Osteoarthritis
10.1080/14789450.2021.1962299 · 2021 · External reference
Increased Rab1a Accelerates Osteoarthritis by Inhibiting Autophagy via Activation of the MTORC1-S6K Pathway
10.1016/j.jare.2024.11.009 · 2024 · External reference
Proteomics and Bioinformatics Analysis of Cartilage in Post-Traumatic Osteoarthritis in a Mini-Pig Model of Anterior Cruciate Ligament Repair
2020 · External reference
Sericin promotes chondrogenic proliferation and differentiation via glycolysis and Smad2/3 TGF-β signaling inductions and alleviates inflammation in three-dimensional models
10.1038/s41598-024-62516-y · 2024 · External reference
Femoroacetabular Impingement in Adolescents and Young Adults
10.1097/nor.0b013e3181a46a1c · 2009 · External reference
Inflammation and Degeneration in Cartilage Samples from Patients with Femoroacetabular Impingement
10.2106/jbjs.o.00443 · 2016 · External reference
Arthroscopy for the Treatment of Femoroacetabular Impingement in the Athlete
10.1016/j.csm.2005.12.006 · 2006 · External reference
Otto Aufranc Award: Identification of Key Molecular Players in the Progression of Hip Osteoarthritis Through Transcriptomes and Epigenetics
10.1016/j.arth.2022.03.013 · 2022 · External reference
Whole-genome RNA Sequencing Identifies Distinct Transcriptomic Profiles in Impingement Cartilage between Patients with Femoroacetabular Impingement and Hip Osteoarthritis
10.1002/jor.25485 · 2023 · External reference
10.3390/metabo14090480
10.3390/metabo14090480 · External reference
Transcriptomic Analysis of Human Cartilage Identified Potential Therapeutic Targets for Hip Osteoarthritis
10.1093/hmg/ddae200 · 2025 · External reference
Widespread Epigenomic, Transcriptomic and Proteomic Differences between Hip Osteophytic and Articular Chondrocytes in Osteoarthritis
10.1093/rheumatology/key101 · 2018 · External reference
10.1371/journal.pone.0199734
10.1371/journal.pone.0199734 · External reference
10.3389/fmolb.2020.592905
10.3389/fmolb.2020.592905 · External reference
Targeted Proteomics of Hip Articular Cartilage in OA and Fracture Patients
10.1002/jor.24158 · 2019 · External reference
Cartilage Matrix Remodelling Differs by Disease State and Joint Type
10.22203/ecm.v034a05 · 2017 · External reference
Clinical Characteristics of Pathogenic ACAN Variants and 3-Year Response to Growth Hormone Treatment: Real-World Data
10.1159/000535651 · 2024 · External reference
Complete Coding Sequence and Deduced Primary Structure of the Human Cartilage Large Aggregating Proteoglycan, Aggrecan. Human-Specific Repeats, and Additional Alternatively Spliced Forms
10.1016/s0021-9258(17)35257-2 · 1991 · External reference
Structure and Function of Aggrecan
10.1038/sj.cr.7290106 · 2002 · External reference
ACAN Mutations as a Cause of Familial Short Stature
10.1297/cpe.26.119 · 2017 · External reference
Articular Cartilage Proteoglycans As Boundary Lubricants: Structure and Frictional Interaction of Surface-Attached Hyaluronan and Hyaluronan–Aggrecan Complexes
10.1021/bm2004912 · 2011 · External reference
Synovial Mesenchymal Progenitor Derived Aggrecan Regulates Cartilage Homeostasis and Endogenous Repair Capacity
10.1038/s41419-022-04919-1 · 2022 · External reference
Blood and Urine Biomarkers in Osteoarthritis—An Update on Cartilage Associated Type II Collagen and Aggrecan Markers
10.1097/bor.0000000000000845 · 2022 · External reference
Cabozantinib Prevents AGEs-Induced Degradation of Type 2 Collagen and Aggrecan in Human Chondrocytes
10.18632/aging.205186 · 2023 · External reference
The Protective Effects of Dulaglutide against Advanced Glycation End Products (AGEs)-Induced Degradation of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes
10.1016/j.cbi.2020.108968 · 2020 · External reference
Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study
10.1155/2021/3668568 · 2021 · External reference
Cartilage Oligomeric Matrix Protein Increases in Photodamaged Skin
10.1016/j.jid.2016.02.802 · 2016 · External reference
10.3390/ijms23169253
10.3390/ijms23169253 · External reference
Cartilage Oligomeric Matrix Protein: COMPopathies and Beyond
10.1016/j.matbio.2018.02.023 · 2018 · External reference
10.3390/ijms22052242
10.3390/ijms22052242 · External reference
Therapeutic Potential of COMP and TIMP-3 in Preserving Cartilage Integrity Compromised by Proteases: A Histo-Mechanical Study
10.1016/j.jmbbm.2025.107183 · 2025 · External reference
Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-Regulated in Experimental Osteoarthritis
10.1074/jbc.m111.248039 · 2011 · External reference
CHRDL2 Inhibits the Progression of Osteoarthritis by Regulating the Balance of Th17/Treg
10.1007/s10616-025-00856-x · 2025 · External reference
Metzincin Proteases and Their Inhibitors: Foes or Friends in Nervous System Physiology?
10.1523/jneurosci.3467-10.2010 · 2010 · External reference
Proteoglycan Degradation by the ADAMTS Family of Proteinases
10.1016/j.bbadis.2011.08.009 · 2011 · External reference
Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 Generates a Neoepitope Associated with Osteoarthritis and Other Forms of Degenerative Joint Disease
10.1016/j.matbio.2024.12.005 · 2025 · External reference
IL-1β-induced MiR-34a Up-regulation Inhibits Cyr61 to Modulate Osteoarthritis Chondrocyte Proliferation through ADAMTS-4
10.1002/jcb.26600 · 2018 · External reference
SOX9 Transduction of a Human Chondrocytic Cell Line Identifies Novel Genes Regulated in Primary Human Chondrocytes and in Osteoarthritis
10.1186/ar2311 · 2007 · External reference
Cytokine Receptor-Like Factor 1 Is Highly Expressed in Damaged Human Knee Osteoarthritic Cartilage and Involved in Osteoarthritis Downstream of TGF-β
10.1007/s00223-009-9311-1 · 2010 · External reference
Suppression of CRLF1 Promotes the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem and Protects Cartilage Tissue from Damage in Osteoarthritis via Activation of MiR-320
10.1186/s10020-021-00369-1 · 2021 · External reference
Inhibition of CRLF1 Expression by MiR-8485 Alleviates IL-1β-Induced Chondrocyte Inflammation, Apoptosis, and Extracellular Matrix Degradation
10.1016/j.intimp.2024.113643 · 2025 · External reference
ENO1 Regulates IL-1β-Induced Chondrocyte Inflammation, Apoptosis and Matrix Degradation Possibly through the Potential Binding to CRLF1
10.1016/j.tice.2024.102504 · 2024 · External reference
METTL3-Mediated M6A Modification of IGFBP7-OT Promotes Osteoarthritis Progression by Regulating the DNMT1/DNMT3a-IGFBP7 Axis
10.1016/j.celrep.2023.112589 · 2023 · External reference
Increase in Production of Matrix Metalloproteinase 13 by Human Articular Chondrocytes Due to Stimulation with S100A4: Role of the Receptor for Advanced Glycation End Products
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