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References from Plasma Metabolomic Alterations Are Associated with T-Cell Senescence, Cytokine Dysregulation, and Prognosis in Elderly COVID-19 Patients. Local targets link to admitted publications; unresolved targets remain external evidence.
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study
10.1016/s0140-6736(20)30566-3 · 2020 · External reference
COVID-19 in older people: A rapid clinical review
10.1093/ageing/afaa093 · 2020 · External reference
Post-acute COVID-19 syndrome
10.1038/s41591-021-01283-z · 2021 · External reference
Risk of persistent and new clinical sequelae among adults aged 65 years and older during the post-acute phase of SARS-CoV-2 infection: Retrospective cohort study
10.1136/bmj-2021-068414 · 2022 · External reference
‘Metabonomics’: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
10.1080/004982599238047 · 1999 · External reference
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
10.1016/j.cell.2020.05.032 · 2020 · External reference
Multiple early factors anticipate post-acute COVID-19 sequelae
10.1016/j.cell.2022.01.014 · 2022 · External reference
Inflammaging: A new immune-metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · 2018 · External reference
Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
10.1016/s1473-3099(20)30484-9 · 2020 · External reference
Elevated CD4(+) T Cell Senescence Associates with Impaired Immune Responsiveness in Severe COVID-19
2024 · External reference
Unresolved reference
External reference
10.3390/metabo13070879
10.3390/metabo13070879 · External reference
Metabolomic profiling of COVID-19 using serum and urine samples in intensive care and medical ward cohorts
10.1038/s41598-024-74641-9 · 2024 · External reference
10.3390/biology10060456
10.3390/biology10060456 · External reference
10.3390/nu10070921
10.3390/nu10070921 · External reference
10.3390/ijms232213933
10.3390/ijms232213933 · External reference
Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice
10.1186/s12986-018-0241-7 · 2018 · External reference
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
10.1038/s41574-021-00626-7 · 2022 · External reference
Mitochondrial dysfunction in the regulation of aging and aging-related diseases
10.1186/s12964-025-02308-7 · 2025 · External reference
Phospholipid remodeling and its derivatives are associated with COVID-19 severity
10.1016/j.jaci.2022.11.032 · 2023 · External reference
Metabolomic characteristics and related pathways in patients with different severity of COVID-19: A systematic review and meta-analysis
10.7189/jogh.15.04056 · 2025 · External reference
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells
10.2147/jir.s532042 · 2025 · External reference
Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca2+ pathway
10.4251/wjgo.v17.i8.107453 · 2025 · External reference
10.1371/journal.pone.0303110
10.1371/journal.pone.0303110 · External reference
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19
10.1002/ctm2.1069 · 2022 · External reference
10.3390/ijms25126538
10.3390/ijms25126538 · External reference
Metabolic signature of COVID-19 progression: Potential prognostic markers for severity and outcome
10.1007/s11306-025-02264-w · 2025 · External reference
Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart
10.1016/j.jlr.2024.100713 · 2024 · External reference
Age-associated reduction in ER-Mitochondrial contacts impairs mitochondrial lipid metabolism and autophagosome formation in the heart
10.1038/s41418-025-01511-w · 2025 · External reference
Integrated Lipidomics and Transcriptomics Characterization upon Aging-Related Changes of Lipid Species and Pathways in Human Bone Marrow Mesenchymal Stem Cells
10.1021/acs.jproteome.8b00936 · 2019 · External reference
Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte
10.1002/jhbp.684 · 2019 · External reference
Immunosenescence: Molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · 2023 · External reference
Lipid metabolism in T cell signaling and function
10.1038/s41589-022-01017-3 · 2022 · External reference
Comprehensive antibody and cytokine profiling in hospitalized COVID-19 patients in relation to clinical outcomes in a large Belgian cohort
10.1038/s41598-023-46421-4 · 2023 · External reference
Cytokine Regulation and Function in T Cells
10.1146/annurev-immunol-061020-053702 · 2021 · External reference
The T cell immune response against SARS-CoV-2
10.1038/s41590-021-01122-w · 2022 · External reference
IL-6 in inflammation, autoimmunity and cancer
10.1093/intimm/dxaa078 · 2021 · External reference
Progress in cytokine research for ARDS: A comprehensive review
10.1515/med-2024-1076 · 2024 · External reference
Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19
10.1016/j.jaci.2021.05.032 · 2021 · External reference
Understanding the pleiotropic effects of CXCL10/IP-10 in the immunopathogenesis of inflammatory rheumatic diseases: Implications for better understanding disease mechanisms
10.1016/j.intimp.2025.114456 · 2025 · External reference
10.3390/v15020556
10.3390/v15020556 · External reference
The metabolomics of human aging: Advances, challenges, and opportunities
10.1126/sciadv.add6155 · 2022 · External reference
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19
10.1002/ctm2.1069 · ExternalCitation · doi-reference
Protective effect of phosphatidylcholine on lysophosphatidylcholine-induced cellular senescence in cholangiocyte
10.1002/jhbp.684 · ExternalCitation · doi-reference
Metabolic signature of COVID-19 progression: Potential prognostic markers for severity and outcome
10.1007/s11306-025-02264-w · ExternalCitation · doi-reference
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
10.1016/j.cell.2020.05.032 · ExternalCitation · doi-reference
Multiple early factors anticipate post-acute COVID-19 sequelae
10.1016/j.cell.2022.01.014 · ExternalCitation · doi-reference
Understanding the pleiotropic effects of CXCL10/IP-10 in the immunopathogenesis of inflammatory rheumatic diseases: Implications for better understanding disease mechanisms
10.1016/j.intimp.2025.114456 · ExternalCitation · doi-reference
Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19
10.1016/j.jaci.2021.05.032 · ExternalCitation · doi-reference
Phospholipid remodeling and its derivatives are associated with COVID-19 severity
10.1016/j.jaci.2022.11.032 · ExternalCitation · doi-reference
Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart
10.1016/j.jlr.2024.100713 · ExternalCitation · doi-reference
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study
10.1016/s0140-6736(20)30566-3 · ExternalCitation · doi-reference
Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
10.1016/s1473-3099(20)30484-9 · ExternalCitation · doi-reference
Integrated Lipidomics and Transcriptomics Characterization upon Aging-Related Changes of Lipid Species and Pathways in Human Bone Marrow Mesenchymal Stem Cells
10.1021/acs.jproteome.8b00936 · ExternalCitation · doi-reference
Immunosenescence: Molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · ExternalCitation · doi-reference
Age-associated reduction in ER-Mitochondrial contacts impairs mitochondrial lipid metabolism and autophagosome formation in the heart
10.1038/s41418-025-01511-w · ExternalCitation · doi-reference
Inflammaging: A new immune-metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · ExternalCitation · doi-reference
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
10.1038/s41574-021-00626-7 · ExternalCitation · doi-reference
Lipid metabolism in T cell signaling and function
10.1038/s41589-022-01017-3 · ExternalCitation · doi-reference
The T cell immune response against SARS-CoV-2
10.1038/s41590-021-01122-w · ExternalCitation · doi-reference
Post-acute COVID-19 syndrome
10.1038/s41591-021-01283-z · ExternalCitation · doi-reference
Comprehensive antibody and cytokine profiling in hospitalized COVID-19 patients in relation to clinical outcomes in a large Belgian cohort
10.1038/s41598-023-46421-4 · ExternalCitation · doi-reference
Metabolomic profiling of COVID-19 using serum and urine samples in intensive care and medical ward cohorts
10.1038/s41598-024-74641-9 · ExternalCitation · doi-reference
‘Metabonomics’: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
10.1080/004982599238047 · ExternalCitation · doi-reference
COVID-19 in older people: A rapid clinical review
10.1093/ageing/afaa093 · ExternalCitation · doi-reference
IL-6 in inflammation, autoimmunity and cancer
10.1093/intimm/dxaa078 · ExternalCitation · doi-reference
The metabolomics of human aging: Advances, challenges, and opportunities
10.1126/sciadv.add6155 · ExternalCitation · doi-reference
Risk of persistent and new clinical sequelae among adults aged 65 years and older during the post-acute phase of SARS-CoV-2 infection: Retrospective cohort study
10.1136/bmj-2021-068414 · ExternalCitation · doi-reference
Cytokine Regulation and Function in T Cells
10.1146/annurev-immunol-061020-053702 · ExternalCitation · doi-reference
Mitochondrial dysfunction in the regulation of aging and aging-related diseases
10.1186/s12964-025-02308-7 · ExternalCitation · doi-reference
Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice
10.1186/s12986-018-0241-7 · ExternalCitation · doi-reference
10.1371/journal.pone.0303110
10.1371/journal.pone.0303110 · ExternalCitation · doi-reference
Progress in cytokine research for ARDS: A comprehensive review
10.1515/med-2024-1076 · ExternalCitation · doi-reference
Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells
10.2147/jir.s532042 · ExternalCitation · doi-reference
10.3390/biology10060456
10.3390/biology10060456 · ExternalCitation · doi-reference
10.3390/ijms232213933
10.3390/ijms232213933 · ExternalCitation · doi-reference
10.3390/ijms25126538
10.3390/ijms25126538 · ExternalCitation · doi-reference
10.3390/metabo13070879
10.3390/metabo13070879 · ExternalCitation · doi-reference
10.3390/nu10070921
10.3390/nu10070921 · ExternalCitation · doi-reference
10.3390/v15020556
10.3390/v15020556 · ExternalCitation · doi-reference
Deoxycholic acid induces reactive oxygen species accumulation and promotes colorectal cancer cell apoptosis through the CaMKII-Ca2+ pathway
10.4251/wjgo.v17.i8.107453 · ExternalCitation · doi-reference
Metabolomic characteristics and related pathways in patients with different severity of COVID-19: A systematic review and meta-analysis
10.7189/jogh.15.04056 · ExternalCitation · doi-reference
