Research graph
References from Multi-Omics Integration Identifies Epithelial-Stromal-Immune Co-Regulators Bridging Ulcerative Colitis and Colorectal Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Ulcerative colitis
10.1016/s0140-6736(16)32126-2 · 2017 · External reference
Ulcerative colitis
10.1038/s41572-020-0205-x · 2020 · External reference
ACG clinical guideline update: Ulcerative colitis in adults
10.14309/ajg.0000000000003463 · 2025 · External reference
The risk of colorectal cancer in ulcerative colitis: A meta-analysis
10.1136/gut.48.4.526 · 2001 · External reference
Clonal evolution of colorectal cancer in IBD
10.1038/nrgastro.2017.1 · 2017 · External reference
Inflammation and colon cancer
10.1053/j.gastro.2010.01.058 · 2010 · External reference
Colorectal cancer in inflammatory bowel disease: Mechanisms and management
10.1053/j.gastro.2021.10.035 · 2022 · External reference
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
10.1016/j.cell.2019.06.029 · 2019 · External reference
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer
10.1038/s41588-020-0636-z · 2020 · External reference
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target
10.1038/s41417-025-00917-5 · 2025 · External reference
10.1186/1471-2105-9-559
10.1186/1471-2105-9-559 · External reference
The MR-Base platform supports systematic causal inference across the human phenome
10.7554/elife.34408 · 2018 · External reference
TCGAbiolinks: An R/Bioconductor package for integrative analysis of TCGA data
10.1093/nar/gkv1507 · 2016 · External reference
A longitudinal single-cell atlas of anti-TNF treatment in inflammatory bowel disease
10.1038/s41590-024-01994-8 · 2024 · External reference
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
10.1038/s41588-021-00913-z · 2021 · External reference
A cross-population atlas of genetic associations for 220 human phenotypes
10.1038/s41588-021-00931-x · 2021 · External reference
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
10.1016/j.celrep.2016.12.019 · 2017 · External reference
Cytokine networks in the pathophysiology of inflammatory bowel disease
10.1016/j.immuni.2019.03.017 · 2019 · External reference
Pro-inflammatory prostaglandins and progression of colorectal cancer
10.1016/j.canlet.2008.03.004 · 2008 · External reference
Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via the CXCL1/8-CXCR2 axis
10.1158/1078-0432.ccr-18-3684 · 2019 · External reference
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
10.1038/nature11465 · 2012 · External reference
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: New findings and future perspectives
10.1186/s12943-021-01428-1 · 2021 · External reference
CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer
10.1002/ijc.29939 · 2016 · External reference
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
10.1084/jem.20131195 · 2013 · External reference
Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker
10.1038/s41416-022-01833-3 · 2022 · External reference
S100A8-mediated inflammatory signaling drives colorectal cancer progression via the CXCL5/CXCR2 axis
10.7150/jca.92588 · 2024 · External reference
The life and works of S100P, from conception to cancer
2016 · External reference
TRIM29 promotes DNA virus infections by inhibiting innate immune response
10.1038/s41467-017-00101-w · 2017 · External reference
10.3389/fgene.2022.949325
10.3389/fgene.2022.949325 · External reference
CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer
10.1002/ijc.29939 · ExternalCitation · doi-reference
Pro-inflammatory prostaglandins and progression of colorectal cancer
10.1016/j.canlet.2008.03.004 · ExternalCitation · doi-reference
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
10.1016/j.cell.2019.06.029 · ExternalCitation · doi-reference
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
10.1016/j.celrep.2016.12.019 · ExternalCitation · doi-reference
Cytokine networks in the pathophysiology of inflammatory bowel disease
10.1016/j.immuni.2019.03.017 · ExternalCitation · doi-reference
Ulcerative colitis
10.1016/s0140-6736(16)32126-2 · ExternalCitation · doi-reference
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
10.1038/nature11465 · ExternalCitation · doi-reference
Clonal evolution of colorectal cancer in IBD
10.1038/nrgastro.2017.1 · ExternalCitation · doi-reference
Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker
10.1038/s41416-022-01833-3 · ExternalCitation · doi-reference
Integrated multidimensional bioinformatics analysis of the molecular mechanisms of ulcerative colitis-associated colorectal cancer and MMP1 as a potential therapeutic target
10.1038/s41417-025-00917-5 · ExternalCitation · doi-reference
TRIM29 promotes DNA virus infections by inhibiting innate immune response
10.1038/s41467-017-00101-w · ExternalCitation · doi-reference
Ulcerative colitis
10.1038/s41572-020-0205-x · ExternalCitation · doi-reference
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer
10.1038/s41588-020-0636-z · ExternalCitation · doi-reference
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
10.1038/s41588-021-00913-z · ExternalCitation · doi-reference
A cross-population atlas of genetic associations for 220 human phenotypes
10.1038/s41588-021-00931-x · ExternalCitation · doi-reference
A longitudinal single-cell atlas of anti-TNF treatment in inflammatory bowel disease
10.1038/s41590-024-01994-8 · ExternalCitation · doi-reference
Inflammation and colon cancer
10.1053/j.gastro.2010.01.058 · ExternalCitation · doi-reference
Colorectal cancer in inflammatory bowel disease: Mechanisms and management
10.1053/j.gastro.2021.10.035 · ExternalCitation · doi-reference
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
10.1084/jem.20131195 · ExternalCitation · doi-reference
TCGAbiolinks: An R/Bioconductor package for integrative analysis of TCGA data
10.1093/nar/gkv1507 · ExternalCitation · doi-reference
The risk of colorectal cancer in ulcerative colitis: A meta-analysis
10.1136/gut.48.4.526 · ExternalCitation · doi-reference
Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via the CXCL1/8-CXCR2 axis
10.1158/1078-0432.ccr-18-3684 · ExternalCitation · doi-reference
10.1186/1471-2105-9-559
10.1186/1471-2105-9-559 · ExternalCitation · doi-reference
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: New findings and future perspectives
10.1186/s12943-021-01428-1 · ExternalCitation · doi-reference
ACG clinical guideline update: Ulcerative colitis in adults
10.14309/ajg.0000000000003463 · ExternalCitation · doi-reference
10.3389/fgene.2022.949325
10.3389/fgene.2022.949325 · ExternalCitation · doi-reference
S100A8-mediated inflammatory signaling drives colorectal cancer progression via the CXCL5/CXCR2 axis
10.7150/jca.92588 · ExternalCitation · doi-reference
The MR-Base platform supports systematic causal inference across the human phenome
10.7554/elife.34408 · ExternalCitation · doi-reference
