Research graph
References from Tumor Inflammation Confounds Radiographic Determination of Extranodal Extension in HPV-Associated Head and Neck Squamous Cell Carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3390/medsci11020042
10.3390/medsci11020042 · External reference
The epidemic of HPV-associated oropharyngeal cancer is here: Is it time to change our treatment paradigms?
10.6004/jnccn.2011.0055 · 2011 · External reference
Human papillomavirus and rising oropharyngeal cancer incidence in the United States
10.1200/jco.2011.36.4596 · 2011 · External reference
Human papillomavirus as a driver of head and neck cancers
10.1038/s41416-019-0602-7 · 2020 · External reference
Head and neck squamous cell carcinoma
10.1038/s41572-020-00224-3 · 2020 · External reference
10.3390/cancers13205206
10.3390/cancers13205206 · External reference
Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study
10.1016/s0140-6736(19)32591-7 · 2019 · External reference
Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer: An analysis of Eastern Cooperative Oncology Group trials
10.1093/annonc/mdu167 · 2014 · External reference
Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522
10.1200/jco.2013.53.5633 · 2014 · External reference
Pathological extranodal extension in head and neck cancer: A prognostic biomarker with therapeutic ramifications and diagnostic pitfalls
10.1016/j.prp.2025.156183 · 2025 · External reference
10.3389/fonc.2023.1263347
10.3389/fonc.2023.1263347 · External reference
Prognostic impact of extranodal extension (ENE) in surgically managed treatment-naive HPV-positive oropharyngeal squamous cell carcinoma with nodal metastasis
10.1038/s41379-022-01120-9 · 2022 · External reference
Correlation between radiologic and pathologic extranodal extension in HPV-associated oropharyngeal cancer: Systematic review
10.1002/hed.27183 · 2022 · External reference
Prognostic Value of Radiologic Extranodal Extension in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
10.3348/kjr.2018.0742 · 2019 · External reference
Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma
10.1002/hed.25791 · 2019 · External reference
Re-examining post-operative chemoradiotherapy in head and neck cancer: An updated long-term combined analysis of RTOG 9501/EORTC 22931
10.1016/j.annonc.2025.07.004 · 2025 · External reference
Accuracy and Prognosis of Extranodal Extension on Radiologic Imaging in Human Papillomavirus-Mediated Oropharyngeal Cancer: A Head and Neck Cancer International Group (HNCIG) Real-world Study
10.1016/j.ijrobp.2025.04.003 · 2025 · External reference
Correlation between radiographic and pathologic lymph node involvement and extranodal extension via CT and PET in HPV-associated oropharyngeal cancer
10.1016/j.oraloncology.2021.105625 · 2021 · External reference
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: Evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial
10.1016/s2589-7500(23)00046-8 · 2023 · External reference
Computed tomography imaging of acute neck inflammatory processes
10.4329/wjr.v2.i3.91 · 2010 · External reference
Imaging of cervical lymphadenopathy in children and young adults
10.2214/ajr.12.8629 · 2012 · External reference
Practical Imaging Approach to Determining the Cause of Nonneoplastic Lymphadenopathy
10.1148/rg.240147 · 2025 · External reference
Criteria for the diagnosis of extranodal extension detected on radiological imaging in head and neck cancer: Head and Neck Cancer International Group consensus recommendations
10.1016/s1470-2045(24)00066-4 · 2024 · External reference
Imaging-detected extranodal extension in head and neck cancer: Clinical implications, diagnostic criteria, and the potential of photon-counting detector CT
10.1007/s11604-025-01894-3 · 2026 · External reference
Tumor-infiltrating immune cells and survival in head and neck squamous cell carcinoma: A retrospective computational study
10.1038/s41598-024-56738-3 · 2024 · External reference
Prognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma
10.1001/jamaoto.2019.2427 · 2019 · External reference
10.3390/cancers13040781
10.3390/cancers13040781 · External reference
Comprehensive analysis of immune cell enrichment in the tumor microenvironment of head and neck squamous cell carcinoma
10.1038/s41598-021-95718-9 · 2021 · External reference
Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors
10.1073/pnas.2216532120 · 2023 · External reference
edgeR v4: Powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
10.1093/nar/gkaf018 · 2025 · External reference
Unresolved reference
External reference
10.1371/journal.pone.0297741
10.1371/journal.pone.0297741 · External reference
NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer
10.18632/oncotarget.28232 · 2022 · External reference
Using clusterProfiler to characterize multiomics data
10.1038/s41596-024-01020-z · 2024 · External reference
Enrichr: A comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
10.1186/1471-2105-14-7
10.1186/1471-2105-14-7 · External reference
Unresolved reference
External reference
10.1007/978-3-319-24277-4_9
10.1007/978-3-319-24277-4_9 · External reference
Unresolved reference
External reference
10.3390/cells9030704
10.3390/cells9030704 · External reference
Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2)
10.1016/j.bcp.2009.08.019 · 2010 · External reference
Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2
10.1016/j.bcp.2012.06.025 · 2012 · External reference
NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
10.1158/0008-5472.can-22-1903 · 2023 · External reference
Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
10.1158/1078-0432.ccr-25-0112 · 2025 · External reference
Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium
10.1038/75556 · 2000 · External reference
The Gene Ontology knowledgebase in 2023
10.1093/genetics/iyad031 · 2023 · External reference
A pathology atlas of the human cancer transcriptome
10.1126/science.aan2507 · 2017 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner
10.1158/1541-7786.mcr-18-0048 · 2019 · External reference
A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway
10.1186/s13046-019-1091-5 · 2019 · External reference
Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
10.18632/oncotarget.2772 · 2015 · External reference
Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures
10.18632/oncotarget.27249 · 2019 · External reference
AdaSampling for Positive-Unlabeled and Label Noise Learning With Bioinformatics Applications
10.1109/tcyb.2018.2816984 · 2019 · External reference
Active label cleaning for improved dataset quality under resource constraints
10.1038/s41467-022-28818-3 · 2022 · External reference
Classification in the Presence of Label Noise: A Survey
10.1109/tnnls.2013.2292894 · 2014 · External reference
Confident Learning: Estimating Uncertainty in Dataset Labels
2021 · External reference
10.1186/s10020-026-01481-w
10.1186/s10020-026-01481-w · External reference
HPV-associated Oropharyngeal Squamous Cell Carcinoma: An Imaging Framework for AJCC Version 9 TNM Staging
10.1148/rycan.260013 · 2026 · External reference
Prognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma
10.1001/jamaoto.2019.2427 · ExternalCitation · doi-reference
Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma
10.1002/hed.25791 · ExternalCitation · doi-reference
Correlation between radiologic and pathologic extranodal extension in HPV-associated oropharyngeal cancer: Systematic review
10.1002/hed.27183 · ExternalCitation · doi-reference
10.1007/978-3-319-24277-4_9
10.1007/978-3-319-24277-4_9 · ExternalCitation · doi-reference
Imaging-detected extranodal extension in head and neck cancer: Clinical implications, diagnostic criteria, and the potential of photon-counting detector CT
10.1007/s11604-025-01894-3 · ExternalCitation · doi-reference
Re-examining post-operative chemoradiotherapy in head and neck cancer: An updated long-term combined analysis of RTOG 9501/EORTC 22931
10.1016/j.annonc.2025.07.004 · ExternalCitation · doi-reference
Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2)
10.1016/j.bcp.2009.08.019 · ExternalCitation · doi-reference
Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2
10.1016/j.bcp.2012.06.025 · ExternalCitation · doi-reference
Accuracy and Prognosis of Extranodal Extension on Radiologic Imaging in Human Papillomavirus-Mediated Oropharyngeal Cancer: A Head and Neck Cancer International Group (HNCIG) Real-world Study
10.1016/j.ijrobp.2025.04.003 · ExternalCitation · doi-reference
Correlation between radiographic and pathologic lymph node involvement and extranodal extension via CT and PET in HPV-associated oropharyngeal cancer
10.1016/j.oraloncology.2021.105625 · ExternalCitation · doi-reference
Pathological extranodal extension in head and neck cancer: A prognostic biomarker with therapeutic ramifications and diagnostic pitfalls
10.1016/j.prp.2025.156183 · ExternalCitation · doi-reference
Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study
10.1016/s0140-6736(19)32591-7 · ExternalCitation · doi-reference
Criteria for the diagnosis of extranodal extension detected on radiological imaging in head and neck cancer: Head and Neck Cancer International Group consensus recommendations
10.1016/s1470-2045(24)00066-4 · ExternalCitation · doi-reference
Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: Evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial
10.1016/s2589-7500(23)00046-8 · ExternalCitation · doi-reference
Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium
10.1038/75556 · ExternalCitation · doi-reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · ExternalCitation · doi-reference
Prognostic impact of extranodal extension (ENE) in surgically managed treatment-naive HPV-positive oropharyngeal squamous cell carcinoma with nodal metastasis
10.1038/s41379-022-01120-9 · ExternalCitation · doi-reference
Human papillomavirus as a driver of head and neck cancers
10.1038/s41416-019-0602-7 · ExternalCitation · doi-reference
Active label cleaning for improved dataset quality under resource constraints
10.1038/s41467-022-28818-3 · ExternalCitation · doi-reference
Head and neck squamous cell carcinoma
10.1038/s41572-020-00224-3 · ExternalCitation · doi-reference
Using clusterProfiler to characterize multiomics data
10.1038/s41596-024-01020-z · ExternalCitation · doi-reference
Comprehensive analysis of immune cell enrichment in the tumor microenvironment of head and neck squamous cell carcinoma
10.1038/s41598-021-95718-9 · ExternalCitation · doi-reference
Tumor-infiltrating immune cells and survival in head and neck squamous cell carcinoma: A retrospective computational study
10.1038/s41598-024-56738-3 · ExternalCitation · doi-reference
Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors
10.1073/pnas.2216532120 · ExternalCitation · doi-reference
Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer: An analysis of Eastern Cooperative Oncology Group trials
10.1093/annonc/mdu167 · ExternalCitation · doi-reference
The Gene Ontology knowledgebase in 2023
10.1093/genetics/iyad031 · ExternalCitation · doi-reference
edgeR v4: Powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
10.1093/nar/gkaf018 · ExternalCitation · doi-reference
Enrichr: A comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · ExternalCitation · doi-reference
AdaSampling for Positive-Unlabeled and Label Noise Learning With Bioinformatics Applications
10.1109/tcyb.2018.2816984 · ExternalCitation · doi-reference
Classification in the Presence of Label Noise: A Survey
10.1109/tnnls.2013.2292894 · ExternalCitation · doi-reference
A pathology atlas of the human cancer transcriptome
10.1126/science.aan2507 · ExternalCitation · doi-reference
Practical Imaging Approach to Determining the Cause of Nonneoplastic Lymphadenopathy
10.1148/rg.240147 · ExternalCitation · doi-reference
HPV-associated Oropharyngeal Squamous Cell Carcinoma: An Imaging Framework for AJCC Version 9 TNM Staging
10.1148/rycan.260013 · ExternalCitation · doi-reference
NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells
10.1158/0008-5472.can-22-1903 · ExternalCitation · doi-reference
Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
10.1158/1078-0432.ccr-25-0112 · ExternalCitation · doi-reference
Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner
10.1158/1541-7786.mcr-18-0048 · ExternalCitation · doi-reference
10.1186/1471-2105-14-7
10.1186/1471-2105-14-7 · ExternalCitation · doi-reference
10.1186/s10020-026-01481-w
10.1186/s10020-026-01481-w · ExternalCitation · doi-reference
A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway
10.1186/s13046-019-1091-5 · ExternalCitation · doi-reference
Human papillomavirus and rising oropharyngeal cancer incidence in the United States
10.1200/jco.2011.36.4596 · ExternalCitation · doi-reference
Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522
10.1200/jco.2013.53.5633 · ExternalCitation · doi-reference
10.1371/journal.pone.0297741
10.1371/journal.pone.0297741 · ExternalCitation · doi-reference
Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures
10.18632/oncotarget.27249 · ExternalCitation · doi-reference
Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
10.18632/oncotarget.2772 · ExternalCitation · doi-reference
NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer
10.18632/oncotarget.28232 · ExternalCitation · doi-reference
Imaging of cervical lymphadenopathy in children and young adults
10.2214/ajr.12.8629 · ExternalCitation · doi-reference
Prognostic Value of Radiologic Extranodal Extension in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma
10.3348/kjr.2018.0742 · ExternalCitation · doi-reference
10.3389/fonc.2023.1263347
10.3389/fonc.2023.1263347 · ExternalCitation · doi-reference
10.3390/cancers13040781
10.3390/cancers13040781 · ExternalCitation · doi-reference
10.3390/cancers13205206
10.3390/cancers13205206 · ExternalCitation · doi-reference
10.3390/cells9030704
10.3390/cells9030704 · ExternalCitation · doi-reference
10.3390/medsci11020042
10.3390/medsci11020042 · ExternalCitation · doi-reference
Computed tomography imaging of acute neck inflammatory processes
10.4329/wjr.v2.i3.91 · ExternalCitation · doi-reference
The epidemic of HPV-associated oropharyngeal cancer is here: Is it time to change our treatment paradigms?
10.6004/jnccn.2011.0055 · ExternalCitation · doi-reference
