Research graph
References from Somatic Mutation Profile in Normal Tissue Adjacent to Tumor in Colorectal Carcinoma Patients: Functional Effect on Gene Expression and Potential Implications for Precision Medicine. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1186/s12885-025-15138-0
10.1186/s12885-025-15138-0 · External reference
10.1038/nature11252
10.1038/nature11252 · External reference
The evolutionary landscape of colorectal tumorigenesis
10.1038/s41559-018-0642-z · 2018 · External reference
Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology
10.1200/jco.2016.71.9807 · 2017 · External reference
Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances
10.3748/wjg.v22.i5.1745 · 2016 · External reference
Prognostic and Predictive Value of PIK3CA Mutations in Metastatic Colorectal Cancer
10.1007/s11523-022-00898-7 · 2022 · External reference
The somatic mutation landscape of normal human colorectal mucosa
10.1038/s41586-019-1672-7 · 2019 · External reference
Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia
10.14309/ctg.0000000000000212 · 2020 · External reference
An evolutionary perspective on field cancerization
10.1038/nrc.2017.102 · 2018 · External reference
Field cancerisation in colorectal cancer: A new frontier or pastures past?
10.3748/wjg.v21.i13.3763 · 2015 · External reference
Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon
10.1016/j.humpath.2009.06.002 · 2010 · External reference
Field cancerization in the colon: A role for aberrant DNA methylation?
10.1093/gastro/got039 · 2014 · External reference
Wnt Signaling and Colorectal Cancer
2017 · External reference
Identification of FAP locus genes from chromosome 5q21
10.1126/science.1651562 · 1991 · External reference
Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli
10.1002/1097-0142(20010715)92:2<332::aid-cncr1327>3.0.co;2-3 · 2001 · External reference
Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
10.1038/s41388-018-0557-9 · 2019 · External reference
Wnt/beta-catenin signaling in development and disease
10.1016/j.cell.2006.10.018 · 2006 · External reference
10.3390/ijms18010197
10.3390/ijms18010197 · External reference
Oncogenic Signaling Pathways in The Cancer Genome Atlas
10.1016/j.cell.2018.03.035 · 2018 · External reference
Comprehensive assessment of actionable genomic alterations in primary colorectal carcinoma using targeted next-generation sequencing
10.1038/s41416-022-01913-4 · 2022 · External reference
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
10.1038/s41422-018-0044-4 · 2018 · External reference
10.3390/ijms25158094
10.3390/ijms25158094 · External reference
10.3390/medicina60030348
10.3390/medicina60030348 · External reference
10.3390/curroncol32120661
10.3390/curroncol32120661 · External reference
10.3390/ijms232214261
10.3390/ijms232214261 · External reference
10.3390/cancers14092250
10.3390/cancers14092250 · External reference
Unresolved reference
External reference
10.3390/cancers15030907
10.3390/cancers15030907 · External reference
10.1186/s12920-022-01294-w
10.1186/s12920-022-01294-w · External reference
10.64898/2026.05.27.728350
10.64898/2026.05.27.728350 · External reference
A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity
10.1053/j.gastro.2020.11.008 · 2021 · External reference
Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival
10.1002/pmic.200500629 · 2006 · External reference
SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial-mesenchymal transition
10.1515/med-2022-0532 · 2022 · External reference
Single-cell dissection of transcriptional heterogeneity in human colon tumors
10.1038/nbt.2038 · 2011 · External reference
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
10.1016/j.cell.2015.05.033 · 2015 · External reference
10.3390/cells15100860
10.3390/cells15100860 · External reference
Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis
10.1016/s0002-9440(10)62371-1 · 2005 · External reference
The VAX2-SERPINE1 axis modulates colorectal cancer cell proliferation and apoptosis through WNT/beta-catenin signaling
10.1016/j.tranon.2026.102703 · 2026 · External reference
Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer
10.1046/j.1523-1747.2000.00993.x · 2000 · External reference
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior
10.1016/j.matbio.2014.04.005 · 2014 · External reference
Expression from the proximal promoter of the carbonic anhydrase 1 gene as a marker for differentiation in colon epithelia
10.1111/j.1432-0436.1993.tb00647.x · 1993 · External reference
PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
10.1186/s12964-023-01225-x · 2023 · External reference
SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells
10.18632/aging.204446 · 2022 · External reference
Metallothionein expression in colorectal cancer: Relevance of different isoforms for tumor progression and patient survival
10.1016/j.humpath.2011.04.015 · 2012 · External reference
10.3389/fimmu.2026.1799765
10.3389/fimmu.2026.1799765 · External reference
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases
10.1016/s0083-6729(08)00414-7 · 2008 · External reference
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines
10.2147/ott.s210800 · 2019 · External reference
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
10.1038/s43018-022-00331-y · 2022 · External reference
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
10.1007/s13659-025-00502-1 · 2025 · External reference
A phase 1/2 first-in-human study of TH9619 in patients with advanced refractory solid tumors (ODIN)
10.1200/jco.2026.44.16_suppl.tps3165 · 2026 · External reference
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
10.1038/s42255-023-00771-5 · 2023 · External reference
The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
10.1515/biol-2021-0121 · 2021 · External reference
Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis
10.1002/art.38094 · 2013 · External reference
Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
10.1021/acs.jmedchem.9b01113 · 2019 · External reference
Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli
10.1002/1097-0142(20010715)92:2<332::aid-cncr1327>3.0.co;2-3 · ExternalCitation · doi-reference
Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis
10.1002/art.38094 · ExternalCitation · doi-reference
Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival
10.1002/pmic.200500629 · ExternalCitation · doi-reference
Prognostic and Predictive Value of PIK3CA Mutations in Metastatic Colorectal Cancer
10.1007/s11523-022-00898-7 · ExternalCitation · doi-reference
Identification and verification of methylenetetrahydrofolate dehydrogenase 1-like protein as the binding target of natural product pseudolaric acid A
10.1007/s13659-025-00502-1 · ExternalCitation · doi-reference
Wnt/beta-catenin signaling in development and disease
10.1016/j.cell.2006.10.018 · ExternalCitation · doi-reference
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer
10.1016/j.cell.2015.05.033 · ExternalCitation · doi-reference
Oncogenic Signaling Pathways in The Cancer Genome Atlas
10.1016/j.cell.2018.03.035 · ExternalCitation · doi-reference
Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon
10.1016/j.humpath.2009.06.002 · ExternalCitation · doi-reference
Metallothionein expression in colorectal cancer: Relevance of different isoforms for tumor progression and patient survival
10.1016/j.humpath.2011.04.015 · ExternalCitation · doi-reference
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior
10.1016/j.matbio.2014.04.005 · ExternalCitation · doi-reference
The VAX2-SERPINE1 axis modulates colorectal cancer cell proliferation and apoptosis through WNT/beta-catenin signaling
10.1016/j.tranon.2026.102703 · ExternalCitation · doi-reference
Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis
10.1016/s0002-9440(10)62371-1 · ExternalCitation · doi-reference
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases
10.1016/s0083-6729(08)00414-7 · ExternalCitation · doi-reference
Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity
10.1021/acs.jmedchem.9b01113 · ExternalCitation · doi-reference
10.1038/nature11252
10.1038/nature11252 · ExternalCitation · doi-reference
Single-cell dissection of transcriptional heterogeneity in human colon tumors
10.1038/nbt.2038 · ExternalCitation · doi-reference
An evolutionary perspective on field cancerization
10.1038/nrc.2017.102 · ExternalCitation · doi-reference
Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
10.1038/s41388-018-0557-9 · ExternalCitation · doi-reference
Comprehensive assessment of actionable genomic alterations in primary colorectal carcinoma using targeted next-generation sequencing
10.1038/s41416-022-01913-4 · ExternalCitation · doi-reference
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
10.1038/s41422-018-0044-4 · ExternalCitation · doi-reference
The evolutionary landscape of colorectal tumorigenesis
10.1038/s41559-018-0642-z · ExternalCitation · doi-reference
The somatic mutation landscape of normal human colorectal mucosa
10.1038/s41586-019-1672-7 · ExternalCitation · doi-reference
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
10.1038/s42255-023-00771-5 · ExternalCitation · doi-reference
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
10.1038/s43018-022-00331-y · ExternalCitation · doi-reference
Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer
10.1046/j.1523-1747.2000.00993.x · ExternalCitation · doi-reference
A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity
10.1053/j.gastro.2020.11.008 · ExternalCitation · doi-reference
Field cancerization in the colon: A role for aberrant DNA methylation?
10.1093/gastro/got039 · ExternalCitation · doi-reference
Expression from the proximal promoter of the carbonic anhydrase 1 gene as a marker for differentiation in colon epithelia
10.1111/j.1432-0436.1993.tb00647.x · ExternalCitation · doi-reference
Identification of FAP locus genes from chromosome 5q21
10.1126/science.1651562 · ExternalCitation · doi-reference
10.1186/s12885-025-15138-0
10.1186/s12885-025-15138-0 · ExternalCitation · doi-reference
10.1186/s12920-022-01294-w
10.1186/s12920-022-01294-w · ExternalCitation · doi-reference
PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
10.1186/s12964-023-01225-x · ExternalCitation · doi-reference
Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology
10.1200/jco.2016.71.9807 · ExternalCitation · doi-reference
A phase 1/2 first-in-human study of TH9619 in patients with advanced refractory solid tumors (ODIN)
10.1200/jco.2026.44.16_suppl.tps3165 · ExternalCitation · doi-reference
Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia
10.14309/ctg.0000000000000212 · ExternalCitation · doi-reference
The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
10.1515/biol-2021-0121 · ExternalCitation · doi-reference
SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial-mesenchymal transition
10.1515/med-2022-0532 · ExternalCitation · doi-reference
SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells
10.18632/aging.204446 · ExternalCitation · doi-reference
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines
10.2147/ott.s210800 · ExternalCitation · doi-reference
10.3389/fimmu.2026.1799765
10.3389/fimmu.2026.1799765 · ExternalCitation · doi-reference
10.3390/cancers14092250
10.3390/cancers14092250 · ExternalCitation · doi-reference
10.3390/cancers15030907
10.3390/cancers15030907 · ExternalCitation · doi-reference
10.3390/cells15100860
10.3390/cells15100860 · ExternalCitation · doi-reference
10.3390/curroncol32120661
10.3390/curroncol32120661 · ExternalCitation · doi-reference
10.3390/ijms18010197
10.3390/ijms18010197 · ExternalCitation · doi-reference
10.3390/ijms232214261
10.3390/ijms232214261 · ExternalCitation · doi-reference
10.3390/ijms25158094
10.3390/ijms25158094 · ExternalCitation · doi-reference
10.3390/medicina60030348
10.3390/medicina60030348 · ExternalCitation · doi-reference
Field cancerisation in colorectal cancer: A new frontier or pastures past?
10.3748/wjg.v21.i13.3763 · ExternalCitation · doi-reference
Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances
10.3748/wjg.v22.i5.1745 · ExternalCitation · doi-reference
10.64898/2026.05.27.728350
10.64898/2026.05.27.728350 · ExternalCitation · doi-reference
