Research graph
References from Clinical Significance of Tumor Infiltrating Lymphocytes and Modulation by Neoadjuvant Chemotherapy in Colorectal Cancer Liver Metastases. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1186/s12885-017-3925-x
10.1186/s12885-017-3925-x · External reference
Epidemiology and Management of Liver Metastases from Colorectal Cancer
10.1097/01.sla.0000217629.94941.cf · 2006 · External reference
Incidence and Survival in Synchronous and Metachronous Liver Metastases from Colorectal Cancer
10.1001/jamanetworkopen.2022.36666 · 2022 · External reference
Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer
10.1016/j.drup.2019.100644 · 2019 · External reference
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
10.1056/nejmoa2402141 · 2024 · External reference
10.3390/ijms18040891
10.3390/ijms18040891 · External reference
First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—The randomised METIMMOX trial
10.1038/s41416-024-02696-6 · 2024 · External reference
First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: A phase 1b/2 trial
10.1038/s41591-023-02497-z · 2023 · External reference
The Liver–Immunity Nexus and Cancer Immunotherapy
10.1158/1078-0432.ccr-21-1193 · 2022 · External reference
Lenvatinib Plus Pembrolizumab Versus Standard of Care for Previously Treated Metastatic Colorectal Cancer: Final Analysis of the Randomized, Open-Label, Phase III LEAP-017 Study
10.1200/jco.23.02736 · 2024 · External reference
Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: A phase 1 trial
10.1038/s41591-024-03083-7 · 2024 · External reference
Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level
10.1158/2159-8290.cd-21-0316 · 2021 · External reference
Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastases
10.1186/s12967-022-03667-2 · 2022 · External reference
Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis
10.1038/s41598-020-67842-5 · 2020 · External reference
Immunology in the liver—From homeostasis to disease
10.1038/nrgastro.2015.200 · 2016 · External reference
Immunity, tolerance and autoimmunity in the liver: A comprehensive review
10.1016/j.jaut.2015.08.020 · 2016 · External reference
Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases
10.1080/15384047.2020.1721252 · 2020 · External reference
IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer
10.1186/s12943-025-02276-z · 2025 · External reference
Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
10.1158/1078-0432.ccr-16-0150 · 2017 · External reference
Objective Analysis and Clinical Significance of the Spatial Tumor-Infiltrating Lymphocyte Patterns in Non–Small Cell Lung Cancer
2023 · External reference
Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non–Small Cell Lung Cancer
10.1158/1078-0432.ccr-20-3655 · 2021 · External reference
Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer
10.1136/jitc-2022-005025 · 2022 · External reference
10.3389/fimmu.2024.1505896
10.3389/fimmu.2024.1505896 · External reference
Microsatellite instable vs stable colon carcinomas: Analysis of tumour heterogeneity, inflammation and angiogenesis
10.1038/bjc.2015.213 · 2015 · External reference
10.1371/journal.pone.0080362
10.1371/journal.pone.0080362 · External reference
Single-cell analysis revealed a potential role of T-cell exhaustion in colorectal cancer with liver metastasis
10.1111/jcmm.18341 · 2024 · External reference
Immune responses in the liver
10.1146/annurev-immunol-051116-052415 · 2018 · External reference
Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses
10.1073/pnas.1706559114 · 2017 · External reference
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC
10.1158/2326-6066.cir-16-0325 · 2017 · External reference
Clinical Response to Immunotherapy Targeting Programmed Cell Death Receptor 1/Programmed Cell Death Ligand 1 in Patients With Treatment-Resistant Microsatellite Stable Colorectal Cancer With and Without Liver Metastases
10.1001/jamanetworkopen.2021.18416 · 2021 · External reference
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
10.1038/s41591-020-1131-x · 2021 · External reference
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis
10.1126/sciimmunol.aba0759 · 2020 · External reference
Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
10.1158/2326-6066.cir-25-0031 · 2025 · External reference
CXCL8 induces M2 macrophage polarization and inhibits CD8+ T cell infiltration to generate an immunosuppressive microenvironment in colorectal cancer
10.1096/fj.202201982rrr · 2023 · External reference
IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer
10.1245/s10434-023-13527-y · 2023 · External reference
Prognostic value of the density of tumor-infiltrating lymphocytes in colorectal cancer liver metastases
10.3892/ol.2021.13098 · 2021 · External reference
Prognostic value of intra-tumoral CD8+/FoxP3+ lymphocyte ratio in patients with resected colorectal cancer liver metastasis
10.1002/jso.25091 · 2018 · External reference
Prognostic Impact of Tumor-Infiltrating Lymphocytes in Primary and Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis
10.1097/dcr.0000000000001332 · 2019 · External reference
The Prognostic Implications of Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Systematic Review and Meta-Analysis
10.1038/s41598-020-60255-4 · 2020 · External reference
Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis
10.1016/s1470-2045(23)00560-0 · 2024 · External reference
Prognostic significance of CD8+ T-cells density in stage III colorectal cancer depends on SDF-1 expression
10.1038/s41598-020-80382-2 · 2021 · External reference
Immune phenotypic linkage between colorectal cancer and liver metastasis
10.1016/j.ccell.2022.02.013 · 2022 · External reference
Treatment of metastatic colorectal cancer: ASCO guideline
10.1200/jco.22.01690 · 2023 · External reference
Systemic chemotherapy for patients with resectable or resected colorectal cancer liver metastases: An individual patient data meta-analysis
10.1016/j.ejca.2025.116092 · 2025 · External reference
Prognostic impact of immune response in resectable colorectal liver metastases treated by surgery alone or surgery with perioperative FOLFOX in the randomised EORTC study 40983
10.1016/j.ejca.2015.08.014 · 2015 · External reference
Survival benefit of neoadjuvant chemotherapy and surgery versus surgery first for resectable colorectal liver metastases: A cohort study
10.1111/ans.16613 · 2021 · External reference
RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer
10.1186/s40425-018-0438-3 · 2018 · External reference
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer
10.1097/dcr.0000000000002323 · 2021 · External reference
Clinical Response to Immunotherapy Targeting Programmed Cell Death Receptor 1/Programmed Cell Death Ligand 1 in Patients With Treatment-Resistant Microsatellite Stable Colorectal Cancer With and Without Liver Metastases
10.1001/jamanetworkopen.2021.18416 · ExternalCitation · doi-reference
Incidence and Survival in Synchronous and Metachronous Liver Metastases from Colorectal Cancer
10.1001/jamanetworkopen.2022.36666 · ExternalCitation · doi-reference
Prognostic value of intra-tumoral CD8+/FoxP3+ lymphocyte ratio in patients with resected colorectal cancer liver metastasis
10.1002/jso.25091 · ExternalCitation · doi-reference
Immune phenotypic linkage between colorectal cancer and liver metastasis
10.1016/j.ccell.2022.02.013 · ExternalCitation · doi-reference
Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer
10.1016/j.drup.2019.100644 · ExternalCitation · doi-reference
Prognostic impact of immune response in resectable colorectal liver metastases treated by surgery alone or surgery with perioperative FOLFOX in the randomised EORTC study 40983
10.1016/j.ejca.2015.08.014 · ExternalCitation · doi-reference
Systemic chemotherapy for patients with resectable or resected colorectal cancer liver metastases: An individual patient data meta-analysis
10.1016/j.ejca.2025.116092 · ExternalCitation · doi-reference
Immunity, tolerance and autoimmunity in the liver: A comprehensive review
10.1016/j.jaut.2015.08.020 · ExternalCitation · doi-reference
Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: A retrospective analysis
10.1016/s1470-2045(23)00560-0 · ExternalCitation · doi-reference
Microsatellite instable vs stable colon carcinomas: Analysis of tumour heterogeneity, inflammation and angiogenesis
10.1038/bjc.2015.213 · ExternalCitation · doi-reference
Immunology in the liver—From homeostasis to disease
10.1038/nrgastro.2015.200 · ExternalCitation · doi-reference
First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—The randomised METIMMOX trial
10.1038/s41416-024-02696-6 · ExternalCitation · doi-reference
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
10.1038/s41591-020-1131-x · ExternalCitation · doi-reference
First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: A phase 1b/2 trial
10.1038/s41591-023-02497-z · ExternalCitation · doi-reference
Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: A phase 1 trial
10.1038/s41591-024-03083-7 · ExternalCitation · doi-reference
The Prognostic Implications of Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Systematic Review and Meta-Analysis
10.1038/s41598-020-60255-4 · ExternalCitation · doi-reference
Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis
10.1038/s41598-020-67842-5 · ExternalCitation · doi-reference
Prognostic significance of CD8+ T-cells density in stage III colorectal cancer depends on SDF-1 expression
10.1038/s41598-020-80382-2 · ExternalCitation · doi-reference
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
10.1056/nejmoa2402141 · ExternalCitation · doi-reference
Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses
10.1073/pnas.1706559114 · ExternalCitation · doi-reference
Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases
10.1080/15384047.2020.1721252 · ExternalCitation · doi-reference
CXCL8 induces M2 macrophage polarization and inhibits CD8+ T cell infiltration to generate an immunosuppressive microenvironment in colorectal cancer
10.1096/fj.202201982rrr · ExternalCitation · doi-reference
Epidemiology and Management of Liver Metastases from Colorectal Cancer
10.1097/01.sla.0000217629.94941.cf · ExternalCitation · doi-reference
Prognostic Impact of Tumor-Infiltrating Lymphocytes in Primary and Metastatic Colorectal Cancer: A Systematic Review and Meta-analysis
10.1097/dcr.0000000000001332 · ExternalCitation · doi-reference
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer
10.1097/dcr.0000000000002323 · ExternalCitation · doi-reference
Survival benefit of neoadjuvant chemotherapy and surgery versus surgery first for resectable colorectal liver metastases: A cohort study
10.1111/ans.16613 · ExternalCitation · doi-reference
Single-cell analysis revealed a potential role of T-cell exhaustion in colorectal cancer with liver metastasis
10.1111/jcmm.18341 · ExternalCitation · doi-reference
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis
10.1126/sciimmunol.aba0759 · ExternalCitation · doi-reference
Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer
10.1136/jitc-2022-005025 · ExternalCitation · doi-reference
Immune responses in the liver
10.1146/annurev-immunol-051116-052415 · ExternalCitation · doi-reference
Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer
10.1158/1078-0432.ccr-16-0150 · ExternalCitation · doi-reference
Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non–Small Cell Lung Cancer
10.1158/1078-0432.ccr-20-3655 · ExternalCitation · doi-reference
The Liver–Immunity Nexus and Cancer Immunotherapy
10.1158/1078-0432.ccr-21-1193 · ExternalCitation · doi-reference
Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level
10.1158/2159-8290.cd-21-0316 · ExternalCitation · doi-reference
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC
10.1158/2326-6066.cir-16-0325 · ExternalCitation · doi-reference
Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
10.1158/2326-6066.cir-25-0031 · ExternalCitation · doi-reference
10.1186/s12885-017-3925-x
10.1186/s12885-017-3925-x · ExternalCitation · doi-reference
IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer
10.1186/s12943-025-02276-z · ExternalCitation · doi-reference
Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastases
10.1186/s12967-022-03667-2 · ExternalCitation · doi-reference
RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer
10.1186/s40425-018-0438-3 · ExternalCitation · doi-reference
Treatment of metastatic colorectal cancer: ASCO guideline
10.1200/jco.22.01690 · ExternalCitation · doi-reference
Lenvatinib Plus Pembrolizumab Versus Standard of Care for Previously Treated Metastatic Colorectal Cancer: Final Analysis of the Randomized, Open-Label, Phase III LEAP-017 Study
10.1200/jco.23.02736 · ExternalCitation · doi-reference
IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer
10.1245/s10434-023-13527-y · ExternalCitation · doi-reference
10.1371/journal.pone.0080362
10.1371/journal.pone.0080362 · ExternalCitation · doi-reference
10.3389/fimmu.2024.1505896
10.3389/fimmu.2024.1505896 · ExternalCitation · doi-reference
10.3390/ijms18040891
10.3390/ijms18040891 · ExternalCitation · doi-reference
Prognostic value of the density of tumor-infiltrating lymphocytes in colorectal cancer liver metastases
10.3892/ol.2021.13098 · ExternalCitation · doi-reference
