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References from RIPK1 in Alzheimer’s Disease: A Context-Dependent Signaling Hub Linking Aβ, Tau, Neuroinflammation, and Regulated Cell Death. Local targets link to admitted publications; unresolved targets remain external evidence.
A clinical perspective on the revised criteria for diagnosis and staging of Alzheimer’s disease
10.1038/s43587-024-00675-3 · 2024 · External reference
NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease
10.1016/j.jalz.2018.02.018 · 2018 · External reference
Alzheimer’s disease
10.1016/s0140-6736(20)32205-4 · 2021 · External reference
Neuroinflammation in Alzheimer’s disease
10.1016/s1474-4422(15)70016-5 · 2015 · External reference
Revised criteria for the diagnosis and staging of Alzheimer’s disease
10.1038/s41591-024-02988-7 · 2024 · External reference
10.3390/biomedicines14050953
10.3390/biomedicines14050953 · External reference
New insights into the genetic etiology of Alzheimer’s disease and related dementias
10.1038/s41588-022-01024-z · 2022 · External reference
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing
10.1038/s41588-019-0358-2 · 2019 · External reference
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease
10.1038/ng.3916 · 2017 · External reference
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
10.1016/j.cell.2017.05.018 · 2017 · External reference
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
10.1016/j.immuni.2017.08.008 · 2017 · External reference
Single-cell transcriptomic analysis of Alzheimer’s disease
10.1038/s41586-019-1195-2 · 2019 · External reference
Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation
10.1101/cshperspect.a036368 · 2020 · External reference
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
10.1038/s41583-018-0093-1 · 2019 · External reference
RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
10.1073/pnas.1714175114 · 2017 · External reference
Necroptosis activation in Alzheimer’s disease
10.1038/nn.4608 · 2017 · External reference
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
10.1038/nature02794 · 2004 · External reference
Caspase 8 inhibits programmed necrosis by processing CYLD
10.1038/ncb2362 · 2011 · External reference
Necroptosis-independent signaling by the RIP kinases in inflammation
10.1007/s00018-016-2203-4 · 2016 · External reference
Initiation and execution mechanisms of necroptosis: An overview
10.1038/cdd.2017.65 · 2017 · External reference
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
10.1016/j.molcel.2008.05.014 · 2008 · External reference
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
10.1016/j.molcel.2006.03.026 · 2006 · External reference
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
10.1016/j.tcb.2016.01.006 · 2016 · External reference
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
10.1016/j.molcel.2018.01.027 · 2018 · External reference
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
10.1016/j.molcel.2015.07.032 · 2015 · External reference
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners
10.1038/s41467-020-19935-y · 2020 · External reference
K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
10.1038/s41467-019-12033-8 · 2019 · External reference
10.1371/journal.pone.0076841
10.1371/journal.pone.0076841 · External reference
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
10.1038/s41419-019-1937-y · 2019 · External reference
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
10.1038/s41467-019-09690-0 · 2019 · External reference
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
10.1038/s41467-017-00406-w · 2017 · External reference
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
10.1016/j.molcel.2017.05.003 · 2017 · External reference
p38(MAPK)/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
10.1038/ncb3614 · 2017 · External reference
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
10.1038/s41586-019-1828-5 · 2020 · External reference
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
10.1038/s41586-019-1548-x · 2019 · External reference
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
10.1038/s41586-019-1830-y · 2020 · External reference
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
10.1016/j.cell.2009.05.037 · 2009 · External reference
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
10.1016/j.cell.2011.11.031 · 2012 · External reference
Activation of necroptosis in multiple sclerosis
10.1016/j.celrep.2015.02.051 · 2015 · External reference
Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease
10.1007/s00401-019-02103-y · 2020 · External reference
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer’s disease hippocampus
10.1186/s40478-021-01264-w · 2021 · External reference
TNF-alpha-dependent neuronal necroptosis regulated in Alzheimer’s disease by coordination of RIPK1-p62 complex with autophagic UVRAG
10.7150/thno.62376 · 2021 · External reference
O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis
10.1126/sciadv.abd3207 · 2021 · External reference
Abeta oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
10.1186/s40478-022-01332-9 · 2022 · External reference
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease
10.1186/s12974-022-02567-y · 2022 · External reference
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
10.1186/s40478-022-01432-6 · 2022 · External reference
Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Abeta Accumulation in Alzheimer’s Disease
10.1016/j.celrep.2020.108447 · 2020 · External reference
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
10.1126/science.abp9556 · 2023 · External reference
Inhibition of an Alzheimer’s disease-associated form of necroptosis rescues neuronal death in mouse models
10.1126/scitranslmed.adf5128 · 2024 · External reference
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients
10.1111/cts.13317 · 2022 · External reference
Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants
10.1111/cts.13690 · 2024 · External reference
Microglial phagocytosis in Alzheimer disease
10.1038/s41582-025-01162-y · 2026 · External reference
Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease
10.1016/j.neuron.2022.03.008 · 2022 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
10.1016/j.celrep.2021.109112 · 2021 · External reference
Nec-1 alleviates cognitive impairment with reduction of Abeta and tau abnormalities in APP/PS1 mice
10.15252/emmm.201606566 · 2017 · External reference
Necrostatin-1 Mitigates Cognitive Dysfunction in Prediabetic Rats with No Alteration in Insulin Sensitivity
10.2337/db19-1128 · 2020 · External reference
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
10.1016/j.cell.2008.10.044 · 2008 · External reference
Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models
10.1038/cddis.2012.176 · 2012 · External reference
Safety, Pharmacokinetics and Target Engagement of a Novel Brain Penetrant RIPK1 Inhibitor (SIR9900) in Healthy Adults and Elderly Participants
10.1111/cts.70151 · 2025 · External reference
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
10.1001/jama.2023.13239 · 2023 · External reference
Lecanemab in Early Alzheimer’s Disease
10.1056/nejmoa2212948 · 2023 · External reference
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
10.1126/scitranslmed.aav6221 · 2019 · External reference
The diagnostic performance of neurofilament light chain in CSF and blood for Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis: A systematic review and meta-analysis
2019 · External reference
Microglia measured by TSPO PET are associated with Alzheimer’s disease pathology and mediate key steps in a disease progression model
10.1002/alz.13699 · 2024 · External reference
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
10.1001/jama.2023.13239 · ExternalCitation · doi-reference
Microglia measured by TSPO PET are associated with Alzheimer’s disease pathology and mediate key steps in a disease progression model
10.1002/alz.13699 · ExternalCitation · doi-reference
Necroptosis-independent signaling by the RIP kinases in inflammation
10.1007/s00018-016-2203-4 · ExternalCitation · doi-reference
Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease
10.1007/s00401-019-02103-y · ExternalCitation · doi-reference
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
10.1016/j.cell.2008.10.044 · ExternalCitation · doi-reference
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
10.1016/j.cell.2009.05.037 · ExternalCitation · doi-reference
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
10.1016/j.cell.2011.11.031 · ExternalCitation · doi-reference
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
10.1016/j.cell.2017.05.018 · ExternalCitation · doi-reference
Activation of necroptosis in multiple sclerosis
10.1016/j.celrep.2015.02.051 · ExternalCitation · doi-reference
Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Abeta Accumulation in Alzheimer’s Disease
10.1016/j.celrep.2020.108447 · ExternalCitation · doi-reference
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
10.1016/j.celrep.2021.109112 · ExternalCitation · doi-reference
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
10.1016/j.immuni.2017.08.008 · ExternalCitation · doi-reference
NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease
10.1016/j.jalz.2018.02.018 · ExternalCitation · doi-reference
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
10.1016/j.molcel.2006.03.026 · ExternalCitation · doi-reference
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
10.1016/j.molcel.2008.05.014 · ExternalCitation · doi-reference
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
10.1016/j.molcel.2015.07.032 · ExternalCitation · doi-reference
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
10.1016/j.molcel.2017.05.003 · ExternalCitation · doi-reference
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
10.1016/j.molcel.2018.01.027 · ExternalCitation · doi-reference
Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease
10.1016/j.neuron.2022.03.008 · ExternalCitation · doi-reference
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
10.1016/j.tcb.2016.01.006 · ExternalCitation · doi-reference
Alzheimer’s disease
10.1016/s0140-6736(20)32205-4 · ExternalCitation · doi-reference
Neuroinflammation in Alzheimer’s disease
10.1016/s1474-4422(15)70016-5 · ExternalCitation · doi-reference
Initiation and execution mechanisms of necroptosis: An overview
10.1038/cdd.2017.65 · ExternalCitation · doi-reference
Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models
10.1038/cddis.2012.176 · ExternalCitation · doi-reference
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
10.1038/nature02794 · ExternalCitation · doi-reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · ExternalCitation · doi-reference
Caspase 8 inhibits programmed necrosis by processing CYLD
10.1038/ncb2362 · ExternalCitation · doi-reference
p38(MAPK)/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection
10.1038/ncb3614 · ExternalCitation · doi-reference
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease
10.1038/ng.3916 · ExternalCitation · doi-reference
Necroptosis activation in Alzheimer’s disease
10.1038/nn.4608 · ExternalCitation · doi-reference
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
10.1038/s41419-019-1937-y · ExternalCitation · doi-reference
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
10.1038/s41467-017-00406-w · ExternalCitation · doi-reference
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
10.1038/s41467-019-09690-0 · ExternalCitation · doi-reference
K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation
10.1038/s41467-019-12033-8 · ExternalCitation · doi-reference
Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners
10.1038/s41467-020-19935-y · ExternalCitation · doi-reference
Microglial phagocytosis in Alzheimer disease
10.1038/s41582-025-01162-y · ExternalCitation · doi-reference
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
10.1038/s41583-018-0093-1 · ExternalCitation · doi-reference
Single-cell transcriptomic analysis of Alzheimer’s disease
10.1038/s41586-019-1195-2 · ExternalCitation · doi-reference
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
10.1038/s41586-019-1548-x · ExternalCitation · doi-reference
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
10.1038/s41586-019-1828-5 · ExternalCitation · doi-reference
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
10.1038/s41586-019-1830-y · ExternalCitation · doi-reference
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing
10.1038/s41588-019-0358-2 · ExternalCitation · doi-reference
New insights into the genetic etiology of Alzheimer’s disease and related dementias
10.1038/s41588-022-01024-z · ExternalCitation · doi-reference
Revised criteria for the diagnosis and staging of Alzheimer’s disease
10.1038/s41591-024-02988-7 · ExternalCitation · doi-reference
A clinical perspective on the revised criteria for diagnosis and staging of Alzheimer’s disease
10.1038/s43587-024-00675-3 · ExternalCitation · doi-reference
Lecanemab in Early Alzheimer’s Disease
10.1056/nejmoa2212948 · ExternalCitation · doi-reference
RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
10.1073/pnas.1714175114 · ExternalCitation · doi-reference
Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation
10.1101/cshperspect.a036368 · ExternalCitation · doi-reference
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients
10.1111/cts.13317 · ExternalCitation · doi-reference
Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants
10.1111/cts.13690 · ExternalCitation · doi-reference
Safety, Pharmacokinetics and Target Engagement of a Novel Brain Penetrant RIPK1 Inhibitor (SIR9900) in Healthy Adults and Elderly Participants
10.1111/cts.70151 · ExternalCitation · doi-reference
O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis
10.1126/sciadv.abd3207 · ExternalCitation · doi-reference
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
10.1126/science.abp9556 · ExternalCitation · doi-reference
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
10.1126/scitranslmed.aav6221 · ExternalCitation · doi-reference
Inhibition of an Alzheimer’s disease-associated form of necroptosis rescues neuronal death in mouse models
10.1126/scitranslmed.adf5128 · ExternalCitation · doi-reference
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease
10.1186/s12974-022-02567-y · ExternalCitation · doi-reference
TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer’s disease hippocampus
10.1186/s40478-021-01264-w · ExternalCitation · doi-reference
Abeta oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
10.1186/s40478-022-01332-9 · ExternalCitation · doi-reference
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
10.1186/s40478-022-01432-6 · ExternalCitation · doi-reference
10.1371/journal.pone.0076841
10.1371/journal.pone.0076841 · ExternalCitation · doi-reference
Nec-1 alleviates cognitive impairment with reduction of Abeta and tau abnormalities in APP/PS1 mice
10.15252/emmm.201606566 · ExternalCitation · doi-reference
Necrostatin-1 Mitigates Cognitive Dysfunction in Prediabetic Rats with No Alteration in Insulin Sensitivity
10.2337/db19-1128 · ExternalCitation · doi-reference
10.3390/biomedicines14050953
10.3390/biomedicines14050953 · ExternalCitation · doi-reference
TNF-alpha-dependent neuronal necroptosis regulated in Alzheimer’s disease by coordination of RIPK1-p62 complex with autophagic UVRAG
10.7150/thno.62376 · ExternalCitation · doi-reference
