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References from Decoding Mitophagy in Breast Cancer: Biological Mechanisms, Dual Roles, and Clinical Implications. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3390/cancers17071102
10.3390/cancers17071102 · External reference
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Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers
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Autophagy Modulation in Therapeutic Strategy of Breast Cancer Drug Resistance
10.7150/jca.97775 · 2024 · External reference
Distinct mechanisms of cell in breast cancer and their clinical implication
10.1007/s10565-025-10104-9 · 2025 · External reference
The pathways of mitophagy for quality control and clearance of mitochondria
10.1038/cdd.2012.81 · 2013 · External reference
Mitophagy in the pathogenesis and management of disease
10.1038/s41422-025-01203-7 · 2026 · External reference
10.1371/journal.pbio.1000298
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Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy
10.1074/jbc.m111.322933 · 2012 · External reference
Mitophagy’s impacts on cancer and neurodegenerative diseases: Implications for future therapies
10.1186/s13045-025-01727-w · 2025 · External reference
Essential role for Nix in autophagic maturation of erythroid cells
10.1038/nature07006 · 2008 · External reference
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
10.1038/ncb2422 · 2012 · External reference
10.1186/s12915-017-0470-7
10.1186/s12915-017-0470-7 · External reference
Phosphorylated ubiquitin chain is the genuine Parkin receptor
10.1083/jcb.201410050 · 2015 · External reference
Sirtuins in mitophagy: Key gatekeepers of mitochondrial quality
10.1007/s11010-025-05358-0 · 2025 · External reference
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
10.1016/j.molcel.2015.08.016 · 2015 · External reference
TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease-NC-ND license
10.1016/j.matbio.2021.01.004 · 2021 · External reference
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
10.1073/pnas.1523926113 · 2016 · External reference
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
10.1016/j.molcel.2023.04.021 · 2023 · External reference
The Role of Mitophagy in Regulating Cell Death
10.1155/2021/6617256 · 2021 · External reference
Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery
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10.1016/b978-0-443-15260-3.00012-0
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TGFB signaling induces mitophagy via PLSCR3-mediated cardiolipin externalization in conjunction with a BNIP3L/NIX-, BNIP3-, and FUNDC1-dependent mechanism
10.1080/15548627.2025.2483441 · 2025 · External reference
Prohibitins, Phb1 and Phb2, function as Atg8 receptors to support yeast mitophagy and also play a negative regulatory role in Atg32 processing
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ESCRT-mediated phagophore sealing during mitophagy
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10.3390/cells8050493
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10.3389/fonc.2012.00171
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Mitophagy-driven multidimensional regulation of tumor immune evasion and context-dependent therapeutic strategies
10.1186/s12967-026-07837-4 · 2026 · External reference
New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases
10.1016/j.biopha.2024.117084 · 2024 · External reference
Reactive oxygen species in cell signaling and cell death: A redox perspective on metabolic and inflammatory disorders
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Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1
10.1016/j.molcel.2015.08.011 · 2015 · External reference
Parkin as a tumor suppressor gene for hepatocellular carcinoma
10.1038/onc.2008.199 · 2008 · External reference
Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25–q27
10.1073/pnas.0931262100 · 2003 · External reference
Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells
10.1074/jbc.m110.108241 · 2010 · External reference
PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN
10.1080/23723556.2017.1329692 · 2017 · External reference
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
10.1038/s41467-017-01947-w · 2017 · External reference
Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor
10.1172/jci185838 · 2024 · External reference
Parkin activates innate immunity and promotes antitumor immune responses
10.1172/jci180983 · 2024 · External reference
10.1158/1538-7445.am2020-72
10.1158/1538-7445.am2020-72 · External reference
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
10.1073/pnas.1113884108 · 2011 · External reference
TAT-ODD-p53 Enhances the Radiosensitivity of Hypoxic Breast Cancer Cells by Inhibiting Parkin-Mediated Mitophagy
10.18632/oncotarget.4002 · 2015 · External reference
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production
10.1038/s41418-021-00760-9 · 2021 · External reference
PINK1 mediated mitophagy enhances breast cancer proliferation through metabolic reprogramming
10.3892/or.2026.9117 · 2026 · External reference
Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis
10.15252/embr.201540759 · 2015 · External reference
Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer
10.1016/j.xcrm.2025.102478 · 2025 · External reference
10.1186/1471-2407-9-175
10.1186/1471-2407-9-175 · External reference
BNIP3 as a progression marker in primary human breast cancer opposing functions in in situ versus invasive cancer
10.1158/1078-0432.ccr-06-1466 · 2007 · External reference
Mitophagy: Insights into its signaling molecules, biological functions, and therapeutic potential in breast cancer
10.1038/s41420-024-02226-6 · 2024 · External reference
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis
10.1002/advs.201903616 · 2020 · External reference
MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis
10.1080/15548627.2020.1850609 · 2021 · External reference
The mitophagy pathway and its implications in human diseases
10.1038/s41392-023-01503-7 · 2023 · External reference
Autophagy and oxidative stress in solid tumors: Mechanisms and therapeutic opportunities
10.1016/j.critrevonc.2025.104820 · 2025 · External reference
HIF-1α Activates Mitophagy through BNIP3 to Inhibit IPEC-J2 Apoptosis under Heat Stress
10.1021/acs.jafc.5c09057 · 2025 · External reference
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1
10.1080/15548627.2023.2182482 · 2023 · External reference
HIF-1-induced mitochondrial ribosome protein L52: A mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia
10.7150/thno.57804 · 2021 · External reference
MANF facilitates breast cancer cell survival under glucose-starvation conditions via PRKN-mediated mitophagy regulation
10.1080/15548627.2024.2392415 · 2025 · External reference
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with ‘Warburg-like’ cancer metabolism and L-lactate production
10.4161/cc.21384 · 2012 · External reference
Metabolic crosstalk among cancer-associated fibroblasts, adipocytes and immune cells as an immunosuppressive tumor microenvironment driver
10.1038/s12276-026-01650-1 · 2026 · External reference
10.3389/fimmu.2026.1760782
10.3389/fimmu.2026.1760782 · External reference
PTEN-induced putative kinase 1 (PINK1) down-regulation in breast cancer samples in association with mitotic rate
10.1016/j.mgene.2020.100748 · 2020 · External reference
Pink1 promotes cell proliferation and affects glycolysis in breast cancer
10.1177/15353702221082613 · 2022 · External reference
PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells
10.1016/j.humpath.2010.05.016 · 2011 · External reference
FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis
10.1016/j.ebiom.2019.02.032 · 2019 · External reference
Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1
10.1007/s12094-018-1958-5 · 2019 · External reference
Crosstalk between mitophagy and breast cancer: Mechanisms of action and clinical applications
10.1007/s00432-026-06434-8 · 2026 · External reference
10.3389/fphys.2025.1716765
10.3389/fphys.2025.1716765 · External reference
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization
10.1038/s41419-022-05345-z · 2022 · External reference
Exosomal microRNA-4535 of Melanoma Stem Cells Promotes Metastasis by Inhibiting Autophagy Pathway
10.1007/s12015-022-10358-4 · 2023 · External reference
Tunneling Nanotubes Promote Intercellular Mitochondria Transfer Followed by Increased Invasiveness in Bladder Cancer Cells
10.18632/oncotarget.14695 · 2017 · External reference
MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function
10.1038/srep09073 · 2015 · External reference
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
10.1038/s41422-022-00766-z · 2023 · External reference
10.3390/cancers16132481
10.3390/cancers16132481 · External reference
Autophagy, cancer stem cells and drug resistance
10.1002/path.5222 · 2019 · External reference
Mitophagy and cancer: Role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration
10.18632/aging.205939 · 2024 · External reference
Mitophagy is a novel protective mechanism for drug-tolerant persister (DTP) cancer cells
10.1080/15548627.2023.2177398 · 2023 · External reference
A mitochondria-interfering nanocomplex cooperates with photodynamic therapy to boost antitumor immunity
10.1016/j.biomaterials.2025.123094 · 2025 · External reference
The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression
10.1038/s41388-022-02199-9 · 2022 · External reference
ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade
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A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission
10.1080/15548627.2015.1056970 · 2015 · External reference
miR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibition
10.1038/s41420-024-01914-7 · 2024 · External reference
Repurposing chlorpromazine for the treatment of triple-negative breast cancer growth and metastasis based on modulation of mitochondria-mediated apoptosis and autophagy/mitophagy
10.1038/s41416-025-02992-9 · 2025 · External reference
Mitochondrial pyruvate dehydrogenase kinase 1 drives bevacizumab resistance and malignant phenotype of TNBC by enhancing mitophagy
10.1016/j.phrs.2025.108081 · 2026 · External reference
Impact of context-dependent autophagy states on tumor progression
10.1038/s43018-023-00546-7 · 2023 · External reference
Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers
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10.3389/fimmu.2026.1740830 · External reference
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10.3389/fimmu.2026.1743222 · External reference
Discovery of a new mitophagy-related gene signature for predicting the outlook and immunotherapy in triple-negative breast cancer
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Multi-omics and experimental analysis unveil theragnostic value and immunological roles of inner membrane mitochondrial protein (IMMT) in breast cancer
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Emerging trends and hot topics in the application of multi-omics in drug discovery: A bibliometric and visualized study
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A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery
10.1016/j.chembiol.2011.05.013 · 2011 · External reference
Mito-QC illuminates mitophagy and mitochondrial architecture in vivo
10.1083/jcb.201603039 · 2016 · External reference
10.3389/fcell.2024.1460061
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Outstanding Questions in Mitophagy: What We Do and Do Not Know
10.1016/j.jmb.2019.06.032 · 2020 · External reference
Mitochondrial degradation: Mitophagy and beyond
10.1016/j.molcel.2023.08.021 · 2023 · External reference
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC
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