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References from CRM1-Dependent Cytoplasmic Accumulation of TRIM27 Is Associated with Glomerular Endothelial Cell Injury in Lupus Nephritis. Local targets link to admitted publications; unresolved targets remain external evidence.
Lupus nephritis-related chronic kidney disease
10.1038/s41584-024-01158-w · 2024 · External reference
Disease-Modifying Therapies in Lupus Nephritis: A Narrative Review Evaluating Currently Used Pharmacologic Agents
10.1007/s40744-025-00752-y · 2025 · External reference
10.3390/ijms26062621
10.3390/ijms26062621 · External reference
10.3390/ijms25169107
10.3390/ijms25169107 · External reference
Telmisartan Mitigates High-Glucose-Induced Injury in Renal Glomerular Endothelial Cells (rGECs) and Albuminuria in Diabetes Mice
10.1021/acs.chemrestox.1c00159 · 2021 · External reference
Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis
10.1155/2021/9993971 · 2021 · External reference
Loss of the Endothelial Glycocalyx Component EMCN Leads to Glomerular Impairment
10.1161/circresaha.124.325218 · 2025 · External reference
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells
10.1038/s41401-024-01421-6 · 2025 · External reference
HMGB1 Encapsulated in Podocyte-Derived Exosomes Plays a Central Role in Glomerular Endothelial Cell Injury in Lupus Nephritis by Regulating TRIM27 Expression
10.1016/j.labinv.2025.104096 · 2025 · External reference
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis
10.15252/embj.2021109777 · 2022 · External reference
TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux
10.1080/15548627.2024.2321831 · 2024 · External reference
TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal
10.1038/s41423-022-00963-1 · 2023 · External reference
TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway
10.1038/s41374-021-00591-9 · 2021 · External reference
Nucleocytoplasmic shuttling of BEFV M protein-modulated by lamin A/C and chromosome maintenance region 1 through a transcription-, carrier- and energy-dependent pathway
10.1016/j.vetmic.2024.110026 · 2024 · External reference
Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase
10.1016/j.bbamcr.2021.119104 · 2021 · External reference
AKT kinases as therapeutic targets
10.1186/s13046-024-03207-4 · 2024 · External reference
Endothelium structure and function in kidney health and disease
10.1038/s41581-018-0098-z · 2019 · External reference
Endothelial cell plasticity in kidney fibrosis and disease
10.1111/apha.14038 · 2023 · External reference
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
10.1016/j.molmed.2020.11.006 · 2021 · External reference
Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury
10.1038/s41581-021-00489-1 · 2022 · External reference
Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1
10.15252/emmm.202114146 · 2021 · External reference
Neutrophil Extracellular Traps Induce Glomerular Endothelial Cell Dysfunction and Pyroptosis in Diabetic Kidney Disease
10.2337/db22-0153 · 2022 · External reference
Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis
10.1172/jci.insight.131252 · 2020 · External reference
TRIM27-USP7 complex promotes tumour progression via STAT3 activation in human hepatocellular carcinoma
10.1111/liv.15346 · 2023 · External reference
TRIM27 suppresses inflammation injuries in pediatric pneumonia by targeting TLR4/NF-κB signaling pathway
10.15586/aei.v50i2.558 · 2022 · External reference
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
10.1016/j.expneurol.2023.114599 · 2024 · External reference
TRIM27-mediated ubiquitination of PPARγ promotes glutamate-induced cell apoptosis and inflammation
10.1016/j.yexcr.2020.112437 · 2021 · External reference
WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly
10.1073/pnas.2300310120 · 2023 · External reference
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
10.1016/j.celrep.2020.108586 · 2021 · External reference
CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function
10.1128/jvi.01273-21 · 2022 · External reference
Nuclear transport proteins: Structure, function, and disease relevance
10.1038/s41392-023-01649-4 · 2023 · External reference
The nuclear export protein XPO1—From biology to targeted therapy
10.1038/s41571-020-00442-4 · 2021 · External reference
Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth
2023 · External reference
Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1
10.1002/ctm2.1260 · 2023 · External reference
Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time
10.1124/pharmrev.120.000082 · 2021 · External reference
Spray-type modifications: An emerging paradigm in post-translational modifications
10.1016/j.tibs.2024.01.008 · 2024 · External reference
10.20944/preprints202401.1678.v1
10.20944/preprints202401.1678.v1 · External reference
EGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling
10.1083/jcb.202001120 · 2020 · External reference
TRIM24 is an insulin-responsive regulator of P-bodies
10.1038/s41467-022-31735-0 · 2022 · External reference
The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
10.1111/cpr.13275 · 2022 · External reference
An insight into PI3k/Akt pathway and associated protein-protein interactions in metabolic syndrome: A recent update
10.1002/jcb.30433 · 2023 · External reference
Akt in cancer: Mediator and more
10.1016/j.semcancer.2019.06.002 · 2019 · External reference
10.3390/antiox11091845
10.3390/antiox11091845 · External reference
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation
10.15252/embr.201948791 · 2020 · External reference
NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling
10.1186/s13578-023-01185-2 · 2023 · External reference
TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs
10.1038/s41419-023-05577-7 · 2023 · External reference
Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to CRM1
10.1002/ctm2.1260 · ExternalCitation · doi-reference
An insight into PI3k/Akt pathway and associated protein-protein interactions in metabolic syndrome: A recent update
10.1002/jcb.30433 · ExternalCitation · doi-reference
Disease-Modifying Therapies in Lupus Nephritis: A Narrative Review Evaluating Currently Used Pharmacologic Agents
10.1007/s40744-025-00752-y · ExternalCitation · doi-reference
Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase
10.1016/j.bbamcr.2021.119104 · ExternalCitation · doi-reference
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
10.1016/j.celrep.2020.108586 · ExternalCitation · doi-reference
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
10.1016/j.expneurol.2023.114599 · ExternalCitation · doi-reference
HMGB1 Encapsulated in Podocyte-Derived Exosomes Plays a Central Role in Glomerular Endothelial Cell Injury in Lupus Nephritis by Regulating TRIM27 Expression
10.1016/j.labinv.2025.104096 · ExternalCitation · doi-reference
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
10.1016/j.molmed.2020.11.006 · ExternalCitation · doi-reference
Akt in cancer: Mediator and more
10.1016/j.semcancer.2019.06.002 · ExternalCitation · doi-reference
Spray-type modifications: An emerging paradigm in post-translational modifications
10.1016/j.tibs.2024.01.008 · ExternalCitation · doi-reference
Nucleocytoplasmic shuttling of BEFV M protein-modulated by lamin A/C and chromosome maintenance region 1 through a transcription-, carrier- and energy-dependent pathway
10.1016/j.vetmic.2024.110026 · ExternalCitation · doi-reference
TRIM27-mediated ubiquitination of PPARγ promotes glutamate-induced cell apoptosis and inflammation
10.1016/j.yexcr.2020.112437 · ExternalCitation · doi-reference
Telmisartan Mitigates High-Glucose-Induced Injury in Renal Glomerular Endothelial Cells (rGECs) and Albuminuria in Diabetes Mice
10.1021/acs.chemrestox.1c00159 · ExternalCitation · doi-reference
TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway
10.1038/s41374-021-00591-9 · ExternalCitation · doi-reference
Nuclear transport proteins: Structure, function, and disease relevance
10.1038/s41392-023-01649-4 · ExternalCitation · doi-reference
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells
10.1038/s41401-024-01421-6 · ExternalCitation · doi-reference
TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs
10.1038/s41419-023-05577-7 · ExternalCitation · doi-reference
TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal
10.1038/s41423-022-00963-1 · ExternalCitation · doi-reference
TRIM24 is an insulin-responsive regulator of P-bodies
10.1038/s41467-022-31735-0 · ExternalCitation · doi-reference
The nuclear export protein XPO1—From biology to targeted therapy
10.1038/s41571-020-00442-4 · ExternalCitation · doi-reference
Endothelium structure and function in kidney health and disease
10.1038/s41581-018-0098-z · ExternalCitation · doi-reference
Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury
10.1038/s41581-021-00489-1 · ExternalCitation · doi-reference
Lupus nephritis-related chronic kidney disease
10.1038/s41584-024-01158-w · ExternalCitation · doi-reference
WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly
10.1073/pnas.2300310120 · ExternalCitation · doi-reference
TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux
10.1080/15548627.2024.2321831 · ExternalCitation · doi-reference
EGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling
10.1083/jcb.202001120 · ExternalCitation · doi-reference
Endothelial cell plasticity in kidney fibrosis and disease
10.1111/apha.14038 · ExternalCitation · doi-reference
The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
10.1111/cpr.13275 · ExternalCitation · doi-reference
TRIM27-USP7 complex promotes tumour progression via STAT3 activation in human hepatocellular carcinoma
10.1111/liv.15346 · ExternalCitation · doi-reference
Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time
10.1124/pharmrev.120.000082 · ExternalCitation · doi-reference
CRM1 Promotes Capsid Disassembly and Nuclear Envelope Translocation of Adenovirus Independently of Its Export Function
10.1128/jvi.01273-21 · ExternalCitation · doi-reference
Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis
10.1155/2021/9993971 · ExternalCitation · doi-reference
Loss of the Endothelial Glycocalyx Component EMCN Leads to Glomerular Impairment
10.1161/circresaha.124.325218 · ExternalCitation · doi-reference
Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis
10.1172/jci.insight.131252 · ExternalCitation · doi-reference
AKT kinases as therapeutic targets
10.1186/s13046-024-03207-4 · ExternalCitation · doi-reference
NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling
10.1186/s13578-023-01185-2 · ExternalCitation · doi-reference
TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis
10.15252/embj.2021109777 · ExternalCitation · doi-reference
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation
10.15252/embr.201948791 · ExternalCitation · doi-reference
Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1
10.15252/emmm.202114146 · ExternalCitation · doi-reference
TRIM27 suppresses inflammation injuries in pediatric pneumonia by targeting TLR4/NF-κB signaling pathway
10.15586/aei.v50i2.558 · ExternalCitation · doi-reference
10.20944/preprints202401.1678.v1
10.20944/preprints202401.1678.v1 · ExternalCitation · doi-reference
Neutrophil Extracellular Traps Induce Glomerular Endothelial Cell Dysfunction and Pyroptosis in Diabetic Kidney Disease
10.2337/db22-0153 · ExternalCitation · doi-reference
10.3390/antiox11091845
10.3390/antiox11091845 · ExternalCitation · doi-reference
10.3390/ijms25169107
10.3390/ijms25169107 · ExternalCitation · doi-reference
10.3390/ijms26062621
10.3390/ijms26062621 · ExternalCitation · doi-reference
