Research graph
References from Distinct Mechanisms of Sodium–Calcium Exchanger NCX1.4 Regulation by Ca2+, ATP, and PIP2. Local targets link to admitted publications; unresolved targets remain external evidence.
Sodium-calcium exchange: A molecular perspective
10.1146/annurev.physiol.62.1.111 · 2000 · External reference
Sodium/calcium exchanger: Influence of metabolic regulation on ion carrier interactions
10.1152/physrev.00018.2005 · 2006 · External reference
Basic and editing mechanisms underlying ion transport and regulation in NCX variants
10.1016/j.ceca.2019.102131 · 2020 · External reference
Regulation of ion transport from within ion transit pathways
10.1085/jgp.201912455 · 2020 · External reference
The Cardiac Na+-Ca2+ Exchanger: From Structure to Function
10.1002/j.2040-4603.2022.tb00196.x · 2021 · External reference
Regulation of cardiac Na+, Ca2+ exchange and KATP potassium channels by PIP2
10.1126/science.273.5277.956 · 1996 · External reference
On the special role of NCX in astrocytes: Translating Na+-transients into intracellular Ca2+ signals
10.1016/j.ceca.2019.102154 · 2020 · External reference
10.3390/ijms24010061
10.3390/ijms24010061 · External reference
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signaling?
10.1016/j.ceca.2023.102818 · 2023 · External reference
Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1
10.1038/s41467-023-41885-4 · 2023 · External reference
Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400
10.1038/s44318-023-00013-0 · 2024 · External reference
Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
10.1038/nsmb.3230 · 2016 · External reference
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger
10.1126/science.1215759 · 2012 · External reference
Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation
10.1073/pnas.1415751111 · 2014 · External reference
Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger
10.1016/j.ceca.2018.09.004 · 2018 · External reference
Dynamic distinctions in the Na+/Ca2+ exchanger adopting the inward- and outward-facing conformational states
10.1074/jbc.m117.787168 · 2017 · External reference
10.3389/fchem.2021.722336
10.3389/fchem.2021.722336 · External reference
10.3390/ijms25136909
10.3390/ijms25136909 · External reference
Conformational free-energy landscapes of a Na+/Ca2+ exchanger explain its alternating-access mechanism and functional specificity
10.1073/pnas.2318009121 · 2024 · External reference
Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium-calcium exchanger (NCX_Mj)
10.1016/j.ceca.2014.08.010 · 2014 · External reference
Characteristic attributes limiting the transport rates in NCX orthologs
10.1016/j.bbamem.2021.183792 · 2022 · External reference
Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants
10.1007/978-3-319-55858-5_3 · 2017 · External reference
10.1371/journal.pone.0039985
10.1371/journal.pone.0039985 · External reference
Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX)
10.1074/jbc.m113.471698 · 2013 · External reference
Unresolved reference
External reference
Identification of a peptide inhibitor of the cardiac sarcolemmal Na+-Ca2+ exchanger
10.1016/s0021-9258(17)35276-6 · 1991 · External reference
The Intracellular Loop of the Na+/Ca2+ Exchanger Contains an “Awareness Ribbon”-Shaped Two-Helix Bundle Domain
10.1021/acs.biochem.8b00300 · 2018 · External reference
Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors
10.1016/j.molcel.2006.03.008 · 2006 · External reference
Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism
10.1073/pnas.0902171106 · 2009 · External reference
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif
10.1074/jbc.c600117200 · 2006 · External reference
Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein
10.1074/jbc.m809012200 · 2009 · External reference
The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: Crystal structures and mutational analysis
10.1073/pnas.0707417104 · 2007 · External reference
Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger
10.1074/jbc.m109.055434 · 2009 · External reference
Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
10.7554/elife.105396 · 2025 · External reference
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP
10.1085/jgp.100.6.933 · 1992 · External reference
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation
10.1085/jgp.100.6.905 · 1992 · External reference
Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents
10.1038/sj.bjp.0704574 · 2002 · External reference
Regulation and deregulation of cardiac Na+-Ca2+ exchange in giant excised sarcolemmal membrane patches
10.1038/344242a0 · 1990 · External reference
Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3)
10.1152/ajpcell.1998.274.2.c415 · 1998 · External reference
Ionic regulatory properties of brain and kidney splice variants of the NCX1 Na+-Ca2+ exchanger
10.1085/jgp.114.5.701 · 1999 · External reference
Kinetic and equilibrium properties of regulatory Ca2+-binding domains in sodium-calcium exchangers 2 and 3
10.1016/j.ceca.2016.01.008 · 2016 · External reference
Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms
10.1038/s41598-017-01102-x · 2017 · External reference
10.3389/fphys.2016.00030
10.3389/fphys.2016.00030 · External reference
Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants
10.1016/j.ceca.2012.04.007 · 2012 · External reference
Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger
10.1074/jbc.m110.214106 · 2011 · External reference
Structural dynamics of Na+ and Ca2+ interactions with full-size mammalian NCX
10.1038/s42003-024-06159-9 · 2024 · External reference
Interaction of PIP2 with the XIP region of the cardiac Na/Ca exchanger
10.1152/ajpcell.2000.278.4.c661 · 2000 · External reference
Dual control of cardiac Na+ Ca2+ exchange by PIP2: Electrophysiological analysis of direct and indirect mechanisms
10.1113/jphysiol.2007.132712 · 2007 · External reference
Calcium- and ATP-dependent regulation of Na/Ca exchange function in BHK cells: Comparison of NCX1 and NCX3 exchangers
10.1016/j.ceca.2018.04.007 · 2018 · External reference
Mechanism of partial reactions in the cardiac Na+-Ca2+ exchange system
10.1111/j.1749-6632.1991.tb17291.x · 1991 · External reference
Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger
10.1038/srep20753 · 2016 · External reference
Two sides of the same coin: Sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions
10.1002/glia.22492 · 2013 · External reference
Physiology of oligodendroglia
10.1152/physrev.00023.2025 · 2026 · External reference
ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex
10.1038/srep33609 · 2016 · External reference
Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes
10.1002/jnr.23995 · 2017 · External reference
Brain distribution of the Na+/Ca2+ exchanger-encoding genes NCX1, NCX2, and NCX3 and their related proteins in the central nervous system
10.1111/j.1749-6632.2002.tb04766.x · 2002 · External reference
Astrocyte sodium signaling and the regulation of neurotransmission
10.1002/glia.22943 · 2016 · External reference
Increased membrane Ca2+ permeability drives astrocytic Ca2+ dynamics during neuronal stimulation at excitatory synapses
10.1002/glia.24450 · 2023 · External reference
Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
10.1038/s41467-024-46751-5 · 2024 · External reference
Potassium channels in vascular smooth muscle cells
10.1152/physrev.00017.2025 · 2026 · External reference
Potassium channel regulation
10.1038/sj.embor.7400003 · 2003 · External reference
10.1371/journal.pone.0138856
10.1371/journal.pone.0138856 · External reference
Calmodulin binds and modulates K+-dependent Na+/Ca2+-exchanger isoform 4, NCKX4
10.1074/jbc.ra120.015037 · 2021 · External reference
Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger
10.1126/science.1239002 · 2013 · External reference
Structural basis for alternating access of a eukaryotic calcium/proton exchanger
10.1038/nature12233 · 2013 · External reference
Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation
10.1073/pnas.1302515110 · 2013 · External reference
Na+/Ca2+ exchangers: Three mammalian gene families control Ca2+ transport
10.1042/bj20070619 · 2007 · External reference
10.3389/fphar.2020.00070
10.3389/fphar.2020.00070 · External reference
Nanodiscs and solution nuclear magnetic resonance
10.1016/j.sbi.2025.103067 · 2025 · External reference
Probing Charge-Controlled Inter-Domain Flexibility: Integrating Experimental and Coarse-Grained Approaches
10.1021/acs.jcim.6c00989 · 2026 · External reference
10.3390/membranes12020227
10.3390/membranes12020227 · External reference
Lipid Nanodiscs for High-Resolution NMR Studies of Membrane Proteins
2025 · External reference
Rise of palmitoylation: A new trick to tune NCX1 activity
10.1016/j.bbamcr.2024.119719 · 2024 · External reference
Regulation of NCX1 by palmitoylation
10.1016/j.ceca.2019.102158 · 2020 · External reference
10.3390/ijms24010598
10.3390/ijms24010598 · External reference
Potassium-dependent sodium-calcium exchanger (NCKX) isoforms and neuronal function
10.1016/j.ceca.2019.102135 · 2020 · External reference
Palmitoylation and regulation of potassium-dependent sodium/calcium exchangers (NCKX)
10.1042/bsr20241051 · 2025 · External reference
Structure-function relationships of K+-dependent Na+/Ca2+ exchangers (NCKX)
10.1016/j.ceca.2019.102153 · 2020 · External reference
The Role of SLC24A5 (NCKX5) in Human Skin Pigmentation: The Importance of Cation Transport Activity
10.1016/j.jmb.2026.169947 · 2026 · External reference
Two sides of the same coin: Sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions
10.1002/glia.22492 · ExternalCitation · doi-reference
Astrocyte sodium signaling and the regulation of neurotransmission
10.1002/glia.22943 · ExternalCitation · doi-reference
Increased membrane Ca2+ permeability drives astrocytic Ca2+ dynamics during neuronal stimulation at excitatory synapses
10.1002/glia.24450 · ExternalCitation · doi-reference
The Cardiac Na+-Ca2+ Exchanger: From Structure to Function
10.1002/j.2040-4603.2022.tb00196.x · ExternalCitation · doi-reference
Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes
10.1002/jnr.23995 · ExternalCitation · doi-reference
Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants
10.1007/978-3-319-55858-5_3 · ExternalCitation · doi-reference
Rise of palmitoylation: A new trick to tune NCX1 activity
10.1016/j.bbamcr.2024.119719 · ExternalCitation · doi-reference
Characteristic attributes limiting the transport rates in NCX orthologs
10.1016/j.bbamem.2021.183792 · ExternalCitation · doi-reference
Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants
10.1016/j.ceca.2012.04.007 · ExternalCitation · doi-reference
Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium-calcium exchanger (NCX_Mj)
10.1016/j.ceca.2014.08.010 · ExternalCitation · doi-reference
Kinetic and equilibrium properties of regulatory Ca2+-binding domains in sodium-calcium exchangers 2 and 3
10.1016/j.ceca.2016.01.008 · ExternalCitation · doi-reference
Calcium- and ATP-dependent regulation of Na/Ca exchange function in BHK cells: Comparison of NCX1 and NCX3 exchangers
10.1016/j.ceca.2018.04.007 · ExternalCitation · doi-reference
Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger
10.1016/j.ceca.2018.09.004 · ExternalCitation · doi-reference
Basic and editing mechanisms underlying ion transport and regulation in NCX variants
10.1016/j.ceca.2019.102131 · ExternalCitation · doi-reference
Potassium-dependent sodium-calcium exchanger (NCKX) isoforms and neuronal function
10.1016/j.ceca.2019.102135 · ExternalCitation · doi-reference
Structure-function relationships of K+-dependent Na+/Ca2+ exchangers (NCKX)
10.1016/j.ceca.2019.102153 · ExternalCitation · doi-reference
On the special role of NCX in astrocytes: Translating Na+-transients into intracellular Ca2+ signals
10.1016/j.ceca.2019.102154 · ExternalCitation · doi-reference
Regulation of NCX1 by palmitoylation
10.1016/j.ceca.2019.102158 · ExternalCitation · doi-reference
Neuronal and astrocyte NCX isoform/splice variants: How do they participate in Na+ and Ca2+ signaling?
10.1016/j.ceca.2023.102818 · ExternalCitation · doi-reference
The Role of SLC24A5 (NCKX5) in Human Skin Pigmentation: The Importance of Cation Transport Activity
10.1016/j.jmb.2026.169947 · ExternalCitation · doi-reference
Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors
10.1016/j.molcel.2006.03.008 · ExternalCitation · doi-reference
Nanodiscs and solution nuclear magnetic resonance
10.1016/j.sbi.2025.103067 · ExternalCitation · doi-reference
Identification of a peptide inhibitor of the cardiac sarcolemmal Na+-Ca2+ exchanger
10.1016/s0021-9258(17)35276-6 · ExternalCitation · doi-reference
The Intracellular Loop of the Na+/Ca2+ Exchanger Contains an “Awareness Ribbon”-Shaped Two-Helix Bundle Domain
10.1021/acs.biochem.8b00300 · ExternalCitation · doi-reference
Probing Charge-Controlled Inter-Domain Flexibility: Integrating Experimental and Coarse-Grained Approaches
10.1021/acs.jcim.6c00989 · ExternalCitation · doi-reference
Regulation and deregulation of cardiac Na+-Ca2+ exchange in giant excised sarcolemmal membrane patches
10.1038/344242a0 · ExternalCitation · doi-reference
Structural basis for alternating access of a eukaryotic calcium/proton exchanger
10.1038/nature12233 · ExternalCitation · doi-reference
Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
10.1038/nsmb.3230 · ExternalCitation · doi-reference
Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1
10.1038/s41467-023-41885-4 · ExternalCitation · doi-reference
Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
10.1038/s41467-024-46751-5 · ExternalCitation · doi-reference
Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms
10.1038/s41598-017-01102-x · ExternalCitation · doi-reference
Structural dynamics of Na+ and Ca2+ interactions with full-size mammalian NCX
10.1038/s42003-024-06159-9 · ExternalCitation · doi-reference
Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400
10.1038/s44318-023-00013-0 · ExternalCitation · doi-reference
Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents
10.1038/sj.bjp.0704574 · ExternalCitation · doi-reference
Potassium channel regulation
10.1038/sj.embor.7400003 · ExternalCitation · doi-reference
Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger
10.1038/srep20753 · ExternalCitation · doi-reference
ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex
10.1038/srep33609 · ExternalCitation · doi-reference
Na+/Ca2+ exchangers: Three mammalian gene families control Ca2+ transport
10.1042/bj20070619 · ExternalCitation · doi-reference
Palmitoylation and regulation of potassium-dependent sodium/calcium exchangers (NCKX)
10.1042/bsr20241051 · ExternalCitation · doi-reference
The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: Crystal structures and mutational analysis
10.1073/pnas.0707417104 · ExternalCitation · doi-reference
Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism
10.1073/pnas.0902171106 · ExternalCitation · doi-reference
Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation
10.1073/pnas.1302515110 · ExternalCitation · doi-reference
Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation
10.1073/pnas.1415751111 · ExternalCitation · doi-reference
Conformational free-energy landscapes of a Na+/Ca2+ exchanger explain its alternating-access mechanism and functional specificity
10.1073/pnas.2318009121 · ExternalCitation · doi-reference
The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif
10.1074/jbc.c600117200 · ExternalCitation · doi-reference
Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger
10.1074/jbc.m109.055434 · ExternalCitation · doi-reference
Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger
10.1074/jbc.m110.214106 · ExternalCitation · doi-reference
Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX)
10.1074/jbc.m113.471698 · ExternalCitation · doi-reference
Dynamic distinctions in the Na+/Ca2+ exchanger adopting the inward- and outward-facing conformational states
10.1074/jbc.m117.787168 · ExternalCitation · doi-reference
Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein
10.1074/jbc.m809012200 · ExternalCitation · doi-reference
Calmodulin binds and modulates K+-dependent Na+/Ca2+-exchanger isoform 4, NCKX4
10.1074/jbc.ra120.015037 · ExternalCitation · doi-reference
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation
10.1085/jgp.100.6.905 · ExternalCitation · doi-reference
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP
10.1085/jgp.100.6.933 · ExternalCitation · doi-reference
Ionic regulatory properties of brain and kidney splice variants of the NCX1 Na+-Ca2+ exchanger
10.1085/jgp.114.5.701 · ExternalCitation · doi-reference
Regulation of ion transport from within ion transit pathways
10.1085/jgp.201912455 · ExternalCitation · doi-reference
Mechanism of partial reactions in the cardiac Na+-Ca2+ exchange system
10.1111/j.1749-6632.1991.tb17291.x · ExternalCitation · doi-reference
Brain distribution of the Na+/Ca2+ exchanger-encoding genes NCX1, NCX2, and NCX3 and their related proteins in the central nervous system
10.1111/j.1749-6632.2002.tb04766.x · ExternalCitation · doi-reference
Dual control of cardiac Na+ Ca2+ exchange by PIP2: Electrophysiological analysis of direct and indirect mechanisms
10.1113/jphysiol.2007.132712 · ExternalCitation · doi-reference
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger
10.1126/science.1215759 · ExternalCitation · doi-reference
Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger
10.1126/science.1239002 · ExternalCitation · doi-reference
Regulation of cardiac Na+, Ca2+ exchange and KATP potassium channels by PIP2
10.1126/science.273.5277.956 · ExternalCitation · doi-reference
Sodium-calcium exchange: A molecular perspective
10.1146/annurev.physiol.62.1.111 · ExternalCitation · doi-reference
Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3)
10.1152/ajpcell.1998.274.2.c415 · ExternalCitation · doi-reference
Interaction of PIP2 with the XIP region of the cardiac Na/Ca exchanger
10.1152/ajpcell.2000.278.4.c661 · ExternalCitation · doi-reference
Potassium channels in vascular smooth muscle cells
10.1152/physrev.00017.2025 · ExternalCitation · doi-reference
Sodium/calcium exchanger: Influence of metabolic regulation on ion carrier interactions
10.1152/physrev.00018.2005 · ExternalCitation · doi-reference
Physiology of oligodendroglia
10.1152/physrev.00023.2025 · ExternalCitation · doi-reference
10.1371/journal.pone.0039985
10.1371/journal.pone.0039985 · ExternalCitation · doi-reference
10.1371/journal.pone.0138856
10.1371/journal.pone.0138856 · ExternalCitation · doi-reference
10.3389/fchem.2021.722336
10.3389/fchem.2021.722336 · ExternalCitation · doi-reference
10.3389/fphar.2020.00070
10.3389/fphar.2020.00070 · ExternalCitation · doi-reference
10.3389/fphys.2016.00030
10.3389/fphys.2016.00030 · ExternalCitation · doi-reference
10.3390/ijms24010061
10.3390/ijms24010061 · ExternalCitation · doi-reference
10.3390/ijms24010598
10.3390/ijms24010598 · ExternalCitation · doi-reference
10.3390/ijms25136909
10.3390/ijms25136909 · ExternalCitation · doi-reference
10.3390/membranes12020227
10.3390/membranes12020227 · ExternalCitation · doi-reference
Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
10.7554/elife.105396 · ExternalCitation · doi-reference
