Research graph
References from Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Endometriosis Is a Chronic Systemic Disease: Clinical Challenges and Novel Innovations
10.1016/s0140-6736(21)00389-5 · 2021 · External reference
Endometriosis: Etiology, Pathobiology, and Therapeutic Prospects
10.1016/j.cell.2021.04.041 · 2021 · External reference
The Role of Small Extracellular Vesicle-miRNAs in Endometriosis
10.1093/humrep/dead216 · 2023 · External reference
Endometriosis Still a Challenge
2014 · External reference
Endometrial Stem Cells: Orchestrating Dynamic Regeneration of Endometrium and Their Implications in Diverse Endometrial Disorders
10.7150/ijbs.89795 · 2024 · External reference
Müllerianosis
2007 · External reference
Embryologic Origin of Endometriosis: Analysis of 101 Human Female Fetuses
10.1002/jcp.22888 · 2012 · External reference
The Ischemic Time Window of Ectopic Endometrial Tissue Crucially Determines Its Ability to Develop into Endometriotic Lesions
10.1038/s41598-022-09577-z · 2022 · External reference
Rethinking the Pathogenesis of Endometriosis: Complex Interactions of Genomic, Epigenetic, and Environmental Factors
10.1111/jog.16089 · 2024 · External reference
10.3390/jpm12020216
10.3390/jpm12020216 · External reference
An Emerging Role for Neutrophils in the Pathogenesis of Endometriosis
10.1038/s44294-025-00059-x · 2025 · External reference
Single-Cell Transcriptomic Analysis of Endometriosis
10.1038/s41588-022-01254-1 · 2023 · External reference
10.3390/cells11132028
10.3390/cells11132028 · External reference
Participant Acceptability Questionnaire Results from the Meatal Swab Yourself with Testing for Infections Collectively (MYSTIC) Study: A Diagnostic Accuracy Study of Rectal and Pharyngeal Swabs Pooled with Meatal Swabs, or First-Catch Urine, for Gonorrhoea and CHLAmydia Detection
10.1136/sextrans-2025-056613 · 2025 · External reference
10.1186/s12916-022-02500-3
10.1186/s12916-022-02500-3 · External reference
Single-Cell Analysis of Endometriosis Reveals a Coordinated Transcriptional Programme Driving Immunotolerance and Angiogenesis across Eutopic and Ectopic Tissues
10.1038/s41556-022-00961-5 · 2022 · External reference
Massively Parallel Digital Transcriptional Profiling of Single Cells
10.1038/ncomms14049 · 2017 · External reference
SCANPY: Large-Scale Single-Cell Gene Expression Data Analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Assessing GPT-4 for Cell Type Annotation in Single-Cell RNA-Seq Analysis
10.1038/s41592-024-02235-4 · 2024 · External reference
Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone HSP90 by Fragment Based Drug Design
10.1021/jm100060b · 2010 · External reference
The Crystal and Cryo-EM Structures of PLCγ2 Reveal Dynamic Interdomain Recognitions in Autoinhibition
10.1126/sciadv.adn6037 · 2024 · External reference
LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and Their Use as Virtual Screening Filters
10.1021/ci049885e · 2005 · External reference
AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading
10.1002/jcc.21334 · 2010 · External reference
GROMACS: High Performance Molecular Simulations through Multi-Level Parallelism from Laptops to Supercomputers
10.1016/j.softx.2015.06.001 · 2015 · External reference
Jr CHARMM36 All-Atom Additive Protein Force Field: Validation Based on Comparison to NMR Data
10.1002/jcc.23354 · 2013 · External reference
Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges
10.1021/ci3003649 · 2012 · External reference
Comparison of Simple Potential Functions for Simulating Liquid Water
10.1063/1.445869 · 1983 · External reference
Canonical Sampling through Velocity Rescaling
10.1063/1.2408420 · 2007 · External reference
Polymorphic Transitions in Single Crystals: A New Molecular Dynamics Method
10.1063/1.328693 · 1981 · External reference
Particle Mesh Ewald: An N⋅log(N) Method for Ewald Sums in Large Systems
10.1063/1.464397 · 1993 · External reference
Unresolved reference
External reference
ClusterProfiler: An R Package for Comparing Biological Themes among Gene Clusters
10.1089/omi.2011.0118 · 2012 · External reference
10.3389/fmolb.2017.00096
10.3389/fmolb.2017.00096 · External reference
HLA-Mediated Tumor Escape Mechanisms That May Impair Immunotherapy Clinical Outcomes via T-Cell Activation
10.3892/ol.2017.6784 · 2017 · External reference
Expression of Phosphoinositide-Specific Phospholipase C Enzymes in Normal Endometrium and in Endometriosis
10.1016/j.fertnstert.2012.04.020 · 2012 · External reference
Heat Shock Protein HSP90 Immunoexpression in Equine Endometrium during Oestrus, Dioestrus and Anoestrus
10.1111/ahe.12598 · 2021 · External reference
Persistent Dysregulation of Genes in the Development of Endometriosis
10.21037/atm-22-4806 · 2022 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Sorafenib Inhibits Growth, Migration, and Angiogenic Potential of Ectopic Endometrial Mesenchymal Stem Cells Derived from Patients with Endometriosis
10.1016/j.fertnstert.2012.08.003 · 2012 · External reference
Inhibition of MAPK and VEGFR by Sorafenib Controls the Progression of Endometriosis
10.1177/1933719115592708 · 2015 · External reference
Alpelisib for -Mutated, Hormone Receptor-Positive Advanced Breast Cancer
10.1056/nejmoa1813904 · 2019 · External reference
Sulindac Improves Stiffness and Quality of Life in Women Taking Aromatase Inhibitors for Breast Cancer
10.1007/s10549-021-06485-0 · 2022 · External reference
Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti-PD-L1 Immunotherapy
10.1158/1535-7163.mct-20-0934 · 2021 · External reference
Unresolved reference
External reference
Gene Expression Profile for Ectopic versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential
10.1210/me.2008-0322 · 2008 · External reference
Th1 and Th2 Ummune Responses Related to Pelvic Endometriosis
1992 · External reference
10.3390/jcm8091468
10.3390/jcm8091468 · External reference
The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action
10.2174/138920207783591690 · 2007 · External reference
10.3390/diagnostics10050255
10.3390/diagnostics10050255 · External reference
The Association between Endometriosis and Autoimmune Diseases: A Systematic Review and Meta-Analysis
10.1093/humupd/dmz014 · 2019 · External reference
HSP90A Inhibition Promotes Anti-Tumor Immunity by Reversing Multi-Modal Resistance and Stem-like Property of Immune-Refractory Tumors
10.1038/s41467-019-14259-y · 2020 · External reference
PLCG2 Is Associated with the Inflammatory Response and Is Induced by Amyloid Plaques in Alzheimer’s Disease
10.1186/s13073-022-01022-0 · 2022 · External reference
10.1056/nejmra1810764
10.1056/nejmra1810764 · External reference
10.3390/ijms24087503
10.3390/ijms24087503 · External reference
Upadacitinib Versus Placebo or Adalimumab in Patients with Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial
10.1002/art.41032 · 2019 · External reference
PI3K/AKT Signaling Pathway Associates with Pyroptosis and Inflammation in Patients with Endometriosis
10.1016/j.jri.2024.104213 · 2024 · External reference
Alpelisib for PIK3CA-Mutated Advanced Gynecological Cancers: First Clues of Clinical Activity
10.1016/j.ygyno.2024.02.029 · 2024 · External reference
Sulindac Suppresses Nuclear Factor-kappaB Activation and RANTES Gene and Protein Expression in Endometrial Stromal Cells from Women with Endometriosis
10.1210/jc.2005-0972 · 2005 · External reference
Identifying Therapeutic Candidates for Endometriosis through a Transcriptomics-Based Drug Repositioning Approach
10.1016/j.isci.2024.109388 · 2024 · External reference
Exploring the Inhibitory Mechanism of Resorcinylic Isoxazole Amine NVP-AUY922 towards the Discovery of Potential Heat Shock Protein 90 (HSP90) Inhibitors
2022 · External reference
The Immunopathophysiology of Endometriosis
10.1016/j.molmed.2018.07.004 · 2018 · External reference
Targeting HSP90 as a Therapeutic Approach for Endometriosis: Insights from Proteomic Analysis
10.1093/reprod/xaaf002 · 2026 · External reference
PLCG2 across Human Disease: Genetic Variants, Signaling Mechanisms, and Clinical Implications
10.1186/s12967-025-07632-7 · 2026 · External reference
Upadacitinib Versus Placebo or Adalimumab in Patients with Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial
10.1002/art.41032 · ExternalCitation · doi-reference
AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading
10.1002/jcc.21334 · ExternalCitation · doi-reference
Jr CHARMM36 All-Atom Additive Protein Force Field: Validation Based on Comparison to NMR Data
10.1002/jcc.23354 · ExternalCitation · doi-reference
Embryologic Origin of Endometriosis: Analysis of 101 Human Female Fetuses
10.1002/jcp.22888 · ExternalCitation · doi-reference
Sulindac Improves Stiffness and Quality of Life in Women Taking Aromatase Inhibitors for Breast Cancer
10.1007/s10549-021-06485-0 · ExternalCitation · doi-reference
Endometriosis: Etiology, Pathobiology, and Therapeutic Prospects
10.1016/j.cell.2021.04.041 · ExternalCitation · doi-reference
Expression of Phosphoinositide-Specific Phospholipase C Enzymes in Normal Endometrium and in Endometriosis
10.1016/j.fertnstert.2012.04.020 · ExternalCitation · doi-reference
Sorafenib Inhibits Growth, Migration, and Angiogenic Potential of Ectopic Endometrial Mesenchymal Stem Cells Derived from Patients with Endometriosis
10.1016/j.fertnstert.2012.08.003 · ExternalCitation · doi-reference
Identifying Therapeutic Candidates for Endometriosis through a Transcriptomics-Based Drug Repositioning Approach
10.1016/j.isci.2024.109388 · ExternalCitation · doi-reference
PI3K/AKT Signaling Pathway Associates with Pyroptosis and Inflammation in Patients with Endometriosis
10.1016/j.jri.2024.104213 · ExternalCitation · doi-reference
The Immunopathophysiology of Endometriosis
10.1016/j.molmed.2018.07.004 · ExternalCitation · doi-reference
GROMACS: High Performance Molecular Simulations through Multi-Level Parallelism from Laptops to Supercomputers
10.1016/j.softx.2015.06.001 · ExternalCitation · doi-reference
Alpelisib for PIK3CA-Mutated Advanced Gynecological Cancers: First Clues of Clinical Activity
10.1016/j.ygyno.2024.02.029 · ExternalCitation · doi-reference
Endometriosis Is a Chronic Systemic Disease: Clinical Challenges and Novel Innovations
10.1016/s0140-6736(21)00389-5 · ExternalCitation · doi-reference
LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and Their Use as Virtual Screening Filters
10.1021/ci049885e · ExternalCitation · doi-reference
Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges
10.1021/ci3003649 · ExternalCitation · doi-reference
Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone HSP90 by Fragment Based Drug Design
10.1021/jm100060b · ExternalCitation · doi-reference
Massively Parallel Digital Transcriptional Profiling of Single Cells
10.1038/ncomms14049 · ExternalCitation · doi-reference
HSP90A Inhibition Promotes Anti-Tumor Immunity by Reversing Multi-Modal Resistance and Stem-like Property of Immune-Refractory Tumors
10.1038/s41467-019-14259-y · ExternalCitation · doi-reference
Single-Cell Analysis of Endometriosis Reveals a Coordinated Transcriptional Programme Driving Immunotolerance and Angiogenesis across Eutopic and Ectopic Tissues
10.1038/s41556-022-00961-5 · ExternalCitation · doi-reference
Single-Cell Transcriptomic Analysis of Endometriosis
10.1038/s41588-022-01254-1 · ExternalCitation · doi-reference
Assessing GPT-4 for Cell Type Annotation in Single-Cell RNA-Seq Analysis
10.1038/s41592-024-02235-4 · ExternalCitation · doi-reference
The Ischemic Time Window of Ectopic Endometrial Tissue Crucially Determines Its Ability to Develop into Endometriotic Lesions
10.1038/s41598-022-09577-z · ExternalCitation · doi-reference
An Emerging Role for Neutrophils in the Pathogenesis of Endometriosis
10.1038/s44294-025-00059-x · ExternalCitation · doi-reference
Alpelisib for -Mutated, Hormone Receptor-Positive Advanced Breast Cancer
10.1056/nejmoa1813904 · ExternalCitation · doi-reference
10.1056/nejmra1810764
10.1056/nejmra1810764 · ExternalCitation · doi-reference
Canonical Sampling through Velocity Rescaling
10.1063/1.2408420 · ExternalCitation · doi-reference
Polymorphic Transitions in Single Crystals: A New Molecular Dynamics Method
10.1063/1.328693 · ExternalCitation · doi-reference
Comparison of Simple Potential Functions for Simulating Liquid Water
10.1063/1.445869 · ExternalCitation · doi-reference
Particle Mesh Ewald: An N⋅log(N) Method for Ewald Sums in Large Systems
10.1063/1.464397 · ExternalCitation · doi-reference
ClusterProfiler: An R Package for Comparing Biological Themes among Gene Clusters
10.1089/omi.2011.0118 · ExternalCitation · doi-reference
The Role of Small Extracellular Vesicle-miRNAs in Endometriosis
10.1093/humrep/dead216 · ExternalCitation · doi-reference
The Association between Endometriosis and Autoimmune Diseases: A Systematic Review and Meta-Analysis
10.1093/humupd/dmz014 · ExternalCitation · doi-reference
Targeting HSP90 as a Therapeutic Approach for Endometriosis: Insights from Proteomic Analysis
10.1093/reprod/xaaf002 · ExternalCitation · doi-reference
Heat Shock Protein HSP90 Immunoexpression in Equine Endometrium during Oestrus, Dioestrus and Anoestrus
10.1111/ahe.12598 · ExternalCitation · doi-reference
Rethinking the Pathogenesis of Endometriosis: Complex Interactions of Genomic, Epigenetic, and Environmental Factors
10.1111/jog.16089 · ExternalCitation · doi-reference
The Crystal and Cryo-EM Structures of PLCγ2 Reveal Dynamic Interdomain Recognitions in Autoinhibition
10.1126/sciadv.adn6037 · ExternalCitation · doi-reference
Participant Acceptability Questionnaire Results from the Meatal Swab Yourself with Testing for Infections Collectively (MYSTIC) Study: A Diagnostic Accuracy Study of Rectal and Pharyngeal Swabs Pooled with Meatal Swabs, or First-Catch Urine, for Gonorrhoea and CHLAmydia Detection
10.1136/sextrans-2025-056613 · ExternalCitation · doi-reference
Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti-PD-L1 Immunotherapy
10.1158/1535-7163.mct-20-0934 · ExternalCitation · doi-reference
Inhibition of MAPK and VEGFR by Sorafenib Controls the Progression of Endometriosis
10.1177/1933719115592708 · ExternalCitation · doi-reference
10.1186/s12916-022-02500-3
10.1186/s12916-022-02500-3 · ExternalCitation · doi-reference
PLCG2 across Human Disease: Genetic Variants, Signaling Mechanisms, and Clinical Implications
10.1186/s12967-025-07632-7 · ExternalCitation · doi-reference
SCANPY: Large-Scale Single-Cell Gene Expression Data Analysis
10.1186/s13059-017-1382-0 · ExternalCitation · doi-reference
PLCG2 Is Associated with the Inflammatory Response and Is Induced by Amyloid Plaques in Alzheimer’s Disease
10.1186/s13073-022-01022-0 · ExternalCitation · doi-reference
Sulindac Suppresses Nuclear Factor-kappaB Activation and RANTES Gene and Protein Expression in Endometrial Stromal Cells from Women with Endometriosis
10.1210/jc.2005-0972 · ExternalCitation · doi-reference
Gene Expression Profile for Ectopic versus Eutopic Endometrium Provides New Insights into Endometriosis Oncogenic Potential
10.1210/me.2008-0322 · ExternalCitation · doi-reference
Persistent Dysregulation of Genes in the Development of Endometriosis
10.21037/atm-22-4806 · ExternalCitation · doi-reference
The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action
10.2174/138920207783591690 · ExternalCitation · doi-reference
10.3389/fmolb.2017.00096
10.3389/fmolb.2017.00096 · ExternalCitation · doi-reference
10.3390/cells11132028
10.3390/cells11132028 · ExternalCitation · doi-reference
10.3390/diagnostics10050255
10.3390/diagnostics10050255 · ExternalCitation · doi-reference
10.3390/ijms24087503
10.3390/ijms24087503 · ExternalCitation · doi-reference
10.3390/jcm8091468
10.3390/jcm8091468 · ExternalCitation · doi-reference
10.3390/jpm12020216
10.3390/jpm12020216 · ExternalCitation · doi-reference
HLA-Mediated Tumor Escape Mechanisms That May Impair Immunotherapy Clinical Outcomes via T-Cell Activation
10.3892/ol.2017.6784 · ExternalCitation · doi-reference
Endometrial Stem Cells: Orchestrating Dynamic Regeneration of Endometrium and Their Implications in Diverse Endometrial Disorders
10.7150/ijbs.89795 · ExternalCitation · doi-reference
