Research graph
References from Bicistronic Lentiviral Architecture Increases Surface Density of Membrane-Associated HIV Entry Inhibitors and Confers Tropism-Independent Protection to Modified Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3389/fcimb.2022.880030
10.3389/fcimb.2022.880030 · External reference
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
10.1056/nejmoa0802905 · 2009 · External reference
Evidence for the Cure of HIV Infection by CCR5Δ32/Δ32 Stem Cell Transplantation
10.1182/blood-2010-09-309591 · 2011 · External reference
10.1371/journal.ppat.1003347
10.1371/journal.ppat.1003347 · External reference
HIV-1 Remission Following CCR5Δ32/Δ32 Haematopoietic Stem-Cell Transplantation
10.1038/s41586-019-1027-4 · 2019 · External reference
Evidence for HIV-1 Cure after CCR5Δ32/Δ32 Allogeneic Haemopoietic Stem-Cell Transplantation 30 Months Post Analytical Treatment Interruption: A Case Report
10.1016/s2352-3018(20)30069-2 · 2020 · External reference
MRNA Transfection of a Novel TAL Effector Nuclease (TALEN) Facilitates Efficient Knockout of HIV Co-Receptor CCR5
10.1093/nar/gkv469 · 2015 · External reference
Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation
10.1056/nejmc1405805 · 2014 · External reference
Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infection
10.1089/hum.2017.032 · 2017 · External reference
Genome Editing of the HIV Co-Receptors CCR5 and CXCR4 by CRISPR-Cas9 Protects CD4+ T Cells from HIV-1 Infection
10.1186/s13578-017-0174-2 · 2017 · External reference
Mutual, Reciprocal SDF-1/CXCR4 Interactions between Hematopoietic and Bone Marrow Stromal Cells Regulate Human Stem Cell Migration and Development in NOD/SCID Chimeric Mice
10.1016/j.exphem.2006.04.002 · 2006 · External reference
CXCR4 Is Required for the Quiescence of Primitive Hematopoietic Cells
10.1084/jem.20072513 · 2008 · External reference
Generation of Human TRIM5α Mutants with High HIV-1 Restriction Activity
10.1038/gt.2010.40 · 2010 · External reference
Human Immunodeficiency Virus Type 1 Restriction by Human–Rhesus Chimeric Tripartite Motif 5α (TRIM 5α) in CD34+ Cell-Derived Macrophages In Vitro and in T Cells In Vivo in Severe Combined Immunodeficient (SCID-Hu) Mice Transplanted with Human Fetal Tissue
10.1089/hum.2007.108 · 2008 · External reference
Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene
10.1089/hum.2015.059 · 2015 · External reference
Safety of CD34+ Hematopoietic Stem Cells and CD4+ T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma
10.1016/j.omtm.2019.02.006 · 2019 · External reference
Engineering Cellular Resistance to HIV-1 Infection In Vivo Using a Dual Therapeutic Lentiviral Vector
10.1038/mtna.2015.10 · 2015 · External reference
Multilineage Polyclonal Engraftment of Cal-1 Gene-Modified Cells and in Vivo Selection after SHIV Infection in a Nonhuman Primate Model of AIDS
10.1038/mtm.2016.7 · 2016 · External reference
Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of Gp41
10.1128/mbio.03589-21 · 2022 · External reference
10.3390/v11080705
10.3390/v11080705 · External reference
A Helical Short-Peptide Fusion Inhibitor with Highly Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus
10.1128/jvi.01839-16 · 2017 · External reference
A Membrane-Anchored Short-Peptide Fusion Inhibitor Fully Protects Target Cells from Infections of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus
10.1128/jvi.01177-19 · 2019 · External reference
Unraveling Viral Drug Targets: A Deep Learning-Based Approach for the Identification of Potential Binding Sites
10.1093/bib/bbad459 · 2023 · External reference
Monoclonal Antibody Profiling of Cell Surface Proteins Associated with the Viral Biofilms on HTLV-1 Transformed Cells
10.4149/av_2015_03_247 · 2015 · External reference
10.1371/journal.ppat.1000788
10.1371/journal.ppat.1000788 · External reference
10.3390/v14010152
10.3390/v14010152 · External reference
Improvement of HIV-1 and Human T Cell Lymphotropic Virus Type 1 Replication-Dependent Vectors via Optimization of Reporter Gene Reconstitution and Modification with Intronic Short Hairpin RNA
10.1128/jvi.01940-15 · 2015 · External reference
Modulation of Human Immunodeficiency Virus Type 1 Infectivity through Incorporation of Tetraspanin Proteins
10.1128/jvi.01044-07 · 2008 · External reference
Clinical Use of Lentiviral Vectors
10.1038/s41375-018-0106-0 · 2018 · External reference
10.1371/journal.pone.0010611
10.1371/journal.pone.0010611 · External reference
10.1371/journal.pone.0018556
10.1371/journal.pone.0018556 · External reference
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
10.1006/meth.2001.1262 · 2001 · External reference
A Distinct Hematopoietic Stem Cell Population for Rapid Multilineage Engraftment in Nonhuman Primates
10.1126/scitranslmed.aan1145 · 2017 · External reference
Purification of Human CD34+CD90+ HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy
10.1016/j.omtm.2020.07.010 · 2020 · External reference
Molecular Regulators of Chemotaxis in Human Hematopoietic Stem Cells
10.1042/bst20240288 · 2024 · External reference
Mobilization-Based Chemotherapy-Free Engraftment of Gene-Edited Human Hematopoietic Stem Cells
10.1016/j.cell.2022.04.039 · 2022 · External reference
10.3389/fimmu.2021.783022
10.3389/fimmu.2021.783022 · External reference
10.1371/journal.ppat.1005983
10.1371/journal.ppat.1005983 · External reference
Expression of CD4 by Human Hematopoietic Progenitors [See Comments]
10.1182/blood.v84.10.3344.3344 · 1994 · External reference
Tailoring CAR Surface Density and Dynamics to Improve CAR-T Cell Therapy
10.1136/jitc-2024-010702 · 2025 · External reference
10.3390/ijms20010003
10.3390/ijms20010003 · External reference
Chemokine Receptor Distribution on the Surface of Repolarizing T Cells
10.1016/j.bpj.2024.02.001 · 2024 · External reference
Chromothriptic Cure of WHIM Syndrome
10.1016/j.cell.2015.01.014 · 2015 · External reference
Clinical GDNF Delivery Methods for Parkinson’s Disease
2026 · External reference
10.3390/ijms21031170
10.3390/ijms21031170 · External reference
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
10.1006/meth.2001.1262 · ExternalCitation · doi-reference
Chemokine Receptor Distribution on the Surface of Repolarizing T Cells
10.1016/j.bpj.2024.02.001 · ExternalCitation · doi-reference
Chromothriptic Cure of WHIM Syndrome
10.1016/j.cell.2015.01.014 · ExternalCitation · doi-reference
Mobilization-Based Chemotherapy-Free Engraftment of Gene-Edited Human Hematopoietic Stem Cells
10.1016/j.cell.2022.04.039 · ExternalCitation · doi-reference
Mutual, Reciprocal SDF-1/CXCR4 Interactions between Hematopoietic and Bone Marrow Stromal Cells Regulate Human Stem Cell Migration and Development in NOD/SCID Chimeric Mice
10.1016/j.exphem.2006.04.002 · ExternalCitation · doi-reference
Safety of CD34+ Hematopoietic Stem Cells and CD4+ T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma
10.1016/j.omtm.2019.02.006 · ExternalCitation · doi-reference
Purification of Human CD34+CD90+ HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy
10.1016/j.omtm.2020.07.010 · ExternalCitation · doi-reference
Evidence for HIV-1 Cure after CCR5Δ32/Δ32 Allogeneic Haemopoietic Stem-Cell Transplantation 30 Months Post Analytical Treatment Interruption: A Case Report
10.1016/s2352-3018(20)30069-2 · ExternalCitation · doi-reference
Generation of Human TRIM5α Mutants with High HIV-1 Restriction Activity
10.1038/gt.2010.40 · ExternalCitation · doi-reference
Multilineage Polyclonal Engraftment of Cal-1 Gene-Modified Cells and in Vivo Selection after SHIV Infection in a Nonhuman Primate Model of AIDS
10.1038/mtm.2016.7 · ExternalCitation · doi-reference
Engineering Cellular Resistance to HIV-1 Infection In Vivo Using a Dual Therapeutic Lentiviral Vector
10.1038/mtna.2015.10 · ExternalCitation · doi-reference
Clinical Use of Lentiviral Vectors
10.1038/s41375-018-0106-0 · ExternalCitation · doi-reference
HIV-1 Remission Following CCR5Δ32/Δ32 Haematopoietic Stem-Cell Transplantation
10.1038/s41586-019-1027-4 · ExternalCitation · doi-reference
Molecular Regulators of Chemotaxis in Human Hematopoietic Stem Cells
10.1042/bst20240288 · ExternalCitation · doi-reference
Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32 Mutation
10.1056/nejmc1405805 · ExternalCitation · doi-reference
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
10.1056/nejmoa0802905 · ExternalCitation · doi-reference
CXCR4 Is Required for the Quiescence of Primitive Hematopoietic Cells
10.1084/jem.20072513 · ExternalCitation · doi-reference
Human Immunodeficiency Virus Type 1 Restriction by Human–Rhesus Chimeric Tripartite Motif 5α (TRIM 5α) in CD34+ Cell-Derived Macrophages In Vitro and in T Cells In Vivo in Severe Combined Immunodeficient (SCID-Hu) Mice Transplanted with Human Fetal Tissue
10.1089/hum.2007.108 · ExternalCitation · doi-reference
Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene
10.1089/hum.2015.059 · ExternalCitation · doi-reference
Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infection
10.1089/hum.2017.032 · ExternalCitation · doi-reference
Unraveling Viral Drug Targets: A Deep Learning-Based Approach for the Identification of Potential Binding Sites
10.1093/bib/bbad459 · ExternalCitation · doi-reference
MRNA Transfection of a Novel TAL Effector Nuclease (TALEN) Facilitates Efficient Knockout of HIV Co-Receptor CCR5
10.1093/nar/gkv469 · ExternalCitation · doi-reference
A Distinct Hematopoietic Stem Cell Population for Rapid Multilineage Engraftment in Nonhuman Primates
10.1126/scitranslmed.aan1145 · ExternalCitation · doi-reference
Modulation of Human Immunodeficiency Virus Type 1 Infectivity through Incorporation of Tetraspanin Proteins
10.1128/jvi.01044-07 · ExternalCitation · doi-reference
A Membrane-Anchored Short-Peptide Fusion Inhibitor Fully Protects Target Cells from Infections of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus
10.1128/jvi.01177-19 · ExternalCitation · doi-reference
A Helical Short-Peptide Fusion Inhibitor with Highly Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus
10.1128/jvi.01839-16 · ExternalCitation · doi-reference
Improvement of HIV-1 and Human T Cell Lymphotropic Virus Type 1 Replication-Dependent Vectors via Optimization of Reporter Gene Reconstitution and Modification with Intronic Short Hairpin RNA
10.1128/jvi.01940-15 · ExternalCitation · doi-reference
Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of Gp41
10.1128/mbio.03589-21 · ExternalCitation · doi-reference
Tailoring CAR Surface Density and Dynamics to Improve CAR-T Cell Therapy
10.1136/jitc-2024-010702 · ExternalCitation · doi-reference
Evidence for the Cure of HIV Infection by CCR5Δ32/Δ32 Stem Cell Transplantation
10.1182/blood-2010-09-309591 · ExternalCitation · doi-reference
Expression of CD4 by Human Hematopoietic Progenitors [See Comments]
10.1182/blood.v84.10.3344.3344 · ExternalCitation · doi-reference
Genome Editing of the HIV Co-Receptors CCR5 and CXCR4 by CRISPR-Cas9 Protects CD4+ T Cells from HIV-1 Infection
10.1186/s13578-017-0174-2 · ExternalCitation · doi-reference
10.1371/journal.pone.0010611
10.1371/journal.pone.0010611 · ExternalCitation · doi-reference
10.1371/journal.pone.0018556
10.1371/journal.pone.0018556 · ExternalCitation · doi-reference
10.1371/journal.ppat.1000788
10.1371/journal.ppat.1000788 · ExternalCitation · doi-reference
10.1371/journal.ppat.1003347
10.1371/journal.ppat.1003347 · ExternalCitation · doi-reference
10.1371/journal.ppat.1005983
10.1371/journal.ppat.1005983 · ExternalCitation · doi-reference
10.3389/fcimb.2022.880030
10.3389/fcimb.2022.880030 · ExternalCitation · doi-reference
10.3389/fimmu.2021.783022
10.3389/fimmu.2021.783022 · ExternalCitation · doi-reference
10.3390/ijms20010003
10.3390/ijms20010003 · ExternalCitation · doi-reference
10.3390/ijms21031170
10.3390/ijms21031170 · ExternalCitation · doi-reference
10.3390/v11080705
10.3390/v11080705 · ExternalCitation · doi-reference
10.3390/v14010152
10.3390/v14010152 · ExternalCitation · doi-reference
Monoclonal Antibody Profiling of Cell Surface Proteins Associated with the Viral Biofilms on HTLV-1 Transformed Cells
10.4149/av_2015_03_247 · ExternalCitation · doi-reference
