References

Neuregulin, a factor with many functions in the life of a schwann cell

10.1002/1521-1878(200011)22:11<987::aid-bies5>3.0.co;2-5 · ExternalCitation · doi-reference

ErbB transmembrane tyrosine kinase receptors are differentially expressed throughout the adult rat central nervous system

10.1002/cne.1127 · ExternalCitation · doi-reference

Multiple personalities of neuregulin gene family members

10.1002/cne.20091 · ExternalCitation · doi-reference

Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain

10.1002/glia.20762 · ExternalCitation · doi-reference

Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathway

10.1002/glia.21124 · ExternalCitation · doi-reference

Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse

10.1002/hipo.10185 · ExternalCitation · doi-reference

An optimized dosing regimen of cimaglermin (neuregulin 1beta3, glial growth factor 2) enhances molecular markers of neuroplasticity and functional recovery after permanent ischemic stroke in rats

10.1002/jnr.23699 · ExternalCitation · doi-reference

Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme

10.1006/mcne.2000.0896 · ExternalCitation · doi-reference

Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival

10.1006/mcne.2000.0967 · ExternalCitation · doi-reference

Neuregulin-1 signalling and antipsychotic treatment: Potential therapeutic targets in a schizophrenia candidate signalling pathway

10.1007/s00213-013-3003-2 · ExternalCitation · doi-reference

Expression of neuregulin and ErbB3 and ErbB4 after a traumatic lesion in the ventral funiculus of the spinal cord and in the intact primary olfactory system

10.1007/s00221-001-0922-7 · ExternalCitation · doi-reference

NRG1-ErbB4 signaling promotes functional recovery in a murine model of traumatic brain injury via regulation of GABA release

10.1007/s00221-019-05680-2 · ExternalCitation · doi-reference

The Level of Neuregulin-1 after Traumatic Brain Injury and Formation of Post-Traumatic Epilepsy

10.1007/s10517-019-04492-2 · ExternalCitation · doi-reference

Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-kappaB pathway

10.1007/s11033-022-07249-9 · ExternalCitation · doi-reference

Neuregulin1beta1 antagonizes apoptosis via ErbB4-dependent activation of PI3-kinase/Akt in APP/PS1 transgenic mice

10.1007/s11064-013-1131-z · ExternalCitation · doi-reference

Effect of neuregulin on apoptosis and expressions of STAT3 and GFAP in rats following cerebral ischemic reperfusion

10.1007/s12031-008-9121-3 · ExternalCitation · doi-reference

Neuroprotection by Exogenous and Endogenous Neuregulin-1 in Mouse Models of Focal Ischemic Stroke

10.1007/s12031-019-01362-4 · ExternalCitation · doi-reference

Targeting Neuroinflammation in Adult Ischemic Stroke: Direct Immunotherapy, Regenerative Cell-Based Strategies, and Translational Challenges-A Systematic Review with Exploratory Meta-analysis

10.1007/s12035-026-05980-z · ExternalCitation · doi-reference

Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury

10.1007/s12975-012-0157-x · ExternalCitation · doi-reference

Neuregulin1-beta Decreases IL-1beta-Induced Neutrophil Adhesion to Human Brain Microvascular Endothelial Cells

10.1007/s12975-014-0347-9 · ExternalCitation · doi-reference

Neuroinflammation in Ischemic Stroke: Mechanisms, Systemic Interactions, and Therapeutic Targets

10.1007/s12975-026-01442-9 · ExternalCitation · doi-reference

Safety, Tolerability, and Pharmacokinetics of Recombinant Human Neuregulin-1 in Healthy Chinese Subjects

10.1007/s40256-023-00585-6 · ExternalCitation · doi-reference

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

10.1016/0092-8674(93)90407-h · ExternalCitation · doi-reference

NRG1 fusion-driven tumors: Biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents

10.1016/j.annonc.2020.08.2335 · ExternalCitation · doi-reference

Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse

10.1016/j.bbr.2003.11.010 · ExternalCitation · doi-reference

Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke

10.1016/j.bbrc.2004.07.149 · ExternalCitation · doi-reference

Nicotinic acetylcholine receptors: Key targets for attenuating neurodegenerative diseases

10.1016/j.biocel.2023.106387 · ExternalCitation · doi-reference

Neuregulin-1 converts reactive astrocytes toward oligodendrocyte lineage cells via upregulating the PI3K-AKT-mTOR pathway to repair spinal cord injury

10.1016/j.biopha.2020.111168 · ExternalCitation · doi-reference

Neuroprotective effects of neuregulin-1 on B35 neuronal cells following ischemia

10.1016/j.brainres.2008.02.059 · ExternalCitation · doi-reference

Differential distribution of neuregulin in human brain and spinal fluid

10.1016/j.brainres.2008.12.047 · ExternalCitation · doi-reference

The possible role of the Akt signaling pathway in schizophrenia

10.1016/j.brainres.2012.06.032 · ExternalCitation · doi-reference

The neuregulin signaling pathway and schizophrenia: From genes to synapses and neural circuits

10.1016/j.brainresbull.2010.07.012 · ExternalCitation · doi-reference

Neuregulins: Versatile growth and differentiation factors in nervous system development and human disease

10.1016/j.brainresrev.2005.11.006 · ExternalCitation · doi-reference

Add-on spironolactone as antagonist of the NRG1-ERBB4 signaling pathway for the treatment of schizophrenia: Study design and methodology of a multicenter randomized, placebo-controlled trial

10.1016/j.conctc.2020.100537 · ExternalCitation · doi-reference

Elevated neuregulin-1β levels correlate with plasma biomarkers of cerebral injury and high stroke risk in children with sickle cell anemia

10.1016/j.endmts.2021.100088 · ExternalCitation · doi-reference

The mechanisms of microgliosis and pain following peripheral nerve injury

10.1016/j.expneurol.2011.08.018 · ExternalCitation · doi-reference

Neuregulin-1/PI3K signaling effects on oligodendrocyte proliferation, remyelination and behaviors deficit in a male mouse model of ischemic stroke

10.1016/j.expneurol.2023.114323 · ExternalCitation · doi-reference

A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients with Systolic Dysfunction and Heart Failure

10.1016/j.jacbts.2016.09.005 · ExternalCitation · doi-reference

A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure

10.1016/j.jacc.2009.12.044 · ExternalCitation · doi-reference

Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease

10.1016/j.jstrokecerebrovasdis.2022.106912 · ExternalCitation · doi-reference

ErbB4 processing is involved in OGD/R induced neuron injury

10.1016/j.jstrokecerebrovasdis.2023.107373 · ExternalCitation · doi-reference

Evaluation of neuregulin-1′s neuroprotection against ischemic injury in rats using diffusion tensor imaging

10.1016/j.mri.2018.07.002 · ExternalCitation · doi-reference

Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy

10.1016/j.nbd.2021.105545 · ExternalCitation · doi-reference

Upregulation of erbB receptors in rat brain after middle cerebral arterial occlusion

10.1016/j.neulet.2004.11.039 · ExternalCitation · doi-reference

Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease

10.1016/j.neulet.2012.10.050 · ExternalCitation · doi-reference

Neuregulin-1 reduces ischemia-induced brain damage in rats

10.1016/j.neurobiolaging.2003.10.012 · ExternalCitation · doi-reference

The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity

10.1016/j.neuron.2007.03.028 · ExternalCitation · doi-reference

Neuregulin-1 enhances depolarization-induced GABA release

10.1016/j.neuron.2007.04.009 · ExternalCitation · doi-reference

Microglia states and nomenclature: A field at its crossroads

10.1016/j.neuron.2022.10.020 · ExternalCitation · doi-reference

Glial growth factor 2 promotes functional recovery with treatment initiated up to 7 days after permanent focal ischemic stroke

10.1016/j.neuropharm.2010.07.017 · ExternalCitation · doi-reference

Biodistribution and brain permeability of the extracellular domain of neuregulin-1-beta1

10.1016/j.neuropharm.2011.08.033 · ExternalCitation · doi-reference

Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission

10.1016/j.neuroscience.2015.08.047 · ExternalCitation · doi-reference

Microglia-mediated neuroinflammation and demyelination contribute to pain and social behavioral deficits after spared nerve injury

10.1016/j.neuroscience.2026.07.023 · ExternalCitation · doi-reference

Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair

10.1016/j.pneurobio.2019.101643 · ExternalCitation · doi-reference

Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury

10.1016/j.taap.2012.05.001 · ExternalCitation · doi-reference

ErbB receptors and the development of the nervous system

10.1016/j.yexcr.2008.10.035 · ExternalCitation · doi-reference

Neuregulins: Functions, forms, and signaling strategies

10.1016/s0014-4827(02)00102-7 · ExternalCitation · doi-reference

The neuregulin GGF2 attenuates free radical release from activated microglial cells

10.1016/s0165-5728(03)00003-1 · ExternalCitation · doi-reference

Neuregulin and erbB receptor expression in normal and diseased human white matter

10.1016/s0165-5728(99)00201-5 · ExternalCitation · doi-reference

Neuregulin expression after focal stroke in the rat

10.1016/s0304-3940(02)01126-6 · ExternalCitation · doi-reference

ErbB-4 activation inhibits apoptosis in PC12 cells

10.1016/s0306-4522(01)00350-5 · ExternalCitation · doi-reference

Neuregulin and ErbB receptor signaling pathways in the nervous system

10.1016/s0959-4388(00)00210-5 · ExternalCitation · doi-reference

Neuregulin induces sustained reactive oxygen species generation to mediate neuronal differentiation

10.1023/a:1015108306171 · ExternalCitation · doi-reference

Multiple essential functions of neuregulin in development

10.1038/378386a0 · ExternalCitation · doi-reference

Neuregulin-1 signaling in brain endothelial cells

10.1038/jcbfm.2008.94 · ExternalCitation · doi-reference

Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination

10.1038/nn.2686 · ExternalCitation · doi-reference

Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia

10.1038/nn1258 · ExternalCitation · doi-reference

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

10.1038/nrn2392 · ExternalCitation · doi-reference

Microglia and neuroinflammation: Function, heterogeneity, and crosstalk

10.1038/s41423-026-01438-3 · ExternalCitation · doi-reference

Antagonizing NRG1-ERBB4 signaling pathway with spironolactone for the treatment of schizophrenia: Results of a randomized controlled drug repositioning clinical trial

10.1038/s43856-026-01714-3 · ExternalCitation · doi-reference

Extended therapeutic window and functional recovery after intraarterial administration of neuregulin-1 after focal ischemic stroke

10.1038/sj.jcbfm.9600212 · ExternalCitation · doi-reference

NIK is a component of the EGF/heregulin receptor signaling complexes

10.1038/sj.onc.1206532 · ExternalCitation · doi-reference

Neuregulin is a mitogen and survival factor for olfactory bulb ensheathing cells and an isoform is produced by astrocytes

10.1046/j.1460-9568.1999.00484.x · ExternalCitation · doi-reference

ErbB-4 activation promotes neurite outgrowth in PC12 cells

10.1046/j.1471-4159.2000.0740979.x · ExternalCitation · doi-reference

Efficacy of Zenocutuzumab in NRG1 Fusion-Positive Cancer

10.1056/nejmoa2405008 · ExternalCitation · doi-reference

The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone

10.1073/pnas.0510410103 · ExternalCitation · doi-reference

Brain neurons and glial cells express Neu differentiation factor/heregulin: A survival factor for astrocytes

10.1073/pnas.91.20.9387 · ExternalCitation · doi-reference

The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis

10.1073/pnas.95.17.10100 · ExternalCitation · doi-reference

Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain

10.1073/pnas.95.4.1888 · ExternalCitation · doi-reference

Failure of spinal cord oligodendrocyte development in mice lacking neuregulin

10.1073/pnas.96.2.731 · ExternalCitation · doi-reference

Neuregulin rescues PC12-ErbB4 cells from cell death induced by H2O2. Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase

10.1074/jbc.m105637200 · ExternalCitation · doi-reference

Cdk5 is involved in neuregulin-dependent activation of PI-3 kinase and Akt activity mediating neuronal survival

10.1074/jbc.m302004200 · ExternalCitation · doi-reference

ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms

10.1074/jbc.m800073200 · ExternalCitation · doi-reference

The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2

10.1089/ars.2012.4671 · ExternalCitation · doi-reference

Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice

10.1089/neu.2007.0372 · ExternalCitation · doi-reference

The role of microglia in the pathobiology of neuropathic pain development: What do we know?

10.1093/bja/aex006 · ExternalCitation · doi-reference

Neuregulin-1 beta 1 is implicated in pathogenesis of multiple sclerosis

10.1093/brain/awaa385 · ExternalCitation · doi-reference

Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury

10.1093/brain/aww039 · ExternalCitation · doi-reference

Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses

10.1093/eurjhf/hfq152 · ExternalCitation · doi-reference

Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease

10.1093/jnen/62.1.42 · ExternalCitation · doi-reference

Neuregulin-1 Mitigates Kidney Injury in Humanized Sickle Cell Mice

10.1096/fj.202504449rr · ExternalCitation · doi-reference

Neurotrophic and neuroprotective effects of the neuregulin glial growth factor-2 on dopaminergic neurons in rat primary midbrain cultures

10.1111/j.1471-4159.2004.02817.x · ExternalCitation · doi-reference

Systemic administration of neuregulin-1beta(1) protects dopaminergic neurons in a mouse model of Parkinson’s disease

10.1111/j.1471-4159.2011.07284.x · ExternalCitation · doi-reference

Systemically administered neuregulin-1beta1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson’s disease

10.1111/jnc.13026 · ExternalCitation · doi-reference

Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling

10.1111/jnc.13395 · ExternalCitation · doi-reference

Identification of heregulin, a specific activator of p185erbB2

10.1126/science.256.5060.1205 · ExternalCitation · doi-reference

ARIA: A neuromuscular junction neuregulin

10.1146/annurev.neuro.20.1.429 · ExternalCitation · doi-reference

ERBB signaling attenuates proinflammatory activation of nonclassical monocytes

10.1152/ajpheart.00486.2016 · ExternalCitation · doi-reference

CD74-NRG1 fusions in lung adenocarcinoma

10.1158/2159-8290.cd-13-0633 · ExternalCitation · doi-reference

Translational Stroke Research: Vision and Opportunities

10.1161/strokeaha.117.017112 · ExternalCitation · doi-reference

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation

10.1165/rcmb.4850 · ExternalCitation · doi-reference

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria

10.1186/1742-2094-11-9 · ExternalCitation · doi-reference

The Alzheimer’s disease beta-secretase enzyme, BACE1

10.1186/1750-1326-2-22 · ExternalCitation · doi-reference

Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway

10.1186/s12974-016-0703-7 · ExternalCitation · doi-reference

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling

10.1186/s12974-018-1147-z · ExternalCitation · doi-reference

Microglia-specific NLRP3 inhibition mitigates hippocampal neuroinflammation and cognitive deficits after hemorrhagic shock with resuscitation

10.1186/s12993-026-00354-w · ExternalCitation · doi-reference

Neurovascular Unit Dysfunction and Cerebral Small Vessel Disease in Parkinson Disease: A Systematic Review and a Meta Analysis

10.1212/wnl.0000000000214873 · ExternalCitation · doi-reference

Isoform-specific expression and function of neuregulin

10.1242/dev.124.18.3575 · ExternalCitation · doi-reference

10.1371/journal.pone.0025108

10.1371/journal.pone.0025108 · ExternalCitation · doi-reference

10.1371/journal.pone.0070338

10.1371/journal.pone.0070338 · ExternalCitation · doi-reference

Neuregulin-1 isoforms are differentially expressed in the intact and regenerating adult rat nervous system

10.1385/jmn:21:2:149 · ExternalCitation · doi-reference

Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: Involvement of PI3K and PKC

10.1385/jmn:26:1:057 · ExternalCitation · doi-reference

ErbB4 Activation Inhibits MPP+-Induced Cell Death In PC12-ErbB4 Cells: Involvement of PI3K and Erk Signaling

10.1385/jmn:29:3:257 · ExternalCitation · doi-reference

Prevention of Alzheimer Pathology by Blocking Neuregulin Signaling on Microglia

10.1523/eneuro.0422-23.2023 · ExternalCitation · doi-reference

Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells

10.1523/jneurosci.19-24-10757.1999 · ExternalCitation · doi-reference

Akt-mediated survival of oligodendrocytes induced by neuregulins

10.1523/jneurosci.20-20-07622.2000 · ExternalCitation · doi-reference

Regulation of neuregulin expression in the injured rat brain and cultured astrocytes

10.1523/jneurosci.21-04-01257.2001 · ExternalCitation · doi-reference

Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro

10.1523/jneurosci.21-13-04740.2001 · ExternalCitation · doi-reference

Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus

10.1523/jneurosci.21-15-05660.2001 · ExternalCitation · doi-reference

Type III neuregulin 1 is required for multiple forms of excitatory synaptic plasticity of mouse cortico-amygdala circuits

10.1523/jneurosci.2888-12.2013 · ExternalCitation · doi-reference

Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo

10.1523/jneurosci.4303-08.2009 · ExternalCitation · doi-reference

Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury

10.1523/jneurosci.5169-09.2010 · ExternalCitation · doi-reference

Neuroinflammation at the Crossroads of Neurodegeneration: The Roles of Microglia and Astrocytes in Parkinson’s Disease, Alzheimer’s Disease, and Multiple Sclerosis

10.17712/1658-3183.2786 · ExternalCitation · doi-reference

10.20944/preprints202401.2149.v2

10.20944/preprints202401.2149.v2 · ExternalCitation · doi-reference

NRG1 Suppresses NLRP3 Inflammasome Activation and Endothelial-Mesenchymal Transition in Cerebral Ischemia-Reperfusion Injury: Association with the AKT/NF-kappaB Pathway

10.2147/jir.s584926 · ExternalCitation · doi-reference

10.3389/fimmu.2025.1670650

10.3389/fimmu.2025.1670650 · ExternalCitation · doi-reference

10.3389/fnagi.2024.1347987

10.3389/fnagi.2024.1347987 · ExternalCitation · doi-reference

10.3389/fncel.2022.980722

10.3389/fncel.2022.980722 · ExternalCitation · doi-reference

10.3389/fncel.2024.1325630

10.3389/fncel.2024.1325630 · ExternalCitation · doi-reference

10.3389/fncel.2026.1739619

10.3389/fncel.2026.1739619 · ExternalCitation · doi-reference

10.3389/fncel.2026.1821227

10.3389/fncel.2026.1821227 · ExternalCitation · doi-reference

10.3389/fneur.2024.1334847

10.3389/fneur.2024.1334847 · ExternalCitation · doi-reference

10.3389/fnmol.2022.970040

10.3389/fnmol.2022.970040 · ExternalCitation · doi-reference

10.3389/fnmol.2026.1741120

10.3389/fnmol.2026.1741120 · ExternalCitation · doi-reference

10.3390/cells11152383

10.3390/cells11152383 · ExternalCitation · doi-reference

10.3390/ijms22094912

10.3390/ijms22094912 · ExternalCitation · doi-reference