Research graph
References from Iron Supplementation and Neurodevelopmental Outcomes in Infancy and Early Childhood: A Review. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3390/ijms24043995
10.3390/ijms24043995 · External reference
Systemic iron homeostasis
10.1152/physrev.00008.2013 · 2013 · External reference
Iron transport proteins: Gateways of cellular and systemic iron homeostasis
10.1074/jbc.r117.786632 · 2017 · External reference
Lipid-Oxidative Enzymes and Fenton-Like Reactions Are Synergistic in Promoting Membrane Lipid Peroxidation
10.1021/jacsau.5c00696 · 2025 · External reference
Hepcidin in the diagnosis of iron disorders
10.1182/blood-2015-12-639112 · 2016 · External reference
10.3389/fphar.2014.00124
10.3389/fphar.2014.00124 · External reference
Iron regulatory proteins and their role in controlling iron metabolism
10.1039/c4mt00164h · 2015 · External reference
Iron homeostasis in the neonate
10.1542/peds.2008-1047 · 2009 · External reference
Development of iron homeostasis in infants and young children
10.3945/ajcn.117.155820 · 2017 · External reference
Diagnosis and Prevention of Iron Deficiency and Iron-Deficiency Anemia in Infants and Young Children (0–3 Years of Age)
10.1542/peds.2010-2576 · 2010 · External reference
10.3390/antiox7040054
10.3390/antiox7040054 · External reference
10.3389/fnut.2024.1474664
10.3389/fnut.2024.1474664 · External reference
Anaemia during pregnancy as a risk factor for infant iron deficiency: Report from the Valencia Infant Anaemia Cohort (VIAC) study
10.1111/j.1365-3016.1990.tb00638.x · 1990 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
10.3390/nu8110693
10.3390/nu8110693 · External reference
Iron deficiency
10.1182/blood-2018-05-815944 · 2019 · External reference
Iron deficiency anaemia
10.1016/s0140-6736(15)60865-0 · 2016 · External reference
10.3389/fphys.2019.00463
10.3389/fphys.2019.00463 · External reference
La nutrición temprana influye en la mielinización y la cognición durante el desarrollo en bebés y niños pequeños
10.1016/j.neuroimage.2017.12.056 · 2018 · External reference
Iron deficiency and child development
10.1177/15648265070284s409 · 2007 · External reference
10.1186/s12868-019-0507-7
10.1186/s12868-019-0507-7 · External reference
Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: Effects on locomotion and cortico-striatal neurotransmission
10.1016/j.expneurol.2010.04.004 · 2010 · External reference
Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination
10.1177/1759091420962681 · 2020 · External reference
The effects of early-life iron deficiency on brain energy metabolism
10.1177/2633105520935104 · 2020 · External reference
Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons
10.1159/000075667 · 2003 · External reference
Iron role paradox in nerve degeneration and regeneration
10.14814/phy2.15908 · 2024 · External reference
Role of iron in brain development, aging, and neurodegenerative diseases
10.1080/07853890.2025.2472871 · 2025 · External reference
Molecular mechanisms of iron and heme metabolism
10.1146/annurev-nutr-062320-112625 · 2022 · External reference
Uptake, metabolism and toxicity of iron oxide nanoparticles in cultured microglia, astrocytes and neurons
10.1186/2193-1801-4-s1-l32 · 2015 · External reference
Calcium, iron and neuronal function
10.1080/15216540701222906 · 2007 · External reference
Iron, brain ageing and neurodegenerative disorders
10.1038/nrn1537 · 2004 · External reference
Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload
10.1002/glia.23806 · 2020 · External reference
Synergistic accumulation of iron and zinc by cultured astrocytes
10.1007/s00702-010-0420-9 · 2010 · External reference
Unresolved reference
External reference
Serum transferrin receptor in children: Usefulness for determining the nature of anemia in infection
10.1097/mph.0b013e31802d751a · 2006 · External reference
Iron status with different infant feeding regimens: Relevance to screening and prevention of iron deficiency
10.1016/s0022-3476(05)80027-7 · 1991 · External reference
10.3390/nu12020447
10.3390/nu12020447 · External reference
10.3390/nu12072001
10.3390/nu12072001 · External reference
Micronutrient interactions: Effects on absorption and bioavailability
10.1079/bjn2000312 · 2001 · External reference
Iron deficiency anemia of infants: Repercussions on growth and development and assessment of treatment with ferrous sulfate
1986 · External reference
Advances in ferroptosis in chronic inflammatory diseases of the upper and lower airways
10.1159/000547363 · 2026 · External reference
The critical role of iron homeostasis in neurodegenerative diseases
10.4103/nrr.nrr-d-24-01382 · 2026 · External reference
Molecular mechanisms of ferroptosis and relevance to inflammation
10.1007/s00011-022-01672-1 · 2023 · External reference
Iron deficiency in children with attention-deficit/hyperactivity disorder
10.1001/archpedi.158.12.1113 · 2004 · External reference
Impact of fetal-neonatal iron deficiency on recognition memory at 2 months of age
10.1016/j.jpeds.2015.08.035 · 2015 · External reference
Effects of daily iron supplementation in 2- to 5-year-old children: A systematic review and meta-analysis
10.1542/peds.2012-2256 · 2013 · External reference
Iron deficiency anemia in infancy: Long-lasting effects on auditory and visual system functioning
10.1203/01.pdr.0000047657.23156.55 · 2003 · External reference
Enteral iron supplementation in infants born extremely preterm and its positive correlation with neurodevelopment: Post hoc analysis of the Preterm Erythropoietin Neuroprotection Trial randomized controlled trial
10.1016/j.jpeds.2021.07.019 · 2021 · External reference
Double burden of iron deficiency in infancy and low socioeconomic status: A longitudinal analysis of cognitive test scores to age 19 years
10.1001/archpedi.160.11.1108 · 2006 · External reference
Unresolved reference
External reference
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function
10.1093/ajcn/85.4.931 · 2007 · External reference
Iron deficiency and infant motor development
10.1016/j.earlhumdev.2007.12.009 · 2008 · External reference
Brain plasticity and behaviour in the developing
2011 · External reference
Iron deficiency and the intellect
10.1016/s0387-7604(02)00148-1 · 2003 · External reference
Iron deficiency in infancy: Applying a physiologic framework for prediction
10.1093/ajcn/84.6.1412 · 2006 · External reference
Iron nutriture of the fetus, neonate, infant, and child
10.1159/000481447 · 2017 · External reference
Iron stores of breastfed infants during the first year of life
10.3390/nu6052023 · 2014 · External reference
Iron deficiency anaemia
10.1016/j.paed.2017.08.004 · 2017 · External reference
Ferroptosis: A double-edged sword
10.1038/s41421-023-00638-9 · 2024 · External reference
Ferroptosis: When metabolism meets cell death
10.1152/physrev.00031.2024 · 2025 · External reference
Ferroptosis: Principles and significance in health and disease
10.1186/s13045-024-01564-3 · 2024 · External reference
10.3389/fmolb.2022.965064
10.3389/fmolb.2022.965064 · External reference
Ferroptosis in Parkinson’s disease: Molecular mechanisms and therapeutic potential
10.1016/j.arr.2023.102077 · 2023 · External reference
10.3390/ijms21228765
10.3390/ijms21228765 · External reference
10.3390/ijms252313042
10.3390/ijms252313042 · External reference
10.3390/ijms17010130
10.3390/ijms17010130 · External reference
Iron deficiency anemia: A global public health concern
10.18231/j.ijcbr.2024.034 · 2024 · External reference
Effect of oral iron therapy on developmental assessment scores in infants with iron deficiency anemia
10.1007/s12098-025-05878-z · 2026 · External reference
10.3390/nu14142976
10.3390/nu14142976 · External reference
Global, Regional, and National Prevalence of Anemia and Its Causesin 204 Countries and Territories, 1990–2019
10.1093/cdn/nzaa053_035 · 2021 · External reference
La declaración PRISMA: Un paso adelante en la mejora de las publicaciones de la Revista Española de Salud Pública
10.4321/s1135-57272013000200001 · 2013 · External reference
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
Evidence based medicine: What it is and what it isn’t
10.1136/bmj.312.7023.71 · 1996 · External reference
Unresolved reference
External reference
Iron supplementation in pregnancy or infancy and motor development: A randomized controlled trial
10.1542/peds.2015-3547 · 2016 · External reference
Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: A randomized controlled trial
10.1038/pr.2017.235 · 2018 · External reference
Randomized controlled trial of iron-fortified versus low-iron infant formula: Developmental outcomes at 16 years
10.1016/j.jpeds.2019.05.030 · 2019 · External reference
10.1186/s12887-019-1679-0
10.1186/s12887-019-1679-0 · External reference
Randomized trial of oral iron and diet advice versus diet advice alone in young children with nonanemic iron deficiency
10.1016/j.jpeds.2021.01.073 · 2021 · External reference
Benefits and risks of iron interventions in infants in rural Bangladesh
10.1056/nejmoa2034187 · 2021 · External reference
10.3389/fnins.2021.769558
10.3389/fnins.2021.769558 · External reference
Neurological development and iron supplementation in healthy late-preterm neonates: A randomized double-blind controlled trial
10.1007/s00431-021-04181-1 · 2022 · External reference
Young adult outcomes associated with lower cognitive functioning in childhood related to iron-fortified formula in infancy
10.1080/1028415x.2020.1804099 · 2022 · External reference
Chronic iron deficiency and cognitive function in early childhood
10.1542/peds.2021-055926 · 2022 · External reference
Supplementation with iron syrup or iron-containing multiple micronutrient powders alters resting brain activity in Bangladeshi children
10.1016/j.tjnut.2022.12.026 · 2023 · External reference
Iron supplementation given to nonanemic infants: Neurocognitive functioning at 16 years
10.1080/1028415x.2021.2013399 · 2023 · External reference
Effect of low-dose iron supplementation on early development in breastfed infants: A randomized clinical trial
10.1001/jamapediatrics.2024.1095 · 2024 · External reference
Impact of early iron supplementation on cognitive outcomes in infants born to anemic mothers: A longitudinal birth cohort analysis
2025 · External reference
Oral iron supplements for children in malaria-endemic areas
2026 · External reference
Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms
10.1016/j.bbamcr.2016.12.002 · 2017 · External reference
Excess iron intake as a factor in growth, infections, and development of infants and young children
10.3945/ajcn.117.156042 · 2017 · External reference
Developmental cascades
10.1017/s0954579410000222 · 2010 · External reference
10.3390/nu14204380
10.3390/nu14204380 · External reference
Iron deficiency in children with attention-deficit/hyperactivity disorder
10.1001/archpedi.158.12.1113 · ExternalCitation · doi-reference
Double burden of iron deficiency in infancy and low socioeconomic status: A longitudinal analysis of cognitive test scores to age 19 years
10.1001/archpedi.160.11.1108 · ExternalCitation · doi-reference
Effect of low-dose iron supplementation on early development in breastfed infants: A randomized clinical trial
10.1001/jamapediatrics.2024.1095 · ExternalCitation · doi-reference
Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload
10.1002/glia.23806 · ExternalCitation · doi-reference
Molecular mechanisms of ferroptosis and relevance to inflammation
10.1007/s00011-022-01672-1 · ExternalCitation · doi-reference
Neurological development and iron supplementation in healthy late-preterm neonates: A randomized double-blind controlled trial
10.1007/s00431-021-04181-1 · ExternalCitation · doi-reference
Synergistic accumulation of iron and zinc by cultured astrocytes
10.1007/s00702-010-0420-9 · ExternalCitation · doi-reference
Effect of oral iron therapy on developmental assessment scores in infants with iron deficiency anemia
10.1007/s12098-025-05878-z · ExternalCitation · doi-reference
Ferroptosis in Parkinson’s disease: Molecular mechanisms and therapeutic potential
10.1016/j.arr.2023.102077 · ExternalCitation · doi-reference
Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms
10.1016/j.bbamcr.2016.12.002 · ExternalCitation · doi-reference
Iron deficiency and infant motor development
10.1016/j.earlhumdev.2007.12.009 · ExternalCitation · doi-reference
Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: Effects on locomotion and cortico-striatal neurotransmission
10.1016/j.expneurol.2010.04.004 · ExternalCitation · doi-reference
Impact of fetal-neonatal iron deficiency on recognition memory at 2 months of age
10.1016/j.jpeds.2015.08.035 · ExternalCitation · doi-reference
Randomized controlled trial of iron-fortified versus low-iron infant formula: Developmental outcomes at 16 years
10.1016/j.jpeds.2019.05.030 · ExternalCitation · doi-reference
Randomized trial of oral iron and diet advice versus diet advice alone in young children with nonanemic iron deficiency
10.1016/j.jpeds.2021.01.073 · ExternalCitation · doi-reference
Enteral iron supplementation in infants born extremely preterm and its positive correlation with neurodevelopment: Post hoc analysis of the Preterm Erythropoietin Neuroprotection Trial randomized controlled trial
10.1016/j.jpeds.2021.07.019 · ExternalCitation · doi-reference
La nutrición temprana influye en la mielinización y la cognición durante el desarrollo en bebés y niños pequeños
10.1016/j.neuroimage.2017.12.056 · ExternalCitation · doi-reference
Iron deficiency anaemia
10.1016/j.paed.2017.08.004 · ExternalCitation · doi-reference
Supplementation with iron syrup or iron-containing multiple micronutrient powders alters resting brain activity in Bangladeshi children
10.1016/j.tjnut.2022.12.026 · ExternalCitation · doi-reference
Iron status with different infant feeding regimens: Relevance to screening and prevention of iron deficiency
10.1016/s0022-3476(05)80027-7 · ExternalCitation · doi-reference
Iron deficiency anaemia
10.1016/s0140-6736(15)60865-0 · ExternalCitation · doi-reference
Iron deficiency and the intellect
10.1016/s0387-7604(02)00148-1 · ExternalCitation · doi-reference
Developmental cascades
10.1017/s0954579410000222 · ExternalCitation · doi-reference
Lipid-Oxidative Enzymes and Fenton-Like Reactions Are Synergistic in Promoting Membrane Lipid Peroxidation
10.1021/jacsau.5c00696 · ExternalCitation · doi-reference
Iron, brain ageing and neurodegenerative disorders
10.1038/nrn1537 · ExternalCitation · doi-reference
Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years: A randomized controlled trial
10.1038/pr.2017.235 · ExternalCitation · doi-reference
Ferroptosis: A double-edged sword
10.1038/s41421-023-00638-9 · ExternalCitation · doi-reference
Iron regulatory proteins and their role in controlling iron metabolism
10.1039/c4mt00164h · ExternalCitation · doi-reference
Benefits and risks of iron interventions in infants in rural Bangladesh
10.1056/nejmoa2034187 · ExternalCitation · doi-reference
Iron transport proteins: Gateways of cellular and systemic iron homeostasis
10.1074/jbc.r117.786632 · ExternalCitation · doi-reference
Micronutrient interactions: Effects on absorption and bioavailability
10.1079/bjn2000312 · ExternalCitation · doi-reference
Role of iron in brain development, aging, and neurodegenerative diseases
10.1080/07853890.2025.2472871 · ExternalCitation · doi-reference
Young adult outcomes associated with lower cognitive functioning in childhood related to iron-fortified formula in infancy
10.1080/1028415x.2020.1804099 · ExternalCitation · doi-reference
Iron supplementation given to nonanemic infants: Neurocognitive functioning at 16 years
10.1080/1028415x.2021.2013399 · ExternalCitation · doi-reference
Calcium, iron and neuronal function
10.1080/15216540701222906 · ExternalCitation · doi-reference
Iron deficiency in infancy: Applying a physiologic framework for prediction
10.1093/ajcn/84.6.1412 · ExternalCitation · doi-reference
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function
10.1093/ajcn/85.4.931 · ExternalCitation · doi-reference
Global, Regional, and National Prevalence of Anemia and Its Causesin 204 Countries and Territories, 1990–2019
10.1093/cdn/nzaa053_035 · ExternalCitation · doi-reference
Serum transferrin receptor in children: Usefulness for determining the nature of anemia in infection
10.1097/mph.0b013e31802d751a · ExternalCitation · doi-reference
Anaemia during pregnancy as a risk factor for infant iron deficiency: Report from the Valencia Infant Anaemia Cohort (VIAC) study
10.1111/j.1365-3016.1990.tb00638.x · ExternalCitation · doi-reference
Evidence based medicine: What it is and what it isn’t
10.1136/bmj.312.7023.71 · ExternalCitation · doi-reference
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
10.1136/bmj.n71 · ExternalCitation · doi-reference
Molecular mechanisms of iron and heme metabolism
10.1146/annurev-nutr-062320-112625 · ExternalCitation · doi-reference
Systemic iron homeostasis
10.1152/physrev.00008.2013 · ExternalCitation · doi-reference
Ferroptosis: When metabolism meets cell death
10.1152/physrev.00031.2024 · ExternalCitation · doi-reference
Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons
10.1159/000075667 · ExternalCitation · doi-reference
Iron nutriture of the fetus, neonate, infant, and child
10.1159/000481447 · ExternalCitation · doi-reference
Advances in ferroptosis in chronic inflammatory diseases of the upper and lower airways
10.1159/000547363 · ExternalCitation · doi-reference
Iron deficiency and child development
10.1177/15648265070284s409 · ExternalCitation · doi-reference
Iron Metabolism in Oligodendrocytes and Astrocytes, Implications for Myelination and Remyelination
10.1177/1759091420962681 · ExternalCitation · doi-reference
The effects of early-life iron deficiency on brain energy metabolism
10.1177/2633105520935104 · ExternalCitation · doi-reference
Hepcidin in the diagnosis of iron disorders
10.1182/blood-2015-12-639112 · ExternalCitation · doi-reference
Iron deficiency
10.1182/blood-2018-05-815944 · ExternalCitation · doi-reference
Uptake, metabolism and toxicity of iron oxide nanoparticles in cultured microglia, astrocytes and neurons
10.1186/2193-1801-4-s1-l32 · ExternalCitation · doi-reference
10.1186/s12868-019-0507-7
10.1186/s12868-019-0507-7 · ExternalCitation · doi-reference
10.1186/s12887-019-1679-0
10.1186/s12887-019-1679-0 · ExternalCitation · doi-reference
Ferroptosis: Principles and significance in health and disease
10.1186/s13045-024-01564-3 · ExternalCitation · doi-reference
Iron deficiency anemia in infancy: Long-lasting effects on auditory and visual system functioning
10.1203/01.pdr.0000047657.23156.55 · ExternalCitation · doi-reference
Iron role paradox in nerve degeneration and regeneration
10.14814/phy2.15908 · ExternalCitation · doi-reference
Iron homeostasis in the neonate
10.1542/peds.2008-1047 · ExternalCitation · doi-reference
Diagnosis and Prevention of Iron Deficiency and Iron-Deficiency Anemia in Infants and Young Children (0–3 Years of Age)
10.1542/peds.2010-2576 · ExternalCitation · doi-reference
Effects of daily iron supplementation in 2- to 5-year-old children: A systematic review and meta-analysis
10.1542/peds.2012-2256 · ExternalCitation · doi-reference
Iron supplementation in pregnancy or infancy and motor development: A randomized controlled trial
10.1542/peds.2015-3547 · ExternalCitation · doi-reference
Chronic iron deficiency and cognitive function in early childhood
10.1542/peds.2021-055926 · ExternalCitation · doi-reference
Iron deficiency anemia: A global public health concern
10.18231/j.ijcbr.2024.034 · ExternalCitation · doi-reference
10.3389/fmolb.2022.965064
10.3389/fmolb.2022.965064 · ExternalCitation · doi-reference
10.3389/fnins.2021.769558
10.3389/fnins.2021.769558 · ExternalCitation · doi-reference
10.3389/fnut.2024.1474664
10.3389/fnut.2024.1474664 · ExternalCitation · doi-reference
10.3389/fphar.2014.00124
10.3389/fphar.2014.00124 · ExternalCitation · doi-reference
10.3389/fphys.2019.00463
10.3389/fphys.2019.00463 · ExternalCitation · doi-reference
10.3390/antiox7040054
10.3390/antiox7040054 · ExternalCitation · doi-reference
10.3390/ijms17010130
10.3390/ijms17010130 · ExternalCitation · doi-reference
10.3390/ijms21228765
10.3390/ijms21228765 · ExternalCitation · doi-reference
10.3390/ijms24043995
10.3390/ijms24043995 · ExternalCitation · doi-reference
10.3390/ijms252313042
10.3390/ijms252313042 · ExternalCitation · doi-reference
10.3390/nu12020447
10.3390/nu12020447 · ExternalCitation · doi-reference
10.3390/nu12072001
10.3390/nu12072001 · ExternalCitation · doi-reference
10.3390/nu14142976
10.3390/nu14142976 · ExternalCitation · doi-reference
10.3390/nu14204380
10.3390/nu14204380 · ExternalCitation · doi-reference
Iron stores of breastfed infants during the first year of life
10.3390/nu6052023 · ExternalCitation · doi-reference
10.3390/nu8110693
10.3390/nu8110693 · ExternalCitation · doi-reference
Development of iron homeostasis in infants and young children
10.3945/ajcn.117.155820 · ExternalCitation · doi-reference
Excess iron intake as a factor in growth, infections, and development of infants and young children
10.3945/ajcn.117.156042 · ExternalCitation · doi-reference
The critical role of iron homeostasis in neurodegenerative diseases
10.4103/nrr.nrr-d-24-01382 · ExternalCitation · doi-reference
La declaración PRISMA: Un paso adelante en la mejora de las publicaciones de la Revista Española de Salud Pública
10.4321/s1135-57272013000200001 · ExternalCitation · doi-reference
