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References from Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
10.1016/j.eclinm.2020.100587 · 2020 · External reference
Association of general and central obesity, and their changes with risk of knee osteoarthritis: A nationwide population-based cohort study
10.1038/s41598-023-30727-4 · 2023 · External reference
Metabolic syndrome, radiographic osteoarthritis progression and chronic pain of the knee among men and women from the general population: The Rotterdam study
10.1016/j.semarthrit.2024.152544 · 2024 · External reference
10.3389/fmed.2024.1323091
10.3389/fmed.2024.1323091 · External reference
10.1371/journal.pone.0333919
10.1371/journal.pone.0333919 · External reference
Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort
2021 · External reference
Osteoarthritis: A disease of the joint as an organ
10.1002/art.34453 · 2012 · External reference
Engineering approaches for RNA-based and cell-based osteoarthritis therapies
10.1038/s41584-023-01067-4 · 2024 · External reference
Drug Delivery Systems Targeting the Knee Microenvironment: A Prospective Strategy for Knee Osteoarthritis Treatment
10.2147/dddt.s564907 · 2025 · External reference
Therapeutic Effects of Fire Needling Acupuncture on Pain Relief and Cartilage Protection in MIA-Induced Knee Osteoarthritis Rats: The Role of Macrophage Polarization in Synovium and Angiogenesis in Subchondral Bone
10.2147/jir.s518829 · 2025 · External reference
10.3390/ijms26146997
10.3390/ijms26146997 · External reference
Pharmacological Diversity of Flavonoids and Their Clinical Application Prospects in Neurological Disorders
10.1002/ptr.70097 · 2025 · External reference
Vitexin attenuates neuropathic pain by regulating astrocyte autophagy flux and polarization via the S1P/ S1PR1-PI3K/ Akt axis
10.1016/j.ejphar.2024.176848 · 2024 · External reference
Vitexin mitigates AIM2 inflammasome-mediated mitochondrial dysfunction and neuroinflammation in chronic constriction injury induced neuropathy model
10.1016/j.intimp.2025.114877 · 2025 · External reference
Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action
10.1016/j.neuropharm.2024.109961 · 2024 · External reference
Vitexin Alleviates Osteoarthritis Progression Through Sirtuin 3-Mediated Inhibition of Chondrocyte Ferroptosis and Mitochondrial Dysfunction
10.1002/ptr.70410 · 2026 · External reference
Nano-formulations for bone-specific delivery of siRNA for CrkII silencing-induced regulation of bone formation and resorption to maximize therapeutic potential for bone-related diseases
10.1039/d2bm02038f · 2023 · External reference
Imeglimin, a novel antidiabetic agent related to metformin, attenuates knee osteoarthritis development and progression through AMPK activation and NF-κB signaling inhibition
10.1016/j.joca.2025.11.007 · 2026 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
Thirteen years of clusterProfiler
2024 · External reference
clusterProfiler: An R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
GeneCards: Integrating information about genes, proteins and diseases
10.1016/s0168-9525(97)01103-7 · 1997 · External reference
Clinimetrics: The Knee injury and Osteoarthritis Outcome Score (KOOS)
10.1016/j.jphys.2024.11.011 · 2025 · External reference
AAV mediated repression of Neat1 lncRNA combined with F8 gene augmentation mitigates pathological mediators of joint disease in haemophilia
10.1111/jcmm.18460 · 2024 · External reference
Acquired hemophilia A associated with Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease: A case report
10.1097/md.0000000000025518 · 2021 · External reference
Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states
10.1182/bloodadvances.2025016474 · 2025 · External reference
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
10.1038/nature10893 · 2012 · External reference
Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor
10.1158/0008-5472.can-12-1690 · 2013 · External reference
Protease-activated receptor 1-mediated matrix metalloprotease signaling in sensory neurons
10.1152/ajpcell.00563.2025 · 2025 · External reference
Activation of Protease-Activated Receptor-1 Causes Chronic Pain in Lupus-Prone Mice Via Suppressing Spinal Glial Glutamate Transporter Function and Enhancing Glutamatergic Synaptic Activity
10.1016/j.jpain.2023.01.003 · 2023 · External reference
Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression
10.1158/2159-8290.cd-22-1467 · 2023 · External reference
10.3389/fphys.2025.1678037
10.3389/fphys.2025.1678037 · External reference
Electroacupuncture Alleviates KOA-Induced Pain and Cartilage Degeneration via NGF/TrkA Pathway
10.2147/jpr.s560506 · 2026 · External reference
Osteoarthritis: A disease of the joint as an organ
10.1002/art.34453 · ExternalCitation · doi-reference
Pharmacological Diversity of Flavonoids and Their Clinical Application Prospects in Neurological Disorders
10.1002/ptr.70097 · ExternalCitation · doi-reference
Vitexin Alleviates Osteoarthritis Progression Through Sirtuin 3-Mediated Inhibition of Chondrocyte Ferroptosis and Mitochondrial Dysfunction
10.1002/ptr.70410 · ExternalCitation · doi-reference
Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
10.1016/j.eclinm.2020.100587 · ExternalCitation · doi-reference
Vitexin attenuates neuropathic pain by regulating astrocyte autophagy flux and polarization via the S1P/ S1PR1-PI3K/ Akt axis
10.1016/j.ejphar.2024.176848 · ExternalCitation · doi-reference
Vitexin mitigates AIM2 inflammasome-mediated mitochondrial dysfunction and neuroinflammation in chronic constriction injury induced neuropathy model
10.1016/j.intimp.2025.114877 · ExternalCitation · doi-reference
Imeglimin, a novel antidiabetic agent related to metformin, attenuates knee osteoarthritis development and progression through AMPK activation and NF-κB signaling inhibition
10.1016/j.joca.2025.11.007 · ExternalCitation · doi-reference
Activation of Protease-Activated Receptor-1 Causes Chronic Pain in Lupus-Prone Mice Via Suppressing Spinal Glial Glutamate Transporter Function and Enhancing Glutamatergic Synaptic Activity
10.1016/j.jpain.2023.01.003 · ExternalCitation · doi-reference
Clinimetrics: The Knee injury and Osteoarthritis Outcome Score (KOOS)
10.1016/j.jphys.2024.11.011 · ExternalCitation · doi-reference
Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action
10.1016/j.neuropharm.2024.109961 · ExternalCitation · doi-reference
Metabolic syndrome, radiographic osteoarthritis progression and chronic pain of the knee among men and women from the general population: The Rotterdam study
10.1016/j.semarthrit.2024.152544 · ExternalCitation · doi-reference
GeneCards: Integrating information about genes, proteins and diseases
10.1016/s0168-9525(97)01103-7 · ExternalCitation · doi-reference
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
10.1038/nature10893 · ExternalCitation · doi-reference
Engineering approaches for RNA-based and cell-based osteoarthritis therapies
10.1038/s41584-023-01067-4 · ExternalCitation · doi-reference
Association of general and central obesity, and their changes with risk of knee osteoarthritis: A nationwide population-based cohort study
10.1038/s41598-023-30727-4 · ExternalCitation · doi-reference
Nano-formulations for bone-specific delivery of siRNA for CrkII silencing-induced regulation of bone formation and resorption to maximize therapeutic potential for bone-related diseases
10.1039/d2bm02038f · ExternalCitation · doi-reference
clusterProfiler: An R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · ExternalCitation · doi-reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · ExternalCitation · doi-reference
Acquired hemophilia A associated with Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease: A case report
10.1097/md.0000000000025518 · ExternalCitation · doi-reference
AAV mediated repression of Neat1 lncRNA combined with F8 gene augmentation mitigates pathological mediators of joint disease in haemophilia
10.1111/jcmm.18460 · ExternalCitation · doi-reference
Protease-activated receptor 1-mediated matrix metalloprotease signaling in sensory neurons
10.1152/ajpcell.00563.2025 · ExternalCitation · doi-reference
Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor
10.1158/0008-5472.can-12-1690 · ExternalCitation · doi-reference
Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression
10.1158/2159-8290.cd-22-1467 · ExternalCitation · doi-reference
Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states
10.1182/bloodadvances.2025016474 · ExternalCitation · doi-reference
10.1371/journal.pone.0333919
10.1371/journal.pone.0333919 · ExternalCitation · doi-reference
Drug Delivery Systems Targeting the Knee Microenvironment: A Prospective Strategy for Knee Osteoarthritis Treatment
10.2147/dddt.s564907 · ExternalCitation · doi-reference
Therapeutic Effects of Fire Needling Acupuncture on Pain Relief and Cartilage Protection in MIA-Induced Knee Osteoarthritis Rats: The Role of Macrophage Polarization in Synovium and Angiogenesis in Subchondral Bone
10.2147/jir.s518829 · ExternalCitation · doi-reference
Electroacupuncture Alleviates KOA-Induced Pain and Cartilage Degeneration via NGF/TrkA Pathway
10.2147/jpr.s560506 · ExternalCitation · doi-reference
10.3389/fmed.2024.1323091
10.3389/fmed.2024.1323091 · ExternalCitation · doi-reference
10.3389/fphys.2025.1678037
10.3389/fphys.2025.1678037 · ExternalCitation · doi-reference
10.3390/ijms26146997
10.3390/ijms26146997 · ExternalCitation · doi-reference
