References

Association between basal forebrain volume and age in the presenilin-1 E280A autosomal dominant Alzheimer’s disease kindred

10.1002/alz.71052 · ExternalCitation · doi-reference

Markers of leucine-rich repeat kinase 2 activity are associated with pathological protein aggregation across neurodegenerative diseases

10.1002/alz70855_107317 · ExternalCitation · doi-reference

c-Jun NH2 -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice

10.1002/hep.31116 · ExternalCitation · doi-reference

Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

10.1002/humu.21582 · ExternalCitation · doi-reference

LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson’s Disease

10.1002/mds.29297 · ExternalCitation · doi-reference

Phenolic-rich extract of avocado Persea americana (var. Colinred) peel blunts paraquat/maneb-induced apoptosis through blocking phosphorylation of LRRK2 kinase in human nerve-like cells

10.1002/tox.23433 · ExternalCitation · doi-reference

Neuroprotective Effect the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson’s Disease

10.1007/s11064-016-1982-1 · ExternalCitation · doi-reference

LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress

10.1007/s11064-024-04141-9 · ExternalCitation · doi-reference

Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson’s Disease

10.1007/s12017-025-08864-y · ExternalCitation · doi-reference

Latent Tri-lineage Potential of Human Menstrual Blood-Derived Mesenchymal Stromal Cells Revealed by Specific In Vitro Culture Conditions

10.1007/s12035-021-02442-6 · ExternalCitation · doi-reference

Rapamycin and mTOR kinase inhibitors

10.1007/s12154-008-0003-5 · ExternalCitation · doi-reference

Rotenone Induces a Neuropathological Phenotype in Cholinergic-like Neurons Resembling Parkinson’s Disease Dementia (PDD)

10.1007/s12640-024-00705-3 · ExternalCitation · doi-reference

Non-drug Therapies for Alzheimer’s Disease: A Review

10.1007/s40120-022-00416-x · ExternalCitation · doi-reference

Significance of NRF2 in physiological and pathological conditions an comprehensive review

10.1016/j.abb.2022.109417 · ExternalCitation · doi-reference

Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

10.1016/j.bbrc.2004.03.110 · ExternalCitation · doi-reference

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

10.1016/j.bbrc.2009.06.142 · ExternalCitation · doi-reference

Alzheimer’s disease risk genes and mechanisms of disease pathogenesis

10.1016/j.biopsych.2014.05.006 · ExternalCitation · doi-reference

LRRK2; a dynamic regulator of cellular trafficking

10.1016/j.brainres.2021.147394 · ExternalCitation · doi-reference

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson’s disease

10.1016/j.ceb.2020.01.001 · ExternalCitation · doi-reference

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

10.1016/j.cell.2010.05.008 · ExternalCitation · doi-reference

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

10.1016/j.cellsig.2015.10.006 · ExternalCitation · doi-reference

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

10.1016/j.celrep.2015.07.050 · ExternalCitation · doi-reference

Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr)

10.1016/j.jalz.2018.12.010 · ExternalCitation · doi-reference

Direct transdifferentiation of human Wharton’s jelly mesenchymal stromal cells into cholinergic-like neurons

10.1016/j.jneumeth.2018.11.019 · ExternalCitation · doi-reference

Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation

10.1016/j.nbd.2020.105081 · ExternalCitation · doi-reference

LRRK2 kinase inhibition protects against Parkinson’s disease-associated environmental toxicants

10.1016/j.nbd.2024.106522 · ExternalCitation · doi-reference

Early-Onset Alzheimer Disease

10.1016/j.ncl.2017.01.005 · ExternalCitation · doi-reference

Structural degeneration of the nucleus basalis of Meynert in mild cognitive impairment and Alzheimer’s disease—Evidence from an MRI-based meta-analysis

10.1016/j.neubiorev.2023.105393 · ExternalCitation · doi-reference

Modulation of signaling pathways by DJ-1: An updated overview

10.1016/j.redox.2022.102283 · ExternalCitation · doi-reference

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

10.1016/j.yexcr.2009.09.014 · ExternalCitation · doi-reference

Intraneuronal Abeta42 accumulation in human brain

10.1016/s0002-9440(10)64700-1 · ExternalCitation · doi-reference

Clinical symptoms in Alzheimer’s disease

10.1016/s0072-9752(07)01219-5 · ExternalCitation · doi-reference

Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer’s disease entorhinal cortex

10.1016/s0304-3940(02)00875-3 · ExternalCitation · doi-reference

The Antiproteinopathy, Antioxidant, and Antiapoptotic Effects of Methylene Blue and 4-Phenylbutyric Acid Alone, and in Combination on Familial Alzheimer’s Disease PSEN1 I416T Cholinergic-like Neurons

10.1021/acschemneuro.4c00472 · ExternalCitation · doi-reference

LRRK2 Inhibitors as Promising Treatment for Parkinson’s Disease

10.1021/acschemneuro.4c00657 · ExternalCitation · doi-reference

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor

10.1021/jm5014055 · ExternalCitation · doi-reference

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

10.1038/cdd.2012.42 · ExternalCitation · doi-reference

Fluorescence microscopy

10.1038/nmeth817 · ExternalCitation · doi-reference

Intracellular amyloid-beta in Alzheimer’s disease

10.1038/nrn2168 · ExternalCitation · doi-reference

Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies

10.1038/s41392-024-01911-3 · ExternalCitation · doi-reference

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

10.1038/s41419-018-0945-7 · ExternalCitation · doi-reference

Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM

10.1038/s41421-023-00639-8 · ExternalCitation · doi-reference

Molecular basis of V-ATPase inhibition by bafilomycin A1

10.1038/s41467-021-22111-5 · ExternalCitation · doi-reference

Genome-wide analysis furthers decoding of Alzheimer disease genetics

10.1038/s41582-022-00678-x · ExternalCitation · doi-reference

Cholinergic-like neurons and cerebral spheroids bearing the PSEN1 p.Ile416Thr variant mirror Alzheimer’s disease neuropathology

10.1038/s41598-023-39630-4 · ExternalCitation · doi-reference

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

10.1038/sj.cdd.4401528 · ExternalCitation · doi-reference

Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta

10.1046/j.1471-4159.2000.0741587.x · ExternalCitation · doi-reference

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

10.1073/pnas.90.20.9513 · ExternalCitation · doi-reference

REDOX reaction at ASK1-Cys250 is essential for activation of JNK and induction of apoptosis

10.1091/mbc.e09-03-0211 · ExternalCitation · doi-reference

Basal forebrain volume reliably predicts the cortical spread of Alzheimer’s degeneration

10.1093/brain/awaa012 · ExternalCitation · doi-reference

Structural (dys)connectivity associates with cholinergic cell density in Alzheimer’s disease

10.1093/brain/awac093 · ExternalCitation · doi-reference

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

10.1093/hmg/dds003 · ExternalCitation · doi-reference

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function

10.1093/hmg/ddz088 · ExternalCitation · doi-reference

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer’s disease

10.1111/pin.12520 · ExternalCitation · doi-reference

LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson’s disease

10.1126/scitranslmed.adl3438 · ExternalCitation · doi-reference

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: A multidimensional study

10.1186/2051-5960-2-61 · ExternalCitation · doi-reference

LRRK2 Biology from structure to dysfunction: Research progresses, but the themes remain the same

10.1186/s13024-019-0344-2 · ExternalCitation · doi-reference

A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects

10.1186/s13073-022-01035-9 · ExternalCitation · doi-reference

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

10.1186/s40478-019-0836-x · ExternalCitation · doi-reference

Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology

10.1242/jcs.01058 · ExternalCitation · doi-reference

10.1371/journal.pbio.2005282

10.1371/journal.pbio.2005282 · ExternalCitation · doi-reference

10.1371/journal.pone.0039132

10.1371/journal.pone.0039132 · ExternalCitation · doi-reference

Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner

10.1523/jneurosci.5156-10.2010 · ExternalCitation · doi-reference

Flow cytometry: Basic principles and applications

10.3109/07388551.2015.1128876 · ExternalCitation · doi-reference

The Amyloid Cascade Hypothesis 2.0: Generalization of the Concept

10.3233/adr-220079 · ExternalCitation · doi-reference

Effect of Lecanemab in Early Alzheimer’s Disease: Mechanistic Interpretation in the Amyloid Cascade Hypothesis 2.0 Perspective

10.3233/jad-230164 · ExternalCitation · doi-reference

10.3389/fnins.2020.00498

10.3389/fnins.2020.00498 · ExternalCitation · doi-reference

10.3389/fnins.2020.00577

10.3389/fnins.2020.00577 · ExternalCitation · doi-reference

10.3390/cells10092380

10.3390/cells10092380 · ExternalCitation · doi-reference

10.3390/cells7100156

10.3390/cells7100156 · ExternalCitation · doi-reference

10.3390/ijms18091865

10.3390/ijms18091865 · ExternalCitation · doi-reference

10.3390/ijms21134777

10.3390/ijms21134777 · ExternalCitation · doi-reference

10.3390/ijms24043895

10.3390/ijms24043895 · ExternalCitation · doi-reference

10.3390/ijms24108957

10.3390/ijms24108957 · ExternalCitation · doi-reference

10.3390/ijms241310474

10.3390/ijms241310474 · ExternalCitation · doi-reference

10.3390/ijms242115744

10.3390/ijms242115744 · ExternalCitation · doi-reference

10.3390/ijms242115951

10.3390/ijms242115951 · ExternalCitation · doi-reference

10.3390/ijms25094925

10.3390/ijms25094925 · ExternalCitation · doi-reference

10.3390/ijms26083756

10.3390/ijms26083756 · ExternalCitation · doi-reference

Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease

10.3390/neurolint15030054 · ExternalCitation · doi-reference

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome

10.5858/2001-125-0489-iaapdo · ExternalCitation · doi-reference