Research graph
References from Preclinical Evaluation of Labetalol for Cutaneous Melanoma Drug Repurposing: Cytotoxic Activity in A375 Cells and Mitochondria-Associated Apoptotic Signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3390/biomedicines11102616
10.3390/biomedicines11102616 · External reference
10.3390/biomedicines12061318
10.3390/biomedicines12061318 · External reference
10.3390/cancers14246052
10.3390/cancers14246052 · External reference
The Role of β-Blockers in Melanoma
10.1007/s11481-019-09876-9 · 2020 · External reference
10.3390/bioengineering10060673
10.3390/bioengineering10060673 · External reference
10.3390/cancers13081819
10.3390/cancers13081819 · External reference
10.3390/ijms21114071
10.3390/ijms21114071 · External reference
Targeting Inflamed and Non-Inflamed Melanomas: Biological Background and Clinical Challenges
10.1016/j.semcancer.2022.06.005 · 2022 · External reference
Current Knowledge about Immunotherapy Resistance for Melanoma and Potential Predictive and Prognostic Biomarkers
2024 · External reference
New Drugs Are Not Enough—Drug Repositioning in Oncology: An Update
2020 · External reference
10.3389/fonc.2020.605714
10.3389/fonc.2020.605714 · External reference
10.3390/pharmaceutics15010083
10.3390/pharmaceutics15010083 · External reference
10.3389/fimmu.2018.00164
10.3389/fimmu.2018.00164 · External reference
β-Adrenoceptors as Drug Targets in Melanoma: Novel Preclinical Evidence for a Role of β3-Adrenoceptors
10.1111/bph.14552 · 2019 · External reference
Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway
10.18632/oncotarget.11599 · 2016 · External reference
10.3390/toxics13110981
10.3390/toxics13110981 · External reference
Beta-Blocker Usage after Malignant Melanoma Diagnosis and Survival: A Population-Based Nested Case-Control Study
10.1111/bjd.12894 · 2014 · External reference
Beta-Adrenergic Blockers’ Supportive and Adverse Role in Hypertension: A Review of Three Generations
2022 · External reference
10.1371/journal.pone.0217038
10.1371/journal.pone.0217038 · External reference
10.3390/cancers14133097
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10.3390/toxics9050092
10.3390/toxics9050092 · External reference
Unresolved reference
External reference
10.3390/app16136472
10.3390/app16136472 · External reference
10.1371/journal.pone.0127610
10.1371/journal.pone.0127610 · External reference
10.3390/pharmaceutics18010089
10.3390/pharmaceutics18010089 · External reference
Neutral red uptake assay for the estimation of cell viability/cytotoxicity
10.1038/nprot.2008.75 · 2008 · External reference
10.3390/medicina61122197
10.3390/medicina61122197 · External reference
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10.3390/life15060954 · External reference
10.3389/fphar.2025.1487854
10.3389/fphar.2025.1487854 · External reference
10.3390/antiox15030296
10.3390/antiox15030296 · External reference
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10.3390/medicina58020167 · External reference
Hen’s egg chorioallantoic membrane test for irritation potential
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Ex Vivo Irritation Evaluation of a Novel Brimonidine Nanoemulsion Using the Hen’s Egg Test on Chorioallantoic Membrane (HET-CAM)
2024 · External reference
Standardization of A375 Human Melanoma Models on Chicken Embryo Chorioallantoic Membrane and Balb/c Nude Mice
10.3892/or.2017.5658 · 2017 · External reference
10.3390/jox16040146
10.3390/jox16040146 · External reference
10.3390/life14030304
10.3390/life14030304 · External reference
10.3390/scipharm89010012
10.3390/scipharm89010012 · External reference
The Melanocyte and the Epidermal Melanin Unit: An Expanded Concept
10.1016/j.det.2007.04.001 · 2007 · External reference
10.3390/ph19040616
10.3390/ph19040616 · External reference
Normal Keratinization in a Spontaneously Immortalized Aneuploid Human Keratinocyte Cell Line
10.1083/jcb.106.3.761 · 1988 · External reference
Isolation, Culture, and Transfection of Melanocytes
10.1002/cpz1.774 · 2023 · External reference
Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and pathways underpinning hepatocellular carcinoma: A drug repurposing endeavor
10.1007/s12032-021-01576-w · 2021 · External reference
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
10.1038/bjc.1972.33 · 1972 · External reference
Inhibition of human melanoma growth by a non-cardioselective β-blocker
10.1038/jid.2014.373 · 2015 · External reference
Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: Role of plasma membrane depolarization
10.18632/oncotarget.4268 · 2015 · External reference
Comparisons of two in vitro cytotoxicity assays—The neutral red (NR) and tetrazolium MTT tests
10.1016/0887-2333(88)90030-6 · 1988 · External reference
In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
10.1016/j.toxlet.2005.07.001 · 2006 · External reference
10.3389/fonc.2020.614288
10.3389/fonc.2020.614288 · External reference
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
10.1073/pnas.88.9.3671 · 1991 · External reference
JC-1: Alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry
10.1038/cddis.2012.171 · 2012 · External reference
10.3390/cells14030187
10.3390/cells14030187 · External reference
New indication for therapeutic potential of an old well-known drug (propranolol) for multiple myeloma
10.1007/s00432-012-1331-y · 2013 · External reference
Efficacy of MitoTracker Green and CMXRosamine to measure changes in mitochondrial membrane potentials in living cells and tissues
10.1002/cyto.a.20033 · 2004 · External reference
Performance of TMRM and MitoTrackers in mitochondrial morphofunctional analysis of primary human skin fibroblasts
10.1016/j.bbabio.2023.149027 · 2024 · External reference
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors
10.1016/j.molcel.2015.01.003 · 2015 · External reference
Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression
10.1038/s41598-018-25340-9 · 2018 · External reference
A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture
10.1016/j.acthis.2017.03.001 · 2017 · External reference
Endothelin-induced apoptosis of A375 human melanoma cells
10.1074/jbc.273.20.12584 · 1998 · External reference
A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation
10.1242/jcs.02959 · 2006 · External reference
Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells
10.1186/1756-9966-32-31 · 2013 · External reference
Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy
10.1038/s41598-022-18324-3 · 2022 · External reference
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10.1016/s0092-8674(00)80434-1 · 1997 · External reference
10.1186/1471-2121-14-32
10.1186/1471-2121-14-32 · External reference
10.3390/ijms24065894
10.3390/ijms24065894 · External reference
10.1186/1472-6750-5-12
10.1186/1472-6750-5-12 · External reference
Propidium Iodide (PI) Uptake Assay to Detect Apoptosis
10.1101/pdb.prot4495 · 2006 · External reference
Methylwogonin exerts anticancer effects in A375 human malignant melanoma cells through apoptosis induction, DNA damage, cell invasion inhibition and downregulation of the mTOR/PI3K/Akt signalling pathway
10.5114/aoms.2018.73711 · 2019 · External reference
Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma
10.1002/cam4.2594 · 2019 · External reference
Comparison of the different protocols of the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) by evaluating the eye irritation potential of surfactants
10.1016/j.tiv.2021.105255 · 2022 · External reference
Evaluation of oleanolic acid, doxorubicin and their association in the treatment of melanoma: Enhanced efficacy and antiangiogenic potential
10.31925/farmacia.2023.6.21 · 2023 · External reference
10.3390/molecules25225442
10.3390/molecules25225442 · External reference
Comparison between HET-CAM protocols and a product use clinical study for eye irritation evaluation of personal care products including cosmetics according to their surfactant composition
10.1016/j.fct.2021.112229 · 2021 · External reference
Eugenol—A natural alternative in dentistry: An in vitro and in ovo biosafety assessment
10.31925/farmacia.2024.5.4 · 2024 · External reference
10.3390/pharmaceutics13081241
10.3390/pharmaceutics13081241 · External reference
Exploring the Functions of Mutant p53 through TP53 Knockout in HaCaT Keratinocytes
10.3390/cimb46020094 · 2024 · External reference
Beta-blockers exert potent anti-tumor effects in cutaneous and uveal melanoma
10.1002/cam4.2594 · ExternalCitation · doi-reference
Isolation, Culture, and Transfection of Melanocytes
10.1002/cpz1.774 · ExternalCitation · doi-reference
Efficacy of MitoTracker Green and CMXRosamine to measure changes in mitochondrial membrane potentials in living cells and tissues
10.1002/cyto.a.20033 · ExternalCitation · doi-reference
New indication for therapeutic potential of an old well-known drug (propranolol) for multiple myeloma
10.1007/s00432-012-1331-y · ExternalCitation · doi-reference
The Role of β-Blockers in Melanoma
10.1007/s11481-019-09876-9 · ExternalCitation · doi-reference
Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and pathways underpinning hepatocellular carcinoma: A drug repurposing endeavor
10.1007/s12032-021-01576-w · ExternalCitation · doi-reference
Hen’s egg chorioallantoic membrane test for irritation potential
10.1016/0278-6915(85)90030-4 · ExternalCitation · doi-reference
Comparisons of two in vitro cytotoxicity assays—The neutral red (NR) and tetrazolium MTT tests
10.1016/0887-2333(88)90030-6 · ExternalCitation · doi-reference
A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture
10.1016/j.acthis.2017.03.001 · ExternalCitation · doi-reference
Performance of TMRM and MitoTrackers in mitochondrial morphofunctional analysis of primary human skin fibroblasts
10.1016/j.bbabio.2023.149027 · ExternalCitation · doi-reference
The Melanocyte and the Epidermal Melanin Unit: An Expanded Concept
10.1016/j.det.2007.04.001 · ExternalCitation · doi-reference
Comparison between HET-CAM protocols and a product use clinical study for eye irritation evaluation of personal care products including cosmetics according to their surfactant composition
10.1016/j.fct.2021.112229 · ExternalCitation · doi-reference
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors
10.1016/j.molcel.2015.01.003 · ExternalCitation · doi-reference
Targeting Inflamed and Non-Inflamed Melanomas: Biological Background and Clinical Challenges
10.1016/j.semcancer.2022.06.005 · ExternalCitation · doi-reference
Comparison of the different protocols of the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) by evaluating the eye irritation potential of surfactants
10.1016/j.tiv.2021.105255 · ExternalCitation · doi-reference
In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
10.1016/j.toxlet.2005.07.001 · ExternalCitation · doi-reference
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10.1016/s0092-8674(00)80434-1 · ExternalCitation · doi-reference
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
10.1038/bjc.1972.33 · ExternalCitation · doi-reference
JC-1: Alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry
10.1038/cddis.2012.171 · ExternalCitation · doi-reference
Inhibition of human melanoma growth by a non-cardioselective β-blocker
10.1038/jid.2014.373 · ExternalCitation · doi-reference
Neutral red uptake assay for the estimation of cell viability/cytotoxicity
10.1038/nprot.2008.75 · ExternalCitation · doi-reference
Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression
10.1038/s41598-018-25340-9 · ExternalCitation · doi-reference
Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy
10.1038/s41598-022-18324-3 · ExternalCitation · doi-reference
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
10.1073/pnas.88.9.3671 · ExternalCitation · doi-reference
Endothelin-induced apoptosis of A375 human melanoma cells
10.1074/jbc.273.20.12584 · ExternalCitation · doi-reference
Normal Keratinization in a Spontaneously Immortalized Aneuploid Human Keratinocyte Cell Line
10.1083/jcb.106.3.761 · ExternalCitation · doi-reference
Propidium Iodide (PI) Uptake Assay to Detect Apoptosis
10.1101/pdb.prot4495 · ExternalCitation · doi-reference
Beta-Blocker Usage after Malignant Melanoma Diagnosis and Survival: A Population-Based Nested Case-Control Study
10.1111/bjd.12894 · ExternalCitation · doi-reference
β-Adrenoceptors as Drug Targets in Melanoma: Novel Preclinical Evidence for a Role of β3-Adrenoceptors
10.1111/bph.14552 · ExternalCitation · doi-reference
10.1186/1471-2121-14-32
10.1186/1471-2121-14-32 · ExternalCitation · doi-reference
10.1186/1472-6750-5-12
10.1186/1472-6750-5-12 · ExternalCitation · doi-reference
Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells
10.1186/1756-9966-32-31 · ExternalCitation · doi-reference
A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation
10.1242/jcs.02959 · ExternalCitation · doi-reference
10.1371/journal.pone.0127610
10.1371/journal.pone.0127610 · ExternalCitation · doi-reference
10.1371/journal.pone.0217038
10.1371/journal.pone.0217038 · ExternalCitation · doi-reference
Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway
10.18632/oncotarget.11599 · ExternalCitation · doi-reference
Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: Role of plasma membrane depolarization
10.18632/oncotarget.4268 · ExternalCitation · doi-reference
Evaluation of oleanolic acid, doxorubicin and their association in the treatment of melanoma: Enhanced efficacy and antiangiogenic potential
10.31925/farmacia.2023.6.21 · ExternalCitation · doi-reference
Eugenol—A natural alternative in dentistry: An in vitro and in ovo biosafety assessment
10.31925/farmacia.2024.5.4 · ExternalCitation · doi-reference
10.3389/fimmu.2018.00164
10.3389/fimmu.2018.00164 · ExternalCitation · doi-reference
10.3389/fonc.2020.605714
10.3389/fonc.2020.605714 · ExternalCitation · doi-reference
10.3389/fonc.2020.614288
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10.3389/fphar.2025.1487854
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10.3390/app16136472
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10.3390/cells14030187
10.3390/cells14030187 · ExternalCitation · doi-reference
Exploring the Functions of Mutant p53 through TP53 Knockout in HaCaT Keratinocytes
10.3390/cimb46020094 · ExternalCitation · doi-reference
10.3390/ijms21114071
10.3390/ijms21114071 · ExternalCitation · doi-reference
10.3390/ijms24065894
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10.3390/toxics13110981 · ExternalCitation · doi-reference
10.3390/toxics9050092
10.3390/toxics9050092 · ExternalCitation · doi-reference
Standardization of A375 Human Melanoma Models on Chicken Embryo Chorioallantoic Membrane and Balb/c Nude Mice
10.3892/or.2017.5658 · ExternalCitation · doi-reference
Methylwogonin exerts anticancer effects in A375 human malignant melanoma cells through apoptosis induction, DNA damage, cell invasion inhibition and downregulation of the mTOR/PI3K/Akt signalling pathway
10.5114/aoms.2018.73711 · ExternalCitation · doi-reference
