Research graph
References from DAMPs and PAMPs in the Perioperative Period: Danger Signaling, Immune Dysfunction, and Oncologic Implications. Local targets link to admitted publications; unresolved targets remain external evidence.
Surgical Stress Response: A Physiological Review of the Endocrine, Immune, and Metabolic Changes
2025 · External reference
Surgery in Older Cancer Patients
10.1007/s11912-026-01740-3 · 2026 · External reference
Global demand for cancer surgery and an estimate of the optimal surgical and anaesthesia workforce between 2018 and 2040: A population-based modelling study
10.1016/s1470-2045(20)30675-6 · 2021 · External reference
Pattern recognition receptors: Function, regulation and therapeutic potential
10.1038/s41392-025-02264-1 · 2025 · External reference
Biomarkers in Onco-anaesthesia: A Narrative Review
2026 · External reference
10.3390/anesthres3010001
10.3390/anesthres3010001 · External reference
Damage-associated molecular patterns (DAMPs) in diseases: Implications for therapy
10.1186/s43556-025-00305-3 · 2025 · External reference
Extracellular Matrix-Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis
10.1016/j.jid.2023.04.030 · 2023 · External reference
10.3390/ijms24043862
10.3390/ijms24043862 · External reference
10.3389/fimmu.2018.00663
10.3389/fimmu.2018.00663 · External reference
Postoperative Innate Immune Dysregulation, Proteomic, and Monocyte Epigenomic Changes After Colorectal Surgery: A Substudy of a Randomized Controlled Trial
10.1213/ane.0000000000007297 · 2025 · External reference
Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients
10.1038/s41598-025-00382-y · 2025 · External reference
Neutrophil extracellular traps formation is associated with postoperative complications in congenital cardiac surgery
10.1038/s41390-024-03717-z · 2025 · External reference
Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: An experimental study
10.1186/1465-9921-9-79 · 2008 · External reference
10.3390/biomedicines10020380
10.3390/biomedicines10020380 · External reference
10.3389/fimmu.2020.01455
10.3389/fimmu.2020.01455 · External reference
Association between periodontitis and postoperative complications in hospital medical surgical procedures: A systematic review
10.21142/2523-2754-1104-2023-177 · 2023 · External reference
Clinical impact of periodontal disease on postoperative complications in gastrointestinal cancer patients
10.1007/s10147-019-01513-y · 2019 · External reference
10.3390/cancers17030368
10.3390/cancers17030368 · External reference
10.3390/cancers15010099
10.3390/cancers15010099 · External reference
10.3390/cancers18081198
10.3390/cancers18081198 · External reference
Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions
10.1093/bja/aet068 · 2013 · External reference
Investigating the impact of mitochondrial DNA: Insights into blood transfusion reactions and mitigation strategies
10.1111/vox.13794 · 2025 · External reference
Transfusion-Related Acute Lung Injury: The Work of DAMPs
10.1159/000345688 · 2013 · External reference
Age of Transfused Blood in Critically Ill Adults
10.1056/nejmoa1500704 · 2015 · External reference
Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion
10.1056/nejmoa1609014 · 2016 · External reference
Effects of red-cell storage duration on patients undergoing cardiac surgery
10.1056/nejmoa1414219 · 2015 · External reference
10.3390/jcm15083017
10.3390/jcm15083017 · External reference
Perioperative Anemia and Transfusion Management in Older Adults with Osteoporotic Hip Fractures: A Narrative Review of Current Evidence and Emerging Strategies
10.2147/cia.s620352 · 2026 · External reference
Red Blood Cell Transfusion: 2023 AABB International Guidelines
10.1001/jama.2023.12914 · 2023 · External reference
Transfusion-related acute lung injury (TRALI): Current understanding, challenges, and future directions
10.15537/smj.2025.46.8.20250233 · 2025 · External reference
Future Preventive and Therapeutic Targets for Transfusion-Related Acute Lung Injury
10.2174/1381612811209023285 · 2012 · External reference
Leukoreduction for the Prevention of Adverse Reactions from Allogeneic Blood Transfusion
2015 · External reference
Revisiting the safety of intraoperative cell salvage in cancer surgery: How to evaluate the functional properties of remaining cancer cells
10.1016/j.ejso.2025.110532 · 2025 · External reference
10.1371/journal.pone.0289177
10.1371/journal.pone.0289177 · External reference
Mechanisms of anesthetic-induced immune dysregulation
10.1007/s44254-025-00117-2 · 2025 · External reference
Propofol Protects Lung Endothelial Barrier Function by Suppression of High-Mobility Group Box 1 (HMGB1) Release and Mitochondrial Oxidative Damage Catalyzed by HMGB1
10.12659/msm.915417 · 2019 · External reference
Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages
10.1590/1414-431x20144222 · 2015 · External reference
Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats
10.1038/srep16849 · 2015 · External reference
Dexmedetomidine directly binds to and inhibits Toll-like receptor 4
10.1016/j.intimp.2024.112975 · 2024 · External reference
MtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice
10.7150/ijbs.91543 · 2024 · External reference
Effects of Remimazolam on Perioperative Inflammatory Response and Neurocognitive Disorders in Elderly Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
10.2147/dddt.s565045 · 2025 · External reference
Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery
10.17219/acem/189227 · 2025 · External reference
Ketamine inhibits LPS-induced HMGB1 release in vitro and in vivo
10.1016/j.intimp.2014.08.003 · 2014 · External reference
Perioperative Pain Management and Cancer Outcomes: A Narrative Review
10.2147/jpr.s432444 · 2023 · External reference
10.3390/cancers16132304
10.3390/cancers16132304 · External reference
10.3389/fimmu.2024.1441020
10.3389/fimmu.2024.1441020 · External reference
Impact of Anesthesia on Cancer Recurrence: A Narrative Review
10.4103/wbjc.wbjc_4_25 · 2024 · External reference
10.3390/cancers16244269
10.3390/cancers16244269 · External reference
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation
10.1016/j.jpsychires.2023.05.082 · 2023 · External reference
10.3389/fphar.2024.1468644
10.3389/fphar.2024.1468644 · External reference
10.3390/cancers13215274
10.3390/cancers13215274 · External reference
10.3390/cells10112898
10.3390/cells10112898 · External reference
Surgical trauma-induced immunosuppression in cancer: Recent advances and the potential therapies
10.1002/ctm2.24 · 2020 · External reference
Recurrence of Breast Cancer after Regional or General Anaesthesia: A Randomised Controlled Trial
10.1016/s0140-6736(19)32313-x · 2019 · External reference
10.3389/fimmu.2024.1334109
10.3389/fimmu.2024.1334109 · External reference
HMGB-1 as a useful prognostic biomarker in sepsis-induced organ failure in patients undergoing PMX-DHP
10.1016/j.jss.2009.11.708 · 2011 · External reference
Methodological and Preanalytical Evaluation of an HMGB1 Immunoassay
2012 · External reference
10.3390/cells11152274
10.3390/cells11152274 · External reference
An Improved Analytic Workflow for Serum mtDNA DAMP Abundance, Fragmentation and Heteroplasmic Variants: A Retrospective Analysis of Acute Respiratory Failure Patients
10.1038/s41598-026-51417-x · 2026 · External reference
Inadequate Reporting of Analytical Characteristics of Biomarkers Used in Clinical Research: A Threat to Interpretation and Replication of Study Findings
10.1373/clinchem.2019.309575 · 2019 · External reference
Factors Masking HMGB1 in Human Serum and Plasma
10.1189/jlb.0306196 · 2007 · External reference
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients with Severe Sepsis: The ACCESS Randomized Trial
10.1001/jama.2013.2194 · 2013 · External reference
A Randomized, Double-Blind, Placebo-Controlled Trial of TAK-242 for the Treatment of Severe Sepsis
10.1097/ccm.0b013e3181e7c5c9 · 2010 · External reference
Low-cost, point-of-care biomarker quantification
10.1016/j.copbio.2022.102738 · 2022 · External reference
An Explainable AI System for the Diagnosis of High-Dimensional Biomedical Data
10.3390/biomedinformatics4010013 · 2024 · External reference
The impact of artificial intelligence on biomarker discovery
10.1042/etls20243003 · 2025 · External reference
Artificial intelligence-based biomarkers for treatment decisions in oncology
10.1016/j.trecan.2024.12.001 · 2025 · External reference
10.3389/fpubh.2025.1633487
10.3389/fpubh.2025.1633487 · External reference
Evaluation of performance measures in predictive artificial intelligence models to support medical decisions: Overview and guidance
10.1016/j.landig.2025.100916 · 2025 · External reference
Medical artificial intelligence and the black box problem: A view based on the ethical principle of “do no harm”
10.1016/j.imed.2023.08.001 · 2024 · External reference
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients with Severe Sepsis: The ACCESS Randomized Trial
10.1001/jama.2013.2194 · ExternalCitation · doi-reference
Red Blood Cell Transfusion: 2023 AABB International Guidelines
10.1001/jama.2023.12914 · ExternalCitation · doi-reference
Surgical trauma-induced immunosuppression in cancer: Recent advances and the potential therapies
10.1002/ctm2.24 · ExternalCitation · doi-reference
Clinical impact of periodontal disease on postoperative complications in gastrointestinal cancer patients
10.1007/s10147-019-01513-y · ExternalCitation · doi-reference
Surgery in Older Cancer Patients
10.1007/s11912-026-01740-3 · ExternalCitation · doi-reference
Mechanisms of anesthetic-induced immune dysregulation
10.1007/s44254-025-00117-2 · ExternalCitation · doi-reference
Low-cost, point-of-care biomarker quantification
10.1016/j.copbio.2022.102738 · ExternalCitation · doi-reference
Revisiting the safety of intraoperative cell salvage in cancer surgery: How to evaluate the functional properties of remaining cancer cells
10.1016/j.ejso.2025.110532 · ExternalCitation · doi-reference
Medical artificial intelligence and the black box problem: A view based on the ethical principle of “do no harm”
10.1016/j.imed.2023.08.001 · ExternalCitation · doi-reference
Ketamine inhibits LPS-induced HMGB1 release in vitro and in vivo
10.1016/j.intimp.2014.08.003 · ExternalCitation · doi-reference
Dexmedetomidine directly binds to and inhibits Toll-like receptor 4
10.1016/j.intimp.2024.112975 · ExternalCitation · doi-reference
Extracellular Matrix-Derived Damage-Associated Molecular Patterns (DAMP): Implications in Systemic Sclerosis and Fibrosis
10.1016/j.jid.2023.04.030 · ExternalCitation · doi-reference
PAG neuronal NMDARs activation mediated morphine-induced hyperalgesia by HMGB1-TLR4 dependent microglial inflammation
10.1016/j.jpsychires.2023.05.082 · ExternalCitation · doi-reference
HMGB-1 as a useful prognostic biomarker in sepsis-induced organ failure in patients undergoing PMX-DHP
10.1016/j.jss.2009.11.708 · ExternalCitation · doi-reference
Evaluation of performance measures in predictive artificial intelligence models to support medical decisions: Overview and guidance
10.1016/j.landig.2025.100916 · ExternalCitation · doi-reference
Artificial intelligence-based biomarkers for treatment decisions in oncology
10.1016/j.trecan.2024.12.001 · ExternalCitation · doi-reference
Recurrence of Breast Cancer after Regional or General Anaesthesia: A Randomised Controlled Trial
10.1016/s0140-6736(19)32313-x · ExternalCitation · doi-reference
Global demand for cancer surgery and an estimate of the optimal surgical and anaesthesia workforce between 2018 and 2040: A population-based modelling study
10.1016/s1470-2045(20)30675-6 · ExternalCitation · doi-reference
Neutrophil extracellular traps formation is associated with postoperative complications in congenital cardiac surgery
10.1038/s41390-024-03717-z · ExternalCitation · doi-reference
Pattern recognition receptors: Function, regulation and therapeutic potential
10.1038/s41392-025-02264-1 · ExternalCitation · doi-reference
Cell-free mitochondrial DNA may predict the risk of post-operative complications and outcomes in surgical aortic valve replacement patients
10.1038/s41598-025-00382-y · ExternalCitation · doi-reference
An Improved Analytic Workflow for Serum mtDNA DAMP Abundance, Fragmentation and Heteroplasmic Variants: A Retrospective Analysis of Acute Respiratory Failure Patients
10.1038/s41598-026-51417-x · ExternalCitation · doi-reference
Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats
10.1038/srep16849 · ExternalCitation · doi-reference
The impact of artificial intelligence on biomarker discovery
10.1042/etls20243003 · ExternalCitation · doi-reference
Effects of red-cell storage duration on patients undergoing cardiac surgery
10.1056/nejmoa1414219 · ExternalCitation · doi-reference
Age of Transfused Blood in Critically Ill Adults
10.1056/nejmoa1500704 · ExternalCitation · doi-reference
Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion
10.1056/nejmoa1609014 · ExternalCitation · doi-reference
Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions
10.1093/bja/aet068 · ExternalCitation · doi-reference
A Randomized, Double-Blind, Placebo-Controlled Trial of TAK-242 for the Treatment of Severe Sepsis
10.1097/ccm.0b013e3181e7c5c9 · ExternalCitation · doi-reference
Investigating the impact of mitochondrial DNA: Insights into blood transfusion reactions and mitigation strategies
10.1111/vox.13794 · ExternalCitation · doi-reference
Transfusion-Related Acute Lung Injury: The Work of DAMPs
10.1159/000345688 · ExternalCitation · doi-reference
Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: An experimental study
10.1186/1465-9921-9-79 · ExternalCitation · doi-reference
Damage-associated molecular patterns (DAMPs) in diseases: Implications for therapy
10.1186/s43556-025-00305-3 · ExternalCitation · doi-reference
Factors Masking HMGB1 in Human Serum and Plasma
10.1189/jlb.0306196 · ExternalCitation · doi-reference
Postoperative Innate Immune Dysregulation, Proteomic, and Monocyte Epigenomic Changes After Colorectal Surgery: A Substudy of a Randomized Controlled Trial
10.1213/ane.0000000000007297 · ExternalCitation · doi-reference
Propofol Protects Lung Endothelial Barrier Function by Suppression of High-Mobility Group Box 1 (HMGB1) Release and Mitochondrial Oxidative Damage Catalyzed by HMGB1
10.12659/msm.915417 · ExternalCitation · doi-reference
10.1371/journal.pone.0289177
10.1371/journal.pone.0289177 · ExternalCitation · doi-reference
Inadequate Reporting of Analytical Characteristics of Biomarkers Used in Clinical Research: A Threat to Interpretation and Replication of Study Findings
10.1373/clinchem.2019.309575 · ExternalCitation · doi-reference
Transfusion-related acute lung injury (TRALI): Current understanding, challenges, and future directions
10.15537/smj.2025.46.8.20250233 · ExternalCitation · doi-reference
Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages
10.1590/1414-431x20144222 · ExternalCitation · doi-reference
Serum HMGB1 as a predictor for postoperative delirium in elderly patients undergoing total hip arthroplasty surgery
10.17219/acem/189227 · ExternalCitation · doi-reference
Association between periodontitis and postoperative complications in hospital medical surgical procedures: A systematic review
10.21142/2523-2754-1104-2023-177 · ExternalCitation · doi-reference
Perioperative Anemia and Transfusion Management in Older Adults with Osteoporotic Hip Fractures: A Narrative Review of Current Evidence and Emerging Strategies
10.2147/cia.s620352 · ExternalCitation · doi-reference
Effects of Remimazolam on Perioperative Inflammatory Response and Neurocognitive Disorders in Elderly Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
10.2147/dddt.s565045 · ExternalCitation · doi-reference
Perioperative Pain Management and Cancer Outcomes: A Narrative Review
10.2147/jpr.s432444 · ExternalCitation · doi-reference
Future Preventive and Therapeutic Targets for Transfusion-Related Acute Lung Injury
10.2174/1381612811209023285 · ExternalCitation · doi-reference
10.3389/fimmu.2018.00663
10.3389/fimmu.2018.00663 · ExternalCitation · doi-reference
10.3389/fimmu.2020.01455
10.3389/fimmu.2020.01455 · ExternalCitation · doi-reference
10.3389/fimmu.2024.1334109
10.3389/fimmu.2024.1334109 · ExternalCitation · doi-reference
10.3389/fimmu.2024.1441020
10.3389/fimmu.2024.1441020 · ExternalCitation · doi-reference
10.3389/fphar.2024.1468644
10.3389/fphar.2024.1468644 · ExternalCitation · doi-reference
10.3389/fpubh.2025.1633487
10.3389/fpubh.2025.1633487 · ExternalCitation · doi-reference
10.3390/anesthres3010001
10.3390/anesthres3010001 · ExternalCitation · doi-reference
10.3390/biomedicines10020380
10.3390/biomedicines10020380 · ExternalCitation · doi-reference
An Explainable AI System for the Diagnosis of High-Dimensional Biomedical Data
10.3390/biomedinformatics4010013 · ExternalCitation · doi-reference
10.3390/cancers13215274
10.3390/cancers13215274 · ExternalCitation · doi-reference
10.3390/cancers15010099
10.3390/cancers15010099 · ExternalCitation · doi-reference
10.3390/cancers16132304
10.3390/cancers16132304 · ExternalCitation · doi-reference
10.3390/cancers16244269
10.3390/cancers16244269 · ExternalCitation · doi-reference
10.3390/cancers17030368
10.3390/cancers17030368 · ExternalCitation · doi-reference
10.3390/cancers18081198
10.3390/cancers18081198 · ExternalCitation · doi-reference
10.3390/cells10112898
10.3390/cells10112898 · ExternalCitation · doi-reference
10.3390/cells11152274
10.3390/cells11152274 · ExternalCitation · doi-reference
10.3390/ijms24043862
10.3390/ijms24043862 · ExternalCitation · doi-reference
10.3390/jcm15083017
10.3390/jcm15083017 · ExternalCitation · doi-reference
Impact of Anesthesia on Cancer Recurrence: A Narrative Review
10.4103/wbjc.wbjc_4_25 · ExternalCitation · doi-reference
MtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice
10.7150/ijbs.91543 · ExternalCitation · doi-reference
