Research graph
References from Viral Reactivation in Immunocompetent Critically Ill Patients. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1371/journal.pone.0178926
10.1371/journal.pone.0178926 · External reference
Viral infections in critical care: A narrative review
10.1111/anae.15946 · 2023 · External reference
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
10.1093/cid/ciz1008 · 2020 · External reference
EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group
10.1093/cid/ciaa1751 · 2021 · External reference
ICU-acquired infections in immunocompromised patients
10.1007/s00134-023-07295-2 · 2024 · External reference
Advocating for the recognition of underlying immunosuppression in critical illness
10.1016/j.eclinm.2025.103300 · 2025 · External reference
10.3390/diseases13080271
10.3390/diseases13080271 · External reference
Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid 19
10.1016/j.numecd.2020.11.012 · 2021 · External reference
Impact of Obesity in Critical Illness
10.1016/j.chest.2021.08.001 · 2021 · External reference
Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): A review of definitions, potential therapies, and research priorities
10.1016/j.bja.2023.11.052 · 2024 · External reference
Virus diseases in ICU patients: A long time underestimated; but be aware of overestimation
10.1007/s00134-006-0203-9 · 2006 · External reference
Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges
10.2147/cia.s365968 · 2023 · External reference
Update in Viral Infections in the Intensive Care Unit
10.3389/fmed.2021.575580 · 2021 · External reference
Cytomegalovirus: A Troll in the ICU? Overview of the Literature and Perspectives for the Future
10.3389/fmed.2020.00188 · 2020 · External reference
Tumour necrosis factor stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells
10.1099/0022-1317-74-11-2333 · 1993 · External reference
Lipopolysaccharide, Tumor Necrosis Factor Alpha, or Interleukin-1β Triggers Reactivation of Latent Cytomegalovirus in Immunocompetent Mice
10.1128/jvi.00216-06 · 2006 · External reference
A Novel Link between Stress and Human Cytomegalovirus (HCMV) Infection: Sympathetic Hyperactivity Stimulates HCMV Activation
10.1006/viro.2000.0367 · 2000 · External reference
Recent Advances in Cytomegalovirus: An Update on Pharmacologic and Cellular Therapies
10.1016/j.bbmt.2014.11.002 · 2015 · External reference
Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells
10.1056/nejm198906293202605 · 1989 · External reference
Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus
10.3389/fmicb.2014.00337 · 2014 · External reference
10.1128/microbiolspec.dmih2-0022-2015
10.1128/microbiolspec.dmih2-0022-2015 · External reference
Cytomegalovirus Infection Incidence and Risk Factors Across Diverse Hematopoietic Cell Transplantation Platforms Using a Standardized Monitoring and Treatment Approach: A Comprehensive Evaluation from a Single Institution
10.1016/j.bbmt.2018.10.011 · 2019 · External reference
Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum
10.1093/cid/ciae321 · 2024 · External reference
Cytomegalovirus reactivation in ICU patients
10.1007/s00134-015-4066-9 · 2016 · External reference
Cytopathology or immunopathology? The puzzle of cytomegalovirus pneumonitis revisited
10.1038/sj.bmt.1702562 · 2000 · External reference
Is Cytomegalovirus interstitial pneumonitis in transplant recipients an immunopathological condition?
10.1016/s0140-6736(87)92560-8 · 1987 · External reference
Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients*
10.1097/ccm.0b013e31819ffea6 · 2009 · External reference
Occult herpes family viral infections are endemic in critically ill surgical patients
10.1097/01.ccm.0000070222.11325.c4 · 2003 · External reference
10.1371/journal.pone.0098819
10.1371/journal.pone.0098819 · External reference
Cytomegalovirus Infection in Critically Ill Patients
10.1378/chest.127.1.233 · 2005 · External reference
Cytomegalovirus Reactivation in Critically Ill Immunocompetent Patients
10.1001/jama.2008.697 · 2008 · External reference
Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
10.1186/s13054-023-04713-1 · 2023 · External reference
Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
10.1186/cc10069 · 2011 · External reference
Cytomegalovirus reactivation in a general, nonimmunosuppressed intensive care unit population: Incidence, risk factors, associations with organ dysfunction, and inflammatory biomarkers
10.1016/j.jcrc.2014.10.002 · 2015 · External reference
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: Risk factors and impact on mortality
10.1007/s00134-022-06716-y · 2022 · External reference
Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome
10.1007/s00134-015-4071-z · 2016 · External reference
Cytomegalovirus Seroprevalence as a Risk Factor for Poor Outcome in Acute Respiratory Distress Syndrome*
10.1097/ccm.0000000000000712 · 2015 · External reference
Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients
10.1001/jamainternmed.2017.0895 · 2017 · External reference
Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness
10.1001/jama.2017.10569 · 2017 · External reference
Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
10.1186/s13613-020-00793-2 · 2021 · External reference
10.1371/journal.pone.0328494
10.1371/journal.pone.0328494 · External reference
Cytomegalovirus reactivation in the lower respiratory tract as an independent risk factor for mortality in critically Ill patients
10.1186/s13054-025-05324-8 · 2025 · External reference
Risk Factors for Cytomegalovirus Reactivation and Its Impact on Clinical Outcomes in Immunocompetent Seropositive Patients Admitted to the Intensive Care Unit: A Single-Center Prospective Observational Study
10.36519/idcm.2025.480 · 2025 · External reference
Sepsis-induced PICS: Immunometabolic mechanisms, emerging biomarkers, and precision management
10.1016/j.tmed.2026.100009 · 2026 · External reference
10.1016/b978-0-08-102723-3.00231-6
10.1016/b978-0-08-102723-3.00231-6 · External reference
Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
10.1128/aac.05016-14 · 2015 · External reference
Managing atypical and typical herpetic central nervous system infections: Results of a multinational study
10.1016/j.cmi.2016.03.027 · 2016 · External reference
Monitoring of herpes simplex virus in the lower respiratory tract of critically ill patients using real-time PCR: A prospective study
10.1111/j.1469-0691.2009.02704.x · 2009 · External reference
Clinical impact of HSV-1 detection in the lower respiratory tract from hospitalized adult patients
10.1111/j.1469-0691.2012.03882.x · 2012 · External reference
Clinical course and spectrum of intensive care unit patients reactivating herpes simplex-1 virus: A retrospective analysis
10.4103/0972-5229.45073 · 2008 · External reference
Herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients
10.1007/s00134-008-1231-4 · 2008 · External reference
HSV-1 reactivation is associated with an increased risk of mortality and in critically ill COVID-19 patients
10.1186/s13054-021-03843-8 · 2021 · External reference
Herpes Simplex Virus Lung Infection in Patients Undergoing Prolonged Mechanical Ventilation
10.1164/rccm.200609-1322oc · 2007 · External reference
Acyclovir for Mechanically Ventilated Patients with Herpes Simplex Virus Oropharyngeal Reactivation
10.1001/jamainternmed.2019.5713 · 2020 · External reference
Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: A systematic review and meta-analysis
10.1186/s13054-020-03296-5 · 2020 · External reference
The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production
10.1128/jvi.02487-09 · 2010 · External reference
10.3390/cancers15184659
10.3390/cancers15184659 · External reference
Epstein-Barr virus reactivation in critically ill immunocompetent patients
10.4103/2319-4170.132905 · 2015 · External reference
Epstein-Barr virus reactivation in sepsis due to community-acquired pneumonia is associated with increased morbidity and an immunosuppressed host transcriptomic endotype
10.1038/s41598-020-66713-3 · 2020 · External reference
Reactivation of Epstein–Barr virus among intensive care patients: A prospective observational study
10.1007/s00134-024-07345-3 · 2024 · External reference
Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase
10.1128/jvi.03505-12 · 2013 · External reference
Dynamics of dual CMV and EBV co-reactivation and emergence of resistance in an HSCT recipient
10.1093/jac/dkaf243 · 2025 · External reference
10.3389/fcimb.2025.1639463
10.3389/fcimb.2025.1639463 · External reference
Increased Epstein–Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
10.1186/s13045-024-01612-y · 2024 · External reference
Thevaricella-zoster virus genome
2010 · External reference
The global disease burden of varicella-zoster virus infection from 1990 to 2019
10.1002/jmv.27538 · 2022 · External reference
Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit
10.1186/1743-422x-10-225 · 2013 · External reference
Severe varicella-zoster virus pneumonia: A multicenter cohort study
10.1186/s13054-017-1731-0 · 2017 · External reference
Unresolved reference
External reference
Cytomegalovirus Reactivation in Critically Ill Immunocompetent Patients
10.1001/jama.2008.697 · ExternalCitation · doi-reference
Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness
10.1001/jama.2017.10569 · ExternalCitation · doi-reference
Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients
10.1001/jamainternmed.2017.0895 · ExternalCitation · doi-reference
Acyclovir for Mechanically Ventilated Patients with Herpes Simplex Virus Oropharyngeal Reactivation
10.1001/jamainternmed.2019.5713 · ExternalCitation · doi-reference
The global disease burden of varicella-zoster virus infection from 1990 to 2019
10.1002/jmv.27538 · ExternalCitation · doi-reference
A Novel Link between Stress and Human Cytomegalovirus (HCMV) Infection: Sympathetic Hyperactivity Stimulates HCMV Activation
10.1006/viro.2000.0367 · ExternalCitation · doi-reference
Virus diseases in ICU patients: A long time underestimated; but be aware of overestimation
10.1007/s00134-006-0203-9 · ExternalCitation · doi-reference
Herpes simplex virus load in bronchoalveolar lavage fluid is related to poor outcome in critically ill patients
10.1007/s00134-008-1231-4 · ExternalCitation · doi-reference
Cytomegalovirus reactivation in ICU patients
10.1007/s00134-015-4066-9 · ExternalCitation · doi-reference
Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome
10.1007/s00134-015-4071-z · ExternalCitation · doi-reference
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: Risk factors and impact on mortality
10.1007/s00134-022-06716-y · ExternalCitation · doi-reference
ICU-acquired infections in immunocompromised patients
10.1007/s00134-023-07295-2 · ExternalCitation · doi-reference
Reactivation of Epstein–Barr virus among intensive care patients: A prospective observational study
10.1007/s00134-024-07345-3 · ExternalCitation · doi-reference
10.1016/b978-0-08-102723-3.00231-6
10.1016/b978-0-08-102723-3.00231-6 · ExternalCitation · doi-reference
Recent Advances in Cytomegalovirus: An Update on Pharmacologic and Cellular Therapies
10.1016/j.bbmt.2014.11.002 · ExternalCitation · doi-reference
Cytomegalovirus Infection Incidence and Risk Factors Across Diverse Hematopoietic Cell Transplantation Platforms Using a Standardized Monitoring and Treatment Approach: A Comprehensive Evaluation from a Single Institution
10.1016/j.bbmt.2018.10.011 · ExternalCitation · doi-reference
Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): A review of definitions, potential therapies, and research priorities
10.1016/j.bja.2023.11.052 · ExternalCitation · doi-reference
Impact of Obesity in Critical Illness
10.1016/j.chest.2021.08.001 · ExternalCitation · doi-reference
Managing atypical and typical herpetic central nervous system infections: Results of a multinational study
10.1016/j.cmi.2016.03.027 · ExternalCitation · doi-reference
Advocating for the recognition of underlying immunosuppression in critical illness
10.1016/j.eclinm.2025.103300 · ExternalCitation · doi-reference
Cytomegalovirus reactivation in a general, nonimmunosuppressed intensive care unit population: Incidence, risk factors, associations with organ dysfunction, and inflammatory biomarkers
10.1016/j.jcrc.2014.10.002 · ExternalCitation · doi-reference
Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid 19
10.1016/j.numecd.2020.11.012 · ExternalCitation · doi-reference
Sepsis-induced PICS: Immunometabolic mechanisms, emerging biomarkers, and precision management
10.1016/j.tmed.2026.100009 · ExternalCitation · doi-reference
Is Cytomegalovirus interstitial pneumonitis in transplant recipients an immunopathological condition?
10.1016/s0140-6736(87)92560-8 · ExternalCitation · doi-reference
Epstein-Barr virus reactivation in sepsis due to community-acquired pneumonia is associated with increased morbidity and an immunosuppressed host transcriptomic endotype
10.1038/s41598-020-66713-3 · ExternalCitation · doi-reference
Cytopathology or immunopathology? The puzzle of cytomegalovirus pneumonitis revisited
10.1038/sj.bmt.1702562 · ExternalCitation · doi-reference
Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells
10.1056/nejm198906293202605 · ExternalCitation · doi-reference
EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group
10.1093/cid/ciaa1751 · ExternalCitation · doi-reference
Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum
10.1093/cid/ciae321 · ExternalCitation · doi-reference
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
10.1093/cid/ciz1008 · ExternalCitation · doi-reference
Dynamics of dual CMV and EBV co-reactivation and emergence of resistance in an HSCT recipient
10.1093/jac/dkaf243 · ExternalCitation · doi-reference
Occult herpes family viral infections are endemic in critically ill surgical patients
10.1097/01.ccm.0000070222.11325.c4 · ExternalCitation · doi-reference
Cytomegalovirus Seroprevalence as a Risk Factor for Poor Outcome in Acute Respiratory Distress Syndrome*
10.1097/ccm.0000000000000712 · ExternalCitation · doi-reference
Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients*
10.1097/ccm.0b013e31819ffea6 · ExternalCitation · doi-reference
Tumour necrosis factor stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells
10.1099/0022-1317-74-11-2333 · ExternalCitation · doi-reference
Viral infections in critical care: A narrative review
10.1111/anae.15946 · ExternalCitation · doi-reference
Monitoring of herpes simplex virus in the lower respiratory tract of critically ill patients using real-time PCR: A prospective study
10.1111/j.1469-0691.2009.02704.x · ExternalCitation · doi-reference
Clinical impact of HSV-1 detection in the lower respiratory tract from hospitalized adult patients
10.1111/j.1469-0691.2012.03882.x · ExternalCitation · doi-reference
Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
10.1128/aac.05016-14 · ExternalCitation · doi-reference
Lipopolysaccharide, Tumor Necrosis Factor Alpha, or Interleukin-1β Triggers Reactivation of Latent Cytomegalovirus in Immunocompetent Mice
10.1128/jvi.00216-06 · ExternalCitation · doi-reference
The Epstein-Barr Virus (EBV)-Encoded Protein Kinase, EBV-PK, but Not the Thymidine Kinase (EBV-TK), Is Required for Ganciclovir and Acyclovir Inhibition of Lytic Viral Production
10.1128/jvi.02487-09 · ExternalCitation · doi-reference
Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase
10.1128/jvi.03505-12 · ExternalCitation · doi-reference
10.1128/microbiolspec.dmih2-0022-2015
10.1128/microbiolspec.dmih2-0022-2015 · ExternalCitation · doi-reference
Herpes Simplex Virus Lung Infection in Patients Undergoing Prolonged Mechanical Ventilation
10.1164/rccm.200609-1322oc · ExternalCitation · doi-reference
Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit
10.1186/1743-422x-10-225 · ExternalCitation · doi-reference
Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
10.1186/cc10069 · ExternalCitation · doi-reference
Increased Epstein–Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
10.1186/s13045-024-01612-y · ExternalCitation · doi-reference
Severe varicella-zoster virus pneumonia: A multicenter cohort study
10.1186/s13054-017-1731-0 · ExternalCitation · doi-reference
Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: A systematic review and meta-analysis
10.1186/s13054-020-03296-5 · ExternalCitation · doi-reference
HSV-1 reactivation is associated with an increased risk of mortality and in critically ill COVID-19 patients
10.1186/s13054-021-03843-8 · ExternalCitation · doi-reference
Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
10.1186/s13054-023-04713-1 · ExternalCitation · doi-reference
Cytomegalovirus reactivation in the lower respiratory tract as an independent risk factor for mortality in critically Ill patients
10.1186/s13054-025-05324-8 · ExternalCitation · doi-reference
Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation
10.1186/s13613-020-00793-2 · ExternalCitation · doi-reference
10.1371/journal.pone.0098819
10.1371/journal.pone.0098819 · ExternalCitation · doi-reference
10.1371/journal.pone.0178926
10.1371/journal.pone.0178926 · ExternalCitation · doi-reference
10.1371/journal.pone.0328494
10.1371/journal.pone.0328494 · ExternalCitation · doi-reference
Cytomegalovirus Infection in Critically Ill Patients
10.1378/chest.127.1.233 · ExternalCitation · doi-reference
Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges
10.2147/cia.s365968 · ExternalCitation · doi-reference
10.3389/fcimb.2025.1639463
10.3389/fcimb.2025.1639463 · ExternalCitation · doi-reference
Cytomegalovirus: A Troll in the ICU? Overview of the Literature and Perspectives for the Future
10.3389/fmed.2020.00188 · ExternalCitation · doi-reference
Update in Viral Infections in the Intensive Care Unit
10.3389/fmed.2021.575580 · ExternalCitation · doi-reference
Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus
10.3389/fmicb.2014.00337 · ExternalCitation · doi-reference
10.3390/cancers15184659
10.3390/cancers15184659 · ExternalCitation · doi-reference
10.3390/diseases13080271
10.3390/diseases13080271 · ExternalCitation · doi-reference
Risk Factors for Cytomegalovirus Reactivation and Its Impact on Clinical Outcomes in Immunocompetent Seropositive Patients Admitted to the Intensive Care Unit: A Single-Center Prospective Observational Study
10.36519/idcm.2025.480 · ExternalCitation · doi-reference
Clinical course and spectrum of intensive care unit patients reactivating herpes simplex-1 virus: A retrospective analysis
10.4103/0972-5229.45073 · ExternalCitation · doi-reference
Epstein-Barr virus reactivation in critically ill immunocompetent patients
10.4103/2319-4170.132905 · ExternalCitation · doi-reference
