Research graph
References from Microbe-Derived Antimicrobial Peptides: Immunomodulation and Gut Microbiota Homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Advances in antimicrobial peptides: From mechanistic insights to chemical modifications
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10.2147/ijn.s445333 · 2024 · External reference
Antimicrobial peptides: Mechanism of action, activity and clinical potential
2021 · External reference
Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus
10.1016/j.biochi.2011.12.016 · 2012 · External reference
Antimicrobial peptides: New hope in the war against multidrug resistance
10.24272/j.issn.2095-8137.2019.062 · 2019 · External reference
The suppressive effects of bursopentine (BP5) on oxidative stress and NF-kB activation in lipopolysaccharide-activated murine peritoneal macrophages
10.1159/000337581 · 2012 · External reference
The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity
10.1007/pl00000914 · 2001 · External reference
10.3390/ijms19010067
10.3390/ijms19010067 · External reference
Antimicrobial peptides—Advances in development of therapeutic applications
10.1016/j.lfs.2020.118407 · 2020 · External reference
The novel biological action of antimicrobial peptides via apoptosis induction
10.4014/jmb.1205.05041 · 2012 · External reference
10.1371/journal.pone.0073659
10.1371/journal.pone.0073659 · External reference
Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT-1080 cells
10.3390/md9101995 · 2011 · External reference
The vast structural diversity of antimicrobial peptides
10.1016/j.tips.2019.04.012 · 2019 · External reference
Antimicrobial peptides: A new frontier in antifungal therapy
10.1128/mbio.02123-20 · 2020 · External reference
10.3390/md22060282
10.3390/md22060282 · External reference
New fungal defensin-like peptides provide evidence for fold change of proteins in evolution
10.1042/bsr20160438 · 2017 · External reference
10.1186/s12864-018-4565-5
10.1186/s12864-018-4565-5 · External reference
Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41
10.3762/bjoc.8.130 · 2012 · External reference
Peptide fusion inhibitors targeting the HIV-1 gp41: A patent review (2009–2014)
10.1517/13543776.2014.987752 · 2015 · External reference
10.3390/cells8070654
10.3390/cells8070654 · External reference
10.3389/fmicb.2013.00294
10.3389/fmicb.2013.00294 · External reference
The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases
10.3390/molecules200815392 · 2015 · External reference
10.3390/ijms222011172
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10.3389/fimmu.2023.1127704
10.3389/fimmu.2023.1127704 · External reference
Immunomodulatory potential of nisin A with application in wound healing
10.1111/wrr.12743 · 2019 · External reference
Anti-inflammatory activity and mechanism of surfactin in lipopolysaccharide-activated macrophages
10.1007/s10753-014-9986-y · 2015 · External reference
Gut microbiota dysbiosis and systemic immune dysfunction in critical ill patients with multidrug-resistant bacterial colonization and infection
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Commensal gut bacteria: Mechanisms of immune modulation
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Enzymes as a reservoir of host defence peptides
10.2174/1568026620666200327173815 · 2020 · External reference
10.3390/ijms23169123
10.3390/ijms23169123 · External reference
The antimicrobial peptide esculentin-1a(1-21)NH(2) stimulates wound healing by promoting angiogenesis through the PI3K/AKT pathway
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10.20944/preprints202007.0375.v1
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10.3390/ijms25094870
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10.3390/antibiotics10060650
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Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2
10.1038/s41598-017-11832-7 · 2017 · External reference
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
10.1038/s41467-019-10646-7 · 2019 · External reference
Protective effect of surfactin on copper sulfate-induced inflammation, oxidative stress, and hepatic injury in zebrafish
10.1111/1348-0421.12924 · 2021 · External reference
10.3389/fmicb.2022.718786
10.3389/fmicb.2022.718786 · External reference
Targeting formyl peptide receptor 1 with anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
10.1111/bph.16073 · 2023 · External reference
Linear gramicidin activates neutrophil functions and the activation is blocked by chemotactic peptide receptor antagonist
10.1016/0014-5793(88)80718-x · 1988 · External reference
Effects of topical antimicrobial agents on the human neutrophil respiratory burst
10.1001/archsurg.1991.01410290079016 · 1991 · External reference
Engineering and characterization of human β-defensin-3 and its analogues and microcin J25 peptides against Mannheimia haemolytica and bovine neutrophils
10.1186/s13567-021-00956-4 · 2021 · External reference
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
10.1038/s41467-019-09915-2 · 2019 · External reference
10.3389/fimmu.2017.00257
10.3389/fimmu.2017.00257 · External reference
Immunomodulatory efficacy of nisin--a bacterial lantibiotic peptide
10.1002/psc.1341 · 2011 · External reference
Plasma membrane potential modulates chemotactic peptide-stimulated cytosolic free Ca2+ changes in human neutrophils
10.1016/s0021-9258(18)61231-1 · 1987 · External reference
Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
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10.1038/srep29373 · 2016 · External reference
Inhibiting PSMα-induced neutrophil necroptosis protects mice with MRSA pneumonia by blocking the agr system
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Pulmonary eosinophilia from inhaled colistin
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Intravenous colistin in the treatment of multidrug-resistant Acinetobacter in neonates
10.1186/s12941-016-0126-4 · 2016 · External reference
Hypersensitivity pneumonitis due to high-dose colistin aerosol therapy
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10.4049/jimmunol.148.1.149 · 1992 · External reference
IL-3-induced histamine release from human basophils. Dissociation from cationic dye binding and down-regulation by Na+ and K+
10.4049/jimmunol.155.5.2652 · 1995 · External reference
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10.4049/jimmunol.145.2.662 · 1990 · External reference
Evaluation of immunomodulatory effects of nisin-containing diets on mice
10.1111/j.1574-695x.1999.tb01262.x · 1999 · External reference
Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes
10.1186/s13568-020-01056-w · 2020 · External reference
10.1371/journal.pone.0162007
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Bacteriocin BacSp222 and its succinylated forms exhibit proinflammatory activities toward innate immune cells
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10.3390/nu17233723
10.3390/nu17233723 · External reference
Cutting edge: Cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome
10.4049/jimmunol.1002657 · 2011 · External reference
Surfactin blocks NO production in lipopolysaccharide-activated macrophages by inhibiting NF-kappaB activation
2008 · External reference
Surfactin inhibits immunostimulatory function of macrophages through blocking NK-kappaB, MAPK and Akt pathway
10.1016/j.intimp.2009.03.013 · 2009 · External reference
Characterization and online detection of surfactin isomers based on HPLC-MS(n) analyses and their inhibitory effects on the overproduction of nitric oxide and the release of TNF-α and IL-6 in LPS-induced macrophages
10.3390/md8102605 · 2010 · External reference
Biofunctionalization of titanium with bacitracin immobilization shows potential for anti-bacteria, osteogenesis and reduction of macrophage inflammation
10.1016/j.colsurfb.2016.05.089 · 2016 · External reference
Bacteriocin microcin J25’s antibacterial infection effects and novel non-microbial regulatory mechanisms: Differential regulation of dopaminergic receptors
10.1186/s40104-024-01115-3 · 2024 · External reference
10.3389/fimmu.2021.811381
10.3389/fimmu.2021.811381 · External reference
Designed symmetrical β-hairpin peptides for treating multidrug-resistant salmonella typhimurium infections
10.1016/j.ejmech.2022.114769 · 2022 · External reference
Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells
10.1007/s10529-007-9552-x · 2008 · External reference
Ohmyungsamycin promotes M1-like inflammatory responses to enhance host defence against Mycobacteroides abscessus infections
10.1080/21505594.2022.2138009 · 2022 · External reference
10.20944/preprints202501.1554.v1
10.20944/preprints202501.1554.v1 · External reference
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Membrane depolarization was required to induce DNA synthesis in murine macrophage cell line PU5-1.8
10.3109/08923979109019708 · 1991 · External reference
10.3389/fphar.2019.00729
10.3389/fphar.2019.00729 · External reference
Immunomodulatory effects of microcin C7 in cyclophosphamide-induced immunosuppressed mice
10.1021/acs.jafc.3c01033 · 2023 · External reference
Surfactin from Bacillus subtilis enhances immune response and contributes to the maintenance of intestinal microbial homeostasis
10.1128/spectrum.00918-24 · 2024 · External reference
Enterocin AS-48 as evidence for the use of bacteriocins as new leishmanicidal agents
10.1128/aac.02288-16 · 2017 · External reference
Sensitization of microcin J25-resistant strains by a membrane-permeabilizing peptide
10.1128/aem.00307-10 · 2010 · External reference
Immunomodulatory effects of nisin in turbot (Scophthalmus maximus L.)
10.1006/fsim.2002.0425 · 2003 · External reference
Spatial attributes of the four-helix bundle group of bacteriocins—The high-resolution structure of BacSp222 in solution
10.1016/j.ijbiomac.2017.10.158 · 2018 · External reference
Antibiotic resistance and virulence genes in nisin-resistant Enterococcus faecalis isolated from raw buffalo milk modulate the innate functions of rat macrophages
10.1111/jam.14343 · 2019 · External reference
Antibacterial and antitumor activity of Bogorol B-JX isolated from Brevibacillus laterosporus JX-5
10.1007/s11274-017-2337-z · 2017 · External reference
Differential in vitro activities of ionophore compounds against Plasmodium falciparum and mammalian cells
10.1128/aac.40.3.602 · 1996 · External reference
10.3389/fmicb.2023.1304825
10.3389/fmicb.2023.1304825 · External reference
Comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells
10.1016/j.bbamem.2010.10.007 · 2011 · External reference
The histamine-liberating action of polymyxin B and its analogs
10.1007/bf00842390 · 1989 · External reference
Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice
10.1002/iid3.204 · 2018 · External reference
Surfactin exerts an anti-cancer effect through inducing allergic reactions in melanoma skin cancer
10.1016/j.intimp.2021.107934 · 2021 · External reference
10.3389/fcimb.2016.00180
10.3389/fcimb.2016.00180 · External reference
Triclosan disrupts immune cell function by depressing Ca(2+) influx following acidification of the cytoplasm
10.1016/j.taap.2020.115205 · 2020 · External reference
Surfactin induces maturation of dendritic cells in vitro
10.1042/bsr20160204 · 2016 · External reference
Characterization of iturin V, a novel antimicrobial lipopeptide from a potential probiotic strain Lactobacillus sp. M31
10.1007/s12602-021-09796-2 · 2021 · External reference
Properties of monocyte-derived dendritic cells loaded with lysates of cancer cells exposed to cytotoxic peptides
10.15407/exp-oncology.2024.04.375 · 2025 · External reference
Induction of cytolytic activity and interferon-gamma production in murine natural killer cells by polymyxins B and E
10.1016/j.intimp.2007.11.001 · 2008 · External reference
10.3389/fvets.2021.813629
10.3389/fvets.2021.813629 · External reference
The effect of enterocin A/P dipeptide on growth performance, glutathione-peroxidase activity, IgA secretion and jejunal morphology in rabbits after experimental methicillin-resistant Staphylococcus epidermidis P3Tr2a infection
10.1007/s11259-023-10277-w · 2024 · External reference
Bacillus-produced surfactin attenuates chronic inflammation in atherosclerotic lesions of ApoE(−/−) mice
10.1016/j.intimp.2016.03.043 · 2016 · External reference
Surfactin mitigates dextran sodium sulfate-induced colitis and behavioral disorders in mice by mediating gut-brain-axis balance
10.1021/acs.jafc.2c07369 · 2023 · External reference
Effect of oral administration of microcin Y on growth performance, intestinal barrier function and gut microbiota of chicks challenged with Salmonella Pullorum
10.1186/s13567-024-01321-x · 2024 · External reference
Stimulation of sodium transport by duramycin in cultured human colonic epithelia
10.1016/s0022-3565(25)20465-7 · 1991 · External reference
Cytosolic pH regulation in chicken enterocytes: Na(+)-independent regulatory cell alkalinization
10.1016/0005-2736(94)00253-l · 1995 · External reference
Ca++-transport across basal-lateral plasma membranes from rat small intestinal epithelial cells
10.1007/bf01870469 · 1982 · External reference
The antibiotic bacitracin protects human intestinal epithelial cells and stem cell-derived intestinal organoids from Clostridium difficile toxin TcdB
10.1155/2019/4149762 · 2019 · External reference
10.1371/journal.pone.0033351
10.1371/journal.pone.0033351 · External reference
10.3390/ijms241411688
10.3390/ijms241411688 · External reference
Bacillus subtilis and surfactin inhibit the transmissible gastroenteritis virus from entering the intestinal epithelial cells
10.1042/bsr20170082 · 2017 · External reference
10.3390/v13010028
10.3390/v13010028 · External reference
10.3389/fimmu.2023.1178462
10.3389/fimmu.2023.1178462 · External reference
Cloning, overexpression, purification of bacteriocin enterocin-B and structural analysis, interaction determination of enterocin-A, B against pathogenic bacteria and human cancer cells
10.1016/j.ijbiomac.2018.05.002 · 2018 · External reference
Effects of bile acids and nisin on the production of enterotoxin by Clostridium perfringens in a nutrient-rich medium
10.1155/2018/7276523 · 2018 · External reference
10.3389/fimmu.2012.00310
10.3389/fimmu.2012.00310 · External reference
Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota
10.1080/19490976.2017.1290759 · 2017 · External reference
Lasso peptide MccY alleviates non-typhoidal salmonellae-induced mouse gut inflammation via regulation of intestinal barrier function and gut microbiota
10.1128/spectrum.01784-23 · 2023 · External reference
Microcin Y utilizes its stable structure and biological activity to regulate the metabolism of intestinal probiotics and effectively clear gut Salmonella
10.1016/j.ijbiomac.2024.133290 · 2024 · External reference
Class IIb microcin MccM interferes with oxidative phosphorylation in Escherichia coli
10.1021/acschembio.4c00226 · 2024 · External reference
Risks related to high-dosage recombinant antimicrobial peptide microcin J25 in mice model: Intestinal microbiota, intestinal barrier function, and immune regulation
10.1021/acs.jafc.8b03405 · 2018 · External reference
Recombinant antimicrobial peptide microcin J25 alleviates DSS-induced colitis via regulating intestinal barrier function and modifying gut microbiota
10.1016/j.biopha.2020.111127 · 2021 · External reference
Dietary supplemented antimicrobial peptide microcin J25 improves the growth performance, apparent total tract digestibility, fecal microbiota, and intestinal barrier function of weaned pigs
10.2527/jas2017.1494 · 2017 · External reference
Therapeutic administration of the recombinant antimicrobial peptide microcin J25 effectively enhances host defenses against gut inflammation and epithelial barrier injury induced by enterotoxigenic Escherichia coli infection
10.1096/fj.201901717r · 2020 · External reference
10.3389/fmicb.2021.780355
10.3389/fmicb.2021.780355 · External reference
Polymeric nanohybrids engineered by chitosan nanoparticles and antimicrobial peptides as novel antimicrobials in food biopreservatives: Risk assessment and anti-foodborne pathogen Escherichia coli O157:H7 infection by immune regulation
10.1021/acs.jafc.2c05308 · 2022 · External reference
Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon
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Ruminococcin C, a promising antibiotic produced by a human gut symbiont
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10.3389/fnut.2022.877948 · External reference
Protective effect of plantaricin bio-LP1 bacteriocin on multidrug-resistance Escherichia coli infection by alleviate the inflammation and modulate of gut-microbiota in BALB/c mice model
10.1016/j.ijbiomac.2023.125700 · 2023 · External reference
Virtual screening of gut microbiome bacteriocins as potential inhibitors of stearoyl-CoA desaturase 1 to regulate adipocyte differentiation and thermogenesis to combat obesity
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10.3390/ani12091108 · External reference
Use of fecal slurry cultures to study in vitro effects of bacteriocins on the gut bacterial populations of infants
10.1007/s12602-019-09614-w · 2020 · External reference
Molecular assessments of antimicrobial protein enterocins and quorum sensing genes and their role in virulence of the genus Enterococcus
10.1007/s12602-024-10278-4 · 2025 · External reference
Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum
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10.3390/microorganisms8121879 · External reference
Tannins and bacitracin differentially modulate gut microbiota of broiler chickens
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Surfactin’s impact on gut microbiota and intestinal tumor cells
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The bacteriocin bactofencin A subtly modulates gut microbial populations
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Symbiont-derived antimicrobials contribute to the control of the lepidopteran gut microbiota
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10.3389/fmicb.2023.1075557
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Staphylococcus warneri dampens SUMOylation and promotes intestinal inflammation
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10.3390/ani10010101 · External reference
Effects of dietary nisin on growth performance, immune function, and gut health of broilers challenged by Clostridium perfringens
10.1093/jas/skae017 · 2024 · External reference
Effects of cyclic antimicrobial lipopeptides from Bacillus subtilis on growth performance, intestinal morphology, and cecal gene expression and microbiota community in broilers
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Effect of nisin on microbiome-brain-gut axis neurochemicals by Escherichia coli-induced diarrhea in mice
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Bacillus velezensis MFF 2.2-derived lipopeptides modulate gut immune response in BALB/c mice maintaining mucosal integrity and systemic safety
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Effect of Bacillus subtilis PB6, a natural probiotic on colon mucosal inflammation and plasma cytokines levels in inflammatory bowel disease
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Beneficial effect of nisin supplementation at different dosages on the growth performance, diarrhea rate, immunity, and fecal microbial community of weaned piglets
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A surfactin lipopeptide adjuvanted hepatitis B vaccines elicit enhanced humoral and cellular immune responses in mice
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10.1089/jop.1989.5.261 · 1989 · External reference
Immunosuppression by gramicidin S of experimental autoimmune uveoretinitis, pinealitis and autoimmune encephalomyelitis
10.1089/jop.1990.6.219 · 1990 · External reference
Gramicidin as a potential immunosuppressant for organ transplantation: Suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat
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Suppression of mitogen-induced lymphocyte proliferation by syringomycin-E
10.1111/j.1574-695x.1996.tb00069.x · 1996 · External reference
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In vitro immunomodulatory effect of nisin on porcine leucocytes
10.1111/jpn.13085 · 2019 · External reference
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10.3390/life13071521 · External reference
A surfactin cyclopeptide of WH1fungin used as a novel adjuvant for intramuscular and subcutaneous immunization in mice
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WH1fungin a surfactin cyclic lipopeptide is a novel oral immunoadjuvant
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Interaction of the antimicrobial peptide pheromone plantaricin A with model membranes: Implications for a novel mechanism of action
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Design and discovery of natural cyclopeptide skeleton based programmed death ligand 1 inhibitor as immune modulator for cancer therapy
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Inhibition of antigen receptor-dependent Ca(2+) signals and NF-AT activation by P2X7 receptors in human B lymphocytes
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The lantibiotic lacticin 3147 prevents systemic spread of Staphylococcus aureus in a murine infection model
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In vitro and in vivo antibacterial effects of nisin against Streptococcus suis
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Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus
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A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo
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Enterocin CRL35 inhibits Listeria monocytogenes in a murine model
10.1089/fpd.2011.0972 · 2012 · External reference
Effects of slow-releasing colistin microspheres on endotoxin-induced sepsis
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Therapeutic and prophylactic effects of oral administration of probiotic Enterococcus faecium Smr18 in Salmonella enterica-infected mice
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Bacterial antagonism in host-associated microbial communities
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Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila
10.1126/science.adg5725 · 2023 · External reference
After a century of nisin research—Where are we now?
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Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
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Bacterial display and screening of posttranslationally thioether-stabilized peptides
10.1128/aem.05550-11 · 2011 · External reference
Ribosomal natural products, tailored to fit
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10.20944/preprints202408.0665.v1
10.20944/preprints202408.0665.v1 · External reference
10.3389/fimmu.2023.1119574
10.3389/fimmu.2023.1119574 · External reference
Antimicrobial peptides and the gut microbiome in inflammatory bowel disease
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10.3390/md23120463
10.3390/md23120463 · External reference
10.3390/antibiotics13090794
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10.3389/fbinf.2026.1749404
10.3389/fbinf.2026.1749404 · External reference
10.3390/bioengineering13020159
10.3390/bioengineering13020159 · External reference
Effects of topical antimicrobial agents on the human neutrophil respiratory burst
10.1001/archsurg.1991.01410290079016 · ExternalCitation · doi-reference
Mast cells partially contribute to mucosal adjuvanticity of surfactin in mice
10.1002/iid3.204 · ExternalCitation · doi-reference
Beneficial effect of nisin supplementation at different dosages on the growth performance, diarrhea rate, immunity, and fecal microbial community of weaned piglets
10.1002/jsfa.14281 · ExternalCitation · doi-reference
Immunomodulatory efficacy of nisin--a bacterial lantibiotic peptide
10.1002/psc.1341 · ExternalCitation · doi-reference
Immunomodulatory effects of nisin in turbot (Scophthalmus maximus L.)
10.1006/fsim.2002.0425 · ExternalCitation · doi-reference
Effect of ionophores on lymphocyte cellular metabolism
10.1007/978-1-4684-8088-7_46 · ExternalCitation · doi-reference
The histamine-liberating action of polymyxin B and its analogs
10.1007/bf00842390 · ExternalCitation · doi-reference
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