Research graph
References from Multidimensional Physiological and Gut Microbiome Profiling Identifies Subtle Physiological Patterns in an Apparently Healthy Aging Indian Cohort: A Cross-Sectional Observational Study. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial dysfunction in aging
10.1016/j.arr.2023.101955 · 2023 · External reference
Oxidative stress, aging, and diseases
10.2147/cia.s158513 · 2018 · External reference
Aging and aging-related diseases: From molecular mechanisms to interventions and treatments
10.1038/s41392-022-01251-0 · 2022 · External reference
Biomarkers of aging: From molecules and surrogates to physiology and function
10.1152/physrev.00045.2024 · 2025 · External reference
10.3390/antiox12040782
10.3390/antiox12040782 · External reference
Free radical theory of aging: Consequences of mitochondrial aging
10.1007/bf02432509 · 1983 · External reference
The crosstalk between mitochondrial quality control and metal-dependent cell death
10.1038/s41419-024-06691-w · 2024 · External reference
10.3390/antiox8100475
10.3390/antiox8100475 · External reference
Mitochondrial quality control as a key determinant of cell survival
10.1016/j.bbamcr.2018.12.012 · 2019 · External reference
The gut microbiota of apparently healthy aged Chinese is similar to that of the apparently healthy young
10.1128/msphere.00327-17 · 2017 · External reference
10.3389/fphys.2017.00319
10.3389/fphys.2017.00319 · External reference
Gut microbiota and aging
10.1080/10408398.2020.1867054 · 2022 · External reference
Mitochondrial and metabolic dysfunction in aging and age-related diseases
10.1038/s41574-021-00626-7 · 2022 · External reference
10.3390/ijerph20105845
10.3390/ijerph20105845 · External reference
Age-dependent changes in GI physiology and microbiota: Time to reconsider?
10.1136/gutjnl-2017-315542 · 2018 · External reference
Microbiome Gut-Brain-Axis: Impact on brain development and mental health
10.1007/s12035-025-04846-0 · 2025 · External reference
The Gut–Brain axis in Autism: Inflammatory mechanisms, molecular insights, and emerging Microbiome-Based therapies
10.1007/s12035-025-05321-6 · 2025 · External reference
Human trials exploring anti-aging medicines
10.1016/j.cmet.2023.12.007 · 2024 · External reference
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
10.1038/s41591-023-02296-6 · 2023 · External reference
Age-Friendly research: Promoting inclusion of older adults in clinical and translational research
10.1017/cts.2023.627 · 2023 · External reference
The MOS 36-item short-form health survey (SF-36)
10.1097/00005650-199206000-00002 · 1992 · External reference
10.1017/s0033291798006667
10.1017/s0033291798006667 · External reference
Frailty in older adults: Evidence for a phenotype
10.1093/gerona/56.3.m146 · 2001 · External reference
Frailty in relation to the accumulation of deficits
10.1093/gerona/62.7.722 · 2007 · External reference
10.1186/s12916-023-02971-y
10.1186/s12916-023-02971-y · External reference
10.3389/fnagi.2025.1508677
10.3389/fnagi.2025.1508677 · External reference
Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults
10.1038/s41598-023-49656-3 · 2024 · External reference
Unresolved reference
External reference
A Systematic Review for Advanced Solutions for Alcohol Use Disorder: Detection, Treatment, and Prevention
2024 · External reference
10.3389/fpubh.2025.1587194
10.3389/fpubh.2025.1587194 · External reference
A novel metabolomic aging score-better than conventional metrics in predicting short-term mortality
10.1080/14737159.2025.2509027 · 2025 · External reference
10.1186/s12916-024-03769-2
10.1186/s12916-024-03769-2 · External reference
The role of psychological and social well-being on physical function trajectories in older adults
10.1093/gerona/glaa114 · 2020 · External reference
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study
10.1186/s12979-022-00326-4 · 2023 · External reference
10.3390/antiox12030651
10.3390/antiox12030651 · External reference
Aerobic Capacity Beyond Cardiorespiratory Fitness Linking Mitochondrial Function, Disease Resilience and apparently healthy aging
10.1096/fj.202500554r · 2025 · External reference
A model for estimating biological age from physiological biomarkers of apparently healthy aging: Cross-sectional study
10.2196/35696 · 2022 · External reference
Unresolved reference
External reference
Sleep patterns, global mental status and mortality risk among middle-aged urban adults
10.1177/13872877241297111 · 2024 · External reference
10.1186/s12889-024-18448-3
10.1186/s12889-024-18448-3 · External reference
Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly
10.1097/md.0000000000008491 · 2017 · External reference
Low-grade chronic inflammation: A shared mechanism for chronic diseases
10.1152/physiol.00021.2024 · 2025 · External reference
Inflammation and cell-to-cell communication, two related aspects in frailty
10.1186/s12979-022-00306-8 · 2022 · External reference
Inflammaging and the sex-frailty paradox
10.1007/s40520-025-03181-7 · 2025 · External reference
Sex differences in mental health among older adults: Investigating time trends and possible risk groups with regard to age, educational level and ethnicity
10.1080/13607863.2020.1847248 · 2021 · External reference
Age and sex trends in depressive symptoms across middle and older adulthood: Comparison of the Canadian Longitudinal Study on aging to American and European cohorts
10.1016/j.jad.2021.08.109 · 2021 · External reference
Exploring the interplay of psychological and biological components of stress response and telomere length in the transition from middle age to late adulthood: A systematic review
10.1002/smi.3389 · 2024 · External reference
Social participation, psychological resilience and depression among widowed older adults in China
10.1186/s12877-023-04168-7 · 2023 · External reference
Sex differences in deterioration of sleep properties associated with aging: A 12-year longitudinal cohort study
10.5664/jcsm.9072 · 2021 · External reference
10.1186/s12889-022-14329-9
10.1186/s12889-022-14329-9 · External reference
10.1186/s12889-021-10636-9
10.1186/s12889-021-10636-9 · External reference
Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study
10.2196/67294 · 2025 · External reference
Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia
10.1126/sciadv.aax7331 · 2019 · External reference
10.1186/s12889-023-15965-5
10.1186/s12889-023-15965-5 · External reference
10.3390/nu12123759
10.3390/nu12123759 · External reference
10.3390/microorganisms9122524
10.3390/microorganisms9122524 · External reference
10.3389/fmicb.2025.1629811
10.3389/fmicb.2025.1629811 · External reference
10.3390/diseases13040115
10.3390/diseases13040115 · External reference
From energy metabolism to mood regulation: The rise of lactate as a therapeutic target
10.1016/j.jare.2025.04.018 · 2026 · External reference
10.3389/fphar.2021.837509
10.3389/fphar.2021.837509 · External reference
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
10.1038/s41398-017-0089-z · 2018 · External reference
10.3390/ijms222010937
10.3390/ijms222010937 · External reference
10.3389/fnagi.2022.820108
10.3389/fnagi.2022.820108 · External reference
Current research progress, opportunities, and challenges of Limosillactobacillus reuteri-based probiotic dietary strategies
10.1080/10408398.2024.2369946 · 2025 · External reference
Microbiome to dictate the occurrence of neurological disorders
10.46439/pathology.1.004 · 2024 · External reference
Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: Enhancing gut probiotics abundance and the tryptophan-melatonin pathway
10.1080/19490976.2024.2320283 · 2024 · External reference
10.3390/microorganisms8122003
10.3390/microorganisms8122003 · External reference
10.3390/ani15050710
10.3390/ani15050710 · External reference
Vitamin biosynthesis in the gut: Interplay between mammalian host and its resident microbiota
10.1128/mmbr.00184-23 · 2025 · External reference
10.3390/nu15153466
10.3390/nu15153466 · External reference
Pediococcus acidilactici CCFM6432 mitigates chronic stress-induced anxiety and gut microbial abnormalities
10.1039/d1fo01608c · 2021 · External reference
10.3389/fcimb.2021.618265
10.3389/fcimb.2021.618265 · External reference
A retrospective study of gut microbiota characteristics in a shanghai elderly cohort of hyperlipidemic patients
10.1016/j.fbio.2024.104156 · 2024 · External reference
Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: A cross-sectional study
10.1186/s12967-022-03801-0 · 2022 · External reference
10.3389/fcimb.2022.946757
10.3389/fcimb.2022.946757 · External reference
Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects
10.1515/biol-2022-0910 · 2024 · External reference
The Role of Interactions along the Brain–Gut–Microbiome Axis in the Regulation of Circadian Rhythms, Sleep Mechanisms, and Their Disorders
10.1007/s11055-024-01712-9 · 2024 · External reference
10.3390/nu15214700
10.3390/nu15214700 · External reference
10.3389/fimmu.2022.781148
10.3389/fimmu.2022.781148 · External reference
A chronic stress-induced microbiome perturbation, highly enriched in Ruminococcaceae_UCG-014, promotes colorectal cancer growth and metastasis
10.7150/ijms.90612 · 2024 · External reference
Unresolved reference
External reference
Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications
10.1080/19490976.2024.2401654 · 2024 · External reference
10.3390/jcm14093103
10.3390/jcm14093103 · External reference
Chronic hepatitis B virus infection imbalances short-chain fatty acids and amino acids in the liver and gut via microbiota modulation
10.1186/s13099-025-00695-3 · 2025 · External reference
Associations of intermittent hypoxia burden with gut microbiota Dysbiosis in adult patients with obstructive sleep apnea
10.2147/nss.s484377 · 2024 · External reference
10.3390/antiox13080985
10.3390/antiox13080985 · External reference
10.3390/nu17213350
10.3390/nu17213350 · External reference
10.3390/nu16142259
10.3390/nu16142259 · External reference
10.3390/nu11071565
10.3390/nu11071565 · External reference
Genomic features and prevalence of Ruminococcus species in humans are associated with age, lifestyle, and disease
10.1016/j.celrep.2024.115018 · 2024 · External reference
Alterations of the intestinal microbiome and metabolome in women with rheumatoid arthritis
10.1007/s10238-023-01161-7 · 2023 · External reference
10.3390/diseases7040058
10.3390/diseases7040058 · External reference
10.3390/nu17132145
10.3390/nu17132145 · External reference
AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome
10.1038/s41591-025-03788-3 · 2025 · External reference
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity
10.1016/j.biopha.2023.115568 · 2023 · External reference
Effects of postbiotics on chronic diarrhea in young adults: A randomized, double-blind, placebo-controlled crossover trial assessing clinical symptoms, gut microbiota, and metabolite profiles
10.1080/19490976.2024.2395092 · 2024 · External reference
The butyrate-producing and spore-forming bacterial genus Coprococcus as a potential biomarker for neurological disorders
10.1017/gmb.2023.14 · 2023 · External reference
Mitochondria as multifaceted regulators of cell death
10.1038/s41580-019-0173-8 · 2020 · External reference
Exploring the interplay of psychological and biological components of stress response and telomere length in the transition from middle age to late adulthood: A systematic review
10.1002/smi.3389 · ExternalCitation · doi-reference
Free radical theory of aging: Consequences of mitochondrial aging
10.1007/bf02432509 · ExternalCitation · doi-reference
Alterations of the intestinal microbiome and metabolome in women with rheumatoid arthritis
10.1007/s10238-023-01161-7 · ExternalCitation · doi-reference
The Role of Interactions along the Brain–Gut–Microbiome Axis in the Regulation of Circadian Rhythms, Sleep Mechanisms, and Their Disorders
10.1007/s11055-024-01712-9 · ExternalCitation · doi-reference
Microbiome Gut-Brain-Axis: Impact on brain development and mental health
10.1007/s12035-025-04846-0 · ExternalCitation · doi-reference
The Gut–Brain axis in Autism: Inflammatory mechanisms, molecular insights, and emerging Microbiome-Based therapies
10.1007/s12035-025-05321-6 · ExternalCitation · doi-reference
Inflammaging and the sex-frailty paradox
10.1007/s40520-025-03181-7 · ExternalCitation · doi-reference
Mitochondrial dysfunction in aging
10.1016/j.arr.2023.101955 · ExternalCitation · doi-reference
Mitochondrial quality control as a key determinant of cell survival
10.1016/j.bbamcr.2018.12.012 · ExternalCitation · doi-reference
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity
10.1016/j.biopha.2023.115568 · ExternalCitation · doi-reference
Genomic features and prevalence of Ruminococcus species in humans are associated with age, lifestyle, and disease
10.1016/j.celrep.2024.115018 · ExternalCitation · doi-reference
Human trials exploring anti-aging medicines
10.1016/j.cmet.2023.12.007 · ExternalCitation · doi-reference
A retrospective study of gut microbiota characteristics in a shanghai elderly cohort of hyperlipidemic patients
10.1016/j.fbio.2024.104156 · ExternalCitation · doi-reference
Age and sex trends in depressive symptoms across middle and older adulthood: Comparison of the Canadian Longitudinal Study on aging to American and European cohorts
10.1016/j.jad.2021.08.109 · ExternalCitation · doi-reference
From energy metabolism to mood regulation: The rise of lactate as a therapeutic target
10.1016/j.jare.2025.04.018 · ExternalCitation · doi-reference
Age-Friendly research: Promoting inclusion of older adults in clinical and translational research
10.1017/cts.2023.627 · ExternalCitation · doi-reference
The butyrate-producing and spore-forming bacterial genus Coprococcus as a potential biomarker for neurological disorders
10.1017/gmb.2023.14 · ExternalCitation · doi-reference
10.1017/s0033291798006667
10.1017/s0033291798006667 · ExternalCitation · doi-reference
Aging and aging-related diseases: From molecular mechanisms to interventions and treatments
10.1038/s41392-022-01251-0 · ExternalCitation · doi-reference
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism
10.1038/s41398-017-0089-z · ExternalCitation · doi-reference
The crosstalk between mitochondrial quality control and metal-dependent cell death
10.1038/s41419-024-06691-w · ExternalCitation · doi-reference
Mitochondrial and metabolic dysfunction in aging and age-related diseases
10.1038/s41574-021-00626-7 · ExternalCitation · doi-reference
Mitochondria as multifaceted regulators of cell death
10.1038/s41580-019-0173-8 · ExternalCitation · doi-reference
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
10.1038/s41591-023-02296-6 · ExternalCitation · doi-reference
AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome
10.1038/s41591-025-03788-3 · ExternalCitation · doi-reference
Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults
10.1038/s41598-023-49656-3 · ExternalCitation · doi-reference
Pediococcus acidilactici CCFM6432 mitigates chronic stress-induced anxiety and gut microbial abnormalities
10.1039/d1fo01608c · ExternalCitation · doi-reference
Gut microbiota and aging
10.1080/10408398.2020.1867054 · ExternalCitation · doi-reference
Current research progress, opportunities, and challenges of Limosillactobacillus reuteri-based probiotic dietary strategies
10.1080/10408398.2024.2369946 · ExternalCitation · doi-reference
Sex differences in mental health among older adults: Investigating time trends and possible risk groups with regard to age, educational level and ethnicity
10.1080/13607863.2020.1847248 · ExternalCitation · doi-reference
A novel metabolomic aging score-better than conventional metrics in predicting short-term mortality
10.1080/14737159.2025.2509027 · ExternalCitation · doi-reference
Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: Enhancing gut probiotics abundance and the tryptophan-melatonin pathway
10.1080/19490976.2024.2320283 · ExternalCitation · doi-reference
Effects of postbiotics on chronic diarrhea in young adults: A randomized, double-blind, placebo-controlled crossover trial assessing clinical symptoms, gut microbiota, and metabolite profiles
10.1080/19490976.2024.2395092 · ExternalCitation · doi-reference
Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications
10.1080/19490976.2024.2401654 · ExternalCitation · doi-reference
Frailty in older adults: Evidence for a phenotype
10.1093/gerona/56.3.m146 · ExternalCitation · doi-reference
Frailty in relation to the accumulation of deficits
10.1093/gerona/62.7.722 · ExternalCitation · doi-reference
The role of psychological and social well-being on physical function trajectories in older adults
10.1093/gerona/glaa114 · ExternalCitation · doi-reference
Aerobic Capacity Beyond Cardiorespiratory Fitness Linking Mitochondrial Function, Disease Resilience and apparently healthy aging
10.1096/fj.202500554r · ExternalCitation · doi-reference
The MOS 36-item short-form health survey (SF-36)
10.1097/00005650-199206000-00002 · ExternalCitation · doi-reference
Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly
10.1097/md.0000000000008491 · ExternalCitation · doi-reference
Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer’s dementia
10.1126/sciadv.aax7331 · ExternalCitation · doi-reference
Vitamin biosynthesis in the gut: Interplay between mammalian host and its resident microbiota
10.1128/mmbr.00184-23 · ExternalCitation · doi-reference
The gut microbiota of apparently healthy aged Chinese is similar to that of the apparently healthy young
10.1128/msphere.00327-17 · ExternalCitation · doi-reference
Age-dependent changes in GI physiology and microbiota: Time to reconsider?
10.1136/gutjnl-2017-315542 · ExternalCitation · doi-reference
Low-grade chronic inflammation: A shared mechanism for chronic diseases
10.1152/physiol.00021.2024 · ExternalCitation · doi-reference
Biomarkers of aging: From molecules and surrogates to physiology and function
10.1152/physrev.00045.2024 · ExternalCitation · doi-reference
Sleep patterns, global mental status and mortality risk among middle-aged urban adults
10.1177/13872877241297111 · ExternalCitation · doi-reference
Social participation, psychological resilience and depression among widowed older adults in China
10.1186/s12877-023-04168-7 · ExternalCitation · doi-reference
10.1186/s12889-021-10636-9
10.1186/s12889-021-10636-9 · ExternalCitation · doi-reference
10.1186/s12889-022-14329-9
10.1186/s12889-022-14329-9 · ExternalCitation · doi-reference
10.1186/s12889-023-15965-5
10.1186/s12889-023-15965-5 · ExternalCitation · doi-reference
10.1186/s12889-024-18448-3
10.1186/s12889-024-18448-3 · ExternalCitation · doi-reference
10.1186/s12916-023-02971-y
10.1186/s12916-023-02971-y · ExternalCitation · doi-reference
10.1186/s12916-024-03769-2
10.1186/s12916-024-03769-2 · ExternalCitation · doi-reference
Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: A cross-sectional study
10.1186/s12967-022-03801-0 · ExternalCitation · doi-reference
Inflammation and cell-to-cell communication, two related aspects in frailty
10.1186/s12979-022-00306-8 · ExternalCitation · doi-reference
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study
10.1186/s12979-022-00326-4 · ExternalCitation · doi-reference
Chronic hepatitis B virus infection imbalances short-chain fatty acids and amino acids in the liver and gut via microbiota modulation
10.1186/s13099-025-00695-3 · ExternalCitation · doi-reference
Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects
10.1515/biol-2022-0910 · ExternalCitation · doi-reference
Oxidative stress, aging, and diseases
10.2147/cia.s158513 · ExternalCitation · doi-reference
Associations of intermittent hypoxia burden with gut microbiota Dysbiosis in adult patients with obstructive sleep apnea
10.2147/nss.s484377 · ExternalCitation · doi-reference
A model for estimating biological age from physiological biomarkers of apparently healthy aging: Cross-sectional study
10.2196/35696 · ExternalCitation · doi-reference
Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study
10.2196/67294 · ExternalCitation · doi-reference
10.3389/fcimb.2021.618265
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10.3389/fcimb.2022.946757
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10.3389/fnagi.2025.1508677
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10.3389/fphys.2017.00319
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Microbiome to dictate the occurrence of neurological disorders
10.46439/pathology.1.004 · ExternalCitation · doi-reference
Sex differences in deterioration of sleep properties associated with aging: A 12-year longitudinal cohort study
10.5664/jcsm.9072 · ExternalCitation · doi-reference
A chronic stress-induced microbiome perturbation, highly enriched in Ruminococcaceae_UCG-014, promotes colorectal cancer growth and metastasis
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