Research graph
References from Aptamer-Based Heterobifunctional Targeted Degraders in Disease Treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage t4 DNA polymerase
10.1126/science.2200121 · 1990 · External reference
Selection of metastatic breast cancer cell-specific aptamers for the capture of CTCs with a metastatic phenotype by cell-selex
10.1016/j.omtn.2018.07.008 · 2018 · External reference
The chemical biology of aptamers
10.1002/anie.200804643 · 2009 · External reference
A novel ph-sensitive multifunctional DNA nanomedicine: An enhanced and harmless gd2 aptamer-mediated strategy for guiding neuroblastoma antitumor therapy
10.2147/ijn.s302450 · 2021 · External reference
Utilizing aptamers in targeted protein degradation strategies for disease therapy
10.1002/path.6422 · 2025 · External reference
Aptamers in drug delivery development
10.1016/j.mattod.2025.06.020 · 2025 · External reference
Aptamer-based applications in delivering cancer gene therapies and beyond: State of the art and the missing links to clinical translation
10.1016/j.addr.2025.115639 · 2025 · External reference
Nanotechnology and aptamers: Applications in drug delivery
10.1016/j.tibtech.2008.04.006 · 2008 · External reference
Aptamer-functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing
10.1002/wnan.1731 · 2021 · External reference
Aptamer-based molecular recognition for biosensor development
10.1007/s00216-010-3987-y · 2010 · External reference
Protein-targeted aptamers in liquid biopsy: From efficient screening to precise cancer diagnosis
10.1039/d5an00864f · 2026 · External reference
Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
10.1038/s41551-018-0343-6 · 2019 · External reference
Discovery of aptamers and the acceleration of the development of targeting research in ophthalmology
10.2147/ijn.s418115 · 2023 · External reference
Aptamer blocking strategy inhibits SARS-COV-2 virus infection
10.1002/anie.202100225 · 2021 · External reference
The bace1-specific DNA aptamer a1 rescues amyloid-β pathology and behavioral deficits in a mouse model of alzheimer’s disease
10.1089/nat.2019.0812 · 2019 · External reference
DNA aptamers targeting bace1 reduce amyloid levels and rescue neuronal deficiency in cultured cells
10.1016/j.omtn.2019.02.025 · 2019 · External reference
Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
10.1038/s12276-025-01494-1 · 2025 · External reference
As1411 aptamer based nanomaterials: A novel approach for breast cancer therapy
10.1016/j.ijbiomac.2025.145125 · 2025 · External reference
Protac targeted protein degraders: The past is prologue
10.1038/s41573-021-00371-6 · 2022 · External reference
Advances in targeting ‘undruggable’ transcription factors with small molecules
10.1038/s41573-021-00199-0 · 2021 · External reference
Ras-targeted therapies: Is the undruggable drugged?
10.1038/s41573-020-0068-6 · 2020 · External reference
Targeted protein degradation: Advances in drug discovery and clinical practice
10.1038/s41392-024-02004-x · 2024 · External reference
Targeted protein degradation: Mechanisms, strategies and application
10.1038/s41392-022-00966-4 · 2022 · External reference
Applications of covalent chemistry in targeted protein degradation
10.1039/d2cs00362g · 2022 · External reference
Discovery of novel exceptionally potent and orally active c-met protacs for the treatment of tumors with met alterations
10.1016/j.apsb.2023.01.014 · 2023 · External reference
Calcineurin is a common target of cyclophilin-cyclosporin a and fkbp-fk506 complexes
10.1016/0092-8674(91)90124-h · 1991 · External reference
Protacs: Chimeric molecules that target proteins to the skp1-cullin-f box complex for ubiquitination and degradation
10.1073/pnas.141230798 · 2001 · External reference
Lysosome-targeting chimaeras for degradation of extracellular proteins
10.1038/s41586-020-2545-9 · 2020 · External reference
The autotac chemical biology platform for targeted protein degradation via the autophagy-lysosome system
10.1038/s41467-022-28520-4 · 2022 · External reference
Vepdegestrant, a protac estrogen receptor degrader, in advanced breast cancer
10.1056/nejmoa2505725 · 2025 · External reference
A novel small-molecule protac selectively promotes tau clearance to improve cognitive functions in alzheimer-like models
10.7150/thno.55680 · 2021 · External reference
Targeted protein degradation in autoimmune diseases: From mechanisms to therapeutic breakthroughs
10.1016/j.jaut.2025.103475 · 2025 · External reference
Overview of epigenetic degraders based on protac, molecular glue, and hydrophobic tagging technologies
10.1016/j.apsb.2023.09.003 · 2024 · External reference
Proteolysis-targeting chimera (protac) delivery system: Advancing protein degraders towards clinical translation
10.1039/d1cs00762a · 2022 · External reference
Proteolysis-targeting chimeras in drug development: A safety perspective
10.1111/bph.15014 · 2020 · External reference
Kinetic ITC of DNA aptamers binding for small molecules and implications for binding assays and biosensors
10.1002/cbic.202400225 · 2024 · External reference
Aptamers as an approach to targeted cancer therapy
10.1186/s12935-024-03295-4 · 2024 · External reference
10.1371/journal.pone.0043836
10.1371/journal.pone.0043836 · External reference
Delivery, effect on cell viability, and plasticity of modified aptamer constructs
10.1089/nat.2015.0592 · 2016 · External reference
Base-modified aptamers obtained by cell-internalization selex facilitate cellular uptake of an antisense oligonucleotide
10.1016/j.omtn.2020.11.016 · 2020 · External reference
Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection
10.1021/nn204165v · 2012 · External reference
Advancing design strategy of protacs for cancer therapy
10.1002/mco2.70258 · 2025 · External reference
Aptamer-based targeted protein degradation
10.1021/acsnano.2c10379 · 2023 · External reference
Leveraging aptamers for targeted protein degradation
10.1016/j.tips.2023.05.008 · 2023 · External reference
Protacs: Past, present and future
10.1039/d2cs00193d · 2022 · External reference
Aptamer-protac conjugates (APCs) for tumor-specific targeting in breast cancer
10.1002/anie.202107347 · 2021 · External reference
Drugtamer-protac conjugation strategy for targeted protac delivery and synergistic antitumor therapy
10.1002/advs.202401623 · 2024 · External reference
Inducible degradation of oncogenic nucleolin using an aptamer-based protac
10.1021/acs.jmedchem.2c01557 · 2023 · External reference
Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53
10.1038/leu.2017.325 · 2018 · External reference
10.3390/cancers13164088
10.3390/cancers13164088 · External reference
Selective degradation of the p53-r175h oncogenic hotspot mutant by an RNA aptamer-based protac
10.1002/ctm2.1191 · 2023 · External reference
An engineered DNA aptamer-based protac for precise therapy of p53-r175h hotspot mutant-driven cancer
10.1016/j.scib.2024.05.017 · 2024 · External reference
Taking the myc out of cancer: Toward therapeutic strategies to directly inhibit c-myc
10.1186/s12943-020-01291-6 · 2021 · External reference
Myc and kras cooperation: From historical challenges to therapeutic opportunities in cancer
10.1038/s41392-024-01907-z · 2024 · External reference
Antitumor effect of anti-c-myc aptamer-based protac for degradation of the c-myc protein
10.1002/advs.202309639 · 2024 · External reference
SFK/FAK signaling attenuates osimertinib efficacy in both drug-sensitive and drug-resistant models of EGFR-mutant lung cancer
10.1158/0008-5472.can-16-2300 · 2017 · External reference
A cyclized bivalent aptamer-based protein degrader targeting receptor tyrosine kinases overcomes resistance to inhibitors in lung cancer
10.1021/acsnano.5c03120 · 2025 · External reference
Tdp-43 and fus in amyotrophic lateral sclerosis and frontotemporal dementia
10.1016/s1474-4422(10)70195-2 · 2010 · External reference
Pathogenesis of fus-associated als and ftd: Insights from rodent models
10.1186/s40478-016-0358-8 · 2016 · External reference
DNA nanoflower oligo-protac for targeted degradation of fus to treat neurodegenerative diseases
10.1038/s41467-025-60039-2 · 2025 · External reference
The host immune response in respiratory virus infection: Balancing virus clearance and immunopathology
10.1007/s00281-016-0558-0 · 2016 · External reference
Influenza virus z-RNAs induce zbp1-mediated necroptosis
10.1016/j.cell.2020.02.050 · 2020 · External reference
DAI/ZBP1/DLM-1 complexes with rip3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vira
10.1016/j.chom.2019.09.004 · 2019 · External reference
The z-nucleic acid sensor ZBP1 in health and disease
10.1084/jem.20221156 · 2023 · External reference
Targeted degradation of ZBP1 with covalent protacs for anti-inflammatory treatment of infections
10.1002/anie.202423524 · 2025 · External reference
The role of reversible and irreversible covalent chemistry in targeted protein degradation
10.1016/j.chembiol.2021.03.005 · 2021 · External reference
Efficient targeted degradation via reversible and irreversible covalent protacs
10.1021/jacs.9b13907 · 2020 · External reference
Covalent chemistry in targeted protein degradation
10.1016/j.addr.2026.115777 · 2026 · External reference
Extracellular and membrane-targeted protein degradation (emtpd): Mechanisms, design frameworks, and therapeutic opportunities
10.59717/j.xinn-drugdisc.2026.100024 · 2026 · External reference
Lytacs that engage the asialoglycoprotein receptor for targeted protein degradation
10.1038/s41589-021-00770-1 · 2021 · External reference
Targeted protein degradation with small molecules for cancer immunotherapy
2025 · External reference
Aptamer-lytacs for targeted degradation of extracellular and membrane proteins
10.1002/anie.202218106 · 2023 · External reference
Covalent lytac enabled by dna aptamers for immune checkpoint degradation therapy
2023 · External reference
Targeted degradation of vegf with bispecific aptamer-based lytacs ameliorates pathological retinal angiogenesis
10.7150/thno.98467 · 2024 · External reference
Phototriggered lytac: Photoactive bispecific aptamer chimera enhances targeted degradation of membrane protein through regulating cell autophagy
10.1021/jacs.5c05456 · 2025 · External reference
Engineered virus-like nanoparticles enable multimodal protein degradation for enhanced tumor therapy
10.1002/adma.202507608 · 2025 · External reference
Targeted dual degradation of her2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in her2-positive breast cancer models
2024 · External reference
Allele-selective lowering of mutant htt protein by htt-lc3 linker compounds
10.1038/s41586-019-1722-1 · 2019 · External reference
Degradation of lipid droplets by chimeric autophagy-tethering compounds
10.1038/s41422-021-00532-7 · 2021 · External reference
Targeted clearance of mitochondria by an autophagy-tethering compound (attec) and its potential therapeutic effects
10.1016/j.scib.2023.10.021 · 2023 · External reference
Emerging new concepts of degrader technologies
10.1016/j.tips.2020.04.005 · 2020 · External reference
Bioorthogonal aptamer-attec conjugates for degradation of alpha-synuclein via autophagy-lysosomal pathway
10.1002/smll.202306760 · 2024 · External reference
An innovative ricin-degrading antidote based on aptamer-autophagy-tethering compound strategy
10.1016/j.ijbiomac.2026.151604 · 2026 · External reference
Pegaptanib, a targeted anti-vegf aptamer for ocular vascular disease
10.1038/nrd1955 · 2006 · External reference
FDA approves second RNA aptamer
10.1038/d41573-023-00148-z · 2023 · External reference
Aptamers as targeted therapeutics: Current potential and challenges
10.1038/nrd.2016.199 · 2017 · External reference
Stability modification of therapeutic aptamers: From biostability bottlenecks to nuclease-resistant construct design
10.1039/d6cb00062b · 2026 · External reference
10.3390/ijms18081683
10.3390/ijms18081683 · External reference
Brush-on-brush architecture enables durable and reversible aptamer therapeutics with minimal peg associated immunogenicity
10.1002/adma.73308 · 2026 · External reference
Recent progress in aptamer discoveries and modifications for therapeutic applications
10.1021/acsami.0c05750 · 2021 · External reference
Intracellular trafficking and endosomal release of oligonucleotides: What we know and what we don’t
10.1089/nat.2018.0727 · 2018 · External reference
Translational pk-pd for targeted protein degradation
10.1039/d2cs00114d · 2022 · External reference
Targeted protein degradation: From mechanisms to clinic
10.1038/s41580-024-00729-9 · 2024 · External reference
Lessons learned in linking protacs from discovery to the clinic
10.1038/s41570-025-00784-6 · 2026 · External reference
Deepaptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model
10.1016/j.omtn.2024.102436 · 2024 · External reference
10.3390/ijms22073605
10.3390/ijms22073605 · External reference
Fragment linker prediction using the deep encoder-decoder network for protacs drug design
10.1021/acs.jcim.2c01287 · 2023 · External reference
Engineered virus-like nanoparticles enable multimodal protein degradation for enhanced tumor therapy
10.1002/adma.202507608 · ExternalCitation · doi-reference
Brush-on-brush architecture enables durable and reversible aptamer therapeutics with minimal peg associated immunogenicity
10.1002/adma.73308 · ExternalCitation · doi-reference
Antitumor effect of anti-c-myc aptamer-based protac for degradation of the c-myc protein
10.1002/advs.202309639 · ExternalCitation · doi-reference
Drugtamer-protac conjugation strategy for targeted protac delivery and synergistic antitumor therapy
10.1002/advs.202401623 · ExternalCitation · doi-reference
The chemical biology of aptamers
10.1002/anie.200804643 · ExternalCitation · doi-reference
Aptamer blocking strategy inhibits SARS-COV-2 virus infection
10.1002/anie.202100225 · ExternalCitation · doi-reference
Aptamer-protac conjugates (APCs) for tumor-specific targeting in breast cancer
10.1002/anie.202107347 · ExternalCitation · doi-reference
Aptamer-lytacs for targeted degradation of extracellular and membrane proteins
10.1002/anie.202218106 · ExternalCitation · doi-reference
Targeted degradation of ZBP1 with covalent protacs for anti-inflammatory treatment of infections
10.1002/anie.202423524 · ExternalCitation · doi-reference
Kinetic ITC of DNA aptamers binding for small molecules and implications for binding assays and biosensors
10.1002/cbic.202400225 · ExternalCitation · doi-reference
Selective degradation of the p53-r175h oncogenic hotspot mutant by an RNA aptamer-based protac
10.1002/ctm2.1191 · ExternalCitation · doi-reference
Advancing design strategy of protacs for cancer therapy
10.1002/mco2.70258 · ExternalCitation · doi-reference
Utilizing aptamers in targeted protein degradation strategies for disease therapy
10.1002/path.6422 · ExternalCitation · doi-reference
Bioorthogonal aptamer-attec conjugates for degradation of alpha-synuclein via autophagy-lysosomal pathway
10.1002/smll.202306760 · ExternalCitation · doi-reference
Aptamer-functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing
10.1002/wnan.1731 · ExternalCitation · doi-reference
Aptamer-based molecular recognition for biosensor development
10.1007/s00216-010-3987-y · ExternalCitation · doi-reference
The host immune response in respiratory virus infection: Balancing virus clearance and immunopathology
10.1007/s00281-016-0558-0 · ExternalCitation · doi-reference
Calcineurin is a common target of cyclophilin-cyclosporin a and fkbp-fk506 complexes
10.1016/0092-8674(91)90124-h · ExternalCitation · doi-reference
Aptamer-based applications in delivering cancer gene therapies and beyond: State of the art and the missing links to clinical translation
10.1016/j.addr.2025.115639 · ExternalCitation · doi-reference
Covalent chemistry in targeted protein degradation
10.1016/j.addr.2026.115777 · ExternalCitation · doi-reference
Discovery of novel exceptionally potent and orally active c-met protacs for the treatment of tumors with met alterations
10.1016/j.apsb.2023.01.014 · ExternalCitation · doi-reference
Overview of epigenetic degraders based on protac, molecular glue, and hydrophobic tagging technologies
10.1016/j.apsb.2023.09.003 · ExternalCitation · doi-reference
Influenza virus z-RNAs induce zbp1-mediated necroptosis
10.1016/j.cell.2020.02.050 · ExternalCitation · doi-reference
The role of reversible and irreversible covalent chemistry in targeted protein degradation
10.1016/j.chembiol.2021.03.005 · ExternalCitation · doi-reference
DAI/ZBP1/DLM-1 complexes with rip3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vira
10.1016/j.chom.2019.09.004 · ExternalCitation · doi-reference
As1411 aptamer based nanomaterials: A novel approach for breast cancer therapy
10.1016/j.ijbiomac.2025.145125 · ExternalCitation · doi-reference
An innovative ricin-degrading antidote based on aptamer-autophagy-tethering compound strategy
10.1016/j.ijbiomac.2026.151604 · ExternalCitation · doi-reference
Targeted protein degradation in autoimmune diseases: From mechanisms to therapeutic breakthroughs
10.1016/j.jaut.2025.103475 · ExternalCitation · doi-reference
Aptamers in drug delivery development
10.1016/j.mattod.2025.06.020 · ExternalCitation · doi-reference
Selection of metastatic breast cancer cell-specific aptamers for the capture of CTCs with a metastatic phenotype by cell-selex
10.1016/j.omtn.2018.07.008 · ExternalCitation · doi-reference
DNA aptamers targeting bace1 reduce amyloid levels and rescue neuronal deficiency in cultured cells
10.1016/j.omtn.2019.02.025 · ExternalCitation · doi-reference
Base-modified aptamers obtained by cell-internalization selex facilitate cellular uptake of an antisense oligonucleotide
10.1016/j.omtn.2020.11.016 · ExternalCitation · doi-reference
Deepaptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model
10.1016/j.omtn.2024.102436 · ExternalCitation · doi-reference
Targeted clearance of mitochondria by an autophagy-tethering compound (attec) and its potential therapeutic effects
10.1016/j.scib.2023.10.021 · ExternalCitation · doi-reference
An engineered DNA aptamer-based protac for precise therapy of p53-r175h hotspot mutant-driven cancer
10.1016/j.scib.2024.05.017 · ExternalCitation · doi-reference
Nanotechnology and aptamers: Applications in drug delivery
10.1016/j.tibtech.2008.04.006 · ExternalCitation · doi-reference
Emerging new concepts of degrader technologies
10.1016/j.tips.2020.04.005 · ExternalCitation · doi-reference
Leveraging aptamers for targeted protein degradation
10.1016/j.tips.2023.05.008 · ExternalCitation · doi-reference
Tdp-43 and fus in amyotrophic lateral sclerosis and frontotemporal dementia
10.1016/s1474-4422(10)70195-2 · ExternalCitation · doi-reference
Fragment linker prediction using the deep encoder-decoder network for protacs drug design
10.1021/acs.jcim.2c01287 · ExternalCitation · doi-reference
Inducible degradation of oncogenic nucleolin using an aptamer-based protac
10.1021/acs.jmedchem.2c01557 · ExternalCitation · doi-reference
Recent progress in aptamer discoveries and modifications for therapeutic applications
10.1021/acsami.0c05750 · ExternalCitation · doi-reference
Aptamer-based targeted protein degradation
10.1021/acsnano.2c10379 · ExternalCitation · doi-reference
A cyclized bivalent aptamer-based protein degrader targeting receptor tyrosine kinases overcomes resistance to inhibitors in lung cancer
10.1021/acsnano.5c03120 · ExternalCitation · doi-reference
Phototriggered lytac: Photoactive bispecific aptamer chimera enhances targeted degradation of membrane protein through regulating cell autophagy
10.1021/jacs.5c05456 · ExternalCitation · doi-reference
Efficient targeted degradation via reversible and irreversible covalent protacs
10.1021/jacs.9b13907 · ExternalCitation · doi-reference
Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection
10.1021/nn204165v · ExternalCitation · doi-reference
FDA approves second RNA aptamer
10.1038/d41573-023-00148-z · ExternalCitation · doi-reference
Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53
10.1038/leu.2017.325 · ExternalCitation · doi-reference
Aptamers as targeted therapeutics: Current potential and challenges
10.1038/nrd.2016.199 · ExternalCitation · doi-reference
Pegaptanib, a targeted anti-vegf aptamer for ocular vascular disease
10.1038/nrd1955 · ExternalCitation · doi-reference
Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
10.1038/s12276-025-01494-1 · ExternalCitation · doi-reference
Targeted protein degradation: Mechanisms, strategies and application
10.1038/s41392-022-00966-4 · ExternalCitation · doi-reference
Myc and kras cooperation: From historical challenges to therapeutic opportunities in cancer
10.1038/s41392-024-01907-z · ExternalCitation · doi-reference
Targeted protein degradation: Advances in drug discovery and clinical practice
10.1038/s41392-024-02004-x · ExternalCitation · doi-reference
Degradation of lipid droplets by chimeric autophagy-tethering compounds
10.1038/s41422-021-00532-7 · ExternalCitation · doi-reference
The autotac chemical biology platform for targeted protein degradation via the autophagy-lysosome system
10.1038/s41467-022-28520-4 · ExternalCitation · doi-reference
DNA nanoflower oligo-protac for targeted degradation of fus to treat neurodegenerative diseases
10.1038/s41467-025-60039-2 · ExternalCitation · doi-reference
Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
10.1038/s41551-018-0343-6 · ExternalCitation · doi-reference
Lessons learned in linking protacs from discovery to the clinic
10.1038/s41570-025-00784-6 · ExternalCitation · doi-reference
Ras-targeted therapies: Is the undruggable drugged?
10.1038/s41573-020-0068-6 · ExternalCitation · doi-reference
Advances in targeting ‘undruggable’ transcription factors with small molecules
10.1038/s41573-021-00199-0 · ExternalCitation · doi-reference
Protac targeted protein degraders: The past is prologue
10.1038/s41573-021-00371-6 · ExternalCitation · doi-reference
Targeted protein degradation: From mechanisms to clinic
10.1038/s41580-024-00729-9 · ExternalCitation · doi-reference
Allele-selective lowering of mutant htt protein by htt-lc3 linker compounds
10.1038/s41586-019-1722-1 · ExternalCitation · doi-reference
Lysosome-targeting chimaeras for degradation of extracellular proteins
10.1038/s41586-020-2545-9 · ExternalCitation · doi-reference
Lytacs that engage the asialoglycoprotein receptor for targeted protein degradation
10.1038/s41589-021-00770-1 · ExternalCitation · doi-reference
Proteolysis-targeting chimera (protac) delivery system: Advancing protein degraders towards clinical translation
10.1039/d1cs00762a · ExternalCitation · doi-reference
Translational pk-pd for targeted protein degradation
10.1039/d2cs00114d · ExternalCitation · doi-reference
Protacs: Past, present and future
10.1039/d2cs00193d · ExternalCitation · doi-reference
Applications of covalent chemistry in targeted protein degradation
10.1039/d2cs00362g · ExternalCitation · doi-reference
Protein-targeted aptamers in liquid biopsy: From efficient screening to precise cancer diagnosis
10.1039/d5an00864f · ExternalCitation · doi-reference
Stability modification of therapeutic aptamers: From biostability bottlenecks to nuclease-resistant construct design
10.1039/d6cb00062b · ExternalCitation · doi-reference
Vepdegestrant, a protac estrogen receptor degrader, in advanced breast cancer
10.1056/nejmoa2505725 · ExternalCitation · doi-reference
Protacs: Chimeric molecules that target proteins to the skp1-cullin-f box complex for ubiquitination and degradation
10.1073/pnas.141230798 · ExternalCitation · doi-reference
The z-nucleic acid sensor ZBP1 in health and disease
10.1084/jem.20221156 · ExternalCitation · doi-reference
Delivery, effect on cell viability, and plasticity of modified aptamer constructs
10.1089/nat.2015.0592 · ExternalCitation · doi-reference
Intracellular trafficking and endosomal release of oligonucleotides: What we know and what we don’t
10.1089/nat.2018.0727 · ExternalCitation · doi-reference
The bace1-specific DNA aptamer a1 rescues amyloid-β pathology and behavioral deficits in a mouse model of alzheimer’s disease
10.1089/nat.2019.0812 · ExternalCitation · doi-reference
Proteolysis-targeting chimeras in drug development: A safety perspective
10.1111/bph.15014 · ExternalCitation · doi-reference
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage t4 DNA polymerase
10.1126/science.2200121 · ExternalCitation · doi-reference
SFK/FAK signaling attenuates osimertinib efficacy in both drug-sensitive and drug-resistant models of EGFR-mutant lung cancer
10.1158/0008-5472.can-16-2300 · ExternalCitation · doi-reference
Aptamers as an approach to targeted cancer therapy
10.1186/s12935-024-03295-4 · ExternalCitation · doi-reference
Taking the myc out of cancer: Toward therapeutic strategies to directly inhibit c-myc
10.1186/s12943-020-01291-6 · ExternalCitation · doi-reference
Pathogenesis of fus-associated als and ftd: Insights from rodent models
10.1186/s40478-016-0358-8 · ExternalCitation · doi-reference
10.1371/journal.pone.0043836
10.1371/journal.pone.0043836 · ExternalCitation · doi-reference
A novel ph-sensitive multifunctional DNA nanomedicine: An enhanced and harmless gd2 aptamer-mediated strategy for guiding neuroblastoma antitumor therapy
10.2147/ijn.s302450 · ExternalCitation · doi-reference
Discovery of aptamers and the acceleration of the development of targeting research in ophthalmology
10.2147/ijn.s418115 · ExternalCitation · doi-reference
10.3390/cancers13164088
10.3390/cancers13164088 · ExternalCitation · doi-reference
10.3390/ijms18081683
10.3390/ijms18081683 · ExternalCitation · doi-reference
10.3390/ijms22073605
10.3390/ijms22073605 · ExternalCitation · doi-reference
Extracellular and membrane-targeted protein degradation (emtpd): Mechanisms, design frameworks, and therapeutic opportunities
10.59717/j.xinn-drugdisc.2026.100024 · ExternalCitation · doi-reference
A novel small-molecule protac selectively promotes tau clearance to improve cognitive functions in alzheimer-like models
10.7150/thno.55680 · ExternalCitation · doi-reference
Targeted degradation of vegf with bispecific aptamer-based lytacs ameliorates pathological retinal angiogenesis
10.7150/thno.98467 · ExternalCitation · doi-reference