Research graph
References from Synthesis of 1,2,4-Oxadiazole Sulfonamide Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors. Local targets link to admitted publications; unresolved targets remain external evidence.
The therapeutic potential of monoamine oxidase inhibitors
10.1038/nrn1883 · 2006 · External reference
MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs
10.1016/j.phrs.2025.107876 · 2025 · External reference
10.20944/preprints202508.1652.v1
10.20944/preprints202508.1652.v1 · External reference
Recent advances in the development of selective hMAO-B inhibitors for neurodegenerative diseases: An update from 2020 to present
10.1016/j.ejmech.2026.118893 · 2026 · External reference
Monoamine oxidase inactivation: From pathophysiology to therapeutics
10.1016/j.addr.2008.06.002 · 2008 · External reference
MAO-inhibitors in Parkinson’s disease
10.5607/en.2011.20.1.1 · 2011 · External reference
Monoamine oxidase: Isoforms and inhibitors in Parkinson’s disease and depressive illness
10.1038/sj.bjp.0706464 · 2006 · External reference
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
10.1007/s00395-023-01012-2 · 2023 · External reference
Monoamine oxidases as sources of oxidants in the heart
10.1016/j.yjmcc.2013.12.032 · 2014 · External reference
Cardiac monoamine oxidases: At the heart of mitochondrial dysfunction
10.1038/s41419-020-2251-4 · 2020 · External reference
Monoamine oxidase A (MAO-A): A promising target for prostate cancer therapy
10.1016/j.canlet.2023.216188 · 2023 · External reference
Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis
10.1172/jci70982 · 2014 · External reference
Investigating the analgesic properties of MAO inhibitors moclobemide, phenelzine, and rasagiline in a sciatic nerve ligation-induced neuropathic pain model
10.1134/s1819712426700248 · 2026 · External reference
Repurposing monoamine oxidase inhibitors (MAOI) for the treatment of rheumatoid arthritis possibly through modulating reactive oxidative stress mediated inflammatory cytokines
10.1007/s10787-022-00945-9 · 2022 · External reference
The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model
10.1016/j.pnpbp.2013.02.005 · 2013 · External reference
10.3390/molecules26123724
10.3390/molecules26123724 · External reference
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
10.1016/0306-4522(94)90311-5 · 1994 · External reference
Oral KDS2010, a monoamine oxidase-B (MAO-B) inhibitor, slows the deterioration of motor coordination in genetic sca1 models by inhibiting astrocytic MAO-B-mediated inflammation
10.1111/jnc.70302 · 2025 · External reference
Patents involving monoamine oxidase (MAO): A comprehensive update (2022–2025) on its inhibitors and applications
10.1080/13543776.2026.2633345 · 2026 · External reference
Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update
10.1002/med.21561 · 2019 · External reference
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: Clinical relevance
10.1016/j.expneurol.2009.11.018 · 2010 · External reference
Zonisamide: Pharmacology and clinical efficacy in epilepsy
10.1111/j.1527-3458.1998.tb00075.x · 1998 · External reference
Zonisamide has beneficial effects on Parkinson’s disease patients
10.1016/s0168-0102(01)00298-x · 2001 · External reference
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: Specificity of inhibition and structure of the human monoamine oxidase B complex
10.1021/jm101359c · 2011 · External reference
Pyridazinone-substituted benzenesulfonamides demonstrate inhibition of monoamine oxidase
10.2174/1570180820666230321090227 · 2024 · External reference
Synthesis and monoamine oxidase inhibition properties of (sulfamoylphenyl)quinoline-4-carboxylic acids
10.1134/s1070363224100049 · 2024 · External reference
10.3390/m1787
10.3390/m1787 · External reference
Synthesis, Antibacterial, and antimonooxidase activity of 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide
10.1134/s1070363223110038 · 2023 · External reference
Monoamine oxidase inhibition by thiazole derivatives substituted with the benzenesulfonamide moiety
10.1007/s00044-024-03346-5 · 2025 · External reference
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B
10.1016/j.bmcl.2019.126677 · 2019 · External reference
Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids
10.1016/j.tetlet.2018.06.019 · 2018 · External reference
Diastereoselective opening of bridged anhydrides by amidoximes providing access to 1,2,4-oxadiazole/norborna(e)ne hybrids
10.1002/ejoc.201900843 · 2019 · External reference
Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety
10.1016/j.tetlet.2017.08.020 · 2017 · External reference
10.3390/molecules29235550
10.3390/molecules29235550 · External reference
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: Safinamide and coumarin analogs
10.1021/jm070677y · 2007 · External reference
Mechanochemical approach for amidoxime synthesis
10.1002/ajoc.70331 · 2026 · External reference
Synthesis, mechanism of formation, and molecular orbital calculations of arylamidoximes
10.1007/s00706-009-0186-7 · 2009 · External reference
Reaction of some aromatic nitriles with hydroxylamine to give amides, and an alternative preparation of amidoximes
10.1039/j39690000861 · 1969 · External reference
Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound CA IX isoform that selectively kill cancer cells in hypoxic environment
10.1016/j.ejmech.2018.12.049 · 2019 · External reference
Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic II and membrane-bound IX isoforms
10.1016/j.bioorg.2017.10.005 · 2018 · External reference
The monoamine oxidase inhibition properties of indazole derivatives
10.1016/j.rechem.2026.103461 · 2026 · External reference
A rapid spectrophotometric assay of monoamine oxidase based on the rate of disappearance of kynuramine
10.1016/s0021-9258(18)69497-9 · 1960 · External reference
Mechanochemical approach for amidoxime synthesis
10.1002/ajoc.70331 · ExternalCitation · doi-reference
Diastereoselective opening of bridged anhydrides by amidoximes providing access to 1,2,4-oxadiazole/norborna(e)ne hybrids
10.1002/ejoc.201900843 · ExternalCitation · doi-reference
Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update
10.1002/med.21561 · ExternalCitation · doi-reference
Monoamine oxidase inhibition by thiazole derivatives substituted with the benzenesulfonamide moiety
10.1007/s00044-024-03346-5 · ExternalCitation · doi-reference
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
10.1007/s00395-023-01012-2 · ExternalCitation · doi-reference
Synthesis, mechanism of formation, and molecular orbital calculations of arylamidoximes
10.1007/s00706-009-0186-7 · ExternalCitation · doi-reference
Repurposing monoamine oxidase inhibitors (MAOI) for the treatment of rheumatoid arthritis possibly through modulating reactive oxidative stress mediated inflammatory cytokines
10.1007/s10787-022-00945-9 · ExternalCitation · doi-reference
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
10.1016/0306-4522(94)90311-5 · ExternalCitation · doi-reference
Monoamine oxidase inactivation: From pathophysiology to therapeutics
10.1016/j.addr.2008.06.002 · ExternalCitation · doi-reference
Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic II and membrane-bound IX isoforms
10.1016/j.bioorg.2017.10.005 · ExternalCitation · doi-reference
1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B
10.1016/j.bmcl.2019.126677 · ExternalCitation · doi-reference
Monoamine oxidase A (MAO-A): A promising target for prostate cancer therapy
10.1016/j.canlet.2023.216188 · ExternalCitation · doi-reference
Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound CA IX isoform that selectively kill cancer cells in hypoxic environment
10.1016/j.ejmech.2018.12.049 · ExternalCitation · doi-reference
Recent advances in the development of selective hMAO-B inhibitors for neurodegenerative diseases: An update from 2020 to present
10.1016/j.ejmech.2026.118893 · ExternalCitation · doi-reference
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: Clinical relevance
10.1016/j.expneurol.2009.11.018 · ExternalCitation · doi-reference
MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs
10.1016/j.phrs.2025.107876 · ExternalCitation · doi-reference
The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model
10.1016/j.pnpbp.2013.02.005 · ExternalCitation · doi-reference
The monoamine oxidase inhibition properties of indazole derivatives
10.1016/j.rechem.2026.103461 · ExternalCitation · doi-reference
Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety
10.1016/j.tetlet.2017.08.020 · ExternalCitation · doi-reference
Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids
10.1016/j.tetlet.2018.06.019 · ExternalCitation · doi-reference
Monoamine oxidases as sources of oxidants in the heart
10.1016/j.yjmcc.2013.12.032 · ExternalCitation · doi-reference
A rapid spectrophotometric assay of monoamine oxidase based on the rate of disappearance of kynuramine
10.1016/s0021-9258(18)69497-9 · ExternalCitation · doi-reference
Zonisamide has beneficial effects on Parkinson’s disease patients
10.1016/s0168-0102(01)00298-x · ExternalCitation · doi-reference
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: Safinamide and coumarin analogs
10.1021/jm070677y · ExternalCitation · doi-reference
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: Specificity of inhibition and structure of the human monoamine oxidase B complex
10.1021/jm101359c · ExternalCitation · doi-reference
The therapeutic potential of monoamine oxidase inhibitors
10.1038/nrn1883 · ExternalCitation · doi-reference
Cardiac monoamine oxidases: At the heart of mitochondrial dysfunction
10.1038/s41419-020-2251-4 · ExternalCitation · doi-reference
Monoamine oxidase: Isoforms and inhibitors in Parkinson’s disease and depressive illness
10.1038/sj.bjp.0706464 · ExternalCitation · doi-reference
Reaction of some aromatic nitriles with hydroxylamine to give amides, and an alternative preparation of amidoximes
10.1039/j39690000861 · ExternalCitation · doi-reference
Patents involving monoamine oxidase (MAO): A comprehensive update (2022–2025) on its inhibitors and applications
10.1080/13543776.2026.2633345 · ExternalCitation · doi-reference
Zonisamide: Pharmacology and clinical efficacy in epilepsy
10.1111/j.1527-3458.1998.tb00075.x · ExternalCitation · doi-reference
Oral KDS2010, a monoamine oxidase-B (MAO-B) inhibitor, slows the deterioration of motor coordination in genetic sca1 models by inhibiting astrocytic MAO-B-mediated inflammation
10.1111/jnc.70302 · ExternalCitation · doi-reference
Synthesis, Antibacterial, and antimonooxidase activity of 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide
10.1134/s1070363223110038 · ExternalCitation · doi-reference
Synthesis and monoamine oxidase inhibition properties of (sulfamoylphenyl)quinoline-4-carboxylic acids
10.1134/s1070363224100049 · ExternalCitation · doi-reference
Investigating the analgesic properties of MAO inhibitors moclobemide, phenelzine, and rasagiline in a sciatic nerve ligation-induced neuropathic pain model
10.1134/s1819712426700248 · ExternalCitation · doi-reference
Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis
10.1172/jci70982 · ExternalCitation · doi-reference
10.20944/preprints202508.1652.v1
10.20944/preprints202508.1652.v1 · ExternalCitation · doi-reference
Pyridazinone-substituted benzenesulfonamides demonstrate inhibition of monoamine oxidase
10.2174/1570180820666230321090227 · ExternalCitation · doi-reference
10.3390/m1787
10.3390/m1787 · ExternalCitation · doi-reference
10.3390/molecules26123724
10.3390/molecules26123724 · ExternalCitation · doi-reference
10.3390/molecules29235550
10.3390/molecules29235550 · ExternalCitation · doi-reference
MAO-inhibitors in Parkinson’s disease
10.5607/en.2011.20.1.1 · ExternalCitation · doi-reference
