Research graph
References from Effects of Protocatechuic Acid on Endothelial Function and HDL Functionality in Hypercholesterolemic Subjects: A Randomized Double-Blind Placebo-Controlled Trial. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of cardiovascular diseases: Projections from 2025 to 2050
10.1093/eurjpc/zwae281 · 2025 · External reference
The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050
10.1016/j.jacc.2025.04.061 · 2025 · External reference
HDL cholesterol efflux capacity and incident cardiovascular events
10.1056/nejmoa1409065 · 2014 · External reference
High-density lipoprotein revisited: Biological functions and clinical relevance
10.1093/eurheartj/ehac605 · 2023 · External reference
Pharmacological targeting of endothelial nitric oxide synthase dysfunction and nitric oxide replacement therapy
10.1016/j.freeradbiomed.2025.06.009 · 2025 · External reference
Flow-induced reprogramming of endothelial cells in atherosclerosis
10.1038/s41569-023-00883-1 · 2023 · External reference
Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action
10.5551/jat.rv17025 · 2018 · External reference
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
10.1172/jci42946 · 2011 · External reference
Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes
10.1093/jn/134.4.785 · 2004 · External reference
New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily
10.1016/j.phrs.2020.105109 · 2020 · External reference
Curcumin-loaded nanoscale coordination polymers for ROS scavenging and anti-inflammatory therapy in atherosclerosis
10.1016/j.mtbio.2025.102152 · 2025 · External reference
Exosomal miR-10b derived from protocatechuic acid-treated efferocytic macrophages inhibits endothelial inflammation by targeting MAP3K7/β-TrCP/NF-κB signaling pathway
10.1016/j.phymed.2026.157939 · 2026 · External reference
Established atherosclerosis might be a prerequisite for chicory and its constituent protocatechuic acid to promote endothelium-dependent vasodilation in mice
10.1002/mnfr.201600002 · 2016 · External reference
10.3389/fnut.2023.1060226
10.3389/fnut.2023.1060226 · External reference
Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b
10.1161/circresaha.112.266502 · 2012 · External reference
Effects of Phenolic Acids-Rich Brussels Chicory on Fasting and Postprandial Vascular Function, HDL Functions, and Subclass Profiles in Healthy Overweight Men: A Randomized, Controlled, Single-Blind, Three-Way Crossover Study
10.1002/mnfr.70423 · 2026 · External reference
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Unresolved reference
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Unresolved reference
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Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia
10.1016/j.ijcard.2006.10.007 · 2007 · External reference
Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction
10.1161/atvbaha.110.204230 · 2010 · External reference
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
10.3945/ajcn.2009.27814 · 2009 · External reference
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
10.1016/j.clnu.2016.11.013 · 2017 · External reference
Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery
10.1161/jaha.119.013915 · 2020 · External reference
Protocatechuic Acid Inhibits Vulnerable Atherosclerotic Lesion Progression in Older Apoe-/- Mice
10.1093/jn/nxaa017 · 2020 · External reference
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK
10.1126/scisignal.abn1372 · 2023 · External reference
Protocatechuic acid from chicory is bioavailable and undergoes partial glucuronidation and sulfation in healthy humans
10.1002/fsn3.1168 · 2019 · External reference
Development of a comprehensive food phenolic acids database and its application: Associations between dietary phenolic acids and risk of mortality
10.1016/j.foodres.2026.119623 · 2026 · External reference
Endothelial cell metabolism in cardiovascular physiology and disease
10.1038/s41569-025-01162-x · 2025 · External reference
Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
10.1016/j.jare.2021.06.023 · 2021 · External reference
HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export
10.1161/circresaha.116.305485 · 2015 · External reference
Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia
10.1186/s12944-024-02371-y · 2024 · External reference
Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: A double-blind randomized controlled trial
10.1016/j.ajcnut.2023.03.017 · 2023 · External reference
Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men
10.3945/ajcn.115.128728 · 2016 · External reference
Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: A randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity
10.3945/ajcn.113.066639 · 2013 · External reference
High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women
10.1161/circulationaha.112.122408 · 2013 · External reference
Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials
10.1016/j.advnut.2023.01.002 · 2023 · External reference
The Effect of Cranberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
10.1002/clc.70254 · 2026 · External reference
Noninvasive assessment of arterial stiffness and risk of atherosclerotic events
10.1161/01.atv.0000060460.52916.d6 · 2003 · External reference
HDL metabolism and function in diabetes mellitus
10.1038/s41574-025-01176-y · 2026 · External reference
10.1136/bmj-2024-081123
10.1136/bmj-2024-081123 · External reference
The Effect of Cranberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
10.1002/clc.70254 · ExternalCitation · doi-reference
Protocatechuic acid from chicory is bioavailable and undergoes partial glucuronidation and sulfation in healthy humans
10.1002/fsn3.1168 · ExternalCitation · doi-reference
Established atherosclerosis might be a prerequisite for chicory and its constituent protocatechuic acid to promote endothelium-dependent vasodilation in mice
10.1002/mnfr.201600002 · ExternalCitation · doi-reference
Effects of Phenolic Acids-Rich Brussels Chicory on Fasting and Postprandial Vascular Function, HDL Functions, and Subclass Profiles in Healthy Overweight Men: A Randomized, Controlled, Single-Blind, Three-Way Crossover Study
10.1002/mnfr.70423 · ExternalCitation · doi-reference
Efficacy of Dietary Polyphenols from Whole Foods and Purified Food Polyphenol Extracts in Optimizing Cardiometabolic Health: A Meta-Analysis of Randomized Controlled Trials
10.1016/j.advnut.2023.01.002 · ExternalCitation · doi-reference
Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: A double-blind randomized controlled trial
10.1016/j.ajcnut.2023.03.017 · ExternalCitation · doi-reference
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
10.1016/j.clnu.2016.11.013 · ExternalCitation · doi-reference
Development of a comprehensive food phenolic acids database and its application: Associations between dietary phenolic acids and risk of mortality
10.1016/j.foodres.2026.119623 · ExternalCitation · doi-reference
Pharmacological targeting of endothelial nitric oxide synthase dysfunction and nitric oxide replacement therapy
10.1016/j.freeradbiomed.2025.06.009 · ExternalCitation · doi-reference
Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia
10.1016/j.ijcard.2006.10.007 · ExternalCitation · doi-reference
The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050
10.1016/j.jacc.2025.04.061 · ExternalCitation · doi-reference
Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
10.1016/j.jare.2021.06.023 · ExternalCitation · doi-reference
Curcumin-loaded nanoscale coordination polymers for ROS scavenging and anti-inflammatory therapy in atherosclerosis
10.1016/j.mtbio.2025.102152 · ExternalCitation · doi-reference
New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily
10.1016/j.phrs.2020.105109 · ExternalCitation · doi-reference
Exosomal miR-10b derived from protocatechuic acid-treated efferocytic macrophages inhibits endothelial inflammation by targeting MAP3K7/β-TrCP/NF-κB signaling pathway
10.1016/j.phymed.2026.157939 · ExternalCitation · doi-reference
Flow-induced reprogramming of endothelial cells in atherosclerosis
10.1038/s41569-023-00883-1 · ExternalCitation · doi-reference
Endothelial cell metabolism in cardiovascular physiology and disease
10.1038/s41569-025-01162-x · ExternalCitation · doi-reference
HDL metabolism and function in diabetes mellitus
10.1038/s41574-025-01176-y · ExternalCitation · doi-reference
HDL cholesterol efflux capacity and incident cardiovascular events
10.1056/nejmoa1409065 · ExternalCitation · doi-reference
High-density lipoprotein revisited: Biological functions and clinical relevance
10.1093/eurheartj/ehac605 · ExternalCitation · doi-reference
Global burden of cardiovascular diseases: Projections from 2025 to 2050
10.1093/eurjpc/zwae281 · ExternalCitation · doi-reference
Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes
10.1093/jn/134.4.785 · ExternalCitation · doi-reference
Protocatechuic Acid Inhibits Vulnerable Atherosclerotic Lesion Progression in Older Apoe-/- Mice
10.1093/jn/nxaa017 · ExternalCitation · doi-reference
Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK
10.1126/scisignal.abn1372 · ExternalCitation · doi-reference
10.1136/bmj-2024-081123
10.1136/bmj-2024-081123 · ExternalCitation · doi-reference
Noninvasive assessment of arterial stiffness and risk of atherosclerotic events
10.1161/01.atv.0000060460.52916.d6 · ExternalCitation · doi-reference
Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction
10.1161/atvbaha.110.204230 · ExternalCitation · doi-reference
Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b
10.1161/circresaha.112.266502 · ExternalCitation · doi-reference
HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export
10.1161/circresaha.116.305485 · ExternalCitation · doi-reference
High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women
10.1161/circulationaha.112.122408 · ExternalCitation · doi-reference
Diagnostic Criteria of Flow-Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin-Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery
10.1161/jaha.119.013915 · ExternalCitation · doi-reference
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
10.1172/jci42946 · ExternalCitation · doi-reference
Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia
10.1186/s12944-024-02371-y · ExternalCitation · doi-reference
10.3389/fnut.2023.1060226
10.3389/fnut.2023.1060226 · ExternalCitation · doi-reference
Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: A randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity
10.3945/ajcn.113.066639 · ExternalCitation · doi-reference
Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men
10.3945/ajcn.115.128728 · ExternalCitation · doi-reference
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
10.3945/ajcn.2009.27814 · ExternalCitation · doi-reference
Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action
10.5551/jat.rv17025 · ExternalCitation · doi-reference
