Research graph
References from Multi-Component Xinjiang Basil Essential Oil Mitigates Alzheimer’s Disease-like Pathology Through Amyloid and Neuroinflammatory Modulation. Local targets link to admitted publications; unresolved targets remain external evidence.
NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease
10.1016/j.jalz.2018.02.018 · 2018 · External reference
The neuropathological diagnosis of Alzheimer’s disease
10.1186/s13024-019-0333-5 · 2019 · External reference
Alzheimer’s disease: Insights into pathology, molecular mechanisms, and therapy
10.1093/procel/pwae026 · 2025 · External reference
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
10.1016/j.cell.2019.09.001 · 2019 · External reference
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
10.1038/s41588-019-0358-2 · 2019 · External reference
The amyloid-β pathway in Alzheimer’s disease
10.1038/s41380-021-01249-0 · 2021 · External reference
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
10.1126/science.ads3972 · 2026 · External reference
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
10.1016/j.cell.2026.03.040 · 2026 · External reference
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aβ pathology
10.1038/s41467-021-27702-w · 2022 · External reference
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin
10.1016/j.immuni.2026.03.007 · 2026 · External reference
Neuroinflammation in Alzheimer disease
10.1038/s41577-024-01104-7 · 2025 · External reference
10.1038/s41467-022-29552-6
10.1038/s41467-022-29552-6 · External reference
The role of neuroinflammation and amyloid in cognitive impairment in an APP/PS1 transgenic mouse model of alzheimer’s disease
10.1111/cns.12677 · 2017 · External reference
Progressive spatial memory impairment, brain amyloid deposition and changes in serum amyloid levels as a function of age in APPswe/PS1dE9 mice
10.2174/1567205015666180709112327 · 2018 · External reference
Effect of Ocimum basilicum L. on cyclo-oxygenase isoforms and prostaglandins involved in thrombosis
10.1016/j.jep.2013.12.051 · 2014 · External reference
10.3390/nu17172877
10.3390/nu17172877 · External reference
10.1016/j.jep.2022.115438
10.1016/j.jep.2022.115438 · External reference
Mechanism of intranasal drug delivery directly to the brain
10.1016/j.lfs.2017.12.025 · 2018 · External reference
10.3390/pharmaceutics11110598
10.3390/pharmaceutics11110598 · External reference
Lecanemab in Early Alzheimer’s Disease
10.1056/nejmoa2212948 · 2023 · External reference
TRAILBLAZER-ALZ 2 Investigators. Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
10.1001/jama.2023.13239 · 2023 · External reference
Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats
10.1080/0361073x.2023.2210240 · 2024 · External reference
Long-term food supplementation with sweet basil (Ocimum basilicum L.) prevents age-associated cognitive decline in female mice
10.1177/02601060241281765 · 2025 · External reference
10.1155/2022/9494548
10.1155/2022/9494548 · External reference
Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
10.1038/s41538-021-00084-5 · 2021 · External reference
Donanemab in Early Alzheimer’s Disease
10.1056/nejmoa2100708 · 2021 · External reference
10.1126/science.adv8269
10.1126/science.adv8269 · External reference
10.1126/science.adw2156
10.1126/science.adw2156 · External reference
Immune Activation in Alzheimer Disease
10.1146/annurev-immunol-101921-035222 · 2024 · External reference
Beyond symptomatic effects: Potential of donepezil as a neuroprotective agent and disease modifier in alzheimer’s disease
10.1111/bph.14030 · 2017 · External reference
The potential effects of Ocimum basilicum on health: A review of pharmacological and toxicological studies
10.1080/17425255.2018.1484450 · 2018 · External reference
10.3390/foods11091239
10.3390/foods11091239 · External reference
Tau biomarkers in Alzheimer’s disease: Towards implementation in clinical practice and trials
10.1016/s1474-4422(22)00168-5 · 2022 · External reference
Mechanisms of sex differences in Alzheimer’s disease
10.1016/j.neuron.2024.01.024 · 2024 · External reference
Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial
10.1001/jamaneurol.2026.0072 · 2026 · External reference
Molecular and spatial signatures of mouse brain aging at single-cell resolution
10.1016/j.cell.2022.12.010 · 2023 · External reference
Rhynchophylline loaded-mPEG-PLGA nanoparticles coated with tween-80 for preliminary study in alzheimer’s disease
10.2147/ijn.s236922 · 2020 · External reference
10.1080/10717544.2023.2189112
10.1080/10717544.2023.2189112 · External reference
Effect of polysorbate 80 on the intranasal absorption and brain distribution of tetramethylpyrazine phosphate in rats
10.1007/s13346-018-0580-y · 2019 · External reference
10.1002/advs.75191
10.1002/advs.75191 · External reference
Updates on mouse models of Alzheimer’s disease
10.1186/s13024-024-00712-0 · 2024 · External reference
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
10.1038/s41593-025-02006-0 · 2025 · External reference
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
10.1186/s40035-025-00499-0 · 2025 · External reference
TRAILBLAZER-ALZ 2 Investigators. Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
10.1001/jama.2023.13239 · ExternalCitation · doi-reference
Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial
10.1001/jamaneurol.2026.0072 · ExternalCitation · doi-reference
10.1002/advs.75191
10.1002/advs.75191 · ExternalCitation · doi-reference
Effect of polysorbate 80 on the intranasal absorption and brain distribution of tetramethylpyrazine phosphate in rats
10.1007/s13346-018-0580-y · ExternalCitation · doi-reference
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
10.1016/j.cell.2019.09.001 · ExternalCitation · doi-reference
Molecular and spatial signatures of mouse brain aging at single-cell resolution
10.1016/j.cell.2022.12.010 · ExternalCitation · doi-reference
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
10.1016/j.cell.2026.03.040 · ExternalCitation · doi-reference
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin
10.1016/j.immuni.2026.03.007 · ExternalCitation · doi-reference
NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease
10.1016/j.jalz.2018.02.018 · ExternalCitation · doi-reference
Effect of Ocimum basilicum L. on cyclo-oxygenase isoforms and prostaglandins involved in thrombosis
10.1016/j.jep.2013.12.051 · ExternalCitation · doi-reference
10.1016/j.jep.2022.115438
10.1016/j.jep.2022.115438 · ExternalCitation · doi-reference
Mechanism of intranasal drug delivery directly to the brain
10.1016/j.lfs.2017.12.025 · ExternalCitation · doi-reference
Mechanisms of sex differences in Alzheimer’s disease
10.1016/j.neuron.2024.01.024 · ExternalCitation · doi-reference
Tau biomarkers in Alzheimer’s disease: Towards implementation in clinical practice and trials
10.1016/s1474-4422(22)00168-5 · ExternalCitation · doi-reference
The amyloid-β pathway in Alzheimer’s disease
10.1038/s41380-021-01249-0 · ExternalCitation · doi-reference
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aβ pathology
10.1038/s41467-021-27702-w · ExternalCitation · doi-reference
10.1038/s41467-022-29552-6
10.1038/s41467-022-29552-6 · ExternalCitation · doi-reference
Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
10.1038/s41538-021-00084-5 · ExternalCitation · doi-reference
Neuroinflammation in Alzheimer disease
10.1038/s41577-024-01104-7 · ExternalCitation · doi-reference
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
10.1038/s41588-019-0358-2 · ExternalCitation · doi-reference
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
10.1038/s41593-025-02006-0 · ExternalCitation · doi-reference
Donanemab in Early Alzheimer’s Disease
10.1056/nejmoa2100708 · ExternalCitation · doi-reference
Lecanemab in Early Alzheimer’s Disease
10.1056/nejmoa2212948 · ExternalCitation · doi-reference
Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats
10.1080/0361073x.2023.2210240 · ExternalCitation · doi-reference
10.1080/10717544.2023.2189112
10.1080/10717544.2023.2189112 · ExternalCitation · doi-reference
The potential effects of Ocimum basilicum on health: A review of pharmacological and toxicological studies
10.1080/17425255.2018.1484450 · ExternalCitation · doi-reference
Alzheimer’s disease: Insights into pathology, molecular mechanisms, and therapy
10.1093/procel/pwae026 · ExternalCitation · doi-reference
Beyond symptomatic effects: Potential of donepezil as a neuroprotective agent and disease modifier in alzheimer’s disease
10.1111/bph.14030 · ExternalCitation · doi-reference
The role of neuroinflammation and amyloid in cognitive impairment in an APP/PS1 transgenic mouse model of alzheimer’s disease
10.1111/cns.12677 · ExternalCitation · doi-reference
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
10.1126/science.ads3972 · ExternalCitation · doi-reference
10.1126/science.adv8269
10.1126/science.adv8269 · ExternalCitation · doi-reference
10.1126/science.adw2156
10.1126/science.adw2156 · ExternalCitation · doi-reference
Immune Activation in Alzheimer Disease
10.1146/annurev-immunol-101921-035222 · ExternalCitation · doi-reference
10.1155/2022/9494548
10.1155/2022/9494548 · ExternalCitation · doi-reference
Long-term food supplementation with sweet basil (Ocimum basilicum L.) prevents age-associated cognitive decline in female mice
10.1177/02601060241281765 · ExternalCitation · doi-reference
The neuropathological diagnosis of Alzheimer’s disease
10.1186/s13024-019-0333-5 · ExternalCitation · doi-reference
Updates on mouse models of Alzheimer’s disease
10.1186/s13024-024-00712-0 · ExternalCitation · doi-reference
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
10.1186/s40035-025-00499-0 · ExternalCitation · doi-reference
Rhynchophylline loaded-mPEG-PLGA nanoparticles coated with tween-80 for preliminary study in alzheimer’s disease
10.2147/ijn.s236922 · ExternalCitation · doi-reference
Progressive spatial memory impairment, brain amyloid deposition and changes in serum amyloid levels as a function of age in APPswe/PS1dE9 mice
10.2174/1567205015666180709112327 · ExternalCitation · doi-reference
10.3390/foods11091239
10.3390/foods11091239 · ExternalCitation · doi-reference
10.3390/nu17172877
10.3390/nu17172877 · ExternalCitation · doi-reference
10.3390/pharmaceutics11110598
10.3390/pharmaceutics11110598 · ExternalCitation · doi-reference
