Research graph
References from Chikungunya Virus E2 N218K Enhances Heparan Sulfate-Dependent Attachment and Viral Internalization While Conferring Partial Attenuation in A129 Mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Genomic insights into the re-emergence of chikungunya virus on Réunion Island, France, 2024 to 2025
10.2807/1560-7917.es.2025.30.22.2500344 · 2025 · External reference
Resurgence of chikungunya in the Indian Ocean region in 2024–2025
10.1093/jtm/taaf055 · 2025 · External reference
Unresolved reference
External reference
Persistent arthralgia associated with chikungunya virus: A study of 88 adult patients on reunion island
10.1086/590003 · 2008 · External reference
10.1371/annotation/850ee20f-2641-46ac-b0c6-ef4ae79b6de6
10.1371/annotation/850ee20f-2641-46ac-b0c6-ef4ae79b6de6 · External reference
A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis
10.2174/1874312901610010129 · 2016 · External reference
Chikungunya virus: Epidemiology, replication, disease mechanisms, and prospective intervention strategies
10.1172/jci84417 · 2017 · External reference
10.1371/journal.pone.0103624
10.1371/journal.pone.0103624 · External reference
10.1371/journal.ppat.0030089
10.1371/journal.ppat.0030089 · External reference
Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry
10.1128/jvi.01025-13 · 2013 · External reference
Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein
10.1128/jvi.06449-11 · 2012 · External reference
Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation
10.1128/jvi.74.2.644-651.2000 · 2000 · External reference
A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization
10.1128/jvi.03116-13 · 2014 · External reference
Heparin binding sites on Ross River virus revealed by electron cryo-microscopy
10.1016/j.virol.2004.11.043 · 2005 · External reference
Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors
10.1128/jvi.01500-20 · 2020 · External reference
Adaptation of alphaviruses to heparan sulfate: Interaction of Sindbis and Semliki forest viruses with liposomes containing lipid-conjugated heparin
10.1128/jvi.76.20.10128-10137.2002 · 2002 · External reference
Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
10.1128/jvi.72.9.7357-7366.1998 · 1998 · External reference
10.1371/journal.ppat.1008876
10.1371/journal.ppat.1008876 · External reference
Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice
10.1128/jvi.01672-14 · 2014 · External reference
Complete genome sequence of a chikungunya virus isolated in Guangdong, China
10.1128/jvi.01289-12 · 2012 · External reference
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor
10.1016/j.cell.2019.04.006 · 2019 · External reference
Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
10.1016/j.cell.2019.04.008 · 2019 · External reference
Mxra8 is a receptor for multiple arthritogenic alphaviruses
10.1038/s41586-018-0121-3 · 2018 · External reference
10.3390/v8070181
10.3390/v8070181 · External reference
A new multiplex RT-qPCR method for the simultaneous detection and discrimination of Zika and chikungunya viruses
10.1016/j.ijid.2019.12.028 · 2020 · External reference
Binding of Sindbis virus to cell surface heparan sulfate
10.1128/jvi.72.9.7349-7356.1998 · 1998 · External reference
MAFFT multiple sequence alignment software version 7: Improvements in performance and usability
10.1093/molbev/mst010 · 2013 · External reference
Unresolved reference
External reference
10.3390/v16111736
10.3390/v16111736 · External reference
Mutagenesis of the Sindbis virus nsP1 protein: Effects on methyltransferase activity and viral infectivity
10.1006/viro.1996.0147 · 1996 · External reference
Chikungunya virus evolution following a large 3’UTR deletion results in host-specific molecular changes in protein-coding regions
10.1093/ve/vey012 · 2018 · External reference
Drosophila heparan sulfate, a novel design
10.1074/jbc.m112.350389 · 2012 · External reference
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection
10.1128/jvi.00432-17 · 2017 · External reference
10.3389/fcell.2023.1085913
10.3389/fcell.2023.1085913 · External reference
10.1371/journal.pntd.0002719
10.1371/journal.pntd.0002719 · External reference
An amino acid substitution in the coding region of the E2 glycoprotein adapts Ross River virus to utilize heparan sulfate as an attachment moiety
10.1128/jvi.75.14.6303-6309.2001 · 2001 · External reference
Basic patches on the E2 glycoprotein of eastern equine encephalitis virus influence viral vascular clearance and dissemination in mice
10.1128/jvi.00602-25 · 2025 · External reference
Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner
10.1093/pnasnexus/pgae119 · 2024 · External reference
Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection
10.1038/s41467-025-62513-3 · 2025 · External reference
Mutagenesis of the Sindbis virus nsP1 protein: Effects on methyltransferase activity and viral infectivity
10.1006/viro.1996.0147 · ExternalCitation · doi-reference
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor
10.1016/j.cell.2019.04.006 · ExternalCitation · doi-reference
Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
10.1016/j.cell.2019.04.008 · ExternalCitation · doi-reference
A new multiplex RT-qPCR method for the simultaneous detection and discrimination of Zika and chikungunya viruses
10.1016/j.ijid.2019.12.028 · ExternalCitation · doi-reference
Heparin binding sites on Ross River virus revealed by electron cryo-microscopy
10.1016/j.virol.2004.11.043 · ExternalCitation · doi-reference
Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection
10.1038/s41467-025-62513-3 · ExternalCitation · doi-reference
Mxra8 is a receptor for multiple arthritogenic alphaviruses
10.1038/s41586-018-0121-3 · ExternalCitation · doi-reference
Drosophila heparan sulfate, a novel design
10.1074/jbc.m112.350389 · ExternalCitation · doi-reference
Persistent arthralgia associated with chikungunya virus: A study of 88 adult patients on reunion island
10.1086/590003 · ExternalCitation · doi-reference
Resurgence of chikungunya in the Indian Ocean region in 2024–2025
10.1093/jtm/taaf055 · ExternalCitation · doi-reference
MAFFT multiple sequence alignment software version 7: Improvements in performance and usability
10.1093/molbev/mst010 · ExternalCitation · doi-reference
Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner
10.1093/pnasnexus/pgae119 · ExternalCitation · doi-reference
Chikungunya virus evolution following a large 3’UTR deletion results in host-specific molecular changes in protein-coding regions
10.1093/ve/vey012 · ExternalCitation · doi-reference
Genome-Wide Screening Uncovers the Significance of N-Sulfation of Heparan Sulfate as a Host Cell Factor for Chikungunya Virus Infection
10.1128/jvi.00432-17 · ExternalCitation · doi-reference
Basic patches on the E2 glycoprotein of eastern equine encephalitis virus influence viral vascular clearance and dissemination in mice
10.1128/jvi.00602-25 · ExternalCitation · doi-reference
Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry
10.1128/jvi.01025-13 · ExternalCitation · doi-reference
Complete genome sequence of a chikungunya virus isolated in Guangdong, China
10.1128/jvi.01289-12 · ExternalCitation · doi-reference
Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors
10.1128/jvi.01500-20 · ExternalCitation · doi-reference
Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice
10.1128/jvi.01672-14 · ExternalCitation · doi-reference
A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization
10.1128/jvi.03116-13 · ExternalCitation · doi-reference
Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein
10.1128/jvi.06449-11 · ExternalCitation · doi-reference
Binding of Sindbis virus to cell surface heparan sulfate
10.1128/jvi.72.9.7349-7356.1998 · ExternalCitation · doi-reference
Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
10.1128/jvi.72.9.7357-7366.1998 · ExternalCitation · doi-reference
Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation
10.1128/jvi.74.2.644-651.2000 · ExternalCitation · doi-reference
An amino acid substitution in the coding region of the E2 glycoprotein adapts Ross River virus to utilize heparan sulfate as an attachment moiety
10.1128/jvi.75.14.6303-6309.2001 · ExternalCitation · doi-reference
Adaptation of alphaviruses to heparan sulfate: Interaction of Sindbis and Semliki forest viruses with liposomes containing lipid-conjugated heparin
10.1128/jvi.76.20.10128-10137.2002 · ExternalCitation · doi-reference
Chikungunya virus: Epidemiology, replication, disease mechanisms, and prospective intervention strategies
10.1172/jci84417 · ExternalCitation · doi-reference
10.1371/annotation/850ee20f-2641-46ac-b0c6-ef4ae79b6de6
10.1371/annotation/850ee20f-2641-46ac-b0c6-ef4ae79b6de6 · ExternalCitation · doi-reference
10.1371/journal.pntd.0002719
10.1371/journal.pntd.0002719 · ExternalCitation · doi-reference
10.1371/journal.pone.0103624
10.1371/journal.pone.0103624 · ExternalCitation · doi-reference
10.1371/journal.ppat.0030089
10.1371/journal.ppat.0030089 · ExternalCitation · doi-reference
10.1371/journal.ppat.1008876
10.1371/journal.ppat.1008876 · ExternalCitation · doi-reference
A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis
10.2174/1874312901610010129 · ExternalCitation · doi-reference
Genomic insights into the re-emergence of chikungunya virus on Réunion Island, France, 2024 to 2025
10.2807/1560-7917.es.2025.30.22.2500344 · ExternalCitation · doi-reference
10.3389/fcell.2023.1085913
10.3389/fcell.2023.1085913 · ExternalCitation · doi-reference
10.3390/v16111736
10.3390/v16111736 · ExternalCitation · doi-reference
10.3390/v8070181
10.3390/v8070181 · ExternalCitation · doi-reference
