Research graph
References from Advanced Ophthalmic Drug Delivery in Homocystinuria Type CblC: A Translational Review of Ophthalmic Pathologies and Therapeutic Opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Vitamin B12 deficiency
10.1038/nrdp.2017.40 · 2017 · External reference
10.2903/j.efsa.2015.4150
10.2903/j.efsa.2015.4150 · External reference
Vitamin B12 in Health and Disease
10.3390/nu2030299 · 2010 · External reference
Combined Methylmalonic Aciduria and Homocystinuria cblC Type of a Taiwanese Infant With c.609G>A and c.567dupT Mutations in the MMACHC Gene
10.1016/j.pedneo.2011.05.006 · 2011 · External reference
Versatile enzymology and heterogeneous phenotypes in cobalamin complementation type C disease
10.1016/j.isci.2022.104981 · 2022 · External reference
Unresolved reference
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Homocystinuria: A rare condition presenting as stroke and megaloblastic anemia
10.4103/1817-1745.76110 · 2010 · External reference
The cblD Defect Causes Either Isolated or Combined Deficiency of Methylcobalamin and Adenosylcobalamin Synthesis
10.1074/jbc.m407733200 · 2004 · External reference
cblE Type of homocystinuria due to methionine synthase reductase deficiency: Functional correction by minigene expression
10.1002/humu.20131 · 2005 · External reference
Methylmalonic acidemia: Current status and research priorities
10.5582/irdr.2018.01026 · 2018 · External reference
Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
10.1016/j.redox.2019.101322 · 2020 · External reference
Three Main Causes of Homocystinuria: CBS, cblC and MTHFR Deficiency. What do they Have in Common?
10.1590/2326-4594-jiems-2019-0007 · 2019 · External reference
Homocystinuria diagnosis and management: It is not all classical
10.1136/jcp-2021-208029 · 2022 · External reference
Defective metabolism of vitamin B12 in fibroblasts from children with methylmalonicaciduria
10.1016/0006-291x(71)90610-3 · 1971 · External reference
10.1016/b978-0-12-391909-0.50043-8
10.1016/b978-0-12-391909-0.50043-8 · External reference
10.1016/b0-12-227055-x/00257-1
10.1016/b0-12-227055-x/00257-1 · External reference
Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders
10.1016/j.biochi.2012.11.004 · 2013 · External reference
Folate and Vitamin B 12 Metabolism: Overview and Interaction with Riboflavin, Vitamin B 6, and Polymorphisms
10.1177/15648265080292s103 · 2008 · External reference
Vitamin B 12, folate, and the methionine remethylation cycle—Biochemistry, pathways, and regulation
10.1002/jimd.12009 · 2019 · External reference
10.3390/cryst12040468
10.3390/cryst12040468 · External reference
Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type
10.1038/ng1683 · 2006 · External reference
Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management
10.1007/s10545-011-9364-y · 2012 · External reference
Distinct clinical, neuroimaging and genetic profiles of late-onset cobalamin C defects (cb1C): A report of 16 Chinese cases
10.1186/s13023-019-1058-9 · 2019 · External reference
10.1186/s12881-015-0196-8
10.1186/s12881-015-0196-8 · External reference
Rapid screening of MMACHC gene mutations by high-resolution melting curve analysis
10.1002/mgg3.1221 · 2020 · External reference
Value of amniotic fluid homocysteine assay in prenatal diagnosis of combined methylmalonic acidemia and homocystinuria, cobalamin C type
10.1186/s13023-021-01762-z · 2021 · External reference
10.3390/cells12040642
10.3390/cells12040642 · External reference
Microcephaly, an etiopathogenic vision
10.1016/j.pedneo.2021.05.008 · 2021 · External reference
Hydrocephalus: Historical analysis and considerations for treatment
10.1186/s40001-022-00798-6 · 2022 · External reference
Paediatric hydrocephalus
10.1038/s41572-024-00519-9 · 2024 · External reference
The clinical picture of early-onset cobalamin C defect (methylmalonic aciduria and homocystinuria)
10.1016/s1751-7222(08)70019-2 · 2008 · External reference
Clinical and genetic analysis of methylmalonic aciduria in 60 patients from Southern China: A single center retrospective study
10.1186/s13023-024-03210-0 · 2024 · External reference
Genetic analysis of four cases of methylmalonic aciduria and homocystinuria, cblC type
2015 · External reference
Management of the Metabolic Acidosis of Chronic Kidney Disease
10.1053/j.ackd.2017.06.006 · 2017 · External reference
Diagnosis of cobalamin C deficiency with renal abnormality from onset in a Chinese child by next generation sequencing: A case report
10.3892/etm.2017.4970 · 2017 · External reference
Unresolved reference
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Hyperammonemia
10.1016/0045-9380(84)90047-1 · 1984 · External reference
Efficacy of early treatment in patients with cobalamin C disease identified by newborn screening: A 16-year experience
10.1038/gim.2016.214 · 2017 · External reference
Prenatal diagnosis of combined methylmalonic acidemia and homocystinuria cobalamin C type using clinical exome sequencing and targeted gene analysis
10.1002/mgg3.1838 · 2021 · External reference
Cobalamin C defect presenting as severe neonatal hyperammonemia
10.1007/s00431-010-1371-8 · 2011 · External reference
10.3389/fped.2022.810495
10.3389/fped.2022.810495 · External reference
High prevalence of structural heart disease in children with cblC-type methylmalonic aciduria and homocystinuria
10.1016/j.ymgme.2009.07.017 · 2009 · External reference
Severe megaloblastic anemia: Vitamin deficiency and other causes
10.3949/ccjm.87a.19072 · 2020 · External reference
Homocystinuria and Megaloblastic Anemia Responsive to Vitamin B12 Therapy: An Inborn Error of Metabolism Due to a Defect in Cobalamin Metabolism
10.1056/nejm198403153101104 · 1984 · External reference
Pulmonary Hypertension: Diagnosis, Management, and Treatment
2019 · External reference
Pulmonary embolism in a child with combined methylmalonic acidemia and homocystinuria
10.1002/ped4.12047 · 2018 · External reference
Cobalamin disorder CblC presenting with hemolytic uremic syndrome and pulmonary hypertension
10.1016/j.nefro.2017.03.019 · 2018 · External reference
10.1186/s12887-020-02130-9
10.1186/s12887-020-02130-9 · External reference
Renal Thrombotic Microangiopathy: A Review
10.1053/j.ajkd.2022.10.014 · 2023 · External reference
Clinical Evaluation and Management of Thrombotic Microangiopathy
10.1002/art.42681 · 2024 · External reference
Hemolytic uremic syndrome with dual caution in an infant: Cobalamin C defect and complement dysregulation successfully treated with eculizumab
10.1007/s00467-018-3941-3 · 2018 · External reference
Adult-onset renal thrombotic microangiopathy and pulmonary arterial hypertension in cobalamin C deficiency
10.1016/s0140-6736(15)00076-8 · 2015 · External reference
Late-onset thrombocytic microangiopathy caused by cblC disease: Association with a factor H mutation
10.1053/j.ajkd.2004.12.004 · 2005 · External reference
Cobalamin C Deficiency Induces a Typical Histopathological Pattern of Renal Arteriolar and Glomerular Thrombotic Microangiopathy
10.1016/j.ekir.2018.05.015 · 2018 · External reference
Thrombotic microangiopathic nephropathy, pulmonary hypertension and nephromegaly: Case report of a patient treated with endothelin receptor antagonist
10.5414/cn106829 · 2012 · External reference
Hemolytic uremic syndrome (HUS) secondary to cobalamin C (cblC) disorder
10.1007/s00467-007-0604-1 · 2007 · External reference
Renal thrombotic microangiopathy in patients with cblC defect: Review of an under-recognized entity
10.1007/s00467-016-3399-0 · 2017 · External reference
Haemolytic uraemic syndrome
10.1111/joim.12546 · 2017 · External reference
Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
10.1182/blood-2005-06-2506 · 2006 · External reference
Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer’s disease?
10.3233/jad-2006-9404 · 2006 · External reference
Psychiatric manifestations of homocystinuria due to cystathionine β-synthase deficiency: Prevalence, natural history, and relationship to neurologic impairment and vitamin B6 -responsiveness
10.1002/ajmg.1320260427 · 1987 · External reference
The adolescent and adult form of cobalamin C disease: Clinical and molecular spectrum
10.1136/jnnp.2007.133025 · 2007 · External reference
Late-onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance
10.1002/ajmg.a.31932 · 2007 · External reference
Manic-depressive Psychosis as the Initial Symptom in Adult Siblings with Late-onset Combined Methylmalonic Aciduria and Homocystinemia, Cobalamin C Type
10.4103/0366-6999.199826 · 2017 · External reference
10.3390/pharmaceutics11070321
10.3390/pharmaceutics11070321 · External reference
10.3390/pharmaceutics12030269
10.3390/pharmaceutics12030269 · External reference
Crystallins in the eye: Function and pathology
10.1016/j.preteyeres.2006.10.003 · 2007 · External reference
Aqueous Humor Dynamics: A Review
10.2174/1874364101004010052 · 2010 · External reference
Vitreous Humor: Composition, Characteristics and Implication on Intravitreal Drug Delivery
10.1080/02713683.2022.2119254 · 2023 · External reference
Ocular manifestations of cobalamin C type methylmalonic aciduria with homocystinuria
10.1016/j.jaapos.2012.02.019 · 2012 · External reference
Homocystinuria and ocular complications–A review
10.4103/ijo.ijo_309_22 · 2022 · External reference
Cobalamin C Deficiency Shows a Rapidly Progressing Maculopathy With Severe Photoreceptor and Ganglion Cell Loss
10.1167/iovs.15-17857 · 2015 · External reference
Ocular phenotype in patients with methylmalonic aciduria and homocystinuria, cobalamin C type
10.1016/j.jaapos.2008.06.008 · 2008 · External reference
Neurodevelopmental and Neuropsychiatric Disorders in Cobalamin C Disease: A Case Report and Review of the Literature
10.1101/mcs.a006179 · 2022 · External reference
Retinitis pigmentosa
10.1186/1750-1172-1-40 · 2006 · External reference
A Novel RP1 Truncating mutation That Causes Autosomal Dominant Retinitis Pigmentosa (ADRP)
10.1016/j.aopr.2024.08.005 · 2024 · External reference
Ocular disease in the cobalamin C defect: A review of the literature and a suggested framework for clinical surveillance
10.1016/j.ymgme.2015.01.012 · 2015 · External reference
Long-term Visual Outcome of Methylmalonic Aciduria and Homocystinuria, Cobalamin C Type
10.1016/j.ophtha.2013.08.034 · 2014 · External reference
Optical coherence tomography morphology and evolution in cblC disease-related maculopathy in a case series of very young patients
10.1111/aos.13441 · 2017 · External reference
Ophthalmic Manifestations and Long-Term Visual Outcomes in Patients with Cobalamin C Deficiency
10.1016/j.ophtha.2015.10.041 · 2016 · External reference
Unresolved reference
External reference
Whole Exome Sequencing Identifies an Adult-Onset Case of Methylmalonic Aciduria and Homocystinuria Type C (cblC) with Non-Syndromic Bull’s Eye Maculopathy
10.3109/13816810.2015.1010736 · 2015 · External reference
Adult-onset CblC deficiency: A challenging diagnosis involving different adult clinical specialists
10.1186/s13023-022-02179-y · 2022 · External reference
Management of nystagmus in children: A review of the literature and current practice in UK specialist services
10.1038/s41433-019-0741-3 · 2020 · External reference
10.3389/fopht.2023.1233866
10.3389/fopht.2023.1233866 · External reference
The impact of strabismus on psychosocial heath and quality of life: A systematic review
10.1016/j.survophthal.2021.03.005 · 2021 · External reference
Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC)
10.1016/s0022-3476(98)70496-2 · 1998 · External reference
Unresolved reference
External reference
Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency
10.1007/s10545-016-9991-4 · 2017 · External reference
Parenteral hydroxocobalamin dose intensification in five patients with different types of early onset intracellular cobalamin defects: Clinical and biochemical responses
2019 · External reference
Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria
10.1016/s0022-3476(88)80114-8 · 1988 · External reference
Cobalamin C defect: Natural history, pathophysiology, and treatment
10.1007/s10545-010-9161-z · 2011 · External reference
10.1016/b978-0-323-46143-6.00013-0
10.1016/b978-0-323-46143-6.00013-0 · External reference
Unresolved reference
External reference
Why I Use Subcutaneous Immunoglobulin (SCIG)
10.1007/s10875-012-9853-2 · 2013 · External reference
Unresolved reference
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Unresolved reference
External reference
Corticosteroids in ophthalmology: Drug delivery innovations, pharmacology, clinical applications, and future perspectives
10.1007/s13346-020-00843-z · 2021 · External reference
Nanomedicine-Based Ophthalmic Drug Delivery Systems for the Treatment of Ocular Diseases
10.2147/ijn.s532074 · 2025 · External reference
10.1016/b978-0-443-15264-1.00019-1
10.1016/b978-0-443-15264-1.00019-1 · External reference
Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: Where do we stand?
10.3109/10717544.2014.936535 · 2016 · External reference
An Overview on Various Approaches and Recent Patents on Gastroretentive Drug Delivery Systems
10.2174/1872211312666180308150218 · 2018 · External reference
An optimized gastroretentive nanosystem for the delivery of levodopa
10.1016/j.ijpharm.2015.08.014 · 2015 · External reference
10.3390/gels3030025
10.3390/gels3030025 · External reference
Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin
10.1016/j.actbio.2015.12.017 · 2016 · External reference
A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
10.1038/nmat4355 · 2015 · External reference
Current trends in pharmaceutical treatment of dry eye disease: A review
10.1016/j.ejps.2022.106206 · 2022 · External reference
Parenteral systems for statin delivery: A review
10.1186/s12944-019-1139-8 · 2019 · External reference
10.1016/b978-012080261-6/50026-x
10.1016/b978-012080261-6/50026-x · External reference
Challenges and Opportunities in dermal/transdermal Delivery
10.4155/tde.10.16 · 2010 · External reference
Microneedles for advanced ocular drug delivery
10.1016/j.addr.2023.115082 · 2023 · External reference
An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery
10.1126/sciadv.adv1661 · 2025 · External reference
Solid implantable devices for sustained drug delivery
10.1016/j.addr.2023.114950 · 2023 · External reference
Rise of implantable drugs: A chronicle of breakthroughs in drug delivery systems
10.1016/j.jsps.2024.102193 · 2024 · External reference
Biodegradable polyurethane nanocomposites containing dexamethasone for ocular route
10.1016/j.msec.2010.10.019 · 2011 · External reference
Intravitreal implants manufactured by supercritical foaming for treating retinal diseases
10.1016/j.jconrel.2023.08.047 · 2023 · External reference
Unresolved reference
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Unresolved reference
External reference
Ophthalmic Drug Dosage Forms: Characterisation and Research Methods
10.1155/2014/861904 · 2014 · External reference
Ocular Drug Delivery
10.1208/s12248-010-9183-3 · 2010 · External reference
10.3390/pharmaceutics14010134
10.3390/pharmaceutics14010134 · External reference
10.21203/rs.3.rs-4619093/v1
10.21203/rs.3.rs-4619093/v1 · External reference
Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye
10.1016/j.exer.2015.10.009 · 2016 · External reference
Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-associated Liposomes
10.1002/smll.201303433 · 2014 · External reference
Ocular drug delivery
10.1517/17425247.3.2.275 · 2006 · External reference
Intracameral Drug Delivery: A Review of Agents, Indications, and Outcomes
10.1089/jop.2022.0144 · 2023 · External reference
Toxic Endothelial Cell Destruction of the Cornea After Routine Extracapsular Cataract Surgery
10.1001/archopht.1990.01070100077038 · 1990 · External reference
Effect of bimatoprost sustained-release intracameral implant on intraocular pressure and medication burden in patients with prior glaucoma surgery
10.1016/j.jfo.2023.07.016 · 2024 · External reference
Influence of serial intravitreal injections on measures of dry eye: A systemic review and meta-analysis
10.1016/j.clae.2024.102127 · 2024 · External reference
Ocular delivery of proteins and peptides: Challenges and novel formulation approaches
10.1016/j.addr.2018.01.008 · 2018 · External reference
Advances in ocular drug delivery: Emphasis on the posterior segment
10.1517/17425247.2014.935338 · 2014 · External reference
Ranibizumab versus Verteporfin Photodynamic Therapy for Neovascular Age-Related Macular Degeneration: Two-Year Results of the ANCHOR Study
10.1016/j.ophtha.2008.10.018 · 2009 · External reference
Ranibizumab for Neovascular Age-Related Macular Degeneration
10.1056/nejmoa054481 · 2006 · External reference
Phase I Study of Intravitreal Injection of Autologous CD34+ Stem Cells from Bone Marrow in Eyes with Vision Loss from Retinitis Pigmentosa
10.1016/j.xops.2024.100589 · 2025 · External reference
Transscleral drug delivery to the posterior eye: Prospects of pharmacokinetic modeling
10.1016/j.addr.2006.07.025 · 2006 · External reference
Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives
10.1016/j.addr.2023.114770 · 2023 · External reference
Extraocular, periocular, and intraocular routes for sustained drug delivery for glaucoma
10.1016/j.preteyeres.2020.100901 · 2021 · External reference
Efficacy evaluation of carboplatin -etoposide Co-loaded PLGA microparticles for subconjunctival chemotherapy in retinoblastoma
10.1016/j.jddst.2024.105333 · 2024 · External reference
Choroidal concentration of interferon after retrobulbar injection
1996 · External reference
A Comparison of Retrobulbar versus Sub-Tenon’s Corticosteroid Therapy for Cystoid Macular Edema Refractory to Topical Medications
10.1016/s0161-6420(97)30065-7 · 1997 · External reference
Pharmacokinetic aspects of retinal drug delivery
10.1016/j.preteyeres.2016.12.001 · 2017 · External reference
Safety of posterior juxtascleral depot administration of the angiostatic cortisene anecortave acetate for treatment of subfoveal choroidal neovascularization in patients with age-related macular degeneration
10.1007/s00417-004-0961-4 · 2005 · External reference
Suprachoroidal space-inducing hydrogel-forming microneedles (SI-HFMN): An innovative platform for drug delivery to the posterior segment of the eye
2025 · External reference
Efficacy and Safety of Suprachoroidal CLS-TA for Macular Edema Secondary to Noninfectious Uveitis
10.1016/j.ophtha.2020.01.006 · 2020 · External reference
Kinetics of macromolecules injected into the subretinal space
10.1016/0014-4835(85)90138-1 · 1985 · External reference
Unresolved reference
External reference
Ocular Drug Delivery: A Comprehensive Review
10.1208/s12249-023-02516-9 · 2023 · External reference
10.3390/ijms20225534
10.3390/ijms20225534 · External reference
Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases
10.1016/j.jconrel.2023.01.018 · 2023 · External reference
Applications of poloxamers in ophthalmic pharmaceutical formulations: An overview
10.1517/17425247.2013.796360 · 2013 · External reference
The Role of Surface Active Agents in Ophthalmic Drug Delivery: A Comprehensive Review
10.1016/j.xphs.2019.01.016 · 2019 · External reference
Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye—Part II—Ocular drug-loaded lipid nanoparticles
10.1016/j.ejpb.2016.10.013 · 2017 · External reference
Interactions between loaded drugs and surfactant molecules in micellar drug delivery systems: A critical review
10.1016/j.molliq.2023.121906 · 2023 · External reference
Selection Criteria for Oils, Surfactants, and Co-Surfactants in Ocular Nanoemulsion Formulation: A Mini Review
10.2174/0113816128350573241202105210 · 2025 · External reference
Polymeric micelles: Authoritative aspects for drug delivery
10.1080/1385772x.2012.688328 · 2012 · External reference
Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol
10.1186/1556-276x-6-275 · 2011 · External reference
Polymer Micelles: An Example of Self-Assembling Polymers
10.1021/jp980386o · 1998 · External reference
10.3390/polym14091635
10.3390/polym14091635 · External reference
10.3390/pharmaceutics12030253
10.3390/pharmaceutics12030253 · External reference
Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies
10.1016/j.jconrel.2017.01.012 · 2017 · External reference
Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: Design, characterisation, toxicity and transcorneal permeation studies
10.1016/j.ejpb.2017.01.008 · 2017 · External reference
10.3390/polym16162240
10.3390/polym16162240 · External reference
Zero order delivery of itraconazole via polymeric micelles incorporated in situ ocular gel for the management of fungal keratitis
10.1016/j.colsurfb.2015.03.059 · 2015 · External reference
10.3390/scipharm87030015
10.3390/scipharm87030015 · External reference
Cyclodextrins as pharmaceutical solubilizers
10.1016/j.addr.2007.05.012 · 2007 · External reference
Cyclodextrins in drug delivery
10.1517/17425247.2.1.335 · 2005 · External reference
Cyclodextrin-based ocular drug delivery systems: A comprehensive review
10.1016/j.ccr.2022.214919 · 2023 · External reference
Studies on the influence of β-cyclodextrin derivatives on the physical stability of famotidine
10.1016/j.saa.2019.04.066 · 2019 · External reference
Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac
10.1155/2018/5260976 · 2018 · External reference
Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye
10.1016/j.ijpharm.2017.04.010 · 2017 · External reference
Role of Cyclodextrins in Ophthalmics
10.2174/1567201043334623 · 2004 · External reference
Supramolecular cyclodextrin complex: Diversity, safety, and applications in ocular therapeutics
10.1016/j.exer.2019.107829 · 2019 · External reference
Delivery of Fenofibrate to Ocular Tissues using 2-Hydroxypropyl-β-cyclodextrin-Based Micelles
10.1016/j.ijpharm.2025.125417 · 2025 · External reference
A Novel Eye Drop Formulation for Potential Treatment of Neovascular Age-Related Macular Degeneration
10.1167/tvst.10.14.23 · 2021 · External reference
10.3390/gels8030167
10.3390/gels8030167 · External reference
Hydrogels for ocular drug delivery and tissue engineering
10.15171/bi.2015.31 · 2015 · External reference
10.3390/gels7040182
10.3390/gels7040182 · External reference
10.3390/ph15030371
10.3390/ph15030371 · External reference
Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations
10.1016/j.jconrel.2019.05.034 · 2019 · External reference
10.3389/fbioe.2020.00228
10.3389/fbioe.2020.00228 · External reference
10.3390/ma17010086
10.3390/ma17010086 · External reference
Preparation and Evaluation of In-Situ-Gels for Ocular Drug Delivery
2009 · External reference
10.3390/biomedicines9091203
10.3390/biomedicines9091203 · External reference
Effect of Hyaluronic Acid/Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease
10.1155/2018/4691417 · 2018 · External reference
Designing lipid nanoparticles for topical ocular drug delivery
10.1016/j.ijpharm.2017.09.017 · 2017 · External reference
10.3390/pharmaceutics10010010
10.3390/pharmaceutics10010010 · External reference
Polysaccharide as renewable responsive biopolymer for in situ gel in the delivery of drug through ocular route
10.1016/j.ijbiomac.2020.02.097 · 2020 · External reference
10.3390/polym14091836
10.3390/polym14091836 · External reference
Thermosensitive glycol chitosan-based hydrogel as a topical ocular drug delivery system for enhanced ocular bioavailability
10.1016/j.ijpharm.2019.118688 · 2019 · External reference
Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review
10.1016/j.jconrel.2020.11.049 · 2021 · External reference
Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system
10.1016/s0168-3659(01)00279-6 · 2001 · External reference
Comparison of ion-activated in situ gelling systems for ocular drug delivery. Part 2: Precorneal retention and in vivo pharmacodynamic study
10.1016/j.ijpharm.2011.03.043 · 2011 · External reference
In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery
10.1208/s12249-010-9413-0 · 2010 · External reference
A novel ion-activated in situ gelling ophthalmic delivery system based on κ-carrageenan for acyclovir
10.1080/03639045.2017.1414232 · 2018 · External reference
Killing three birds with one stone: Multi-stage metabolic regulation mediated by clinically usable berberine liposome to overcome photodynamic immunotherapy resistance
10.1016/j.cej.2022.140164 · 2023 · External reference
Optimization and Characterization of Thymoquinone-Loaded Liposomes with Enhanced Topical Anti-inflammatory Activity
10.1208/s12249-018-1166-1 · 2018 · External reference
10.3390/pharmaceutics13071013
10.3390/pharmaceutics13071013 · External reference
Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection
10.1080/17425247.2021.1872542 · 2021 · External reference
10.3390/ph17040511
10.3390/ph17040511 · External reference
Ocular drug delivery systems: A comprehensive review of innovative formulations, challenges and opportunities
10.30574/gscbps.2024.29.2.0421 · 2024 · External reference
Ciprofloxacin as Ocular Liposomal Hydrogel
10.1208/s12249-009-9373-4 · 2010 · External reference
Preparation and ocular pharmacokinetics of ganciclovir liposomes
10.1208/aapsj0903044 · 2007 · External reference
10.3389/fphar.2022.838168
10.3389/fphar.2022.838168 · External reference
Long acting injectables & implants: Advances in intraocular drug delivery
10.1016/j.ijpharm.2025.126058 · 2025 · External reference
A Review on Graphene-Based Nanomaterials in Biomedical Applications and Risks in Environment and Health
10.1007/s40820-018-0206-4 · 2018 · External reference
A Review on Nanoparticles: Synthesis, Characterization and Applications
2021 · External reference
10.3389/fphar.2022.903519
10.3389/fphar.2022.903519 · External reference
Polymeric nanoparticulate system: A potential approach for ocular drug delivery
10.1016/j.jconrel.2008.12.018 · 2009 · External reference
10.3390/pharmaceutics16081092
10.3390/pharmaceutics16081092 · External reference
Pharmaceutical Nanotechnology Nanoparticle-Based Topical Ophthalmic Formulations for Sustained Celecoxib Release
10.1002/jps.23417 · 2013 · External reference
Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
10.1016/j.ijpharm.2007.12.007 · 2008 · External reference
10.3390/pharmaceutics13040523
10.3390/pharmaceutics13040523 · External reference
Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: Applications, advantages and disadvantages
10.4103/1735-5362.235156 · 2018 · External reference
Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids
2024 · External reference
Noninvasive ocular delivery of adalimumab-loaded nanostructured lipid carriers for targeted retinitis pigmentosa therapy
10.1016/j.biopha.2025.117962 · 2025 · External reference
Itraconazole loaded nano-structured lipid carrier for topical ocular delivery: Optimization and evaluation
10.1016/j.sjbs.2021.11.006 · 2022 · External reference
10.1007/978-1-62703-475-3
10.1007/978-1-62703-475-3 · External reference
10.3390/nano7060122
10.3390/nano7060122 · External reference
Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine
10.1016/j.matdes.2020.108805 · 2020 · External reference
Investigating the effectiveness of Difluprednate-Loaded core-shell lipid-polymeric hybrid nanoparticles for ocular delivery
10.1016/j.ijpharm.2023.123006 · 2023 · External reference
Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride
10.1016/j.ijbiomac.2018.05.113 · 2018 · External reference
10.3390/nano10061191
10.3390/nano10061191 · External reference
A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system
10.1016/j.ijpharm.2022.121878 · 2022 · External reference
Niosome-Encapsulated Gentamicin for Ophthalmic Controlled Delivery
10.1208/s12249-008-9105-1 · 2008 · External reference
Betaxolol-loaded niosomes integrated within pH-sensitive in situ forming gel for management of glaucoma
10.1016/j.ijpharm.2021.120380 · 2021 · External reference
Design and in vitro evaluation of doxycycline hyclate niosomes as a potential ocular delivery system
10.1016/j.ijpharm.2019.06.022 · 2019 · External reference
Nanotechnology approaches for ocular drug delivery
10.4103/0974-9233.106384 · 2013 · External reference
Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration
10.1002/jps.21079 · 2008 · External reference
Dendrimers as a promising tool in ocular therapeutics: Latest advances and perspectives
10.1016/j.ijpharm.2016.07.031 · 2016 · External reference
Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
10.1038/nbt995 · 2004 · External reference
Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration
10.1016/j.biomaterials.2011.10.010 · 2012 · External reference
Acetazolamide encapsulated dendritic nano-architectures for effective glaucoma management in rabbits
10.1016/j.ijpharm.2013.11.043 · 2014 · External reference
10.3390/nano10050847
10.3390/nano10050847 · External reference
Nanocrystal for ocular drug delivery: Hope or hype
2016 · External reference
Recent advances in nanocrystal-based technologies applied for ocular drug delivery
10.1080/17425247.2024.2311119 · 2024 · External reference
Application of Drug Nanocrystal Technologies on Oral Drug Delivery of Poorly Soluble Drugs
10.1007/s11095-012-0889-z · 2013 · External reference
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10.1016/j.ijpharm.2014.03.048 · 2014 · External reference
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10.1021/acsanm.2c01715 · 2022 · External reference
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10.1016/j.ijpharm.2025.126272 · 2025 · External reference
Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds
10.1021/acs.jafc.1c06747 · 2022 · External reference
Preparation and in-vitro evaluation of fluorometholone cubosomes for ocular delivery
2023 · External reference
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10.1016/j.drudis.2016.01.004 · 2016 · External reference
Novel cubosome based system for ocular delivery of acetazolamide
10.1080/10717544.2021.1989090 · 2021 · External reference
Cubosomes as Targeted Drug Delivery Systems—A Biopharmaceutical Approach
10.2174/1570163811666140505125923 · 2014 · External reference
Formulation and Evaluation of Moxifloxacin Hydrochloride Loaded Cubosomal Gel for Ocular Delivery
10.22270/jddt.v14i3.6464 · 2024 · External reference
Emulsions and microemulsions for ocular drug delivery
10.1016/s1773-2247(11)50010-3 · 2011 · External reference
Emulsion types, stability mechanisms and rheology: A review
2018 · External reference
10.3390/colloids7010016
10.3390/colloids7010016 · External reference
Therapeutic challenges in ocular delivery of lipid based emulsion
2018 · External reference
Nanoemulsions as Ophthalmic Drug Delivery Systems
10.4274/tjps.galenos.2020.59319 · 2021 · External reference
Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate
10.1016/j.ijpharm.2005.05.036 · 2005 · External reference
Ocular emulsions and dry eye: A case study of a non-biological complex drug product delivered to a complex organ to treat a complex disease
10.5639/gabij.2017.0601.004 · 2017 · External reference
10.3390/ph14010068
10.3390/ph14010068 · External reference
10.1016/b978-0-323-91864-0.00007-3
10.1016/b978-0-323-91864-0.00007-3 · External reference
Spanlastics—A novel nanovesicular carrier system for ocular delivery
10.1016/j.ijpharm.2011.04.027 · 2011 · External reference
Biological properties of extracellular vesicles and their physiological functions
10.3402/jev.v4.27066 · 2015 · External reference
Applying extracellular vesicles based therapeutics in clinical trials—An ISEV position paper
10.3402/jev.v4.30087 · 2015 · External reference
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10.1039/d5pm00097a · 2025 · External reference
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10.1016/j.jconrel.2024.06.029 · 2024 · External reference
Extracellular vesicles in dry eye disease and Sjögren’s syndrome: A systematic review on their diagnostic and therapeutic role
10.1016/j.survophthal.2025.01.003 · 2025 · External reference
Platelet-derived extracellular vesicle drug delivery system loaded with kaempferol for treating corneal neovascularization
10.1016/j.biomaterials.2025.123205 · 2025 · External reference
Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy
10.1021/nn506599f · 2015 · External reference
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10.1021/acs.molpharmaceut.6b00488 · 2016 · External reference
10.3390/pharmaceutics15030951
10.3390/pharmaceutics15030951 · External reference
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
1997 · External reference
Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
10.1211/jpp.57.12.0005 · 2005 · External reference
Toxic Endothelial Cell Destruction of the Cornea After Routine Extracapsular Cataract Surgery
10.1001/archopht.1990.01070100077038 · ExternalCitation · doi-reference
Psychiatric manifestations of homocystinuria due to cystathionine β-synthase deficiency: Prevalence, natural history, and relationship to neurologic impairment and vitamin B6 -responsiveness
10.1002/ajmg.1320260427 · ExternalCitation · doi-reference
Late-onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance
10.1002/ajmg.a.31932 · ExternalCitation · doi-reference
Clinical Evaluation and Management of Thrombotic Microangiopathy
10.1002/art.42681 · ExternalCitation · doi-reference
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10.1002/humu.20131 · ExternalCitation · doi-reference
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10.1002/jps.23417 · ExternalCitation · doi-reference
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10.1002/mgg3.1221 · ExternalCitation · doi-reference
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10.1002/mgg3.1838 · ExternalCitation · doi-reference
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10.1002/ped4.12047 · ExternalCitation · doi-reference
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10.1002/smll.201303433 · ExternalCitation · doi-reference
10.1007/978-1-62703-475-3
10.1007/978-1-62703-475-3 · ExternalCitation · doi-reference
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10.1007/s00417-004-0961-4 · ExternalCitation · doi-reference
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10.1007/s00467-018-3941-3 · ExternalCitation · doi-reference
Cobalamin C defect: Natural history, pathophysiology, and treatment
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Hyperammonemia
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10.1016/b978-0-323-46143-6.00013-0
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10.1016/b978-0-323-91864-0.00007-3
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10.1016/b978-0-443-15264-1.00019-1
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10.1016/j.jaapos.2008.06.008 · ExternalCitation · doi-reference
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10.1016/j.msec.2010.10.019 · ExternalCitation · doi-reference
Cobalamin disorder CblC presenting with hemolytic uremic syndrome and pulmonary hypertension
10.1016/j.nefro.2017.03.019 · ExternalCitation · doi-reference
Ranibizumab versus Verteporfin Photodynamic Therapy for Neovascular Age-Related Macular Degeneration: Two-Year Results of the ANCHOR Study
10.1016/j.ophtha.2008.10.018 · ExternalCitation · doi-reference
Long-term Visual Outcome of Methylmalonic Aciduria and Homocystinuria, Cobalamin C Type
10.1016/j.ophtha.2013.08.034 · ExternalCitation · doi-reference
Ophthalmic Manifestations and Long-Term Visual Outcomes in Patients with Cobalamin C Deficiency
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Combined Methylmalonic Aciduria and Homocystinuria cblC Type of a Taiwanese Infant With c.609G>A and c.567dupT Mutations in the MMACHC Gene
10.1016/j.pedneo.2011.05.006 · ExternalCitation · doi-reference
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10.1016/j.preteyeres.2006.10.003 · ExternalCitation · doi-reference
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Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
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10.1016/j.ymgme.2009.07.017 · ExternalCitation · doi-reference
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Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC)
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