Research graph
References from Studies on the Phytochemical Variability of Xanthine Alkaloids from the Leaves of Ilex guayusa Loes. in the Amazon Region of Ecuador. Local targets link to admitted publications; unresolved targets remain external evidence.
Evolution of Amazonian biodiversity: A review
10.1590/1809-4392202103601 · 2024 · External reference
Modelling the known and unknown plant biodiversity of the Amazon Basin
10.1111/j.1365-2699.2007.01737.x · 2007 · External reference
Amazon plant diversity revealed by a taxonomically verified species list
10.1073/pnas.1706756114 · 2017 · External reference
10.3390/land11020221
10.3390/land11020221 · External reference
Geodiversity assessment to regional scale: Ecuador as a case study
10.1016/j.envsci.2022.06.009 · 2022 · External reference
Unresolved reference
External reference
10.3390/molecules30132837
10.3390/molecules30132837 · External reference
10.1371/journal.pone.0349762
10.1371/journal.pone.0349762 · External reference
LC-MS Metabolomics and Chemotaxonomy of Caffeine-Containing Holly (Ilex) Species and Related Taxa in the Aquifoliaceae
10.1021/acs.jafc.8b07168 · 2019 · External reference
Caffeine as a psychomotor stimulant: Mechanism of action
10.1007/s00018-003-3269-3 · 2004 · External reference
10.3390/ijms23031862
10.3390/ijms23031862 · External reference
10.3389/fnbeh.2025.1547970
10.3389/fnbeh.2025.1547970 · External reference
Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults
10.1002/hbm.25949 · 2022 · External reference
10.3390/nu15041042
10.3390/nu15041042 · External reference
Subcritical water extraction of Ilex guayusa for regulatory-compliant neuro-metabolic functional ingredients
10.1016/j.scp.2026.102338 · 2026 · External reference
Formulation and evaluation of a functional beverage from Ilex guayusa Loes. (Aquifoliaceae): Chemical analysis, antioxidant activity, and sensory acceptance
10.1016/j.foohum.2026.101075 · 2026 · External reference
A Comprehensive Review on Pharmacological Potentials of Caffeine
10.31069/japsr.v6i3.04 · 2023 · External reference
Prevalence of caffeine consumers, daily caffeine consumption, and factors associated with caffeine use among active duty United States military personnel
10.1186/s12937-022-00774-0 · 2022 · External reference
Health benefits and mechanisms of theobromine
10.1016/j.jff.2024.106126 · 2024 · External reference
Theobromine as a multi-target therapeutic agent: Analgesic, anti-inflammatory, and anti-arthritic potential with network pharmacology insights
10.1016/j.pharma.2025.04.007 · 2025 · External reference
Association between Dietary Theobromine and Cognitive Function in a Representative American Population: A Cross-Sectional Study
10.14283/jpad.2022.39 · 2022 · External reference
Comparative Antioxidant and Anti-cholinesterase Properties of Catechin, Caffeine and Theobromine
10.4314/njbmb.v39i2.8 · 2024 · External reference
Theophylline for the management of respiratory disorders in adults in the 21st century: A scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network
10.1002/phar.2843 · 2023 · External reference
Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague–Dawley Rats
10.1089/jmf.2024.k.0275 · 2025 · External reference
Chemodiversity and Biological Properties of Endangered Medicinal Herb Trillium govanianum along Himalayan Elevation Gradient
10.1002/cbdv.202500471 · 2025 · External reference
10.3389/fpls.2022.973197
10.3389/fpls.2022.973197 · External reference
Influence of altitudinal variation on the chemodiversity and in-vitro antioxidant potential of essential oils of Micromeria biflora (Buch.-Ham. ex D. Don) Benth. from Uttarakhand, India
10.1016/j.bse.2025.105019 · 2025 · External reference
“Somos Amazonia,” a New Inter-indigenous Identity in the Ecuadorian Amazonia: Beyond a Tacit Jus Aplidia of Ecological Origin?
10.19053/01233769.8983 · 2020 · External reference
10.3390/land12122141
10.3390/land12122141 · External reference
Caracterización fitoquímica de la especie Ilex guayusa Loes. y elaboración de un prototipo de fitofármaco de interés comercial
10.17163/lgr.n6.2007.01 · 2007 · External reference
Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products
10.1093/chromsci/46.2.144 · 2008 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Antioxidant and Anti-Inflammatory Properties of Ilex guayusa Tea Preparations: A Comparison to Camellia sinensis Teas
10.1039/c7fo01067b · 2017 · External reference
Ritualistic Use of the Holly Ilex guayusa by Amazonian Jívaro Indians
10.1016/0378-8741(91)90156-8 · 1991 · External reference
Biological Activity of Extracts from Guayusa Leaves (Ilex guayusa Loes.) Obtained by Supercritical CO2 and Ethanol as Cosolvent
10.1016/j.supflu.2019.104543 · 2019 · External reference
Influence of Abiotic Stress Signals on Secondary Metabolites in Plants
10.4161/psb.6.11.17613 · 2011 · External reference
10.3389/fpls.2019.00939
10.3389/fpls.2019.00939 · External reference
Exploring variability in the methylxanthine content within Ilex guayusa Loes: Impact of soil conditions, age, and sunlight exposure
2025 · External reference
WorldClim 2: New 1-km Spatial Resolution Climate Surfaces for Global Land Areas
10.1002/joc.5086 · 2017 · External reference
Compound specific trends of chemical defences in Ficus along an elevational gradient reflect a complex selective landscape
10.1007/s10886-020-01173-7 · 2020 · External reference
Comparison of bean biochemical composition and beverage quality of Arabica hybrids involving Sudanese-Ethiopian origins with traditional varieties at various elevations in Central America
10.1093/treephys/26.9.1239 · 2006 · External reference
Influence of environmental factors, wet processing and their interactions on the biochemical composition of green Arabica coffee beans
10.1016/j.foodchem.2009.05.048 · 2010 · External reference
Tackling intraspecific genetic structure in distribution models better reflects species geographical range
10.1002/ece3.2010 · 2016 · External reference
10.3390/d13050182
10.3390/d13050182 · External reference
10.3389/fpls.2020.00969
10.3389/fpls.2020.00969 · External reference
10.3390/plants11070976
10.3390/plants11070976 · External reference
The Dilemma of Plants: To Grow or Defend
10.1086/417659 · 1992 · External reference
Out of the Quagmire of Plant Defense Hypotheses
10.1086/367580 · 2003 · External reference
Characteristics of Soil Nutrients, Heavy Metals and Tea Quality in Different Intercropping Patterns
10.1007/s10457-019-00463-8 · 2020 · External reference
The Influence of Leaf Age on Methylxanthines, Total Phenolic Content, and Free Radical Scavenging Capacity of Ilex paraguariensis Aqueous Extracts
2015 · External reference
Untargeted Metabolic Profiling Reveals Geography as the Strongest Predictor of Metabolic Phenotypes of a Cosmopolitan Weed
10.1002/ece3.4195 · 2018 · External reference
Population Genetic Variation Characterization of the Boreal Tree Acer ginnala in Northern China
10.1038/s41598-020-70444-w · 2020 · External reference
Genotype-by-Environment Interaction and Plasticity: Exploring Genomic Responses of Plants to the Abiotic Environment
10.1146/annurev-ecolsys-110512-135806 · 2013 · External reference
Effect of Light Intensity and Processing Conditions on Bioactive Compounds in Mate Extracted from Yerba Mate (Ilex paraguariensis A. St.-Hil.)
10.1016/j.foodchem.2018.06.028 · 2018 · External reference
Elemental composition and physicochemical properties postharvest of the yerba mate produced in different cultivation systems and environments
10.1038/s41598-026-46932-w · 2026 · External reference
10.3390/mol2net-02-03868
10.3390/mol2net-02-03868 · External reference
Chemodiversity and Biological Properties of Endangered Medicinal Herb Trillium govanianum along Himalayan Elevation Gradient
10.1002/cbdv.202500471 · ExternalCitation · doi-reference
Tackling intraspecific genetic structure in distribution models better reflects species geographical range
10.1002/ece3.2010 · ExternalCitation · doi-reference
Untargeted Metabolic Profiling Reveals Geography as the Strongest Predictor of Metabolic Phenotypes of a Cosmopolitan Weed
10.1002/ece3.4195 · ExternalCitation · doi-reference
Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults
10.1002/hbm.25949 · ExternalCitation · doi-reference
WorldClim 2: New 1-km Spatial Resolution Climate Surfaces for Global Land Areas
10.1002/joc.5086 · ExternalCitation · doi-reference
Theophylline for the management of respiratory disorders in adults in the 21st century: A scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network
10.1002/phar.2843 · ExternalCitation · doi-reference
Caffeine as a psychomotor stimulant: Mechanism of action
10.1007/s00018-003-3269-3 · ExternalCitation · doi-reference
Characteristics of Soil Nutrients, Heavy Metals and Tea Quality in Different Intercropping Patterns
10.1007/s10457-019-00463-8 · ExternalCitation · doi-reference
Compound specific trends of chemical defences in Ficus along an elevational gradient reflect a complex selective landscape
10.1007/s10886-020-01173-7 · ExternalCitation · doi-reference
Ritualistic Use of the Holly Ilex guayusa by Amazonian Jívaro Indians
10.1016/0378-8741(91)90156-8 · ExternalCitation · doi-reference
Influence of altitudinal variation on the chemodiversity and in-vitro antioxidant potential of essential oils of Micromeria biflora (Buch.-Ham. ex D. Don) Benth. from Uttarakhand, India
10.1016/j.bse.2025.105019 · ExternalCitation · doi-reference
Geodiversity assessment to regional scale: Ecuador as a case study
10.1016/j.envsci.2022.06.009 · ExternalCitation · doi-reference
Influence of environmental factors, wet processing and their interactions on the biochemical composition of green Arabica coffee beans
10.1016/j.foodchem.2009.05.048 · ExternalCitation · doi-reference
Effect of Light Intensity and Processing Conditions on Bioactive Compounds in Mate Extracted from Yerba Mate (Ilex paraguariensis A. St.-Hil.)
10.1016/j.foodchem.2018.06.028 · ExternalCitation · doi-reference
Formulation and evaluation of a functional beverage from Ilex guayusa Loes. (Aquifoliaceae): Chemical analysis, antioxidant activity, and sensory acceptance
10.1016/j.foohum.2026.101075 · ExternalCitation · doi-reference
Health benefits and mechanisms of theobromine
10.1016/j.jff.2024.106126 · ExternalCitation · doi-reference
Theobromine as a multi-target therapeutic agent: Analgesic, anti-inflammatory, and anti-arthritic potential with network pharmacology insights
10.1016/j.pharma.2025.04.007 · ExternalCitation · doi-reference
Subcritical water extraction of Ilex guayusa for regulatory-compliant neuro-metabolic functional ingredients
10.1016/j.scp.2026.102338 · ExternalCitation · doi-reference
Biological Activity of Extracts from Guayusa Leaves (Ilex guayusa Loes.) Obtained by Supercritical CO2 and Ethanol as Cosolvent
10.1016/j.supflu.2019.104543 · ExternalCitation · doi-reference
LC-MS Metabolomics and Chemotaxonomy of Caffeine-Containing Holly (Ilex) Species and Related Taxa in the Aquifoliaceae
10.1021/acs.jafc.8b07168 · ExternalCitation · doi-reference
Population Genetic Variation Characterization of the Boreal Tree Acer ginnala in Northern China
10.1038/s41598-020-70444-w · ExternalCitation · doi-reference
Elemental composition and physicochemical properties postharvest of the yerba mate produced in different cultivation systems and environments
10.1038/s41598-026-46932-w · ExternalCitation · doi-reference
Antioxidant and Anti-Inflammatory Properties of Ilex guayusa Tea Preparations: A Comparison to Camellia sinensis Teas
10.1039/c7fo01067b · ExternalCitation · doi-reference
Amazon plant diversity revealed by a taxonomically verified species list
10.1073/pnas.1706756114 · ExternalCitation · doi-reference
Out of the Quagmire of Plant Defense Hypotheses
10.1086/367580 · ExternalCitation · doi-reference
The Dilemma of Plants: To Grow or Defend
10.1086/417659 · ExternalCitation · doi-reference
Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague–Dawley Rats
10.1089/jmf.2024.k.0275 · ExternalCitation · doi-reference
Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products
10.1093/chromsci/46.2.144 · ExternalCitation · doi-reference
Comparison of bean biochemical composition and beverage quality of Arabica hybrids involving Sudanese-Ethiopian origins with traditional varieties at various elevations in Central America
10.1093/treephys/26.9.1239 · ExternalCitation · doi-reference
Modelling the known and unknown plant biodiversity of the Amazon Basin
10.1111/j.1365-2699.2007.01737.x · ExternalCitation · doi-reference
Genotype-by-Environment Interaction and Plasticity: Exploring Genomic Responses of Plants to the Abiotic Environment
10.1146/annurev-ecolsys-110512-135806 · ExternalCitation · doi-reference
Prevalence of caffeine consumers, daily caffeine consumption, and factors associated with caffeine use among active duty United States military personnel
10.1186/s12937-022-00774-0 · ExternalCitation · doi-reference
10.1371/journal.pone.0349762
10.1371/journal.pone.0349762 · ExternalCitation · doi-reference
Association between Dietary Theobromine and Cognitive Function in a Representative American Population: A Cross-Sectional Study
10.14283/jpad.2022.39 · ExternalCitation · doi-reference
Evolution of Amazonian biodiversity: A review
10.1590/1809-4392202103601 · ExternalCitation · doi-reference
Caracterización fitoquímica de la especie Ilex guayusa Loes. y elaboración de un prototipo de fitofármaco de interés comercial
10.17163/lgr.n6.2007.01 · ExternalCitation · doi-reference
“Somos Amazonia,” a New Inter-indigenous Identity in the Ecuadorian Amazonia: Beyond a Tacit Jus Aplidia of Ecological Origin?
10.19053/01233769.8983 · ExternalCitation · doi-reference
A Comprehensive Review on Pharmacological Potentials of Caffeine
10.31069/japsr.v6i3.04 · ExternalCitation · doi-reference
10.3389/fnbeh.2025.1547970
10.3389/fnbeh.2025.1547970 · ExternalCitation · doi-reference
10.3389/fpls.2019.00939
10.3389/fpls.2019.00939 · ExternalCitation · doi-reference
10.3389/fpls.2020.00969
10.3389/fpls.2020.00969 · ExternalCitation · doi-reference
10.3389/fpls.2022.973197
10.3389/fpls.2022.973197 · ExternalCitation · doi-reference
10.3390/d13050182
10.3390/d13050182 · ExternalCitation · doi-reference
10.3390/ijms23031862
10.3390/ijms23031862 · ExternalCitation · doi-reference
10.3390/land11020221
10.3390/land11020221 · ExternalCitation · doi-reference
10.3390/land12122141
10.3390/land12122141 · ExternalCitation · doi-reference
10.3390/mol2net-02-03868
10.3390/mol2net-02-03868 · ExternalCitation · doi-reference
10.3390/molecules30132837
10.3390/molecules30132837 · ExternalCitation · doi-reference
10.3390/nu15041042
10.3390/nu15041042 · ExternalCitation · doi-reference
10.3390/plants11070976
10.3390/plants11070976 · ExternalCitation · doi-reference
Influence of Abiotic Stress Signals on Secondary Metabolites in Plants
10.4161/psb.6.11.17613 · ExternalCitation · doi-reference
Comparative Antioxidant and Anti-cholinesterase Properties of Catechin, Caffeine and Theobromine
10.4314/njbmb.v39i2.8 · ExternalCitation · doi-reference
