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References from Modulation of DNA Damage by Epstein–Barr Virus (EBV). Local targets link to admitted publications; unresolved targets remain external evidence.
Epstein-Barr Virus Turns 50
10.1126/science.1252786 · 2014 · External reference
Epstein-Barr Virus
2021 · External reference
Epstein-Barr virus: Biology and clinical disease
10.1016/j.cell.2022.08.026 · 2022 · External reference
Estimating the global burden of Epstein–Barr virus-related cancers
2021 · External reference
Epstein–Barr virus as a leading cause of multiple sclerosis: Mechanisms and implications
2023 · External reference
10.3389/fimmu.2020.623944
10.3389/fimmu.2020.623944 · External reference
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
10.1126/scitranslmed.ady0210 · 2025 · External reference
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
10.1126/science.abj8222 · 2022 · External reference
Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule
10.1093/emboj/16.20.6131 · 1997 · External reference
Regulation of the latent-lytic switch in Epstein–Barr virus
10.1016/j.semcancer.2014.01.002 · 2014 · External reference
10.1101/2024.06.14.598975
10.1101/2024.06.14.598975 · External reference
Latency and lytic replication in Epstein–Barr virus-associated oncogenesis
10.1038/s41579-019-0249-7 · 2019 · External reference
10.1007/978-3-319-22822-8
10.1007/978-3-319-22822-8 · External reference
Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model
10.1128/jvi.79.22.13993-14003.2005 · 2005 · External reference
The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV
10.1002/ijc.2910080312 · 1971 · External reference
10.3389/fimmu.2023.1331730
10.3389/fimmu.2023.1331730 · External reference
Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice
10.1073/pnas.95.20.11963 · 1998 · External reference
Hallmarks of cancer—Then and now, and beyond
10.1016/j.cell.2025.12.049 · 2026 · External reference
Global burden of deaths from Epstein-Barr virus attributable malignancies 1990–2010
10.1186/1750-9378-9-38 · 2014 · External reference
Causes and consequences of DNA single-strand breaks
10.1016/j.tibs.2023.11.001 · 2024 · External reference
DNA double-strand breaks: Their cellular and clinical impact
10.1038/sj.onc.1210868 · 2007 · External reference
Mechanisms and Consequences of Double-strand DNA Break Formation in Chromatin
10.1002/jcp.25048 · 2016 · External reference
DNA damage repair: Historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
10.1038/s41392-021-00648-7 · 2021 · External reference
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
10.1038/s41392-020-0150-x · 2020 · External reference
Endogenous DNA Damage as a Source of Genomic Instability in Cancer
10.1016/j.cell.2017.01.002 · 2017 · External reference
Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair
10.1101/cshperspect.a016428 · 2014 · External reference
R-loops as cellular regulators and genomic threats
10.1016/j.molcel.2019.01.024 · 2019 · External reference
Structure-forming repeats and their impact on genome stability
2020 · External reference
Replication stress and cancer
10.1038/nrc3916 · 2015 · External reference
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
10.1016/j.cell.2011.03.044 · 2011 · External reference
V(D)J Recombination: Mechanism, Errors, and Fidelity
10.1128/microbiolspec.mdna3-0041-2014 · 2014 · External reference
Single-strand break repair and genetic disease
10.1038/nrg2380 · 2008 · External reference
Oxidative DNA damage: Mechanisms, mutation, and disease
10.1096/fj.02-0752rev · 2003 · External reference
DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
10.1101/cshperspect.a012559 · 2013 · External reference
Oxidative DNA damage and disease: Induction, repair and significance
10.1016/j.mrrev.2003.11.001 · 2004 · External reference
Withaferin A inhibits EBV-driven lymphomagenesis through multiple mechanisms, including EBNA1 degradation
10.1182/blood.2025029771 · 2026 · External reference
DNA Adducts with Lipid Peroxidation Products
10.1074/jbc.r700051200 · 2008 · External reference
Mechanisms and functions of DNA mismatch repair
10.1038/cr.2007.115 · 2007 · External reference
Regulation of AID, the B-cell genome mutator
10.1101/gad.200014.112 · 2013 · External reference
Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory
10.1016/j.immuni.2016.01.011 · 2016 · External reference
The DNA Damage Response: Ten Years After
10.1016/j.molcel.2007.11.015 · 2007 · External reference
DNA Damage Sensing by the ATM and ATR Kinases
10.1101/cshperspect.a012716 · 2013 · External reference
Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle
10.1016/j.cels.2017.09.015 · 2017 · External reference
DNA damage-induced cell death by apoptosis
10.1016/j.molmed.2006.07.007 · 2006 · External reference
DNA damage induces p53-independent apoptosis through ribosome stalling
10.1126/science.adh7950 · 2024 · External reference
The DNA-damage response in human biology and disease
10.1038/nature08467 · 2009 · External reference
DNA repair and the contribution to chemotherapy resistance
10.1186/s13073-025-01488-8 · 2025 · External reference
10.3390/cancers12082051
10.3390/cancers12082051 · External reference
Non-homologous DNA end joining and alternative pathways to double-strand break repair
10.1038/nrm.2017.48 · 2017 · External reference
The endless tale of non-homologous end-joining
10.1038/cr.2008.3 · 2008 · External reference
Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
2021 · External reference
Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine
10.1073/pnas.87.2.686 · 1990 · External reference
Structure and mechanism for DNA lesion recognition
10.1038/cr.2008.175 · 2007 · External reference
Translesion DNA Polymerases
10.1101/cshperspect.a010363 · 2013 · External reference
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
10.1016/j.cell.2007.06.013 · 2007 · External reference
Cellular senescence and tumor suppressor gene p16
10.1002/ijc.27316 · 2011 · External reference
Nucleotide Excision Repair in Eukaryotes
2013 · External reference
An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells
10.1016/j.chom.2010.11.004 · 2010 · External reference
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation
10.1016/j.cmet.2019.06.003 · 2019 · External reference
Metabolic stress is a barrier to Epstein–Barr virus-mediated B-cell immortalization
10.1073/pnas.1517141113 · 2016 · External reference
First Days in the Life of Naive Human B Lymphocytes Infected with Epstein-Barr Virus
10.1128/mbio.01723-19 · 2019 · External reference
Limited nucleotide pools restrict Epstein–Barr virus-mediated B-cell immortalization
10.1038/oncsis.2017.46 · 2017 · External reference
Oxidative stress enables Epstein–Barr virus-induced B-cell transformation by posttranscriptional regulation of viral and cellular growth-promoting factors
2015 · External reference
The Latent Membrane Protein 1 (LMP1)
2015 · External reference
10.3389/fonc.2018.00015
10.3389/fonc.2018.00015 · External reference
The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization
2019 · External reference
Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas
10.1073/pnas.2022495118 · 2021 · External reference
Epstein–Barr virus latency programs dynamically sensitize B cells to ferroptosis
10.1073/pnas.2118300119 · 2022 · External reference
Epstein–Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis
2025 · External reference
10.1371/journal.ppat.1008030
10.1371/journal.ppat.1008030 · External reference
10.1371/journal.ppat.1007394
10.1371/journal.ppat.1007394 · External reference
Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy
10.1038/onc.2014.32 · 2014 · External reference
Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-κB Signaling Pathways
10.1128/jvi.02168-16 · 2017 · External reference
10.1007/978-3-319-22834-1
10.1007/978-3-319-22834-1 · External reference
Epstein–Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci
10.1101/gr.264705.120 · 2021 · External reference
The Proto-Oncogene c-myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2
10.1128/jvi.73.5.4481-4484.1999 · 1999 · External reference
Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth
10.1073/pnas.1108892108 · 2011 · External reference
c-Myc and Cancer Metabolism
10.1158/1078-0432.ccr-12-0977 · 2012 · External reference
10.1371/journal.ppat.1010920
10.1371/journal.ppat.1010920 · External reference
Reactive oxygen signaling and MAPK activation distinguish Epstein–Barr Virus (EBV)-positive versus EBV-negative Burkitt’s lymphoma
10.1073/pnas.0408381102 · 2005 · External reference
Epstein–Barr virus promotes genomic instability in Burkitt’s lymphoma
10.1038/sj.onc.1210324 · 2007 · External reference
The Epstein–Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species
10.1073/pnas.0810619106 · 2009 · External reference
Changes in the Nasopharyngeal Carcinoma Nuclear Proteome Induced by the EBNA1 Protein of Epstein-Barr Virus Reveal Potential Roles for EBNA1 in Metastasis and Oxidative Stress Responses
10.1128/jvi.05648-11 · 2012 · External reference
Three Epstein–Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints
10.1038/onc.2009.258 · 2009 · External reference
10.1371/journal.ppat.1009208
10.1371/journal.ppat.1009208 · External reference
Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival
10.1128/mbio.01530-21 · 2021 · External reference
Epstein-Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection
10.1073/pnas.1901314116 · 2019 · External reference
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma
10.1073/pnas.1903991116 · 2019 · External reference
10.3389/fimmu.2023.1210818
10.3389/fimmu.2023.1210818 · External reference
The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice
10.1016/s1535-6108(02)00236-2 · 2003 · External reference
Excised DNA circles from V(D)J recombination promote relapsed leukaemia
10.1038/s41586-025-09372-6 · 2025 · External reference
RAG Represents a Widespread Threat to the Lymphocyte Genome
10.1016/j.cell.2015.07.009 · 2015 · External reference
Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus
10.3390/v5010226 · 2013 · External reference
Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2
10.1128/jvi.69.12.8155-8158.1995 · 1995 · External reference
Peripheral Blood Lymphocytes Express Recombination-Activating Genes 1 and 2 during Epstein-Barr Virus–Induced Infectious Mononucleosis
10.1086/423211 · 2004 · External reference
Expression of recombination activating genes (RAG-1 and RAG-2) in Epstein-Barr virus-bearing B cells
10.1182/blood.v85.5.1289.bloodjournal8551289 · 1995 · External reference
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
10.1038/ni.1612 · 2008 · External reference
Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A
10.1128/jvi.00983-06 · 2006 · External reference
Germinal centres: Role in B-cell physiology and malignancy
10.1038/nri2217 · 2008 · External reference
Rescue of “crippled” germinal center B cells from apoptosis by Epstein-Barr virus
10.1182/blood-2005-06-2341 · 2005 · External reference
Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
10.1128/mbio.02444-23 · 2024 · External reference
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
10.1038/nature01760 · 2003 · External reference
AID and Somatic Hypermutation
10.1016/s0065-2776(10)05006-6 · 2010 · External reference
A licensing step links AID to transcription elongation for mutagenesis in B cells
10.1038/s41467-018-03387-6 · 2018 · External reference
Two levels of protection for the B cell genome during somatic hypermutation
10.1038/nature06547 · 2008 · External reference
Uracil-DNA glycosylases—Structural and functional perspectives on an essential family of DNA repair enzymes
10.1002/pro.2554 · 2014 · External reference
Base Excision Repair
10.1101/cshperspect.a012583 · 2013 · External reference
Characterization of the Uracil-DNA Glycosylase Activity of Epstein-Barr Virus BKRF3 and Its Role in Lytic Viral DNA Replication
2006 · External reference
10.1371/journal.ppat.1011252
10.1371/journal.ppat.1011252 · External reference
Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations
10.1016/j.molimm.2006.03.018 · 2007 · External reference
Epstein–Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma
10.1002/eji.202249820 · 2022 · External reference
Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells
10.1084/jem.20160120 · 2016 · External reference
EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching1
10.4049/jimmunol.171.10.5215 · 2003 · External reference
Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth
10.1182/blood-2006-05-021303 · 2006 · External reference
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
10.1016/j.cell.2004.08.006 · 2004 · External reference
Initiation of Epstein-Barr Virus Lytic Replication Requires Transcription and the Formation of a Stable RNA-DNA Hybrid Molecule at OriLyt
10.1128/jvi.02175-10 · 2011 · External reference
10.3390/microorganisms8111824
10.3390/microorganisms8111824 · External reference
10.1371/journal.ppat.1007179
10.1371/journal.ppat.1007179 · External reference
Heterogeneous Expression of Epstein-Barr Virus Latent Proteins in Endemic Burkitt’s Lymphoma
10.1182/blood.v86.2.659.bloodjournal862659 · 1995 · External reference
Epstein–Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression
10.1093/nar/gkv212 · 2015 · External reference
Interaction sites of the Epstein–Barr virus Zta transcription factor with the host genome in epithelial cells
10.1099/acmi.0.000282 · 2021 · External reference
Epstein-Barr virus inactivates the transcriptome and disrupts the chromatin architecture of its host cell in the first phase of lytic reactivation
10.1093/nar/gkab099 · 2021 · External reference
Reconstructing EBV reactivation and DNA damage response kinetics in morphologic pseudotime
10.1073/pnas.2609598123 · 2026 · External reference
10.1371/journal.pone.0126088
10.1371/journal.pone.0126088 · External reference
The “Bridge” in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection
10.1128/jvi.00309-12 · 2012 · External reference
The Epstein-Barr Virus Alkaline Exonuclease BGLF5 Serves Pleiotropic Functions in Virus Replication
10.1128/jvi.00170-09 · 2009 · External reference
Epstein–Barr Virus DNase (BGLF5) induces genomic instability in human epithelial cells
10.1093/nar/gkp1169 · 2010 · External reference
Epstein-Barr virus BALF3 mediates genomic instability and progressive malignancy in nasopharyngeal carcinoma
10.18632/oncotarget.2323 · 2014 · External reference
Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats
10.1038/s41586-023-05923-x · 2023 · External reference
Activators of the Epstein-Barr Virus Lytic Program Concomitantly Induce Apoptosis, but Lytic Gene Expression Protects from Cell Death
10.1128/jvi.75.5.2400-2410.2001 · 2001 · External reference
EBNA3C Attenuates the Function of p53 through Interaction with Inhibitor of Growth Family Proteins 4 and 5
2010 · External reference
Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene
10.1128/jvi.70.12.8653-8659.1996 · 1996 · External reference
Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression
10.1128/jvi.01022-18 · 2018 · External reference
Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma
10.1182/blood-2013-07-517649 · 2014 · External reference
10.1371/journal.pbio.0030404
10.1371/journal.pbio.0030404 · External reference
An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival
10.1084/jem.20072581 · 2008 · External reference
NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma
10.1073/pnas.2535550123 · 2026 · External reference
Role of NEK2 in tumorigenesis and tumor progression
10.1016/j.molmed.2024.07.013 · 2025 · External reference
Human oncogenic herpesvirus latency proteins activate NEK2 to promote chromosomal instability and tumorigenesis
10.1073/pnas.2535073123 · 2026 · External reference
The Cellular Ataxia Telangiectasia-Mutated Kinase Promotes Epstein-Barr Virus Lytic Reactivation in Response to Multiple Different Types of Lytic Reactivation-Inducing Stimuli
10.1128/jvi.01850-12 · 2012 · External reference
Epstein-Barr Virus Lytic Replication Elicits ATM Checkpoint Signal Transduction While Providing an S-phase-like Cellular Environment
10.1074/jbc.m411405200 · 2005 · External reference
A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein
10.1128/jvi.00262-18 · 2018 · External reference
Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses
10.1073/pnas.2203782119 · 2022 · External reference
The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD
10.1128/jvi.01070-19 · 2019 · External reference
Epstein-Barr Virus Protein Kinase BGLF4 Is a Virion Tegument Protein That Dissociates from Virions in a Phosphorylation-Dependent Process and Phosphorylates the Viral Immediate-Early Protein BZLF1
10.1128/jvi.02674-05 · 2006 · External reference
Phosphorylation of MCM4 at Sites Inactivating DNA Helicase Activity of the MCM4-MCM6-MCM7 Complex during Epstein-Barr Virus Productive Replication
10.1128/jvi.00678-06 · 2006 · External reference
Epstein-Barr Virus BGLF4 Kinase Induces Premature Chromosome Condensation through Activation of Condensin and Topoisomerase II
10.1128/jvi.00120-07 · 2007 · External reference
10.1371/journal.pone.0039217
10.1371/journal.pone.0039217 · External reference
10.1371/journal.ppat.1013009
10.1371/journal.ppat.1013009 · External reference
DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions
10.1093/narcan/zcaa028 · 2020 · External reference
DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells
10.1093/nar/gkac1116 · 2022 · External reference
Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase η Recruitment to DNA Damage Sites
10.1128/jvi.00588-12 · 2012 · External reference
10.1371/journal.ppat.1003960
10.1371/journal.ppat.1003960 · External reference
The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1
10.1128/jvi.00600-17 · 2017 · External reference
The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity
10.1128/jvi.00536-14 · 2014 · External reference
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells
10.1182/blood-2006-05-020545 · 2007 · External reference
The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma
10.1002/path.2487 · 2009 · External reference
EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma
10.1002/path.5018 · 2018 · External reference
10.1371/journal.ppat.1007221
10.1371/journal.ppat.1007221 · External reference
The ATM/ATR Signaling Effector Chk2 Is Targeted by Epstein-Barr Virus Nuclear Antigen 3C To Release the G2/M Cell Cycle Block
10.1128/jvi.00053-07 · 2007 · External reference
The EBNA- 3 gene family proteins disrupt the G2/M checkpoint
2003 · External reference
10.1371/journal.pbio.2001992
10.1371/journal.pbio.2001992 · External reference
Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression
10.1073/pnas.1019599108 · 2011 · External reference
10.1371/journal.ppat.1000951
10.1371/journal.ppat.1000951 · External reference
LMP1 of Epstein–Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression
10.1038/sj.onc.1203515 · 2000 · External reference
Targeting genomic instability in cancer
10.1016/j.cell.2026.03.035 · 2026 · External reference
