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References from Macrophages Drive Ferroptosis Resistance after Radiotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Contemporary radiotherapy: Present and future
10.1016/s0140-6736(21)00233-6 · 2021 · External reference
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Evidence-based clinical recommendations for hypofractionated radiotherapy: Exploring efficacy and safety - Part 1. Brain and head and neck
10.3857/roj.2023.00899 · External reference
Hyperfractionated or accelerated radiotherapy in head and neck cancer: A meta-analysis
10.1016/s0140-6736(06)69121-6 · 2006 · External reference
10.1038/nrc2587
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10.1016/j.cell.2020.10.027
10.1016/j.cell.2020.10.027 · External reference
Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor
10.1002/advs.202204177 · 2023 · External reference
10.1038/nm.2385
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10.1016/j.cell.2010.02.027
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10.1016/j.trecan.2016.05.002
10.1016/j.trecan.2016.05.002 · External reference
Radiation therapy induces macrophages to suppress T-cell responses against pancreatic tumors in mice
10.1053/j.gastro.2016.02.070 · 2016 · External reference
Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma
10.1126/sciadv.adh9069 · 2023 · External reference
Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade
10.15252/emmm.201809342 · 2018 · External reference
10.1158/2326-6066.cir-18-0633
10.1158/2326-6066.cir-18-0633 · External reference
Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy
10.1186/s12967-024-05118-6 · 2024 · External reference
10.1038/s41586-025-08994-0
10.1038/s41586-025-08994-0 · External reference
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
10.1038/s41467-020-17914-x · 2020 · External reference
Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity
10.1172/jci137001 · 2021 · External reference
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
10.1038/s41467-021-23442-z · 2021 · External reference
10.1038/s43018-022-00456-0
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10.1016/j.ccr.2011.08.025
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10.1038/ncb3041
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Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer
10.1111/j.1365-2559.2005.02176.x · 2005 · External reference
Macrophages-triggered sequential remodeling of endothelium-interstitial matrix to form pre-metastatic niche in microfluidic tumor microenvironment
10.1002/advs.201900195 · 2019 · External reference
10.4143/crt.2006.38.1.1
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A “quickscore” method for immunohistochemical semiquantitation: Validation for oestrogen receptor in breast carcinomas
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10.1038/nmeth.1923
10.1038/nmeth.1923 · External reference
BEDTools: A flexible suite of utilities for comparing genomic features
10.1093/bioinformatics/btq033 · 2010 · External reference
Bioconductor: Open software development for computational biology and bioinformatics
10.1186/gb-2004-5-10-r80 · 2004 · External reference
10.1021/acs.jproteome.6b00848
10.1021/acs.jproteome.6b00848 · External reference
FerrDb V2: Update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations
10.1093/nar/gkac935 · 2023 · External reference
10.1038/s41568-023-00634-x
10.1038/s41568-023-00634-x · External reference
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
10.1038/ncomms1786 · 2012 · External reference
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
10.1016/s1535-6108(04)00115-1 · 2004 · External reference
SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis
10.1186/s12967-021-03042-7 · 2021 · External reference
10.1158/2159-8290.cd-19-0338
10.1158/2159-8290.cd-19-0338 · External reference
GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression
10.1016/j.bbrc.2020.03.079 · 2020 · External reference
Pentraxin-3 modulates hepatocyte ferroptosis and the innate immune response in LPS-induced liver injury
10.1186/s43556-024-00227-6 · 2024 · External reference
10.1038/s41422-019-0263-3
10.1038/s41422-019-0263-3 · External reference
10.1016/j.jhep.2023.03.016
10.1016/j.jhep.2023.03.016 · External reference
10.1073/pnas.1603244113
10.1073/pnas.1603244113 · External reference
10.1038/nchembio.2239
10.1038/nchembio.2239 · External reference
10.1038/nchembio.2238
10.1038/nchembio.2238 · External reference
10.1016/j.canlet.2021.12.011
10.1016/j.canlet.2021.12.011 · External reference
IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma
10.1038/bjc.2016.327 · 2016 · External reference
10.1038/nature07623
10.1038/nature07623 · External reference
10.1016/j.cmet.2021.09.002
10.1016/j.cmet.2021.09.002 · External reference
Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy
10.7150/thno.54793 · 2021 · External reference
Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice
10.7150/thno.86103 · 2023 · External reference
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4
10.1074/jbc.m114.599712 · 2014 · External reference
Protease-activated receptor 2 induces ROS-mediated inflammation through Akt-mediated NF-κB and FoxO6 modulation during skin photoaging
10.1016/j.redox.2021.102022 · 2021 · External reference
Cancer statistics, 2025
2025 · External reference
10.1038/s41571-022-00709-y
10.1038/s41571-022-00709-y · External reference
10.1016/j.cell.2012.03.042
10.1016/j.cell.2012.03.042 · External reference
10.1016/j.ccell.2024.03.011
10.1016/j.ccell.2024.03.011 · External reference
10.1021/acschembio.9b00939
10.1021/acschembio.9b00939 · External reference
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
10.1172/jci152067 · 2021 · External reference
A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers
10.1038/s41467-022-29905-1 · 2022 · External reference
Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance
10.1016/j.drup.2023.101032 · 2024 · External reference
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
10.1038/nature24297 · 2017 · External reference
10.1038/nature23007
10.1038/nature23007 · External reference
10.1016/j.molcel.2021.12.001
10.1016/j.molcel.2021.12.001 · External reference
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy
10.1038/s41467-021-26407-4 · 2021 · External reference
10.1158/0008-5472.can-18-0118
10.1158/0008-5472.can-18-0118 · External reference
10.1172/jci87848
10.1172/jci87848 · External reference
10.1182/blood-2005-04-1655
10.1182/blood-2005-04-1655 · External reference
EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands
10.1002/jlb.2a0320-283rr · 2020 · External reference
Ephrin-A1/EphA4-mediated adhesion of monocytes to endothelial cells
10.1016/j.bbamcr.2013.05.017 · 2013 · External reference
Paradoxes of the EphB4 receptor in cancer
10.1158/0008-5472.can-07-0525 · 2007 · External reference
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment
10.1038/s41467-022-31124-7 · 2022 · External reference
10.1038/s41392-024-01769-5
10.1038/s41392-024-01769-5 · External reference
