Research graph
References from A Boolean Seven-Layer Platelet Decision Model Models Consistently the Logic and Semiquantitatively the Dynamics of Platelet Activation and Inhibition. Local targets link to admitted publications; unresolved targets remain external evidence.
Human cytomegalovirus–platelet interaction triggers toll-like receptor 2–dependent proinflammatory and proangiogenic responses
10.1161/atvbaha.114.303287 · 2014 · External reference
A descriptive and quantitative immunohistochemical study demonstrating a spectrum of platelet recruitment patterns across pulmonary infections including COVID-19
10.1093/ajcp/aqaa230 · 2021 · External reference
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
10.1186/s13045-020-00954-7 · 2020 · External reference
Mechanisms involved in the development of thrombocytopenia in patients with COVID-19
10.1016/j.thromres.2020.06.008 · 2020 · External reference
10.1126/science.1181928
10.1126/science.1181928 · External reference
10.1016/j.blre.2014.10.003
10.1016/j.blre.2014.10.003 · External reference
Platelet interaction with activated endothelium: Mechanistic insights from microfluidics
10.1182/blood-2017-04-780825 · 2017 · External reference
10.1080/09537104.2018.1430358
10.1080/09537104.2018.1430358 · External reference
10.1182/blood.2020007252
10.1182/blood.2020007252 · External reference
10.1007/s00441-017-2727-4
10.1007/s00441-017-2727-4 · External reference
Horizontal microRNA transfer by platelets—Evidence and implications
10.3389/fphys.2021.678362 · 2021 · External reference
10.1016/j.atherosclerosis.2020.04.018
10.1016/j.atherosclerosis.2020.04.018 · External reference
Immunothrombosis and its underlying biological mechanisms
10.1016/j.htct.2023.05.008 · 2024 · External reference
The era of thromboinflammation: Platelets are dynamic sensors and effector cells during infectious diseases
10.3389/fimmu.2019.02204 · 2019 · External reference
10.1016/j.it.2011.06.009
10.1016/j.it.2011.06.009 · External reference
Interactions of platelets with circulating tumor cells contribute to cancer metastasis
10.1038/s41598-021-94735-y · 2021 · External reference
Effects of the interactions between platelets with other cells in tumor growth and progression
10.3389/fimmu.2023.1165989 · 2023 · External reference
Platelets and cancer-associated thrombosis: Focusing on the platelet activation receptor CLEC-2 and podoplanin
10.1182/hematology.2019001388 · 2019 · External reference
Bidirectional interaction between cancer cells and platelets provides potential strategies for cancer therapies
10.3389/fonc.2021.764119 · 2021 · External reference
10.1182/blood-2018-11-882993
10.1182/blood-2018-11-882993 · External reference
10.1161/atvbaha.124.320149
10.1161/atvbaha.124.320149 · External reference
Platelet biology and functions: New concepts and clinical perspectives
10.1038/s41569-018-0110-0 · 2019 · External reference
10.1161/atvbaha.122.317162
10.1161/atvbaha.122.317162 · External reference
10.1042/cs20220208
10.1042/cs20220208 · External reference
Platelet in thrombo-inflammation: Unraveling new therapeutic targets
10.3389/fimmu.2022.1039843 · 2022 · External reference
Role of platelet biomarkers in inflammatory response
10.1186/s40364-020-00207-2 · 2020 · External reference
Platelets in thrombosis and atherosclerosis: A double-edged sword
10.1016/j.ajpath.2024.05.010 · 2024 · External reference
10.1038/s41569-021-00552-1
10.1038/s41569-021-00552-1 · External reference
Differential inhibition of human atherosclerotic plaque-induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: Functional and imaging studies
10.1016/j.jacc.2015.03.573 · 2015 · External reference
The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation
10.1016/j.redox.2013.12.023 · 2014 · External reference
10.1016/j.jtha.2024.05.014
10.1016/j.jtha.2024.05.014 · External reference
10.1056/nejmra071014
10.1056/nejmra071014 · External reference
Platelet hyper-reactivity in active inflammatory arthritis is unique to the adenosine diphosphate pathway: A novel finding and potential therapeutic target
10.1093/rheumatology/kep377 · 2010 · External reference
Inflammation-mediated platelet hyperactivity in aging
10.21037/aob.2020.03.01 · 2020 · External reference
Inflammaging and platelet hyperreactivity: A new therapeutic target?
10.1111/jth.14670 · 2020 · External reference
TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
10.1182/blood.2019000200 · 2019 · External reference
Computational modeling of platelet activation signatures in response to diverse immune and hemostatic agonists
10.1080/09537104.2025.2572982 · 2025 · External reference
Quantitative proteomics analysis reveals similar release profiles following specific PAR-1 or PAR-4 stimulation of platelets
10.1093/cvr/cvu113 · 2014 · External reference
10.1182/blood-2011-01-330910
10.1182/blood-2011-01-330910 · External reference
Intelligent classification of platelet aggregates by agonist type
10.7554/elife.52938 · 2020 · External reference
Experimental and mathematical model of platelet hemostasis kinetics
10.3390/cells14090677 · 2025 · External reference
A modular systems-biological modelling framework studies cyclic nucleotide signaling in platelets
10.1016/j.jtbi.2022.111222 · 2022 · External reference
Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: Feedback loops, titrated phosphorylations and pharmacological modulation
10.1186/1752-0509-5-178 · 2011 · External reference
Signaling network analysis reveals fostamatinib as a potential drug to control platelet hyperactivation during SARS-CoV-2 infection
10.3389/fimmu.2023.1285345 · 2023 · External reference
10.3390/ijms262110780
10.3390/ijms262110780 · External reference
Comparison of the central human and mouse platelet signaling cascade by systems biological analysis
10.1186/s12864-020-07215-4 · 2020 · External reference
10.1182/blood-2011-10-387308
10.1182/blood-2011-10-387308 · External reference
10.1039/c3mb25597b
10.1039/c3mb25597b · External reference
Dynamical modelling of prostaglandin signalling in platelets reveals individual receptor contributions and feedback properties
10.1039/c3mb70142e · 2013 · External reference
A comparative analysis of the bistability switch for platelet aggregation by logic-ODE based dynamical modeling
10.1039/c4mb00170b · 2014 · External reference
10.1161/atvbaha.117.310391
10.1161/atvbaha.117.310391 · External reference
Influence of platelet-rich plasma on the immune response of human monocyte-derived dendritic cells and macrophages stimulated with Aspergillus fumigatus
10.1016/j.ijmm.2016.11.010 · 2017 · External reference
Dynamic simulation of regulatory networks using SQUAD
10.1186/1471-2105-8-462 · 2007 · External reference
Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis
10.1038/s41598-022-27098-7 · 2023 · External reference
Platelets and mitochondria: The calcium connection
10.1007/s11033-025-10389-3 · 2025 · External reference
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion
10.7554/elife.55351 · 2020 · External reference
Platelet purinergic receptors in thrombosis and inflammation
10.1055/a-1113-0711 · 2020 · External reference
10.3390/ijms252312611
10.3390/ijms252312611 · External reference
Platelet activation and signaling in thrombus formation
10.1182/blood.2024025320 · 2025 · External reference
Platelets and diseases: Signal transduction and advances in targeted therapy
10.1038/s41392-025-02198-8 · 2025 · External reference
Endothelial cell control of thrombosis
10.1186/s12872-015-0124-z · 2015 · External reference
10.1007/s00441-021-03471-2
10.1007/s00441-021-03471-2 · External reference
10.1124/pr.117.014530
10.1124/pr.117.014530 · External reference
10.1038/nature04702
10.1038/nature04702 · External reference
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
10.1038/16711 · 1999 · External reference
The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
10.1084/jem.20080302 · 2008 · External reference
The Mg2+ and Mg2+-nucleotide-regulated channel-kinase TRPM7
10.1007/978-3-540-34891-7_19 · 2007 · External reference
10.1007/s00018-018-2786-z
10.1007/s00018-018-2786-z · External reference
10.1111/jth.13302
10.1111/jth.13302 · External reference
The connection between Rap1 and Talin1 in the activation of integrins in blood cells
10.3389/fcell.2022.908622 · 2022 · External reference
10.1182/blood-2013-03-487850
10.1182/blood-2013-03-487850 · External reference
Cyclic nucleotide-dependent inhibitory signaling interweaves with activating pathways to determine platelet responses
10.1002/rth2.12122 · 2018 · External reference
A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis
10.1038/s41467-018-06638-8 · 2018 · External reference
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
10.1182/blood-2012-04-416594 · 2012 · External reference
Phosphoproteome of resting human platelets
10.1021/pr0704130 · 2008 · External reference
Temporal quantitative phosphor-proteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition
10.1182/blood-2016-05-714048 · 2017 · External reference
Platelet signaling
10.1007/978-3-642-29423-5_3 · 2012 · External reference
10.1152/physiol.00020.2016
10.1152/physiol.00020.2016 · External reference
Secrets of platelet exocytosis—What do we really know about platelet secretion mechanisms?
10.1111/bjh.12682 · 2013 · External reference
10.1161/atvbaha.110.207522
10.1161/atvbaha.110.207522 · External reference
Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake
10.1093/cvr/cvp205 · 2009 · External reference
10.1016/j.csbj.2014.11.008
10.1016/j.csbj.2014.11.008 · External reference
10.1016/j.niox.2018.03.008
10.1016/j.niox.2018.03.008 · External reference
10.1111/bph.15500
10.1111/bph.15500 · External reference
Blood collection, platelet isolation and measurement of platelet count and size in mice—A practical guide
10.1080/09537104.2018.1528345 · 2019 · External reference
Platelet genomics: The role of platelet size and number in health and disease
10.1080/09537104.2016.1257113 · 2017 · External reference
10.3390/ijms22094521
10.3390/ijms22094521 · External reference
Bernard-Soulier syndrome
10.3324/haematol.2010.039883 · 2011 · External reference
10.1161/atvbaha.113.303113
10.1161/atvbaha.113.303113 · External reference
Molecular diagnosis of inherited coagulation and bleeding disorders
10.1055/s-0039-1687889 · 2019 · External reference
Population-based frequency of naturally occurring loss-of-function variants in genes associated with platelet disorders
10.1111/jth.15113 · 2021 · External reference
Global burden of thrombosis: Epidemiologic aspects
10.1161/circresaha.115.306841 · 2016 · External reference
Thrombosis: A major contributor to global disease burden
10.1161/atvbaha.114.304488 · 2014 · External reference
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019
10.1016/s0140-6736(20)30925-9 · 2020 · External reference
Epidemiology and prevention of venous thromboembolism
10.1038/s41569-022-00787-6 · 2023 · External reference
Development and application of an agent-based model for the simulation of the extravasation process of circulating tumor cells
10.1002/cnm.3679 · 2023 · External reference
An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts
10.1038/s41598-023-30884-6 · 2023 · External reference
Investigation of the essential role of platelet–tumor cell interactions in metastasis progression using an agent-based model
10.1186/1742-4682-11-17 · 2014 · External reference
Ischemia/reperfusion injury in acute human and experimental stroke: Focus on thrombo-inflammatory mechanisms and treatments
10.1186/s42466-024-00355-y · 2024 · External reference
10.1038/s44161-023-00254-6
10.1038/s44161-023-00254-6 · External reference
Jimena: Efficient computing and system state identification for genetic regulatory networks
10.1186/1471-2105-14-306 · 2013 · External reference
10.1016/j.ccell.2017.07.004
10.1016/j.ccell.2017.07.004 · External reference
10.1182/blood.2020007214
10.1182/blood.2020007214 · External reference
The PRIDE database at 20 years: 2025 update
10.1093/nar/gkae1011 · 2025 · External reference
Unresolved reference
External reference
10.1007/978-3-319-24277-4
10.1007/978-3-319-24277-4 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
Unresolved reference
External reference
PhosR enables processing and functional analysis of phosphoproteomic data
10.1016/j.celrep.2021.108771 · 2021 · External reference
Unresolved reference
2024 · External reference
Welcome to the tidyverse
10.21105/joss.01686 · 2019 · External reference
