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References from Scoparone-Induced Phase Separation of ZDHHC12 Drives Ferroptosis via ATG12 S-palmitoylation and Ferritinophagy in Liver Fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
10.34133/research.0435
10.34133/research.0435 · External reference
Acetyl-CoA acyltransferase 2 palmitoylation drives liver fibrosis by inducing hepatic stellate cell ferroptosis
10.1016/j.redox.2026.104035 · 2026 · External reference
The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease
2024 · External reference
10.1038/s41418-024-01322-5
10.1038/s41418-024-01322-5 · External reference
10.34133/research.0323
10.34133/research.0323 · External reference
10.1080/15548627.2026.2656779
10.1080/15548627.2026.2656779 · External reference
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells
10.1080/15548627.2018.1503146 · 2018 · External reference
Role of S-palmitoylation in digestive system diseases
10.1038/s41420-025-02629-z · 2025 · External reference
Protein S-palmitoylation: Dynamic regulatory networks, physiological functions, and new frontiers in targeted therapy
10.1016/j.phrs.2026.108181 · 2026 · External reference
Artemether relieves liver fibrosis by triggering ferroptosis in hepatic stellate cells via DHHC12-mediated S-palmitoylation of the BECN1 protein
10.1016/j.freeradbiomed.2025.02.031 · 2025 · External reference
Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity
10.1126/sciimmunol.adp7302 · 2024 · External reference
ZDHHC16-induced GPX2 S-palmitoylation promotes lenvatinib resistance and inhibits lenvatinib-induced immunogenic cell death in hepatocellular carcinoma
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10.1038/s43018-025-00937-y
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10.34133/research.0954
10.34133/research.0954 · External reference
10.1016/j.cell.2026.05.002
10.1016/j.cell.2026.05.002 · External reference
CSDE1 promotes viral immune evasion through RNA-dependent and phosphorylation-modulated liquid-liquid phase separation
10.1038/s41467-026-72409-5 · 2026 · External reference
Macrophage-derived SPP1 promotes subretinal fibrosis by YAP1 phase separation in retinal pigment epithelium
10.1016/j.metabol.2026.156648 · 2026 · External reference
Liquid-liquid phase separation in human health and diseases
10.1038/s41392-021-00678-1 · 2021 · External reference
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10.1038/s41586-023-06255-6 · External reference
10.1016/j.phrs.2020.105170
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10.1111/pbi.70398
10.1111/pbi.70398 · External reference
Scoparone ameliorates metabolic dysfunction-associated steatotic liver disease by regulating the miR-3073a-3p/CAMKK2 axis
10.1016/j.jep.2026.121590 · 2026 · External reference
YTHDF2-orchestrated m6A methylation of BECN1 induces scoparone-mediated hepatic stellate cell ferroptosis to attenuate liver fibrosis
10.1016/j.phymed.2026.157912 · 2026 · External reference
10.1016/j.tcb.2026.03.008
10.1016/j.tcb.2026.03.008 · External reference
Ferroptosis at the intersection of metabolism and immunity in pancreatitis and pancreatic cancer
10.1016/j.smim.2026.102049 · 2026 · External reference
NOP2-mediated 5-methylcytosine regulates lipid metabolism reprogramming to prime tumors for ferroptosis in bladder cancer progression
10.7150/ijbs.126325 · 2026 · External reference
Deletion of Tfap2a in hepatocytes and macrophages promotes the progression of hepatocellular carcinoma by regulating SREBP1/FASN/ACC pathway and anti-inflammatory effect of IL10
10.1038/s41419-025-07500-8 · 2025 · External reference
10.34133/cancomm.0017
10.34133/cancomm.0017 · External reference
Dietary palmitic acid drives a palmitoyltransferase ZDHHC15-YAP feedback loop promoting tumor metastasis
10.1002/advs.202409883 · 2025 · External reference
Protein S-palmitoylation: Potential strategy for inflammation-related diseases
10.1016/j.jpha.2025.101490 · 2026 · External reference
10.1002/fsn3.4176
10.1002/fsn3.4176 · External reference
Vesicle tethering and fusion promoted by LC3/GABARAP proteins is modulated by the ATG12-ATG5-ATG16L1 complex
10.1080/15548627.2023.2202557 · 2023 · External reference
Stable coacervate microdroplets as robust microreactors for enhanced enzymatic catalysis
10.1002/smll.202514871 · 2026 · External reference
10.1080/15548627.2019.1687985
10.1080/15548627.2019.1687985 · External reference
N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells
10.1016/j.redox.2021.102151 · 2021 · External reference
RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis
10.1172/jci197923 · 2026 · External reference
The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells
10.1016/j.redox.2020.101619 · 2020 · External reference
Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1α/SLC7A11 pathway
10.1111/cpr.13158 · 2022 · External reference
10.1016/j.apsb.2021.12.007
10.1016/j.apsb.2021.12.007 · External reference
S-palmitoylation in ferroptosis: Molecular mechanisms, modulators, and interplay with autophagy
10.1007/s10495-025-02227-5 · 2026 · External reference
10.1016/j.molcel.2025.09.009
10.1016/j.molcel.2025.09.009 · External reference
ZDHHC2-dependent palmitoylation dictates ferroptosis and castration sensitivity in prostate cancer via controlling ACSL4 degradation and lipid peroxidation
10.1002/advs.202514077 · 2026 · External reference
Recent advances in S-palmitoylation and its emerging roles in human diseases
10.1186/s13045-025-01738-7 · 2025 · External reference
Polyphyllin VI induces Forkhead box O3 nuclear liquid-liquid phase separation to promote mitophagy in breast cancer
10.1016/j.phymed.2026.158166 · 2026 · External reference
Liquid-liquid phase separation in aging: Novel insights in the pathogenesis and therapeutics
10.1016/j.arr.2024.102583 · 2024 · External reference
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis
10.7150/thno.94789 · 2024 · External reference
Decoding NLRP3: Phase separation enters the scene
10.1038/s41422-025-01120-9 · 2025 · External reference
FSP1 in cancer: Not just a phase
10.1038/s41568-023-00607-0 · 2023 · External reference
Protein lipidation in the tumor microenvironment: Enzymology, signaling pathways, and therapeutics
10.1186/s12943-025-02309-7 · 2025 · External reference
Scoparone enhances the stability of TAT protein by inhibiting the ubiquitin-proteasome pathway, regulates mitochondrial damage against chronic alcoholic liver disease
10.1016/j.jep.2026.121746 · 2026 · External reference
Scoparone alleviates nonalcoholic fatty liver disease by modulating the PPARα signaling pathway
10.1016/j.ejphar.2024.177033 · 2024 · External reference
CCDC120 phase separation contributes to desmosomal integrity and cardiac function
10.1038/s41467-026-72821-x · 2026 · External reference
