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References from Fosmanogepix: A comprehensive review of its origin, mechanism, antifungal efficacy, and resistance (Review). Local targets link to admitted publications; unresolved targets remain external evidence.
Global incidence and mortality of severe fungal disease
10.1016/s1473-3099(23)00692-8 · 2024 · External reference
Editorial: the World Health Organization (WHO) fungal priority pathogens list in response to emerging fungal pathogens during the COVID-19 pandemic
10.12659/msm.939088 · 2022 · External reference
COVID-19-associated fungal infections: An urgent need for alternative therapeutic approach?
10.3389/fmicb.2022.919501 · 2022 · External reference
Climate change: Shifting boundaries of fungal disease in Europe and beyond
10.1136/thorax-2024-222168 · 2025 · External reference
Interconnected worlds: A comprehensive review of fungal defenses, antimicrobial resistance, and their evolutionary dynamics
10.3897/imafungus.17.171995 · 2026 · External reference
Differentiation of Pneumocystis jirovecii pneumonia from colonization: A clinical decision framework incorporating risk stratification and next-generation sequencing thresholds
10.1186/s12879-025-11235-4 · 2025 · External reference
Novel model to predict risk of invasive fungal infection and fungal prophylaxis timing
10.1128/spectrum.02958-24 · 2025 · External reference
Fungal drug response and antimicrobial resistance
10.3390/jof9050565 · 2023 · External reference
The Lancet Infectious Diseases: An exciting time for antifungal therapy
10.1016/s1473-3099(23)00380-8 · 2023 · External reference
Antifungal pipeline
10.3389/fcimb.2021.732223 · 2021 · External reference
Liposomal amphotericin B: A review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections
10.2165/00003495-200969030-00010 · 2009 · External reference
Fungal lanosterol 14α-demethylase: A target for next-generation antifungal design
10.1016/j.bbapap.2019.02.008 · 2020 · External reference
Fungal resistance to echinocandins and the MDR phenomenon in Candida glabrata
10.3390/jof4030105 · 2018 · External reference
Resistance of Candida to azoles and echinocandins worldwide
10.1016/j.cmi.2019.03.028 · 2019 · External reference
5-flucytosine longitudinal antifungal susceptibility testing of Cryptococcus neoformans: A substudy of the EnACT trial testing oral amphotericin
10.1093/ofid/ofad596 · 2023 · External reference
Emerging drugs and vaccines for candidemia
10.1111/myc.12265 · 2014 · External reference
Candida auris genetics and emergence
10.1146/annurev-micro-032521-015858 · 2023 · External reference
Unresolved reference
External reference
New antifungal strategies and drug development against WHO critical priority fungal pathogens
10.3389/fcimb.2025.1662442 · 2025 · External reference
The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin
10.1007/s40265-021-01611-0 · 2021 · External reference
Antimicrobial activity of manogepix, a first-in-class antifungal, and comparator agents tested against contemporary invasive fungal isolates from an international surveillance programme (2018-2019)
10.1016/j.jgar.2021.04.012 · 2021 · External reference
Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis
10.1128/aac.00366-11 · 2011 · External reference
Pharmacodynamics, mechanisms of action and resistance, and spectrum of activity of new antifungal agents
10.3390/jof8080857 · 2022 · External reference
Safety and pharmacokinetics of intravenous and oral fosmanogepix, a first-in-class antifungal agent, in healthy volunteers
10.1128/aac.01623-22 · 2023 · External reference
Fosmanogepix for the treatment of invasive mold diseases caused by Aspergillus species and rare molds: A phase 2, open-label study (AEGIS)
10.1093/cid/ciaf185 · 2025 · External reference
Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly
10.1046/j.1365-2958.2003.03481.x · 2003 · External reference
GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast
10.1074/jbc.m301044200 · 2003 · External reference
E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis
10.1128/aac.00731-11 · 2012 · External reference
In vitro activity of APX2041, a new Gwt1 inhibitor, and in vivo efficacy of the prodrug APX2104 against Aspergillus fumigatus
10.1128/aac.00682-21 · 2021 · External reference
10.1021/id5000212 · 2015 · Admitted local publication
Calcineurin inhibitors synergize with manogepix to kill diverse human fungal pathogens
10.3390/jof8101102 · 2022 · External reference
New perspectives on antimicrobial agents: Fosmanogepix
10.1128/aac.00324-26 · 2026 · External reference
Rho2-dependent cell wall remodeling boosts the fungistatic activity of manogepix against Aspergillus fumigatus
10.1016/j.tcsw.2025.100166 · 2025 · External reference
The wound microbiota: Microbial mechanisms of impaired wound healing and infection
10.1038/s41579-024-01035-z · 2024 · External reference
Antibiofilm activity of manogepix, ibrexafungerp, amphotericin B, rezafungin, and caspofungin against Candida spp. biofilms of reference and clinical strains
10.1128/aac.00137-25 · 2025 · External reference
Evaluation of resistance development to the Gwt1 inhibitor manogepix (APX001A) in Candida species
10.1128/aac.01387-19 · 2019 · External reference
Structural insights into the inhibition mechanism of fungal GWT1 by manogepix
10.1038/s41467-024-53512-x · 2024 · External reference
Enhanced efflux pump expression in Candida mutants results in decreased manogepix susceptibility
10.1128/aac.00261-20 · 2020 · External reference
TAC1b mutation in Candida auris decreases manogepix susceptibility owing to increased CDR1 expression
10.1128/aac.01508-24 · 2025 · External reference
Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris (Candidozyma auris), Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus)
10.1128/aac.00680-25 · 2025 · External reference
Calcium-calmodulin-calcineurin signaling: A globally conserved virulence cascade in eukaryotic microbial pathogens
10.1016/j.chom.2019.08.004 · 2019 · External reference
Fungal cell wall: Emerging antifungals and drug resistance
10.3389/fmicb.2019.02573 · 2019 · External reference
Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata
10.1128/mbio.02546-25 · 2026 · External reference
Fosmanogepix: the novel anti-fungal agent's comprehensive review of in vitro, in vivo, and current insights from advancing clinical trials
10.7759/cureus.59210 · 2024 · External reference
Manogepix (APX001A) displays potent in vitro activity against human pathogenic yeast, but with an unexpected correlation to fluconazole MICs
10.1128/aac.00429-20 · 2020 · External reference
APX001A in vitro activity against contemporary blood isolates and Candida auris determined by the EUCAST reference method
10.1128/aac.01225-18 · 2018 · External reference
In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method
10.1016/j.diagmicrobio.2011.05.001 · 2011 · External reference
In vitro activity of APX001A (Manogepix) and comparator agents against 1,706 fungal Isolates collected during an international surveillance program in 2017
10.1128/aac.00840-19 · 2019 · External reference
The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant Candida albicans
10.1128/aac.03944-14 · 2015 · External reference
In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds
10.1128/aac.00291-11 · 2011 · External reference
Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: Comparison of CLSI and European committee on antimicrobial susceptibility testing methods
10.1093/jac/dkr342 · 2011 · External reference
In vitro activity of manogepix and comparators against infrequently encountered yeast and mold isolates from the SENTRY Surveillance Program (2017-2022)
10.1128/aac.01132-23 · 2024 · External reference
New treatment options for critically important WHO fungal priority pathogens
10.1016/j.cmi.2024.03.006 · 2025 · External reference
In vitro and in vivo evaluation of APX001A/APX001 and other Gwt1 inhibitors against Cryptococcus
10.1128/aac.00523-18 · 2018 · External reference
2043. In vitro activity of manogepix against 2,810 fungal isolates from the SENTRY surveillance program (2020-2021) stratified by infection type
2022 · External reference
In vitro activity of APX001A against rare moulds using EUCAST and CLSI methodologies
10.1093/jac/dkz022 · 2019 · External reference
In vitro antifungal activity of manogepix and other antifungal agents against South African Candida auris isolates from bloodstream infections
10.1128/spectrum.01717-21 · 2022 · External reference
Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods
10.1128/aac.05414-11 · 2012 · External reference
In vitro activity of manogepix against multidrug-resistant and panresistant Candida auris from the New York outbreak
10.1128/aac.01124-20 · 2020 · External reference
Manogepix (APX001A) in vitro activity against Candida auris: Head-to-head comparison of EUCAST and CLSI MICs
10.1128/aac.00656-20 · 2020 · External reference
Antifungal susceptibility surveillance of clinical moulds to olorofim, manogepix, amphotericin B, triazoles and echinocandins at 10 tertiary hospitals in China (2019-24)
10.1093/jac/dkag016 · 2026 · External reference
In vitro activity of manogepix (APX001A) and comparators against contemporary molds: MEC comparison and preliminary experience with colorimetric MIC determination
10.1128/aac.00730-20 · 2020 · External reference
Environmental hot spots and resistance-associated application practices for azole-resistant Aspergillus fumigatus, Denmark, 2020-2023
10.3201/eid3008.240096 · 2024 · External reference
Manogepix, the active moiety of the investigational agent fosmanogepix, demonstrates in vitro activity against members of the Fusarium oxysporum and Fusarium solani species complexes
10.1128/aac.02343-20 · 2021 · External reference
Fosmanogepix (APX001) is effective in the treatment of pulmonary murine mucormycosis due to Rhizopus arrhizus
10.1128/aac.00178-20 · 2020 · External reference
In vitro and in vivo evaluation of the antifungal activity of APX001A/APX001 against Candida auris
10.1128/aac.02319-17 · 2018 · External reference
Efficacy of delayed therapy with fosmanogepix (APX001) in a murine model of Candida auris invasive candidiasis
10.1128/aac.01120-19 · 2019 · External reference
APX001 is effective in the treatment of murine invasive pulmonary aspergillosis
10.1128/aac.01713-18 · 2019 · External reference
APX001 and other Gwt1 inhibitor prodrugs are effective in experimental Coccidioides immitis pneumonia
10.1128/aac.01715-18 · 2019 · External reference
Fosmanogepix (APX001) is effective in the treatment of immunocompromised mice infected with invasive pulmonary scedosporiosis or disseminated fusariosis
10.1128/aac.01735-19 · 2020 · External reference
The combination treatment of fosmanogepix and liposomal amphotericin B is superior to monotherapy in treating experimental invasive mold infections
10.1128/aac.00380-22 · 2022 · External reference
First-in-human study to assess safety, tolerability and pharmacokinetics of APX001 administered by intravenous infusion to healthy subjects
2017 · External reference
Phase 1 study to assess safety, tolerability and pharmacokinetics of single and multiple oral doses of APX001 and to investigate the effect of food on APX001 bioavailability
2017 · External reference
Phase 1b safety and pharmacokinetics of intravenous and oral fosmanogepix in patients with acute myeloid leukaemia and neutropenia
10.1093/jac/dkad269 · 2023 · External reference
Clinical efficacy and safety of a novel antifungal, fosmanogepix, in patients with candidemia caused by Candida auris: Results from a phase 2 trial
10.1128/aac.01419-22 · 2023 · External reference
Clinical safety and efficacy of novel antifungal, fosmanogepix, for the treatment of candidaemia: Results from a phase 2 trial
10.1093/jac/dkad256 · 2023 · External reference
Fosmanogepix treatment for coccidioidomycosis under an expanded access program
10.1093/cid/ciag271 · 2026 · External reference
The importance of antimicrobial resistance in medical mycology
10.1038/s41467-022-32249-5 · 2022 · External reference
Heightened efficacy of anidulafungin when used in combination with manogepix or 5-flucytosine against Candida auris in vitro
10.1128/aac.01645-22 · 2023 · External reference
The combination of manogepix and itraconazole is synergistic and inhibits the growth of Madurella mycetomatis in vitro but not in vivo
10.1093/mmy/myad118 · 2023 · External reference
Novel approaches in the management of mucormycosis
10.1007/s12281-023-00463-3 · 2023 · External reference
Efficacy and pharmacokinetics of fosmanogepix (APX001) in the treatment of Candida endophthalmitis and hematogenous meningoencephalitis in nonneutropenic rabbits
10.1128/aac.01795-20 · 2021 · External reference
Antifungal agents in the 21st century: advances, challenges, and future perspectives
10.3390/idr17040091 · 2025 · External reference
Antifungal chemotherapies and immunotherapies for the future
10.1111/pim.12960 · 2023 · External reference
Aminopyrifen, a novel 2-aminonicotinate fungicide with a unique effect and broad-spectrum activity against plant pathogenic fungi
10.1584/jpestics.d20-094 · 2021 · External reference
Understanding inflammatory bowel disease: an integrative framework of microbiome, metabolome, and immunological biomarkers
2025 · External reference
Activity of novel antifungal compound APX001A against a large collection of Candida auris
10.1093/jac/dky302 · 2018 · External reference
In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods
10.1128/aac.00570-11 · 2011 · External reference
In vivo pharmacokinetics and pharmacodynamics of APX001 against Candida spp. in a neutropenic disseminated Candidiasis mouse model
10.1128/aac.02542-17 · 2018 · External reference
Significantly improved pharmacokinetics enhances in vivo efficacy of APX001 against echinocandin- and multidrug resistant Candida isolates in a mouse model of invasive Candidiasis
10.1128/aac.00425-18 · 2018 · External reference
APX001 pharmacokinetic/pharmacodynamic target determination against Aspergillus fumigatus in an in vivo model of invasive pulmonary Aspergillosis
10.1128/aac.02372-18 · 2019 · External reference
Galactomannan is a biomarker of Fosmanogepix (APX001) efficacy in treating experimental invasive pulmonary Aspergillosis
10.1128/aac.01966-19 · 2019 · External reference