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References from Transforming growth factor β‑activated kinase 1 as a central integrator of immune‑microbiota crosstalk in colitis (Review). Local targets link to admitted publications; unresolved targets remain external evidence.
The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease
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Molecular targets associated with ulcerative colitis and the benefits of atractylenolides-based therapy
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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
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TAK1 in vascular signaling: ‘Friend or foe’?
10.2147/jir.s458948 · 2024 · External reference
TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
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Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024
10.3389/fimmu.2024.1437570 · 2024 · External reference
Ubiquitination-activated TAB-TAK1-IKK-NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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Cell type-specific function of TAK1 in innate immune signaling
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Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
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Activation of TGF-β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease
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Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis
10.1371/journal.pone.0004561 · 2009 · External reference
Macrophage polarization in inflammatory bowel disease
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Metabolic programming of macrophage functions and pathogens control
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Histological evaluation in ulcerative colitis
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Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis
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The role of enterobacteriaceae in gut microbiota dysbiosis in inflammatory bowel diseases
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A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
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Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host
10.1186/s13059-019-1879-9 · 2019 · External reference
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
10.1016/j.cmet.2011.02.018 · 2011 · External reference
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
10.3945/jn.109.104638 · 2009 · External reference
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10.2147/jir.s300989 · 2021 · External reference
Butyrate inhibits inflammatory responses through NFkappaB inhibition: Implications for Crohn's disease
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Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate
10.1016/j.redox.2018.02.007 · 2018 · External reference
Early innate immune responses to bacterial LPS
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Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
10.1038/ajg.2010.281 · 2010 · External reference
Pattern recognition receptor signaling and cytokine networks in microbial defenses and regulation of intestinal barriers: Implications for inflammatory bowel disease
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Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation
10.1038/mi.2015.48 · 2016 · External reference
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
10.1038/s41575-023-00768-1 · 2023 · External reference
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
10.1053/j.gastro.2004.12.042 · 2005 · External reference
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
10.1016/s0002-9440(10)62264-x · 2005 · External reference
Basic biology and role of interleukin-17 in immunity and inflammation
10.1111/prd.12083 · 2015 · External reference
The role of IL-22 in intestinal health and disease
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Cytokines in inflammatory bowel disease
10.1038/nri3661 · 2014 · External reference
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
10.1172/jci19836 · 2004 · External reference
Interleukin-23 and Th17 cells in the control of gut inflammation
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Differential regulation of chemokines by IL-17 in colonic epithelial cells
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IFN-γ, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases
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IL-22 increases permeability of intestinal epithelial tight junctions by enhancing claudin-2 expression
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Human neutrophil elastase proteolytic activity in ulcerative colitis favors the loss of function of therapeutic monoclonal antibodies
10.2147/jir.s234710 · 2020 · External reference
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Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
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IgG and Fcγ receptors in intestinal immunity and inflammation
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IgA responses to microbiota
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Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease
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Distinct commensals induce interleukin-1β via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury
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Anti-commensal IgG drives intestinal inflammation and type 17 immunity in ulcerative colitis
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Interleukin-1 and related cytokines in the regulation of inflammation and immunity
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IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells
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The role of Th17 cells in inflammatory bowel disease and the research progress
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GM-CSF: A promising target in inflammation and autoimmunity
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A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation
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Apoptosis of crypt epithelial cells in ulcerative colitis
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IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
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Autophagy in inflammatory bowel disease: Immunization, etiology, and therapeutic potential
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TAK1-TABs complex: A central signalosome in inflammatory responses
10.3389/fimmu.2020.608976 · 2021 · External reference
Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling
10.1038/s41420-021-00447-7 · 2021 · External reference
Sinapic acid alleviates inflammatory bowel disease (IBD) through localization of tight junction proteins by direct binding to TAK1 and improves intestinal microbiota
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TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
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E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2
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RNF186/EPHB2 axis is essential in regulating TNF signaling for colorectal tumorigenesis in colorectal epithelial cells
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An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis
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GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2
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Discovery of first-in-class TAK1-MKK3 protein-protein interaction (PPI) inhibitor (R)-STU104 for the treatment of ulcerative colitis through modulating TNF-α production
10.1021/acs.jmedchem.1c02198 · 2022 · External reference
CD137 signaling regulates acute colitis via RALDH2-expressing CD11b-CD103+ DCs
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Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis
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Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion
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Conditional deletion of TAK1 in T cells reveals a pivotal role of TCRαβ+ intraepithelial lymphocytes in preventing lymphopenia-associated colitis
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