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References from Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO‑1/FTH1 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Calcific aortic valve disease: From molecular and cellular mechanisms to medical therapy
10.1093/eurheartj/ehab757 · 2022 · External reference
Global burden of calcific aortic valve disease and attributable risk factors from 1990 to 2019
10.3389/fcvm.2022.1003233 · 2022 · External reference
Contribution of oxidative stress (OS) in calcific aortic valve disease (CAVD): From pathophysiology to therapeutic targets
10.3390/cells11172663 · 2022 · External reference
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification
10.1093/eurheartj/ehac037 · 2022 · External reference
Potential ferroptosis key genes in calcific aortic valve disease
10.3389/fcvm.2022.916841 · 2022 · External reference
Nesfatin-1 mitigates calcific aortic valve disease via suppressing ferroptosis mediated by GSH/GPX4 and ZIP8/SOD2 axes
10.1016/j.freeradbiomed.2024.06.004 · 2024 · External reference
The role of sirtuin-1 in the vasculature: Focus on aortic aneurysm
10.3389/fphys.2020.01047 · 2020 · External reference
SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury
10.1080/02656736.2022.2094476 · 2022 · External reference
Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway
10.1186/s10020-023-00714-6 · 2023 · External reference
Uremic toxin p-cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin-1 signaling
10.3892/mmr.2026.13872 · 2026 · External reference
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway
10.1111/acel.13377 · 2021 · External reference
LncRNA TUG regulates osteogenic differentiation of bone marrow mesenchymal stem cells via miRNA-204/SIRT 1
2022 · External reference
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
10.1093/humrep/deaa363 · 2021 · External reference
Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation
10.1186/s10020-023-00735-1 · 2023 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
Unresolved reference
2011 · External reference
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease
10.1016/j.redox.2023.102629 · 2023 · External reference
Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1/p53 axis
10.1016/j.phymed.2024.155533 · 2024 · External reference
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
10.1186/s12974-022-02400-6 · 2022 · External reference
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease
10.1111/jpi.12948 · 2024 · External reference
Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification
10.1093/cvr/cvaa134 · 2021 · External reference
Luteolin protects against vascular calcification by modulating SIRT1/CXCR4 signaling pathway and promoting autophagy
10.1208/s12248-024-00982-y · 2024 · External reference
Sirtuin-1 and Its relevance in vascular calcification
10.3390/ijms21051593 · 2020 · External reference
Mechanism and treatment of Sirtuin family in vascular calcification
10.3389/fcvm.2025.1732281 · 2025 · External reference
Mitochondria homeostasis and vascular medial calcification
10.1007/s00223-021-00828-1 · 2021 · External reference
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria
10.1016/j.dnarep.2009.01.021 · 2009 · External reference
Loss-of-function mitochondrial DNA polymerase gamma variants cause vascular smooth muscle cells to secrete a diffusible mitogenic factor
10.3389/fphys.2024.1488248 · 2025 · External reference
Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins
10.1111/j.1742-4658.2011.08010.x · 2011 · External reference
Dynamin-related protein 1 inhibition attenuates cardiovascular calcification in the presence of oxidative stress
10.1161/circresaha.116.310293 · 2017 · External reference
Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria
10.3389/fcvm.2022.972836 · 2022 · External reference
Irisin alleviates vascular calcification by inhibiting VSMC osteoblastic transformation and mitochondria dysfunction via AMPK/Drp1 signaling pathway in chronic kidney disease
10.1016/j.atherosclerosis.2022.02.007 · 2022 · External reference
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα
10.1016/j.bcp.2022.115379 · 2023 · External reference
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects
10.1016/j.freeradbiomed.2021.01.033 · 2021 · External reference
Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy
10.1038/s41419-024-07260-x · 2024 · External reference
Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification
10.1016/j.kint.2022.07.034 · 2022 · External reference
Programmed cell death in atherosclerosis and vascular calcification
10.1038/s41419-022-04923-5 · 2022 · External reference
Activation of Nrf2/HO-1 antioxidant pathway by heme attenuates calcification of human lens epithelial cells
10.3390/ph15050493 · 2022 · External reference
Endothelial-cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage
10.1073/pnas.90.20.9285 · 1993 · External reference
Ferritin: A cytoprotective antioxidant strategem of endothelium
10.1016/s0021-9258(19)37165-0 · 1992 · External reference
Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells
10.1111/jcmm.12682 · 2016 · External reference
Potential role of H-ferritin in mitigating valvular mineralization
10.1161/atvbaha.118.312191 · 2019 · External reference
Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells
10.1681/asn.2008070788 · 2009 · External reference
Heme, heme oxygenase, and ferritin: How the vascular endothelium survives (and dies) in an iron-rich environment
10.1089/ars.2007.1787 · 2007 · External reference
Empagliflozin attenuates vascular calcification in mice with chronic kidney disease by regulating the NFR2/HO-1 anti-inflammatory pathway through AMPK activation
10.3390/ijms241210016 · 2023 · External reference
Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2/HO-1 pathway
10.1007/s11010-015-2559-z · 2015 · External reference
Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway
10.1016/j.intimp.2024.111665 · 2024 · External reference
Corrigendum to 'Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2/HO-1 signaling pathway' [Biomed. Pharmacother. 121 (2020) 109676]
10.1016/j.biopha.2019.109808 · 2020 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
10.1006/meth.2001.1262 · ExternalCitation · doi-reference
Mitochondria homeostasis and vascular medial calcification
10.1007/s00223-021-00828-1 · ExternalCitation · doi-reference
Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2/HO-1 pathway
10.1007/s11010-015-2559-z · ExternalCitation · doi-reference
Irisin alleviates vascular calcification by inhibiting VSMC osteoblastic transformation and mitochondria dysfunction via AMPK/Drp1 signaling pathway in chronic kidney disease
10.1016/j.atherosclerosis.2022.02.007 · ExternalCitation · doi-reference
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα
10.1016/j.bcp.2022.115379 · ExternalCitation · doi-reference
Corrigendum to 'Cytoprotective effect of Fufang Lurong Jiangu capsule against hydrogen peroxide-induced oxidative stress in bone marrow stromal cell-derived osteoblasts through the Nrf2/HO-1 signaling pathway' [Biomed. Pharmacother. 121 (2020) 109676]
10.1016/j.biopha.2019.109808 · ExternalCitation · doi-reference
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria
10.1016/j.dnarep.2009.01.021 · ExternalCitation · doi-reference
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects
10.1016/j.freeradbiomed.2021.01.033 · ExternalCitation · doi-reference
Nesfatin-1 mitigates calcific aortic valve disease via suppressing ferroptosis mediated by GSH/GPX4 and ZIP8/SOD2 axes
10.1016/j.freeradbiomed.2024.06.004 · ExternalCitation · doi-reference
Punicalagin from pomegranate ameliorates TNF-α/IFN-γ-induced inflammatory responses in HaCaT cells via regulation of SIRT1/STAT3 axis and Nrf2/HO-1 signaling pathway
10.1016/j.intimp.2024.111665 · ExternalCitation · doi-reference
Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification
10.1016/j.kint.2022.07.034 · ExternalCitation · doi-reference
Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1/p53 axis
10.1016/j.phymed.2024.155533 · ExternalCitation · doi-reference
Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease
10.1016/j.redox.2023.102629 · ExternalCitation · doi-reference
Ferritin: A cytoprotective antioxidant strategem of endothelium
10.1016/s0021-9258(19)37165-0 · ExternalCitation · doi-reference
Programmed cell death in atherosclerosis and vascular calcification
10.1038/s41419-022-04923-5 · ExternalCitation · doi-reference
Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy
10.1038/s41419-024-07260-x · ExternalCitation · doi-reference
Endothelial-cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage
10.1073/pnas.90.20.9285 · ExternalCitation · doi-reference
SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury
10.1080/02656736.2022.2094476 · ExternalCitation · doi-reference
Heme, heme oxygenase, and ferritin: How the vascular endothelium survives (and dies) in an iron-rich environment
10.1089/ars.2007.1787 · ExternalCitation · doi-reference
Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification
10.1093/cvr/cvaa134 · ExternalCitation · doi-reference
Calcific aortic valve disease: From molecular and cellular mechanisms to medical therapy
10.1093/eurheartj/ehab757 · ExternalCitation · doi-reference
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification
10.1093/eurheartj/ehac037 · ExternalCitation · doi-reference
Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis
10.1093/humrep/deaa363 · ExternalCitation · doi-reference
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway
10.1111/acel.13377 · ExternalCitation · doi-reference
Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins
10.1111/j.1742-4658.2011.08010.x · ExternalCitation · doi-reference
Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells
10.1111/jcmm.12682 · ExternalCitation · doi-reference
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease
10.1111/jpi.12948 · ExternalCitation · doi-reference
Potential role of H-ferritin in mitigating valvular mineralization
10.1161/atvbaha.118.312191 · ExternalCitation · doi-reference
Dynamin-related protein 1 inhibition attenuates cardiovascular calcification in the presence of oxidative stress
10.1161/circresaha.116.310293 · ExternalCitation · doi-reference
Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway
10.1186/s10020-023-00714-6 · ExternalCitation · doi-reference
Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation
10.1186/s10020-023-00735-1 · ExternalCitation · doi-reference
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
10.1186/s12974-022-02400-6 · ExternalCitation · doi-reference
Luteolin protects against vascular calcification by modulating SIRT1/CXCR4 signaling pathway and promoting autophagy
10.1208/s12248-024-00982-y · ExternalCitation · doi-reference
Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells
10.1681/asn.2008070788 · ExternalCitation · doi-reference
Global burden of calcific aortic valve disease and attributable risk factors from 1990 to 2019
10.3389/fcvm.2022.1003233 · ExternalCitation · doi-reference
Potential ferroptosis key genes in calcific aortic valve disease
10.3389/fcvm.2022.916841 · ExternalCitation · doi-reference
Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria
10.3389/fcvm.2022.972836 · ExternalCitation · doi-reference
Mechanism and treatment of Sirtuin family in vascular calcification
10.3389/fcvm.2025.1732281 · ExternalCitation · doi-reference
The role of sirtuin-1 in the vasculature: Focus on aortic aneurysm
10.3389/fphys.2020.01047 · ExternalCitation · doi-reference
Loss-of-function mitochondrial DNA polymerase gamma variants cause vascular smooth muscle cells to secrete a diffusible mitogenic factor
10.3389/fphys.2024.1488248 · ExternalCitation · doi-reference
Contribution of oxidative stress (OS) in calcific aortic valve disease (CAVD): From pathophysiology to therapeutic targets
10.3390/cells11172663 · ExternalCitation · doi-reference
Sirtuin-1 and Its relevance in vascular calcification
10.3390/ijms21051593 · ExternalCitation · doi-reference
Empagliflozin attenuates vascular calcification in mice with chronic kidney disease by regulating the NFR2/HO-1 anti-inflammatory pathway through AMPK activation
10.3390/ijms241210016 · ExternalCitation · doi-reference
Activation of Nrf2/HO-1 antioxidant pathway by heme attenuates calcification of human lens epithelial cells
10.3390/ph15050493 · ExternalCitation · doi-reference
Uremic toxin p-cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin-1 signaling
10.3892/mmr.2026.13872 · ExternalCitation · doi-reference
