Research graph
References from Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review). Local targets link to admitted publications; unresolved targets remain external evidence.
Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factorsin 204 Countries and Territories, 1990-2023
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Inflammasomes in cardiovascular diseases: Current knowledge and future perspectives
10.3390/ijms26125439 · 2025 · External reference
Nlrc4 Inflammasome expression after acute myocardial infarction in rats
10.3390/ijms26083697 · 2025 · External reference
Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis
10.1186/s12967-025-06551-x · 2025 · External reference
Inflammation and hypertension: Underlying mechanisms and emerging understandings
10.1002/jcp.31019 · 2023 · External reference
The role of systemic immune-inflammatory index in predicting contrast-induced nephropathy in non-ST-segment elevation myocardial infarction cases
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Overlap between nutritional indices in patients with acute coronary syndrome: A focus on albumin
2024 · External reference
The roles of neutrophils in cardiovascular diseases
10.3389/fcvm.2025.1526170 · 2025 · External reference
Neutrophil extracellular traps participate in cardiovascular diseases: Recent experimental and clinical insights
10.1161/circresaha.120.315931 · 2020 · External reference
Neutrophil extracellular traps kill bacteria
10.1126/science.1092385 · 2004 · External reference
Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor
10.1159/000363242 · 2014 · External reference
Neutrophil extracellular traps (NET) induced by different stimuli: A comparative proteomic analysis
10.1371/journal.pone.0218946 · 2019 · External reference
Neutrophil extracellular traps in homeostasis and disease
10.1038/s41392-024-01933-x · 2024 · External reference
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
10.1038/nchembio.496 · 2011 · External reference
Protein kinase C isoforms mediate the formation of neutrophil extracellular traps
10.1016/j.intimp.2022.109448 · 2023 · External reference
Neutrophil extracellular traps: From physiology to pathology
10.1093/cvr/cvab329 · 2022 · External reference
NETosis: Molecular mechanisms, role in physiology and pathology
10.1134/s0006297920100065 · 2020 · External reference
Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases
10.1152/physrev.00062.2021 · 2023 · External reference
The emerging role of neutrophil extracellular traps in fungal infection
10.3389/fcimb.2022.900895 · 2022 · External reference
SK3 channel and mitochondrial ROS mediate NADPH oxidaseindependent NETosis induced by calcium influx
10.1073/pnas.1414055112 · 2015 · External reference
Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
10.1126/science.aaa8064 · 2015 · External reference
Microdomains, inflammation, and atherosclerosis
10.1161/circresaha.115.306246 · 2016 · External reference
Hyperglycemia induces neutrophil extracellular traps formation through an NADPH Oxidase-dependent pathway in diabetic retinopathy
10.3389/fimmu.2018.03076 · 2019 · External reference
Role of HMGB1 in the interplay between NETosis and Thrombosis in ischemic stroke: A review
10.3390/cells9081794 · 2020 · External reference
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice
10.1182/blood-2016-09-741298 · 2017 · External reference
Intracellular communication and immunothrombosis in sepsis
10.1111/jth.15852 · 2022 · External reference
Platelet FcγRIIA in immunity and thrombosis: Adaptive immunothrombosis
10.1111/jth.15265 · 2021 · External reference
Targeted delivery of protein arginine deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity
2021 · External reference
Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages
10.1080/15384101.2019.1662678 · 2019 · External reference
Exploring neutrophil extracellular traps in cardiovascular pathologies: The impact of lipid profiles, PAD4, and radiation
10.32604/biocell.2025.062789 · 2025 · External reference
Macrophages: The Good, the bad, and the gluttony
10.3389/fimmu.2021.708186 · 2021 · External reference
Tissue-resident macrophages
10.1038/ni.2705 · 2013 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
Macrophage M1/M2 polarization
10.1016/j.ejphar.2020.173090 · 2020 · External reference
Inhibition of Macrophage ARID3A alleviates myocardial ischemia-reperfusion injury after heart transplantation by reducing THBS1/CD47 Signaling-mediated neutrophil extracellular traps formation
10.1002/advs.202509952 · 2025 · External reference
Internalisation of neutrophils extracellular traps by macrophages aggravate rheumatoid arthritis via Rab5a
10.1136/rmdopen-2023-003847 · 2024 · External reference
Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy
10.3389/fcell.2022.876147 · 2022 · External reference
Neutrophil extracellular traps modulate inflammatory markers and uptake of oxidized LDL by human and murine macrophages
10.1371/journal.pone.0259894 · 2021 · External reference
Neutrophil extracellular traps induce MCP-1 at the culprit site in ST-Segment elevation myocardial infarction
10.3389/fcell.2020.564169 · 2020 · External reference
Neutrophil extracellular traps and monocyte subsets at the culprit lesion site of myocardial infarction patients
10.1038/s41598-019-52671-y · 2019 · External reference
Neutrophil extracellular traps induce endothelial cell activation and tissue factor production through Interleukin-1α and cathepsin G
10.1161/atvbaha.118.311150 · 2018 · External reference
Neutrophil extracellular traps promote angiogenesis: Evidence from vascular pathology in pulmonary hypertension
10.1161/atvbaha.116.307634 · 2016 · External reference
Hyperglycemia-induced STING signaling activation leads to aortic endothelial injury in diabetes
10.1186/s12964-023-01393-w · 2023 · External reference
Emerging role of the cGAS-STING pathway in cardiovascular diseases: Biologic function, mechanisms and targeted therapy
10.1186/s10020-025-01273-8 · 2025 · External reference
Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injury
10.1038/s41420-023-01614-8 · 2023 · External reference
Thrombosis formation on atherosclerotic lesions and plaque rupture
10.1111/joim.12296 · 2014 · External reference
P-selectin promotes neutrophil extracellular trap formation in mice
10.1182/blood-2015-01-624023 · 2015 · External reference
Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2
10.7554/elife.53353 · 2020 · External reference
Cell Type-Specific roles of NF-κB linking inflammation and thrombosis
10.3389/fimmu.2019.00085 · 2019 · External reference
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis
10.1038/s44161-022-00108-7 · 2022 · External reference
Double-stranded DNA enhances platelet activation, thrombosis, and myocardial injury via cyclic GMP-AMP synthase
10.1093/cvr/cvae218 · 2025 · External reference
Cardiac fibroblast diversity
10.1146/annurev-physiol-021119-034527 · 2020 · External reference
TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies
10.1016/j.ejphar.2021.174510 · 2021 · External reference
Myocardial fibrosis in hypertrophic cardiomyopathy: A perspective from fibroblasts
10.3390/ijms241914845 · 2023 · External reference
Transforming growth factor-β in tissue fibrosis
10.1084/jem.20190103 · 2020 · External reference
Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
10.1161/01.cir.0000020689.12472.e0 · 2002 · External reference
Compromised Anti-inflammatory action of neutrophil extracellular traps in PAD4-deficient mice contributes to aggravated acute inflammation after myocardial infarction
10.3389/fimmu.2019.02313 · 2019 · External reference
NETs promote pathogenic cardiac fibrosis and participate in ventricular aneurysm formation after ischemia injury through the facilitation of perivascular fibrosis
10.1016/j.bbrc.2021.10.068 · 2021 · External reference
Fibroblast and immune cell Cross-Talk in cardiac fibrosis
10.1007/s11886-023-01877-8 · 2023 · External reference
WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death
10.1074/jbc.m809757200 · 2009 · External reference
Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase
10.1023/a:1021655023870 · 2003 · External reference
Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro
10.1161/01.res.86.12.1259 · 2000 · External reference
Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart
10.1074/jbc.m111.246173 · 2012 · External reference
Neutrophil extracellular traps aggravate uremic cardiomyopathy by inducing myocardial fibroblast pyroptosis
10.1038/s41598-025-02383-3 · 2025 · External reference
Neutrophil extracellular traps induce Tissue-invasive monocytes in granulomatosis with polyangiitis
10.3389/fimmu.2019.02617 · 2019 · External reference
Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
10.1016/j.ajpath.2011.06.001 · 2011 · External reference
Neutrophil Extracellular traps drive Endothelial-to-Mesenchymal transition
10.1161/atvbaha.117.309002 · 2017 · External reference
Extracellular DNA traps promote thrombosis
10.1073/pnas.1005743107 · 2010 · External reference
Bioprinted thrombosis-on-a-chip
10.1039/c6lc00380j · 2016 · External reference
Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation
10.2353/ajpath.2008.070347 · 2008 · External reference
Coronary neutrophil extracellular trap burden and deoxyribonuclease activity in ST-elevation acute coronary syndrome are predictors of ST-segment resolution and infarct size
10.1161/circresaha.116.304944 · 2015 · External reference
Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction
10.1093/cvr/cvab217 · 2022 · External reference
Neutrophil extracellular trap components associate with infarct size, ventricular function, and clinical outcome in STEMI
10.1155/2019/7816491 · 2019 · External reference
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction
10.1007/s00395-019-0740-3 · 2019 · External reference
S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis
10.1038/s41467-025-56978-5 · 2025 · External reference
EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization
10.1093/cvr/cvab269 · 2022 · External reference
Histological substrate of atrial biopsies in patients with lone atrial fibrillation
10.1161/01.cir.96.4.1180 · 1997 · External reference
MiR-146a regulates neutrophil extracellular trap formation that predicts adverse cardiovascular events in patients with atrial fibrillation
10.1161/atvbaha.117.310597 · 2018 · External reference
Interaction between neutrophil extracellular traps and cardiomyocytes contributes to atrial fibrillation progression
10.1038/s41392-023-01497-2 · 2023 · External reference
Chronic mild stress exacerbates atrial fibrillation and neutrophil extracellular traps formation through S100A8/A9 signaling
10.1038/s41392-025-02199-7 · 2025 · External reference
Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis
10.1093/cvr/cvac052 · 2023 · External reference
Neutrophil CAPNS1 regulates cardiac inflammation and injury by promoting NETosis in CVB3-induced myocarditis
10.1016/j.freeradbiomed.2026.03.007 · 2026 · External reference
Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis
10.1007/s00395-022-00948-1 · 2022 · External reference
Correlation between the level of peripheral blood neutrophil extracellular trap nets and T cell expression and prognosis in patients with infective endocarditis
2022 · External reference
Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated platelets
10.1161/circulationaha.114.011432 · 2015 · External reference
Streptococcus gordonii type VII secretion system substrate EsxA induces neutrophil extracellular trap formation in infective endocarditis
10.1038/s41598-025-27543-3 · 2025 · External reference
Neutrophil extracellular traps enhance Staphylococcus aureus vegetation formation through interaction with platelets in infective endocarditis
10.1055/s-0039-1678665 · 2019 · External reference
Active NET formation in Libman-Sacks endocarditis without antiphospholipid antibodies: A dramatic onset of systemic lupus erythematosus
10.1080/08916934.2018.1514496 · 2018 · External reference
Epidemiology and aetiology of heart failure
10.1038/nrcardio.2016.25 · 2016 · External reference
Inflammatory mediators and the failing heart: Past, present, and the foreseeable future
10.1161/01.res.0000043825.01705.1b · 2002 · External reference
Neutrophil extracellular traps in myocardial tissue drive cardiac dysfunction and adverse outcomes in patients with heart failure with dilated cardiomyopathy
10.1161/circheartfailure.123.011057 · 2024 · External reference
Expression level of neutrophil extracellular traps in peripheral blood of patients with chronic heart failure complicated with venous thrombosis and its clinical significance
10.1186/s13019-024-02506-3 · 2024 · External reference
KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression
10.1172/jci147191 · 2022 · External reference
HMGB1-promoted neutrophil extracellular traps contribute to cardiac diastolic dysfunction in mice
10.1161/jaha.121.023800 · 2022 · External reference
Von Willebrand factor exacerbates heart failure through formation of neutrophil extracellular traps
10.1093/eurheartj/ehae517 · 2024 · External reference
DEL-1 deficiency aggravates pressure overload-induced heart failure by promoting neutrophil infiltration and neutrophil extracellular traps formation
10.1016/j.bcp.2023.115912 · 2023 · External reference
Inflammation in atherosclerosis
10.1038/nature01323 · 2002 · External reference
Presence of luminal neutrophil extracellular traps in atherosclerosis
10.1160/th11-09-0650 · 2012 · External reference
Neutrophil extracellular trap burden correlates with the stenosis of coronary atherosclerosis
10.7717/peerj.15471 · 2023 · External reference
Low shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation
10.1016/j.atherosclerosis.2024.117473 · 2024 · External reference
Exosomes derived from oxLDL-stimulated macrophages induce neutrophil extracellular traps to drive atherosclerosis
10.1080/15384101.2019.1654797 · 2019 · External reference
Exosome-encapsulated miR-505 from ox-LDL-treated vascular endothelial cells aggravates atherosclerosis by inducing NET formation
10.1093/abbs/gmz123 · 2019 · External reference
Increased intracellular Cl− concentration mediates neutrophil extracellular traps formation in atherosclerotic cardiovascular diseases
10.1038/s41401-022-00911-9 · 2022 · External reference
Mitochondrial oxidative stress promotes atherosclerosis and neutrophil extracellular traps in aged mice
10.1161/atvbaha.117.309580 · 2017 · External reference
Hypercholesterolemia impairs clearance of neutrophil extracellular traps and promotes inflammation and atherosclerotic plaque progression
10.1161/atvbaha.120.316389 · 2021 · External reference
Macrophage DNases limit neutrophil extracellular trap-mediated defective efferocytosis in atherosclerosis
10.1161/circresaha.125.326353 · 2025 · External reference
Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice
10.1172/jci.insight.134796 · 2020 · External reference
Neutrophil elastase promotes neointimal hyperplasia by targeting toll-like receptor 4 (TLR4)-NF-κB signalling
10.1111/bph.15583 · 2021 · External reference
Endotoxinemia accelerates atherosclerosis through electrostatic Charge-mediated monocyte adhesion
10.1161/circulationaha.120.046677 · 2021 · External reference
Paeonol inhibits NETs-mediated foam cell inflammation through the CitH3/NLRP3/caspase-1 signaling pathway in atherosclerosis
10.1016/j.intimp.2025.114340 · 2025 · External reference
Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension
10.1016/j.advms.2021.02.004 · 2021 · External reference
NETosis drives blood pressure elevation and vascular dysfunction in hypertension
10.1161/circresaha.123.323897 · 2024 · External reference
Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension
10.1172/jci.insight.148668 · 2021 · External reference
IsoLGs (Isolevuglandins) drive neutrophil migration in hypertension and are essential for the formation of neutrophil extracellular traps
10.1161/hypertensionaha.122.19305 · 2022 · External reference
Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension
10.1097/hjh.0000000000003231 · 2022 · External reference
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis
10.3389/fimmu.2025.1712786 · 2026 · External reference
Pathophysiology and epidemiology of abdominal aortic aneurysms
10.1038/nrcardio.2010.180 · 2011 · External reference
Novel role of IL (Interleukin)-1β in neutrophil extracellular trap formation and abdominal aortic aneurysms
10.1161/atvbaha.117.309897 · 2018 · External reference
Highly sensitive magnetic particle imaging of abdominal aortic aneurysm NETosis with anti-Ly6G iron oxide nanoparticles
10.1038/s41420-024-02156-3 · 2024 · External reference
PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm
10.1172/jci.insight.183237 · 2024 · External reference
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation
10.1016/j.chom.2022.09.004 · 2022 · External reference
Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis
10.1038/s12276-023-00986-2 · 2023 · External reference
Neutrophil extracellular trap-induced ferroptosis promotes abdominal aortic aneurysm formation via SLC25A11-mediated depletion of mitochondrial glutathione
10.1016/j.freeradbiomed.2024.05.036 · 2024 · External reference
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway
10.1016/j.trsl.2022.11.010 · 2023 · External reference
Inhibition of peptidyl arginine deiminase 4-Dependent neutrophil extracellular trap formation reduces angiotensin II-Induced abdominal aortic aneurysm rupture in mice
10.3389/fcvm.2021.676612 · 2021 · External reference
Neutrophil proteases promote experimental abdominal aortic aneurysm via extracellular trap release and plasmacytoid dendritic cell activation
10.1161/atvbaha.116.307786 · 2016 · External reference
Aortic valve stenosis: From basic mechanisms to novel therapeutic targets
10.1161/atvbaha.119.313067 · 2020 · External reference
Aortic stenosis, atherosclerosis, and skeletal bone: Is there a common link with calcification and inflammation?
10.1093/eurheartj/eht034 · 2013 · External reference
A Rock and a hard place: Chiseling away at the multiple mechanisms of aortic stenosis
10.1161/circulationaha.117.027776 · 2017 · External reference
NETosis is associated with the severity of aortic stenosis: Links with inflammation
10.1016/j.ijcard.2019.03.047 · 2019 · External reference
Deoxyribonuclease is prognostic in patients undergoing transcatheter aortic valve replacement
10.1111/eci.13595 · 2021 · External reference
Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis
10.1161/atvbaha.107.154989 · 2008 · External reference
Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation
10.1016/j.freeradbiomed.2016.01.004 · 2016 · External reference
Mechanisms of aortic stenosis
10.1016/j.jjcc.2017.11.007 · 2018 · External reference
Inhalable dry powder formulations of the commercialised form of Deoxyribonuclease I-a dried alternative for the treatment of cystic fibrosis
10.1016/j.ejps.2026.107463 · 2026 · External reference
Physiology and pathophysiology of mucus and mucolytic use in critically ill patients
10.1186/s13054-025-05286-x · 2025 · External reference
Neutrophil extracellular traps directly induce epithelial and endothelial cell death: A predominant role of histones
10.1371/journal.pone.0032366 · 2012 · External reference
Engineering actin-resistant human DNase I for treatment of cystic fibrosis
10.1073/pnas.93.16.8225 · 1996 · External reference
Intra- and extracellular degradation of neutrophil extracellular traps by macrophages and dendritic cells
10.4049/jimmunol.1800159 · 2019 · External reference
Gene-targeted mice lacking the Trex1 (DNase III) 3′->5'DNA exonuclease develop inflammatory myocarditis
10.1128/mcb.24.15.6719-6727.2004 · 2004 · External reference
Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction
10.1186/s40635-015-0072-z · 2015 · External reference
Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis
10.1182/blood-2013-07-514984 · 2014 · External reference
Non-anticoagulant heparin attenuates histone-mediated platelet-leukocyte aggregation and neutrophil extracellular trap formation in a canine whole blood model
10.3389/fvets.2026.1778453 · 2026 · External reference
Thrombomodulin alfa attenuates the procoagulant effect and cytotoxicity of extracellular histones through the promotion of protein C activation
10.1016/j.thromres.2017.10.019 · 2017 · External reference
Human CRP defends against the toxicity of circulating histones
10.4049/jimmunol.1203181 · 2013 · External reference
Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: A multicenter retrospective cohort study
10.1186/s12931-025-03100-4 · 2025 · External reference
Neutrophil elastase inhibition ameliorates Endotoxin-induced myocardial injury accompanying degradation of cardiac capillary glycocalyx
10.1097/shk.0000000000001482 · 2020 · External reference
SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury
10.1016/s0014-2999(03)01298-6 · 2003 · External reference
Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms
10.1016/j.jvs.2014.07.102 · 2016 · External reference
Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis
10.1161/circresaha.114.303312 · 2014 · External reference
Peptidylarginine deiminase 4-mediated citrullination in human disease: Molecular mechanisms and therapeutic targeting
10.3389/fphar.2026.1854078 · 2026 · External reference
Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction
10.1016/j.intimp.2019.106055 · 2020 · External reference
Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis
10.26508/lsa.202302055 · 2023 · External reference
Colchicine inhibits NETs and alleviates cardiac remodeling after acute myocardial infarction
10.1007/s10557-022-07326-y · 2024 · External reference
Colchicine in cardiovascular medicine: Current perspectives on mechanisms and clinical therapeutics
10.1016/j.pharmthera.2026.109053 · 2026 · External reference
H2 Inhibits the formation of neutrophil extracellular traps
10.1016/j.jacbts.2021.11.005 · 2022 · External reference
Anthracyclines suppress both NADPH Oxidase-dependent and -independent NETosis in human neutrophils
10.3390/cancers11091328 · 2019 · External reference
Neutrophil Extracellular traps in ST-Segment elevation myocardial infarction: Reduced by tocilizumab and associated with infarct size
10.1016/j.jacadv.2024.101193 · 2024 · External reference
Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis
10.1016/j.bbadis.2019.165542 · 2019 · External reference
Itaconate suppresses formation of neutrophil extracellular traps (NETs): Involvement of Hypoxia-Inducible factor 1α (Hif-1α) and heme oxygenase (HO-1)
10.3389/fimmu.2022.864638 · 2022 · External reference
Inhibition of Macrophage ARID3A alleviates myocardial ischemia-reperfusion injury after heart transplantation by reducing THBS1/CD47 Signaling-mediated neutrophil extracellular traps formation
10.1002/advs.202509952 · ExternalCitation · doi-reference
Inflammation and hypertension: Underlying mechanisms and emerging understandings
10.1002/jcp.31019 · ExternalCitation · doi-reference
Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction
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Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis
10.1007/s00395-022-00948-1 · ExternalCitation · doi-reference
Colchicine inhibits NETs and alleviates cardiac remodeling after acute myocardial infarction
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Fibroblast and immune cell Cross-Talk in cardiac fibrosis
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Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension
10.1016/j.advms.2021.02.004 · ExternalCitation · doi-reference
Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
10.1016/j.ajpath.2011.06.001 · ExternalCitation · doi-reference
Low shear stress exacerbates atherosclerosis by inducing the generation of neutrophil extracellular traps via Piezo1-mediated mechanosensation
10.1016/j.atherosclerosis.2024.117473 · ExternalCitation · doi-reference
Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis
10.1016/j.bbadis.2019.165542 · ExternalCitation · doi-reference
NETs promote pathogenic cardiac fibrosis and participate in ventricular aneurysm formation after ischemia injury through the facilitation of perivascular fibrosis
10.1016/j.bbrc.2021.10.068 · ExternalCitation · doi-reference
DEL-1 deficiency aggravates pressure overload-induced heart failure by promoting neutrophil infiltration and neutrophil extracellular traps formation
10.1016/j.bcp.2023.115912 · ExternalCitation · doi-reference
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation
10.1016/j.chom.2022.09.004 · ExternalCitation · doi-reference
Macrophage M1/M2 polarization
10.1016/j.ejphar.2020.173090 · ExternalCitation · doi-reference
TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies
10.1016/j.ejphar.2021.174510 · ExternalCitation · doi-reference
Inhalable dry powder formulations of the commercialised form of Deoxyribonuclease I-a dried alternative for the treatment of cystic fibrosis
10.1016/j.ejps.2026.107463 · ExternalCitation · doi-reference
Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation
10.1016/j.freeradbiomed.2016.01.004 · ExternalCitation · doi-reference
Neutrophil extracellular trap-induced ferroptosis promotes abdominal aortic aneurysm formation via SLC25A11-mediated depletion of mitochondrial glutathione
10.1016/j.freeradbiomed.2024.05.036 · ExternalCitation · doi-reference
Neutrophil CAPNS1 regulates cardiac inflammation and injury by promoting NETosis in CVB3-induced myocarditis
10.1016/j.freeradbiomed.2026.03.007 · ExternalCitation · doi-reference
NETosis is associated with the severity of aortic stenosis: Links with inflammation
10.1016/j.ijcard.2019.03.047 · ExternalCitation · doi-reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · ExternalCitation · doi-reference
Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction
10.1016/j.intimp.2019.106055 · ExternalCitation · doi-reference
Protein kinase C isoforms mediate the formation of neutrophil extracellular traps
10.1016/j.intimp.2022.109448 · ExternalCitation · doi-reference
Paeonol inhibits NETs-mediated foam cell inflammation through the CitH3/NLRP3/caspase-1 signaling pathway in atherosclerosis
10.1016/j.intimp.2025.114340 · ExternalCitation · doi-reference
Neutrophil Extracellular traps in ST-Segment elevation myocardial infarction: Reduced by tocilizumab and associated with infarct size
10.1016/j.jacadv.2024.101193 · ExternalCitation · doi-reference
H2 Inhibits the formation of neutrophil extracellular traps
10.1016/j.jacbts.2021.11.005 · ExternalCitation · doi-reference
Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factorsin 204 Countries and Territories, 1990-2023
10.1016/j.jacc.2025.08.015 · ExternalCitation · doi-reference
Mechanisms of aortic stenosis
10.1016/j.jjcc.2017.11.007 · ExternalCitation · doi-reference
Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms
10.1016/j.jvs.2014.07.102 · ExternalCitation · doi-reference
Colchicine in cardiovascular medicine: Current perspectives on mechanisms and clinical therapeutics
10.1016/j.pharmthera.2026.109053 · ExternalCitation · doi-reference
Thrombomodulin alfa attenuates the procoagulant effect and cytotoxicity of extracellular histones through the promotion of protein C activation
10.1016/j.thromres.2017.10.019 · ExternalCitation · doi-reference
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo-YAP pathway
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