Research graph
References from miR‑222‑3p inhibits diabetic skin wound healing by targeting APLN. Local targets link to admitted publications; unresolved targets remain external evidence.
Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom
10.1111/dme.13054 · 2016 · External reference
Diabetic foot ulcers: A review
10.1001/jama.2023.10578 · 2023 · External reference
Research advances on the mechanism of refractory healing of diabetic foot ulcer
2022 · External reference
Stem cells and angiogenesis: Implications and limitations in enhancing chronic diabetic foot ulcer healing
10.3390/cells11152287 · 2022 · External reference
Role of microRNAs in vascular diseases, inflammation, and angiogenesis
10.1093/cvr/cvn156 · 2008 · External reference
An overview of microRNAs: Biology, functions, therapeutics, and analysis methods
10.1002/jcp.27486 · 2019 · External reference
Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications
10.1016/j.phrs.2022.106135 · 2022 · External reference
The role of microRNAs in the healing of diabetic ulcers
10.1111/iwj.13070 · 2019 · External reference
Enhanced expression of mir-34c in peripheral plasma associated with diabetic foot ulcer in type 2 diabetes patients
10.2147/dmso.s326066 · 2021 · External reference
Decreased expression of miR-204-3p in peripheral blood and wound margin tissue associated with the onset and poor wound healing of diabetic foot ulcers
10.1111/iwj.13890 · 2023 · External reference
Increased expression of miR-155 in peripheral blood and wound margin tissue of type 2 diabetes mellitus patients associated with diabetic foot ulcer
10.2147/dmso.s376292 · 2022 · External reference
Role of increased miR-222-3p expression in peripheral blood and wound marginal tissues of type 2 diabetes mellitus patients with diabetic foot ulcer
10.2147/dmso.s410986 · 2023 · External reference
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes
10.1042/cs20220099 · 2022 · External reference
Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer
10.1016/j.diabres.2019.01.002 · 2018 · External reference
Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases
10.1152/physrev.00001.2019 · 2020 · External reference
Dicarbonyl stress in diabetic vascular disease
10.3390/ijms23116186 · 2022 · External reference
Advanced glycation endproducts in diabetes-related macrovascular complications: focus on methylglyoxal
10.1016/j.tem.2022.11.004 · 2023 · External reference
Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous wounds
10.1042/cs20050026 · 2005 · External reference
G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway
10.1161/circresaha.109.201186 · 2009 · External reference
A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia
10.1038/s41467-020-20560-y · 2021 · External reference
Neural progenitor-derived Apelin controls tip cell behavior and vascular patterning
10.1126/sciadv.adk1174 · 2024 · External reference
Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice
10.1126/sciadv.aaz0359 · 2020 · External reference
International union of basic and clinical pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function
10.1124/pr.110.002949 · 2010 · External reference
Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo
10.1016/j.ydbio.2006.04.452 · 2006 · External reference
Xapelin and Xmsr are required for cardiovascular development in Xenopus laevis
10.1016/j.ydbio.2006.06.028 · 2006 · External reference
Apelin controls angiogenesis-dependent glioblastoma growth
10.3390/ijms21114179 · 2020 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1-dependent autophagy
10.1111/bph.15701 · 2022 · External reference
Exosomes derived from minor salivary gland mesenchymal stem cells: A promising novel exosome exhibiting pro-angiogenic and wound healing effects similar to those of adipose-derived stem cell exosomes
10.1186/s13287-024-04069-5 · 2024 · External reference
Higher gestational weight gain delays wound healing and reduces expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells
10.1113/jp284871 · 2023 · External reference
A novel controllable hydrogen sulfide-releasing molecule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunction
10.1159/000366339 · 2014 · External reference
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
10.1006/bbrc.1998.9489 · 1998 · External reference
Promoting effects of the adipokine, apelin, on diabetic nephropathy
10.1371/journal.pone.0060457 · 2013 · External reference
Apelin-13 stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells
10.3892/mmr.2014.1984 · 2014 · External reference
Apelin-13 inhibits methylglyoxal-induced unfolded protein responses and endothelial dysfunction via regulating AMPK pathway
10.3390/ijms21114069 · 2020 · External reference
A novel glycoprotein from earthworm extract PvE-3: Insights of their characteristics for promoting diabetic wound healing and attenuating methylglyoxal-induced cell damage
10.1016/j.ijbiomac.2023.124267 · 2023 · External reference
Methylglyoxal-modified human serum albumin binds to leukocyte myeloperoxidase and inhibits its enzymatic activity
10.3390/antiox11112263 · 2022 · External reference
Evaluation of immunomodulatory responses and changed wound healing in type 2 diabetes-A study exploiting dermal fibroblasts from diabetic and non-diabetic human donors
10.3390/cells10112931 · 2021 · External reference
Attenuation of methylglyoxal-induced glycation and cellular dysfunction in wound healing by Centella cordifolia
10.1016/j.sjbs.2020.11.016 · 2021 · External reference
Dual Glyoxalase-1 and β-Klotho gene-activated scaffold reduces methylglyoxal and reprograms diabetic adipose-derived stem cells: Prospects in improved wound healing
10.3390/pharmaceutics16020265 · 2024 · External reference
Methylglyoxal scavengers attenuate angiogenesis dysfunction induced by methylglyoxal and oxygen-glucose deprivation
10.1155/2022/8854457 · 2022 · External reference
Ameliorating methylglyoxal-induced progenitor cell dysfunction for tissue repair in diabetes
10.2337/db18-0933 · 2019 · External reference
Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis
10.1161/circresaha.107.153916 · 2007 · External reference
High glucose-induced endothelial progenitor cell dysfunction
10.1177/1479164117719058 · 2017 · External reference
MiR-222-3p downregulation prompted the migration, invasion and recruitment of endothelial progenitor cells via ADIPOR1 expression increase-induced AMKP activation
10.1016/j.mvr.2021.104134 · 2021 · External reference
MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis
10.1016/j.atherosclerosis.2015.06.031 · 2015 · External reference
MicroRNAs: Genomics, biogenesis, mechanism, and function
10.1016/s0092-8674(04)00045-5 · 2004 · External reference
Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state
10.7554/elife.55589 · 2020 · External reference
Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
10.1530/joe-20-0398 · 2021 · External reference
HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
10.1111/1523-1747.ep12613748 · 1992 · External reference
Vaccarin regulates diabetic chronic wound healing through FOXP2/AGGF1 Pathways
10.3390/ijms21061966 · 2020 · External reference
Salvianolic acid B improves diabetic skin wound repair through Pink1/Parkin-mediated mitophagy
10.1080/13813455.2024.2387693 · 2025 · External reference
Fabrication of hydroxyapatite/chitosan composite hydrogels loaded with exosomes derived from miR-126-3p overexpressed synovial mesenchymal stem cells for diabetic chronic wound healing
10.1039/c6tb01560c · 2016 · External reference
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents
10.1038/s41467-025-62320-w · 2025 · External reference
