Research graph
References from PINK1 promotes the progression of lung squamous cell carcinoma through the FAK/AKT/RhoA/vinculin pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries
2026 · External reference
TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation
10.1038/s41418-023-01239-5 · 2024 · External reference
FHL2 facilitates LUSC growth and therapy resistance through PI3K/AKT/mTOR activation
10.1016/j.jbc.2025.110332 · 2025 · External reference
THY1 is a prognostic-related biomarker via mediating immune infiltration in lung squamous cell carcinoma (LUSC)
10.18632/aging.205880 · 2024 · External reference
Construction of a prognostic model for lung squamous cell carcinoma based on seven N6-methylandenosine-related autophagy genes
10.3934/mbe.2021333 · 2021 · External reference
A four-gene autophagy-related prognostic model signature and its association with immune phenotype in lung squamous cell carcinoma
2024 · External reference
Mitochondrial quality control in human health and disease
2024 · External reference
Mitochondrial quality control: From molecule to organelle
10.1007/s00018-021-03775-0 · 2021 · External reference
Mitochondrial quality control in kidney injury and repair
10.1038/s41581-020-00369-0 · 2021 · External reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · 2012 · External reference
Mitophagy: A mechanism for plant growth and survival
10.1016/j.tplants.2018.02.010 · 2018 · External reference
Mitochondrial quality control mechanisms and the PHB (Prohibitin) complex
10.3390/cells7120238 · 2018 · External reference
Mitochondrial unfolded protein-related responses across kingdoms: Similar problems, different regulators
10.1016/j.mito.2020.05.009 · 2020 · External reference
Vinculin orchestrates prostate cancer progression by regulating tumor cell invasion, migration, and proliferation
10.1002/pros.24113 · 2021 · External reference
The mitochondrion as an emerging therapeutic target in cancer
10.1016/j.molmed.2019.06.009 · 2020 · External reference
Pan-cancer analysis of the mitophagy-related protein PINK1 as a biomarker for the immunological and prognostic role
10.3389/fonc.2020.569887 · 2020 · External reference
Lost in translation: endoplasmic reticulum-mitochondria crosstalk in idiopathic pulmonary fibrosis
10.1165/rcmb.2020-0273ed · 2020 · External reference
ATF4 mediates mitochondrial unfolded protein response in alveolar epithelial cells
10.1165/rcmb.2020-0107oc · 2020 · External reference
Gene expression-based classification of non-small cell lung carcinomas and survival prediction
10.1371/journal.pone.0010312 · 2010 · External reference
Multi-institutional prospective validation of prognostic mRNA signatures in early stage squamous lung cancer (Alliance)
10.1016/j.jtho.2020.07.005 · 2020 · External reference
Biomarker discovery in non-small cell lung cancer: Integrating gene expression profiling, meta-analysis, and tissue microarray validation
10.1158/1078-0432.ccr-12-1139 · 2013 · External reference
Validation of a histology-independent prognostic gene signature for early-stage, non-small-cell lung cancer including stage IA patients
10.1097/jto.0000000000000042 · 2014 · External reference
Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients
10.1158/1078-0432.ccr-11-0196 · 2011 · External reference
A novel mitochondrial unfolded protein response-related risk signature to predict prognosis, immunotherapy and sorafenib sensitivity in hepatocellular carcinoma
10.1007/s10495-024-01945-6 · 2024 · External reference
plotnineSeqSuite: A python package for visualizing sequence data using ggplot2 style
10.1186/s12864-023-09677-8 · 2023 · External reference
The sva package for removing batch effects and other unwanted variation in high-throughput experiments
10.1093/bioinformatics/bts034 · 2012 · External reference
TFIIB-related factor 2 inhibits lung squamous carcinoma cell apoptosis through SLC8A3-mediated mitochondrial homeostasis
10.1038/s41419-025-07813-8 · 2025 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
10.1038/s41591-018-0136-1 · 2018 · External reference
A super-enhancer-related gene signature predicts prognosis and immune microenvironment features in glioma
10.14715/cmb/2025.71.6.14 · 2025 · External reference
Maftools: Efficient and comprehensive analysis of somatic variants in cancer
10.1101/gr.239244.118 · 2018 · External reference
oncoPredict: An R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data
10.1093/bib/bbab260 · 2021 · External reference
Almonertinib inhibits liver cancer progression by triggering autophagy-dependent ferroptosis through inhibition of the PI3K/Akt1/mTOR pathway
10.1016/j.bcp.2025.117628 · 2026 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
p53-inducible gene 3 promotes cell migration and invasion by activating the FAK/Src pathway in lung adenocarcinoma
10.1111/cas.13818 · 2018 · External reference
Circ_0002638 drives squamous cell lung cancer (LUSC) progression and chemotherapy resistance by inhibiting ferroptosis via SENP1-mediated deSUMOylation of ACSL4
10.1016/j.lfs.2025.123728 · 2025 · External reference
Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR
10.1016/j.semcancer.2017.05.002 · 2017 · External reference
Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549
10.18632/aging.202584 · 2021 · External reference
Folding the mitochondrial UPR into the integrated stress response
10.1016/j.tcb.2020.03.001 · 2020 · External reference
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin
10.1007/s13258-021-01145-5 · 2021 · External reference
A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60
10.1172/jci149906 · 2022 · External reference
Targeting the lysosomal degradation of Rab22a-NeoF1 fusion protein for osteosarcoma lung metastasis
10.1002/advs.202205483 · 2023 · External reference
PINK1 is a negative regulator of growth and the warburg effect in glioblastoma
10.1158/0008-5472.can-15-3079 · 2016 · External reference
Silencing of PINK1 represses cell growth, migration and induces apoptosis of lung cancer cells
10.1016/j.biopha.2018.06.128 · 2018 · External reference
In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment
10.1073/pnas.2511890122 · 2025 · External reference
PINK1 alleviates myocardial hypoxia-reoxygenation injury by ameliorating mitochondrial dysfunction
10.1016/j.bbrc.2017.01.061 · 2017 · External reference
High expression of PINK1 promotes proliferation and chemoresistance of NSCLC
10.3892/or.2017.5486 · 2017 · External reference
Roles and inhibitors of FAK in cancer: Current advances and future directions
10.3389/fphar.2024.1274209 · 2024 · External reference
FAK in cancer: From mechanisms to therapeutic strategies
10.3390/ijms23031726 · 2022 · External reference
Targeting FAK in anticancer combination therapies
10.1038/s41568-021-00340-6 · 2021 · External reference
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
10.1136/gutjnl-2022-327927 · 2023 · External reference
CPNE8 promotes gastric cancer metastasis by modulating focal adhesion pathway and tumor microenvironment
10.7150/ijbs.76425 · 2022 · External reference
ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK/PI3K/AKT activation in a ceRNA manner
10.1186/s12943-024-01944-w · 2024 · External reference
FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors
10.1186/s13058-020-01310-w · 2020 · External reference
Inhibitors of the PI3K/Akt/mTOR pathway in prostate cancer chemoprevention and intervention
10.3390/pharmaceutics13081195 · 2021 · External reference
Activation of PI3K/AKT/mTOR pathway causes drug resistance in breast cancer
10.3389/fphar.2021.628690 · 2021 · External reference
Rho-GTPases subfamily: Cellular defectors orchestrating viral infection
10.1186/s11658-025-00722-w · 2025 · External reference
The role of RhoA, RhoB and RhoC GTPases in Cell morphology, proliferation and migration in human cytomegalovirus (HCMV) infected glioblastoma cells
10.1159/000438612 · 2016 · External reference
Vinculin anchors contractile actin to the cardiomyocyte adherens junction
10.1091/mbc.e19-04-0216 · 2019 · External reference
Comprehensive profiling of serum exosomes by a multi-omics approach reveals potential diagnostic markers for brain metastasis in lung cancer
10.3390/cancers17121929 · 2025 · External reference
