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References from Loperamide enhances the radiosensitivity of cervical cancer cells via ferroptosis induction. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of cervical cancer: Current estimates, temporal trend and future projections based on the GLOBOCAN 2022
2025 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative
10.1016/s2214-109x(22)00501-0 · 2023 · External reference
Minimum standards for radiation therapy in the treatment of cervical cancer in the U.S.: A consensus statement by SGO, ASTRO, and ABS addressing the WHO Cervical Cancer Elimination Campaign goals
10.1016/j.ygyno.2025.07.029 · 2025 · External reference
Molecular mechanisms of tumor resistance to radiotherapy
10.1186/s12943-023-01801-2 · 2023 · External reference
Hypoxia induces a mitotic survival advantage after radiotherapy in head and neck cancer cells
10.1002/ijc.70479 · 2026 · External reference
Molecular mechanisms of Radiation-induced cancer cell death: A primer
10.3389/fcell.2020.00041 · 2020 · External reference
Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity
10.1038/s41419-023-06211-2 · 2023 · External reference
Strategies to improve radiotherapy with targeted drugs
10.1038/nrc3007 · 2011 · External reference
Therapeutic implications for overcoming radiation resistance in cancer therapy
10.3390/ijms161125991 · 2015 · External reference
Ferroptosis: Principles and significance in health and disease
10.1186/s13045-024-01564-3 · 2024 · External reference
Ferroptosis: Mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Inducing ferroptosis to enhance radiotherapy in head and neck cancer: Mechanisms, radiosensitization strategies, and normal tissue considerations
10.3390/cells15090812 · 2026 · External reference
Inhibitors of APE1 redox and ATM synergistically sensitize osteosarcoma cells to ionizing radiation by inducing ferroptosis
10.1016/j.intimp.2024.112672 · 2024 · External reference
10.1038/s41698-026-01526-7 · 2026 · Admitted local publication
RSL3 sensitizes glioma cells to ionizing radiation by suppressing TGM2-dependent DNA damage repair and epithelial-mesenchymal transition
10.1016/j.redox.2024.103438 · 2024 · External reference
Repurposing sulfasalazine as a radiosensitizer in hypoxic human colorectal cancer
10.3390/cancers15082363 · 2023 · External reference
Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer
10.1016/j.freeradbiomed.2025.12.060 · 2026 · External reference
Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4-mediated ferroptosis
2019 · External reference
Ferroptosis in cancer and cancer immunotherapy
10.1002/cac2.12250 · 2022 · External reference
Involvement of ferroptosis-defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma
10.1002/osi2.1227 · 2024 · External reference
Loperamide cardiac toxicity: Pathophysiology, presentation, and management
2022 · External reference
Clinical review: Loperamide toxicity
10.1016/j.annemergmed.2017.04.008 · 2017 · External reference
Loperamide potentiates doxorubicin sensitivity in triple-negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl-2: In vitro and molecular docking study
10.1002/jbt.22938 · 2022 · External reference
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death
10.1080/15548627.2021.1874208 · 2021 · External reference
Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein
10.1097/00000542-200204000-00019 · 2002 · External reference
Drug combination studies and their synergy quantification using the Chou-Talalay method
10.1158/0008-5472.can-09-1947 · 2010 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
Directed cell invasion and migration during metastasis
10.1016/j.ceb.2011.12.004 · 2012 · External reference
The reversibility of cancer radioresistance: A novel potential way to identify factors contributing to tumor radioresistance
10.1007/s13577-023-00871-0 · 2023 · External reference
Ferroptosis: An iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Targeting ferroptosis in cervical cancer: Mechanistic insights and therapeutic opportunities
10.1016/j.cellsig.2025.112122 · 2025 · External reference
Ferroptosis-immune crosstalk in cervical cancer: Mechanisms and therapeutic implications
10.3389/fimmu.2025.1657905 · 2025 · External reference
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
10.1038/s41422-019-0263-3 · 2020 · External reference
GPX4, ferroptosis, and diseases
10.1016/j.biopha.2024.116512 · 2024 · External reference
Research progress of ferroptosis in cervical cancer treatment
10.1080/07853890.2025.2611208 · 2026 · External reference
Propofol augments Paclitaxel-induced cervical cancer cell ferroptosis in vitro
10.3389/fphar.2022.816432 · 2022 · External reference
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
10.1158/2159-8290.cd-19-0338 · 2019 · External reference
Overcoming radioresistance in hepatocellular carcinoma through ferroptosis modulation and exosomal biomarkers
10.1016/j.ijrobp.2025.06.2690 · 2025 · External reference
Transcriptome investigation and in vitro verification of Curcumin-induced HO-1 as a feature of ferroptosis in breast cancer cells
10.1155/2020/3469840 · 2020 · External reference
Risk of cardiac lesion with chronic and acute use of Loperamide-an integrative review
10.3390/jcdd9120431 · 2022 · External reference