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References from Changes in seminal plasma metabolites and the vital role of tyrosol in men with asthenozoospermia. Local targets link to admitted publications; unresolved targets remain external evidence.
Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis
10.1093/hropen/hoac051 · 2022 · External reference
A unique view on male infertility around the globe
10.1186/s12958-015-0032-1 · 2015 · External reference
Global, regional, and national prevalence and trends of infertility among individuals of reproductive age (15-49 years) from 1990 to 2021, with projections to 2040
10.1093/humrep/deae292 · 2025 · External reference
Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility
10.5534/wjmh.190055 · 2019 · External reference
Environmental toxins and male fertility
10.1007/s11934-018-0804-1 · 2018 · External reference
Large-scale mtDNA deletions as genetic biomarkers for susceptibility to male infertility: a systematic review and meta-analysis
10.1016/j.ijbiomac.2020.04.216 · 2020 · External reference
Genetic and epigenetic landscape of male infertility
10.1016/j.tig.2025.07.007 · 2025 · External reference
Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia
10.5653/cerm.2023.06555 · 2024 · External reference
Antioxidant supplements and semen parameters: an evidence based review
2016 · External reference
Antioxidants for male subfertility
2019 · External reference
Sperm cryodamage in ruminants: understanding the molecular changes induced by the cryopreservation process to optimize sperm quality
10.3390/ijms21082781 · 2020 · External reference
Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development
10.3390/antiox10071025 · 2021 · External reference
Assessment of DNA integrity and morphology of ejaculated spermatozoa from fertile and infertile men before and after cryopreservation
10.1093/humrep/16.6.1191 · 2001 · External reference
Effect of freeze-thawing procedure on chromatin stability, morphological alteration and membrane integrity of human spermatozoa in fertile and subfertile men
10.1046/j.1365-2605.1999.00162.x · 1999 · External reference
Total antioxidant capacity of seminal plasma is different in fertile and infertile men
10.1016/s0015-0282(16)57870-4 · 1995 · External reference
Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility
10.1371/journal.pone.0181115 · 2017 · External reference
Metabolomic profiling of human semen in patients with oligospermia using high performance liquid chromatography-tandem mass spectrometry
10.1038/s41598-024-74658-0 · 2024 · External reference
Metabolomic signature of the seminal plasma in men with severe oligoasthenospermia
10.1111/andr.12882 · 2020 · External reference
Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients
10.1002/imt2.166 · 2024 · External reference
The mechanism of oxidative stress in asthenozoospermia and antioxidant strategies: a review
10.3389/fendo.2025.1670762 · 2025 · External reference
Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum
10.1021/ac8019366 · 2009 · External reference
Global metabolic profiling of animal and human tissues via UPLC-MS
10.1038/nprot.2012.135 · 2013 · External reference
MetaboLights: open data repository for metabolomics
10.1093/nar/gkad1045 · 2024 · External reference
HMDB: the human metabolome database
10.1093/nar/gkl923 · 2007 · External reference
MassBank: a public repository for sharing mass spectral data for life sciences
10.1002/jms.1777 · 2010 · External reference
LMSD: LIPID MAPS structure database
10.1093/nar/gkl838 · 2007 · External reference
Increased cryo-survival rate in ejaculated human sperm from infertile men following pre-freeze in vitro myo-inositol supplementation
10.5653/cerm.2018.45.4.177 · 2018 · External reference
Low acrosin activity is associated with decreased Spam1/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells
10.1007/s00441-023-03826-x · 2023 · External reference
Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst
10.1038/nprot.2011.319 · 2011 · External reference
Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats
10.1080/13880209.2017.1315603 · 2017 · External reference
Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis
10.3109/13880209.2015.1042980 · 2016 · External reference
Tyrosol prevents ischemia/reperfusion-induced cardiac injury in H9c2 cells: involvement of ROS, Hsp70, JNK and ERK, and apoptosis
10.3390/molecules20033758 · 2015 · External reference
Hydroxytyrosol: its role in the prevention of cardiovascular diseases
10.1016/j.heliyon.2023.e12963 · 2023 · External reference
Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation
10.1017/s0007114515000884 · 2015 · External reference
Sperm selection in natural conception: what can we learn from mother nature to improve assisted reproduction outcomes? Hum Reprod Update
2015 · External reference
The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly
10.18632/oncotarget.14950 · 2017 · External reference
Metabolomic profiling of human spermatozoa in idiopathic asthenozoospermia patients using gas chromatography-mass spectrometry
2018 · External reference
Urinary metabolome identifies signatures of oligozoospermic infertile men
10.1016/j.fertnstert.2014.03.033 · 2014 · External reference
Isolation of Lactobacillus plantarum subsp plantarum producing C30 carotenoid 4,4'-diaponeurosporene and the assessment of its antioxidant activity
10.4014/jmb.1909.09007 · 2019 · External reference
Semen creatine and creatine kinase activity as an indicator of sperm quality
10.7754/clin.lab.2020.191248 · 2020 · External reference
Mechanism of hydrogen peroxide formation by spermatozoa and the role of amino-acids in sperm motility
10.1038/159544a0 · 1947 · External reference
Targeted amino acids profiling of human seminal plasma from teratozoospermia patients using LC-MS/MS
10.1007/s43032-023-01272-2 · 2023 · External reference
Signaling mechanisms in mammalian sperm motility
10.1095/biolreprod.116.144337 · 2017 · External reference
The role of l-arginine-no system in female reproduction: a narrative review
10.3390/ijms232314908 · 2022 · External reference
One-carbon metabolism, spermatogenesis, and male infertility
10.1177/1933719112459232 · 2013 · External reference
Structural specializations of the sperm tail
10.1016/j.cell.2023.05.026 · 2023 · External reference
Lipid metabolism
10.1146/annurev.bi.33.070164.001035 · 1964 · External reference
Reproduction, fat metabolism, and life span: what is the connection?
10.1016/j.cmet.2012.12.003 · 2013 · External reference
Fatty acid profile and metabolism are related to human sperm parameters and are relevant in idiopathic infertility and varicocele
2020 · External reference
Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice
10.1016/j.jhazmat.2024.134165 · 2024 · External reference
Inhibition of sperm respiration and reversibility of the effects of metabolic inhibitors
10.1016/s0021-9258(18)72289-8 · 1943 · External reference
Semen analysis and sperm function testing
10.1038/aja.2011.58 · 2012 · External reference
Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats
10.1016/j.neulet.2006.08.094 · 2007 · External reference
Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling
10.2174/156720511796391845 · 2011 · External reference
Effects of thymol and carvacrol on sperm quality and oxidant/antioxidant balance in rats
10.1080/13813455.2018.1476979 · 2019 · External reference
Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation
2008 · External reference
Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells
10.1177/0748233709103028 · 2009 · External reference
Tyrosol prevents AlCl3 induced male reproductive damage by suppressing apoptosis and activating the Nrf-2/HO-1 pathway
10.1111/and.13499 · 2020 · External reference
Reactive oxygen species-induced alterations in H19-Igf2 methylation patterns, seminal plasma metabolites, and semen quality
10.1007/s10815-018-1350-y · 2019 · External reference
Antioxidant effect of hydroxytyrosol on human sperm quality during in vitro incubation
10.1111/and.12595 · 2017 · External reference
Neuroprotective effects of salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro
10.1007/s12640-011-9290-7 · 2012 · External reference
Cryopreservation of sperm: indications, methods and results
10.1097/01.ju.0000084820.98430.b8 · 2003 · External reference
Effects of cryopreservation on human sperm acrosomes
10.1093/oxfordjournals.humrep.a137526 · 1991 · External reference
Protective effects of l-carnitine on astheno-and normozoospermic human semen samples during cryopreservation
10.1017/s0967199415000180 · 2016 · External reference
The causes of reduced fertility with cryopreserved semen
2000 · External reference
Catalase improves motility, vitality and DNA integrity of cryopreserved human spermatozoa
10.1111/j.1439-0272.2012.01310.x · 2013 · External reference
Vitamin E supplementation in semen-freezing medium improves the motility and protects sperm from freeze-thaw-induced DNA damage
10.1016/j.fertnstert.2010.10.005 · 2011 · External reference
Protective effects of ascorbate and catalase on human spermatozoa during cryopreservation
10.2164/jandrol.109.007849 · 2010 · External reference
Effect of freezing-thawing process and quercetin on human sperm survival and DNA integrity
10.1016/j.cryobiol.2012.09.003 · 2012 · External reference
Relationship of sperm parameters with levels of reactive oxygen species in semen specimens
10.1016/s0022-5347(17)32829-x · 1994 · External reference
Sperm DNA damage in men from infertile couples
10.1111/j.1745-7262.2008.00417.x · 2008 · External reference
Human spermatozoal nuclear maturity in normozoospermia and asthenozoospermia
10.3109/01485018808986737 · 1988 · External reference
Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants
10.1093/humrep/13.6.1429 · 1998 · External reference
Acrosin activity is a good predictor of boar sperm freezability
10.1016/j.theriogenology.2015.02.005 · 2015 · External reference
Biochemical and molecular studies of the proacrosin/acrosin system in patients with unexplained infertility
10.1016/s0015-0282(03)00372-8 · 2003 · External reference
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility
10.1016/j.fertnstert.2004.06.063 · 2005 · External reference
Combined analysis of the transcriptome, proteome and metabolome in human cryopreserved sperm
10.5534/wjmh.230091 · 2024 · External reference
Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients
10.1002/imt2.166 · ExternalCitation · doi-reference
MassBank: a public repository for sharing mass spectral data for life sciences
10.1002/jms.1777 · ExternalCitation · doi-reference
Low acrosin activity is associated with decreased Spam1/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells
10.1007/s00441-023-03826-x · ExternalCitation · doi-reference
Reactive oxygen species-induced alterations in H19-Igf2 methylation patterns, seminal plasma metabolites, and semen quality
10.1007/s10815-018-1350-y · ExternalCitation · doi-reference
Environmental toxins and male fertility
10.1007/s11934-018-0804-1 · ExternalCitation · doi-reference
Neuroprotective effects of salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro
10.1007/s12640-011-9290-7 · ExternalCitation · doi-reference
Targeted amino acids profiling of human seminal plasma from teratozoospermia patients using LC-MS/MS
10.1007/s43032-023-01272-2 · ExternalCitation · doi-reference
Structural specializations of the sperm tail
10.1016/j.cell.2023.05.026 · ExternalCitation · doi-reference
Reproduction, fat metabolism, and life span: what is the connection?
10.1016/j.cmet.2012.12.003 · ExternalCitation · doi-reference
Effect of freezing-thawing process and quercetin on human sperm survival and DNA integrity
10.1016/j.cryobiol.2012.09.003 · ExternalCitation · doi-reference
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility
10.1016/j.fertnstert.2004.06.063 · ExternalCitation · doi-reference
Vitamin E supplementation in semen-freezing medium improves the motility and protects sperm from freeze-thaw-induced DNA damage
10.1016/j.fertnstert.2010.10.005 · ExternalCitation · doi-reference
Urinary metabolome identifies signatures of oligozoospermic infertile men
10.1016/j.fertnstert.2014.03.033 · ExternalCitation · doi-reference
Hydroxytyrosol: its role in the prevention of cardiovascular diseases
10.1016/j.heliyon.2023.e12963 · ExternalCitation · doi-reference
Large-scale mtDNA deletions as genetic biomarkers for susceptibility to male infertility: a systematic review and meta-analysis
10.1016/j.ijbiomac.2020.04.216 · ExternalCitation · doi-reference
Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice
10.1016/j.jhazmat.2024.134165 · ExternalCitation · doi-reference
Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats
10.1016/j.neulet.2006.08.094 · ExternalCitation · doi-reference
Acrosin activity is a good predictor of boar sperm freezability
10.1016/j.theriogenology.2015.02.005 · ExternalCitation · doi-reference
Genetic and epigenetic landscape of male infertility
10.1016/j.tig.2025.07.007 · ExternalCitation · doi-reference
Biochemical and molecular studies of the proacrosin/acrosin system in patients with unexplained infertility
10.1016/s0015-0282(03)00372-8 · ExternalCitation · doi-reference
Total antioxidant capacity of seminal plasma is different in fertile and infertile men
10.1016/s0015-0282(16)57870-4 · ExternalCitation · doi-reference
Inhibition of sperm respiration and reversibility of the effects of metabolic inhibitors
10.1016/s0021-9258(18)72289-8 · ExternalCitation · doi-reference
Relationship of sperm parameters with levels of reactive oxygen species in semen specimens
10.1016/s0022-5347(17)32829-x · ExternalCitation · doi-reference
Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation
10.1017/s0007114515000884 · ExternalCitation · doi-reference
Protective effects of l-carnitine on astheno-and normozoospermic human semen samples during cryopreservation
10.1017/s0967199415000180 · ExternalCitation · doi-reference
Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum
10.1021/ac8019366 · ExternalCitation · doi-reference
Mechanism of hydrogen peroxide formation by spermatozoa and the role of amino-acids in sperm motility
10.1038/159544a0 · ExternalCitation · doi-reference
Semen analysis and sperm function testing
10.1038/aja.2011.58 · ExternalCitation · doi-reference
Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst
10.1038/nprot.2011.319 · ExternalCitation · doi-reference
Global metabolic profiling of animal and human tissues via UPLC-MS
10.1038/nprot.2012.135 · ExternalCitation · doi-reference
Metabolomic profiling of human semen in patients with oligospermia using high performance liquid chromatography-tandem mass spectrometry
10.1038/s41598-024-74658-0 · ExternalCitation · doi-reference
Effect of freeze-thawing procedure on chromatin stability, morphological alteration and membrane integrity of human spermatozoa in fertile and subfertile men
10.1046/j.1365-2605.1999.00162.x · ExternalCitation · doi-reference
Effects of thymol and carvacrol on sperm quality and oxidant/antioxidant balance in rats
10.1080/13813455.2018.1476979 · ExternalCitation · doi-reference
Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats
10.1080/13880209.2017.1315603 · ExternalCitation · doi-reference
Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis
10.1093/hropen/hoac051 · ExternalCitation · doi-reference
Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants
10.1093/humrep/13.6.1429 · ExternalCitation · doi-reference
Assessment of DNA integrity and morphology of ejaculated spermatozoa from fertile and infertile men before and after cryopreservation
10.1093/humrep/16.6.1191 · ExternalCitation · doi-reference
Global, regional, and national prevalence and trends of infertility among individuals of reproductive age (15-49 years) from 1990 to 2021, with projections to 2040
10.1093/humrep/deae292 · ExternalCitation · doi-reference
MetaboLights: open data repository for metabolomics
10.1093/nar/gkad1045 · ExternalCitation · doi-reference
LMSD: LIPID MAPS structure database
10.1093/nar/gkl838 · ExternalCitation · doi-reference
HMDB: the human metabolome database
10.1093/nar/gkl923 · ExternalCitation · doi-reference
Effects of cryopreservation on human sperm acrosomes
10.1093/oxfordjournals.humrep.a137526 · ExternalCitation · doi-reference
Signaling mechanisms in mammalian sperm motility
10.1095/biolreprod.116.144337 · ExternalCitation · doi-reference
Cryopreservation of sperm: indications, methods and results
10.1097/01.ju.0000084820.98430.b8 · ExternalCitation · doi-reference
Antioxidant effect of hydroxytyrosol on human sperm quality during in vitro incubation
10.1111/and.12595 · ExternalCitation · doi-reference
Tyrosol prevents AlCl3 induced male reproductive damage by suppressing apoptosis and activating the Nrf-2/HO-1 pathway
10.1111/and.13499 · ExternalCitation · doi-reference
Metabolomic signature of the seminal plasma in men with severe oligoasthenospermia
10.1111/andr.12882 · ExternalCitation · doi-reference
Catalase improves motility, vitality and DNA integrity of cryopreserved human spermatozoa
10.1111/j.1439-0272.2012.01310.x · ExternalCitation · doi-reference
Sperm DNA damage in men from infertile couples
10.1111/j.1745-7262.2008.00417.x · ExternalCitation · doi-reference
Lipid metabolism
10.1146/annurev.bi.33.070164.001035 · ExternalCitation · doi-reference
Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells
10.1177/0748233709103028 · ExternalCitation · doi-reference
One-carbon metabolism, spermatogenesis, and male infertility
10.1177/1933719112459232 · ExternalCitation · doi-reference
A unique view on male infertility around the globe
10.1186/s12958-015-0032-1 · ExternalCitation · doi-reference
Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility
10.1371/journal.pone.0181115 · ExternalCitation · doi-reference
The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly
10.18632/oncotarget.14950 · ExternalCitation · doi-reference
Protective effects of ascorbate and catalase on human spermatozoa during cryopreservation
10.2164/jandrol.109.007849 · ExternalCitation · doi-reference
Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling
10.2174/156720511796391845 · ExternalCitation · doi-reference
Human spermatozoal nuclear maturity in normozoospermia and asthenozoospermia
10.3109/01485018808986737 · ExternalCitation · doi-reference
Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis
10.3109/13880209.2015.1042980 · ExternalCitation · doi-reference
The mechanism of oxidative stress in asthenozoospermia and antioxidant strategies: a review
10.3389/fendo.2025.1670762 · ExternalCitation · doi-reference
Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development
10.3390/antiox10071025 · ExternalCitation · doi-reference
Sperm cryodamage in ruminants: understanding the molecular changes induced by the cryopreservation process to optimize sperm quality
10.3390/ijms21082781 · ExternalCitation · doi-reference
The role of l-arginine-no system in female reproduction: a narrative review
10.3390/ijms232314908 · ExternalCitation · doi-reference
Tyrosol prevents ischemia/reperfusion-induced cardiac injury in H9c2 cells: involvement of ROS, Hsp70, JNK and ERK, and apoptosis
10.3390/molecules20033758 · ExternalCitation · doi-reference
Isolation of Lactobacillus plantarum subsp plantarum producing C30 carotenoid 4,4'-diaponeurosporene and the assessment of its antioxidant activity
10.4014/jmb.1909.09007 · ExternalCitation · doi-reference
Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility
10.5534/wjmh.190055 · ExternalCitation · doi-reference
Combined analysis of the transcriptome, proteome and metabolome in human cryopreserved sperm
10.5534/wjmh.230091 · ExternalCitation · doi-reference
Increased cryo-survival rate in ejaculated human sperm from infertile men following pre-freeze in vitro myo-inositol supplementation
10.5653/cerm.2018.45.4.177 · ExternalCitation · doi-reference
Beneficial effects of oral antioxidant supplementation on semen quality parameters, reproductive hormones, and sperm DNA integrity in men with idiopathic oligoasthenoteratozoospermia
10.5653/cerm.2023.06555 · ExternalCitation · doi-reference
Semen creatine and creatine kinase activity as an indicator of sperm quality
10.7754/clin.lab.2020.191248 · ExternalCitation · doi-reference
