Research graph
References from Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis. Local targets link to admitted publications; unresolved targets remain external evidence.
Multiple roles of PLK1 in mitosis and meiosis
10.3390/cells12010187 · 2023 · External reference
Molecular dynamics of PLK1 during mitosis
10.1080/23723548.2014.954507 · 2014 · External reference
Regulating a key mitotic regulator, polo-like kinase 1 (PLK1)
10.1002/cm.21504 · 2018 · External reference
Polo-like kinase 1 as a potential therapeutic target and prognostic factor for various human malignancies: a systematic review and meta-analysis
10.3389/fonc.2022.917366 · 2022 · External reference
Cell cycle proteins as promising targets in cancer therapy
10.1038/nrc.2016.138 · 2017 · External reference
Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology
10.1634/theoncologist.2009-0010 · 2009 · External reference
Onvansertib in combination with FOLFIRI and bevacizumab in second-line treatment of KRAS-mutant metastatic colorectal cancer: a phase Ib clinical study
10.1158/1078-0432.ccr-23-3053 · 2024 · External reference
A phase Ib study of onvansertib, a novel oral PLK1 inhibitor, in combination therapy for patients with relapsed or refractory acute myeloid leukemia
10.1158/1078-0432.ccr-20-2586 · 2020 · External reference
The polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy
10.7150/thno.61711 · 2021 · External reference
Onvansertib in combination with chemotherapy and bevacizumab in second-line treatment of KRAS-mutant metastatic colorectal cancer: a single-arm, phase II trial
10.1200/jco-24-01266 · 2025 · External reference
A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy
10.1093/neuonc/noab207 · 2022 · External reference
Survivorship in adolescents and young adults with cancer
10.1093/jncimonographs/lgab003 · 2021 · External reference
Adolescent and young adult cancer survivorship: the new frontier for investigation
10.1002/cncr.32064 · 2019 · External reference
Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association
10.1161/cir.0b013e3182a88099 · 2013 · External reference
Pre-treatment fertility preservation and post-treatment reproduction in long-term survivors of adolescent and young adult (AYA) cancer
10.1007/s11764-024-01538-x · 2025 · External reference
Priorities in fertility decisions for reproductive-aged cancer patients: fertility attitudes and cancer treatment Study
10.1089/jayao.2016.0072 · 2017 · External reference
Fertility perspectives and priorities among male adolescents and young adults in cancer survivorship
10.1002/pbc.27019 · 2018 · External reference
Effects of chemotherapy and radiotherapy on spermatogenesis in humans
10.1016/j.fertnstert.2013.08.010 · 2013 · External reference
Testicular function following chemo-radiotherapy
10.1016/j.ejogrb.2003.11.002 · 2004 · External reference
4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1
10.4161/cc.21770 · 2012 · External reference
Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes
2021 · External reference
PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis
10.15252/embr.202051030 · 2021 · External reference
AKT inhibition sensitizes to polo-Like kinase 1 inhibitor onvansertib in prostate cancer
10.1158/1535-7163.mct-23-0933 · 2024 · External reference
PLK1 inhibition-based combination therapies for cancer management
10.1016/j.tranon.2021.101332 · 2022 · External reference
Identification of PLK1 as a new therapeutic target in mucinous ovarian carcinoma
10.3390/cancers12030672 · 2020 · External reference
Germ cell-somatic cell interactions during spermatogenesis
2003 · External reference
Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development
10.1002/ijc.21034 · 2005 · External reference
Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0
10.1371/journal.pbio.3000411 · 2020 · External reference
Single-cell transcriptomic and pharmacological studies of onvansertib for small cell lung cancer treatment
10.1016/j.biopha.2025.118307 · 2025 · External reference
Murine polo like kinase 1 gene is expressed in meiotic testicular germ cells and oocytes
10.1002/mrd.1080410403 · 1995 · External reference
BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes
10.7554/elife.84057 · 2023 · External reference
The Cep192-organized Aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly
10.1016/j.molcel.2014.06.016 · 2014 · External reference
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome
10.1083/jcb.202009083 · 2021 · External reference
Regulation of 4E-BP1 activity in the mammalian oocyte
10.1080/15384101.2017.1295178 · 2017 · External reference
Centrosome function and assembly in animal cells
10.1038/nrm4062 · 2015 · External reference
Ectopic expression of cenexin1 S796A mutant in ODF2+/- knockout background causes a sperm tail development defect
10.12717/dr.2012.16.4.363 · 2012 · External reference
Microtubular dysfunction and male infertility
10.5534/wjmh.180066 · 2020 · External reference
Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis
10.1093/hropen/hoac051 · 2022 · External reference
P4 reproductive medicine: prediction, prevention, personalization, and participation in infertility care
10.3390/jcm13195860 · 2024 · External reference
Premature ovarian failure and fertility in long-term survivors of Hodgkin's lymphoma: a European organisation for research and treatment of cancer lymphoma group and groupe d'etude des lymphomes de l'adulte cohort study
10.1200/jco.2011.37.1989 · 2012 · External reference
Effect of cancer therapy on pituitary-testicular axis
10.1046/j.1365-2605.2002.00365.x · 2002 · External reference
Long-term fertility function sequelae in young male cancer survivors
10.5534/wjmh.220102 · 2023 · External reference
Male infertility in cancer patients: review of the literature
10.1111/j.1442-2042.2010.02484.x · 2010 · External reference
Anticancer treatment and fertility: effect of therapeutic modalities on reproductive system and functions
10.1016/j.critrevonc.2015.08.002 · 2016 · External reference
Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer
10.1007/s10815-012-9786-y · 2012 · External reference
A functional link between Polo-like kinase 1 and the mammalian target-of-rapamycin pathway?
10.4161/cc.9.9.11295 · 2014 · External reference
The mammalian blood-testis barrier: its biology and regulation
10.1210/er.2014-1101 · 2015 · External reference
Regulating a key mitotic regulator, polo-like kinase 1 (PLK1)
10.1002/cm.21504 · ExternalCitation · doi-reference
Adolescent and young adult cancer survivorship: the new frontier for investigation
10.1002/cncr.32064 · ExternalCitation · doi-reference
Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development
10.1002/ijc.21034 · ExternalCitation · doi-reference
Murine polo like kinase 1 gene is expressed in meiotic testicular germ cells and oocytes
10.1002/mrd.1080410403 · ExternalCitation · doi-reference
Fertility perspectives and priorities among male adolescents and young adults in cancer survivorship
10.1002/pbc.27019 · ExternalCitation · doi-reference
Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer
10.1007/s10815-012-9786-y · ExternalCitation · doi-reference
Pre-treatment fertility preservation and post-treatment reproduction in long-term survivors of adolescent and young adult (AYA) cancer
10.1007/s11764-024-01538-x · ExternalCitation · doi-reference
Single-cell transcriptomic and pharmacological studies of onvansertib for small cell lung cancer treatment
10.1016/j.biopha.2025.118307 · ExternalCitation · doi-reference
Anticancer treatment and fertility: effect of therapeutic modalities on reproductive system and functions
10.1016/j.critrevonc.2015.08.002 · ExternalCitation · doi-reference
Testicular function following chemo-radiotherapy
10.1016/j.ejogrb.2003.11.002 · ExternalCitation · doi-reference
Effects of chemotherapy and radiotherapy on spermatogenesis in humans
10.1016/j.fertnstert.2013.08.010 · ExternalCitation · doi-reference
The Cep192-organized Aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly
10.1016/j.molcel.2014.06.016 · ExternalCitation · doi-reference
PLK1 inhibition-based combination therapies for cancer management
10.1016/j.tranon.2021.101332 · ExternalCitation · doi-reference
Cell cycle proteins as promising targets in cancer therapy
10.1038/nrc.2016.138 · ExternalCitation · doi-reference
Centrosome function and assembly in animal cells
10.1038/nrm4062 · ExternalCitation · doi-reference
Effect of cancer therapy on pituitary-testicular axis
10.1046/j.1365-2605.2002.00365.x · ExternalCitation · doi-reference
Regulation of 4E-BP1 activity in the mammalian oocyte
10.1080/15384101.2017.1295178 · ExternalCitation · doi-reference
Molecular dynamics of PLK1 during mitosis
10.1080/23723548.2014.954507 · ExternalCitation · doi-reference
Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome
10.1083/jcb.202009083 · ExternalCitation · doi-reference
Priorities in fertility decisions for reproductive-aged cancer patients: fertility attitudes and cancer treatment Study
10.1089/jayao.2016.0072 · ExternalCitation · doi-reference
Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis
10.1093/hropen/hoac051 · ExternalCitation · doi-reference
Survivorship in adolescents and young adults with cancer
10.1093/jncimonographs/lgab003 · ExternalCitation · doi-reference
A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy
10.1093/neuonc/noab207 · ExternalCitation · doi-reference
Male infertility in cancer patients: review of the literature
10.1111/j.1442-2042.2010.02484.x · ExternalCitation · doi-reference
A phase Ib study of onvansertib, a novel oral PLK1 inhibitor, in combination therapy for patients with relapsed or refractory acute myeloid leukemia
10.1158/1078-0432.ccr-20-2586 · ExternalCitation · doi-reference
Onvansertib in combination with FOLFIRI and bevacizumab in second-line treatment of KRAS-mutant metastatic colorectal cancer: a phase Ib clinical study
10.1158/1078-0432.ccr-23-3053 · ExternalCitation · doi-reference
AKT inhibition sensitizes to polo-Like kinase 1 inhibitor onvansertib in prostate cancer
10.1158/1535-7163.mct-23-0933 · ExternalCitation · doi-reference
Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association
10.1161/cir.0b013e3182a88099 · ExternalCitation · doi-reference
Onvansertib in combination with chemotherapy and bevacizumab in second-line treatment of KRAS-mutant metastatic colorectal cancer: a single-arm, phase II trial
10.1200/jco-24-01266 · ExternalCitation · doi-reference
Premature ovarian failure and fertility in long-term survivors of Hodgkin's lymphoma: a European organisation for research and treatment of cancer lymphoma group and groupe d'etude des lymphomes de l'adulte cohort study
10.1200/jco.2011.37.1989 · ExternalCitation · doi-reference
The mammalian blood-testis barrier: its biology and regulation
10.1210/er.2014-1101 · ExternalCitation · doi-reference
Ectopic expression of cenexin1 S796A mutant in ODF2+/- knockout background causes a sperm tail development defect
10.12717/dr.2012.16.4.363 · ExternalCitation · doi-reference
Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0
10.1371/journal.pbio.3000411 · ExternalCitation · doi-reference
PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis
10.15252/embr.202051030 · ExternalCitation · doi-reference
Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology
10.1634/theoncologist.2009-0010 · ExternalCitation · doi-reference
Polo-like kinase 1 as a potential therapeutic target and prognostic factor for various human malignancies: a systematic review and meta-analysis
10.3389/fonc.2022.917366 · ExternalCitation · doi-reference
Identification of PLK1 as a new therapeutic target in mucinous ovarian carcinoma
10.3390/cancers12030672 · ExternalCitation · doi-reference
Multiple roles of PLK1 in mitosis and meiosis
10.3390/cells12010187 · ExternalCitation · doi-reference
P4 reproductive medicine: prediction, prevention, personalization, and participation in infertility care
10.3390/jcm13195860 · ExternalCitation · doi-reference
4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1
10.4161/cc.21770 · ExternalCitation · doi-reference
A functional link between Polo-like kinase 1 and the mammalian target-of-rapamycin pathway?
10.4161/cc.9.9.11295 · ExternalCitation · doi-reference
Microtubular dysfunction and male infertility
10.5534/wjmh.180066 · ExternalCitation · doi-reference
Long-term fertility function sequelae in young male cancer survivors
10.5534/wjmh.220102 · ExternalCitation · doi-reference
The polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy
10.7150/thno.61711 · ExternalCitation · doi-reference
BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes
10.7554/elife.84057 · ExternalCitation · doi-reference
