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References from Multispecies translational evaluation of an NMDA receptor modulator reveals analgesic, autonomic-stabilizing, and stress mitigating effects without evidence of abuse liability. Local targets link to admitted publications; unresolved targets remain external evidence.
A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons
10.1002/prp2.859 · 2021 · External reference
The alkaloids of Anabasis aphylla L. (I. Communication.)
10.1002/cber.19310640213 · 1931 · External reference
CNS4 causes subtype-specific changes in agonist efficacy and reversal potential of permeant cations in NMDA receptors
2023 · External reference
Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator
10.1016/j.jpet.2025.103401 · 2025 · External reference
Nonrodent safety and pharmacokinetics supporting clinical development of a novel N-methyl-D-aspartate receptor modulator (CNS4)
10.1016/j.jpet.2026.104787 · 2026 · External reference
Mechanisms of phencyclidine (PCP)-n-methyl-d-aspartate (NMDA) receptor interaction: implications for drug abuse research
1989 · External reference
Memantine (Namenda) for moderate to severe Alzheimer’s disease
2004 · External reference
10.1016/0304-3959(92)90041-9
10.1016/0304-3959(92)90041-9 · External reference
10.1523/jneurosci.0601-23.2023
10.1523/jneurosci.0601-23.2023 · External reference
10.1113/jp277428
10.1113/jp277428 · External reference
10.1113/jphysiol.2013.263814
10.1113/jphysiol.2013.263814 · External reference
10.1016/0165-0270(94)90144-9
10.1016/0165-0270(94)90144-9 · External reference
10.1523/jneurosci.0183-23.2023
10.1523/jneurosci.0183-23.2023 · External reference
10.1016/s0304-3959(97)00141-3
10.1016/s0304-3959(97)00141-3 · External reference
Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score
10.1017/s096272860003178x · 2007 · External reference
10.1038/s41386-023-01614-3
10.1038/s41386-023-01614-3 · External reference
Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry
10.1038/s41598-018-22020-6 · 2018 · External reference
10.1016/j.jpsychires.2022.04.035
10.1016/j.jpsychires.2022.04.035 · External reference
10.1038/s41586-022-04993-7
10.1038/s41586-022-04993-7 · External reference
10.1038/s41380-021-01093-2
10.1038/s41380-021-01093-2 · External reference
10.1016/s0091-3057(02)00859-6
10.1016/s0091-3057(02)00859-6 · External reference
Involvement of N-methyl-D-aspartate (NMDA) receptors in noncompetitive NMDA receptor antagonist-induced hyperlocomotion in mice
10.1016/0091-3057(94)00379-w · 1995 · External reference
Characterization of MK-801-induced behavior as a putative rat model of psychosis
10.1016/s0022-3565(24)35047-5 · 1999 · External reference
10.1016/s0014-2999(01)01219-5
10.1016/s0014-2999(01)01219-5 · External reference
Effects of NMDA and non-NMDA ionotropic glutamate receptors in the medial preoptic area on body temperature in awake rats
10.1016/j.jtherbio.2016.07.020 · 2016 · External reference
10.1111/j.1476-5381.1973.tb08243.x
10.1111/j.1476-5381.1973.tb08243.x · External reference
10.3390/brainsci16020189
10.3390/brainsci16020189 · External reference
10.1146/annurev.neuro.29.051605.113009
10.1146/annurev.neuro.29.051605.113009 · External reference
10.1016/j.neuropharm.2011.07.036
10.1016/j.neuropharm.2011.07.036 · External reference
10.1038/nrn3138
10.1038/nrn3138 · External reference
10.1016/j.phrs.2025.107918
10.1016/j.phrs.2025.107918 · External reference
10.1111/jnc.70064
10.1111/jnc.70064 · External reference
10.1007/s00018-019-03047-y
10.1007/s00018-019-03047-y · External reference
10.1586/ecp.11.17
10.1586/ecp.11.17 · External reference
10.1213/01.ane.0000081061.12235.55
10.1213/01.ane.0000081061.12235.55 · External reference
10.1111/j.1460-9568.2008.06100.x
10.1111/j.1460-9568.2008.06100.x · External reference
10.3390/cells11244049
10.3390/cells11244049 · External reference
10.1016/j.jneumeth.2005.01.003
10.1016/j.jneumeth.2005.01.003 · External reference
10.1038/sj.bjp.0704110
10.1038/sj.bjp.0704110 · External reference
10.1124/jpet.114.213694
10.1124/jpet.114.213694 · External reference
10.1124/pr.109.002451
10.1124/pr.109.002451 · External reference
10.1038/nrn3504
10.1038/nrn3504 · External reference
10.1523/jneurosci.05-11-02909.1985
10.1523/jneurosci.05-11-02909.1985 · External reference
10.1523/jneurosci.2717-15.2016
10.1523/jneurosci.2717-15.2016 · External reference
10.1038/ncomms3258
10.1038/ncomms3258 · External reference
Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats
10.1016/j.brainres.2016.05.001 · 2016 · External reference
10.1161/hypertensionaha.109.146605
10.1161/hypertensionaha.109.146605 · External reference
10.1371/journal.pone.0121022
10.1371/journal.pone.0121022 · External reference
10.3390/biom13121736
10.3390/biom13121736 · External reference
Glutamatergic neural transmission in the nucleus tractus solitarius: N-methyl-D-aspartate receptors
10.1046/j.1440-1681.2002.03662.x · 2002 · External reference
The alkaloids of Anabasis aphylla L. (I. Communication.)
10.1002/cber.19310640213 · ExternalCitation · doi-reference
A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons
10.1002/prp2.859 · ExternalCitation · doi-reference
10.1007/s00018-019-03047-y
10.1007/s00018-019-03047-y · ExternalCitation · doi-reference
Involvement of N-methyl-D-aspartate (NMDA) receptors in noncompetitive NMDA receptor antagonist-induced hyperlocomotion in mice
10.1016/0091-3057(94)00379-w · ExternalCitation · doi-reference
10.1016/0165-0270(94)90144-9
10.1016/0165-0270(94)90144-9 · ExternalCitation · doi-reference
10.1016/0304-3959(92)90041-9
10.1016/0304-3959(92)90041-9 · ExternalCitation · doi-reference
Nitric oxide modulates blood pressure through NMDA receptors in the rostral ventrolateral medulla of conscious rats
10.1016/j.brainres.2016.05.001 · ExternalCitation · doi-reference
10.1016/j.jneumeth.2005.01.003
10.1016/j.jneumeth.2005.01.003 · ExternalCitation · doi-reference
Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator
10.1016/j.jpet.2025.103401 · ExternalCitation · doi-reference
Nonrodent safety and pharmacokinetics supporting clinical development of a novel N-methyl-D-aspartate receptor modulator (CNS4)
10.1016/j.jpet.2026.104787 · ExternalCitation · doi-reference
10.1016/j.jpsychires.2022.04.035
10.1016/j.jpsychires.2022.04.035 · ExternalCitation · doi-reference
Effects of NMDA and non-NMDA ionotropic glutamate receptors in the medial preoptic area on body temperature in awake rats
10.1016/j.jtherbio.2016.07.020 · ExternalCitation · doi-reference
10.1016/j.neuropharm.2011.07.036
10.1016/j.neuropharm.2011.07.036 · ExternalCitation · doi-reference
10.1016/j.phrs.2025.107918
10.1016/j.phrs.2025.107918 · ExternalCitation · doi-reference
10.1016/s0014-2999(01)01219-5
10.1016/s0014-2999(01)01219-5 · ExternalCitation · doi-reference
Characterization of MK-801-induced behavior as a putative rat model of psychosis
10.1016/s0022-3565(24)35047-5 · ExternalCitation · doi-reference
10.1016/s0091-3057(02)00859-6
10.1016/s0091-3057(02)00859-6 · ExternalCitation · doi-reference
10.1016/s0304-3959(97)00141-3
10.1016/s0304-3959(97)00141-3 · ExternalCitation · doi-reference
Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score
10.1017/s096272860003178x · ExternalCitation · doi-reference
10.1038/ncomms3258
10.1038/ncomms3258 · ExternalCitation · doi-reference
10.1038/nrn3138
10.1038/nrn3138 · ExternalCitation · doi-reference
10.1038/nrn3504
10.1038/nrn3504 · ExternalCitation · doi-reference
10.1038/s41380-021-01093-2
10.1038/s41380-021-01093-2 · ExternalCitation · doi-reference
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10.1038/s41386-023-01614-3 · ExternalCitation · doi-reference
10.1038/s41586-022-04993-7
10.1038/s41586-022-04993-7 · ExternalCitation · doi-reference
Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry
10.1038/s41598-018-22020-6 · ExternalCitation · doi-reference
10.1038/sj.bjp.0704110
10.1038/sj.bjp.0704110 · ExternalCitation · doi-reference
Glutamatergic neural transmission in the nucleus tractus solitarius: N-methyl-D-aspartate receptors
10.1046/j.1440-1681.2002.03662.x · ExternalCitation · doi-reference
10.1111/j.1460-9568.2008.06100.x
10.1111/j.1460-9568.2008.06100.x · ExternalCitation · doi-reference
10.1111/j.1476-5381.1973.tb08243.x
10.1111/j.1476-5381.1973.tb08243.x · ExternalCitation · doi-reference
10.1111/jnc.70064
10.1111/jnc.70064 · ExternalCitation · doi-reference
10.1113/jp277428
10.1113/jp277428 · ExternalCitation · doi-reference
10.1113/jphysiol.2013.263814
10.1113/jphysiol.2013.263814 · ExternalCitation · doi-reference
10.1124/jpet.114.213694
10.1124/jpet.114.213694 · ExternalCitation · doi-reference
10.1124/pr.109.002451
10.1124/pr.109.002451 · ExternalCitation · doi-reference
10.1146/annurev.neuro.29.051605.113009
10.1146/annurev.neuro.29.051605.113009 · ExternalCitation · doi-reference
10.1161/hypertensionaha.109.146605
10.1161/hypertensionaha.109.146605 · ExternalCitation · doi-reference
10.1213/01.ane.0000081061.12235.55
10.1213/01.ane.0000081061.12235.55 · ExternalCitation · doi-reference
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10.1523/jneurosci.05-11-02909.1985
10.1523/jneurosci.05-11-02909.1985 · ExternalCitation · doi-reference
10.1523/jneurosci.0601-23.2023
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10.3390/biom13121736
10.3390/biom13121736 · ExternalCitation · doi-reference
10.3390/brainsci16020189
10.3390/brainsci16020189 · ExternalCitation · doi-reference
10.3390/cells11244049
10.3390/cells11244049 · ExternalCitation · doi-reference
