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References from The chemorepellent effect of metformin limits bacterial penetration into mammalian mucus by altering bacterial motility. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
10.1016/j.immuni.2021.12.013
10.1016/j.immuni.2021.12.013 · External reference
Epidemiology of Type 2 Diabetes – Global Burden of Disease and Forecasted Trends
2020 · External reference
10.15252/emmm.201404169
10.15252/emmm.201404169 · External reference
10.3390/ijms22031156
10.3390/ijms22031156 · External reference
NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells
10.1016/j.freeradbiomed.2015.07.154 · 2015 · External reference
10.1080/19490976.2025.2587964
10.1080/19490976.2025.2587964 · External reference
10.1016/j.jada.2008.01.022
10.1016/j.jada.2008.01.022 · External reference
10.1073/pnas.0407076101
10.1073/pnas.0407076101 · External reference
10.1080/19490976.2024.2405547
10.1080/19490976.2024.2405547 · External reference
10.1016/j.chom.2017.03.010
10.1016/j.chom.2017.03.010 · External reference
10.1016/j.lanmic.2026.101389
10.1016/j.lanmic.2026.101389 · External reference
Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans
10.1016/j.jcmgh.2017.04.001 · 2017 · External reference
10.1016/j.mib.2011.11.002
10.1016/j.mib.2011.11.002 · External reference
10.1080/17474124.2017.1343143
10.1080/17474124.2017.1343143 · External reference
10.1007/s11739-023-03329-1
10.1007/s11739-023-03329-1 · External reference
10.1038/nrgastro.2013.35
10.1038/nrgastro.2013.35 · External reference
10.1073/pnas.0803124105
10.1073/pnas.0803124105 · External reference
Circulating microbiota and metabolites: Insights into cardiovascular diseases
10.1002/jcla.24779 · 2022 · External reference
10.1073/pnas.2209936120
10.1073/pnas.2209936120 · External reference
The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling
10.3390/cells13181590 · 2024 · External reference
10.3390/ph14020122
10.3390/ph14020122 · External reference
10.2337/dc20-2257
10.2337/dc20-2257 · External reference
10.1007/s00125-008-1053-5
10.1007/s00125-008-1053-5 · External reference
Accumulation of metformin by tissues of the normal and diabetic mouse
10.3109/00498259409043220 · 1994 · External reference
10.1016/j.molmet.2023.101805
10.1016/j.molmet.2023.101805 · External reference
10.1038/nm.4345
10.1038/nm.4345 · External reference
10.2337/dc16-1324
10.2337/dc16-1324 · External reference
10.3389/fmed.2025.1484656
10.3389/fmed.2025.1484656 · External reference
10.1038/nature25979
10.1038/nature25979 · External reference
10.1128/aem.01357-14
10.1128/aem.01357-14 · External reference
Metformin promotes bacterial surface aggregation by inhibiting the swimming motility of flagellated Escherichia coli
10.1002/jobm.202200716 · 2023 · External reference
10.3389/fmicb.2021.792406
10.3389/fmicb.2021.792406 · External reference
The Role of the Bacterial Flagellum in Adhesion and Virulence
10.3390/biology2041242 · 2013 · External reference
10.1016/j.azn.2025.09.001
10.1016/j.azn.2025.09.001 · External reference
TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity
10.2147/jir.s407521 · 2023 · External reference
10.1126/science.1179721
10.1126/science.1179721 · External reference
10.3389/fphar.2021.726707
10.3389/fphar.2021.726707 · External reference
10.1038/s41586-020-2269-x
10.1038/s41586-020-2269-x · External reference
Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition
10.1371/journal.ppat.1014012 · 2026 · External reference
Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa
10.4314/ahs.v17i3.24 · 2017 · External reference
10.1038/nrm1524
10.1038/nrm1524 · External reference
10.1103/physrevlett.128.248101
10.1103/physrevlett.128.248101 · External reference
10.1038/s41594-020-0497-2
10.1038/s41594-020-0497-2 · External reference
Precision Sensing by Two Opposing Gradient Sensors: How Does Escherichia coli Find its Preferred pH Level?
10.1016/j.bpj.2013.04.054 · 2013 · External reference
10.1128/jb.188.10.3487-3493.2006
10.1128/jb.188.10.3487-3493.2006 · External reference
10.1016/j.micres.2018.11.001
10.1016/j.micres.2018.11.001 · External reference
10.1002/advs.201902227
10.1002/advs.201902227 · External reference
10.1186/s12866-022-02629-4
10.1186/s12866-022-02629-4 · External reference
10.1063/1.4982820
10.1063/1.4982820 · External reference
10.48550/arxiv.2603.20764
10.48550/arxiv.2603.20764 · External reference
10.1103/physrevlett.101.038102
10.1103/physrevlett.101.038102 · External reference
10.1038/sj.emboj.7601610
10.1038/sj.emboj.7601610 · External reference
Regulatory Networks in Helicobacter pylori: The Roles of Two-Component Systems and CsrA in Stress Adaptation
10.1016/j.jmii.2025.06.009 · 2025 · External reference
10.1007/bf02686090
10.1007/bf02686090 · External reference
10.3389/fcimb.2013.00115
10.3389/fcimb.2013.00115 · External reference
10.1073/pnas.120163297
10.1073/pnas.120163297 · External reference
10.1038/msb4100050
10.1038/msb4100050 · External reference
10.1073/pnas.94.20.10541
10.1073/pnas.94.20.10541 · External reference
10.1073/pnas.94.20.10487
10.1073/pnas.94.20.10487 · External reference
10.1128/jb.165.1.34-40.1986
10.1128/jb.165.1.34-40.1986 · External reference
10.1038/s41522-026-00946-4
10.1038/s41522-026-00946-4 · External reference
10.1038/s41467-019-13538-y
10.1038/s41467-019-13538-y · External reference
10.3389/fimmu.2022.953196
10.3389/fimmu.2022.953196 · External reference
10.1007/s00125-015-3844-9
10.1007/s00125-015-3844-9 · External reference
10.1146/annurev-med-042320-021020
10.1146/annurev-med-042320-021020 · External reference
Bacterial chemotaxis: the five sensors of a bacterium
10.1016/s0960-9822(98)00098-0 · 1998 · External reference
pH sensing in bacterial chemotaxis
1999 · External reference
10.1016/j.cell.2019.08.003
10.1016/j.cell.2019.08.003 · External reference
10.1128/iai.70.1.1-4.2002
10.1128/iai.70.1.1-4.2002 · External reference
10.1093/femsre/fuab038
10.1093/femsre/fuab038 · External reference
10.7554/elife.77266
10.7554/elife.77266 · External reference
Deciphering Bacterial Chemorepulsion: The Complex Response of Microbes to Environmental Stimuli
10.3390/microorganisms12081706 · 2024 · External reference
10.3389/fendo.2023.1232143
10.3389/fendo.2023.1232143 · External reference
10.1016/j.celrep.2025.116919
10.1016/j.celrep.2025.116919 · External reference
10.1016/j.molmed.2019.11.006
10.1016/j.molmed.2019.11.006 · External reference
10.1186/s13075-024-03293-x
10.1186/s13075-024-03293-x · External reference
10.1038/srep40878
10.1038/srep40878 · External reference
10.1038/s41591-022-01688-4
10.1038/s41591-022-01688-4 · External reference
10.1136/gutjnl-2021-325753
10.1136/gutjnl-2021-325753 · External reference
10.1038/s41586-021-04177-9
10.1038/s41586-021-04177-9 · External reference
Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation
10.1111/j.1464-5491.2006.01858.x · 2006 · External reference
10.2337/dc18-s002
10.2337/dc18-s002 · External reference
10.7554/elife.65088
10.7554/elife.65088 · External reference
10.1038/s41587-023-01688-w
10.1038/s41587-023-01688-w · External reference
10.1016/0016-5085(81)90503-5
10.1016/0016-5085(81)90503-5 · External reference
10.1084/jem.20181635
10.1084/jem.20181635 · External reference
10.1038/nmeth.2019
10.1038/nmeth.2019 · External reference
10.1098/rsif.2025.0857
10.1098/rsif.2025.0857 · External reference
Unique Features of Metformin: A Combined Experimental, Theoretical, and Simulation Study of Its Structure, Dynamics, and Interaction Energetics with DNA Grooves
10.1021/acs.jpcb.7b11928 · 2018 · External reference
10.1529/biophysj.107.108811
10.1529/biophysj.107.108811 · External reference
10.1038/s42003-021-02190-2
10.1038/s42003-021-02190-2 · External reference
10.1002/advs.201902227
10.1002/advs.201902227 · ExternalCitation · doi-reference
Circulating microbiota and metabolites: Insights into cardiovascular diseases
10.1002/jcla.24779 · ExternalCitation · doi-reference
Metformin promotes bacterial surface aggregation by inhibiting the swimming motility of flagellated Escherichia coli
10.1002/jobm.202200716 · ExternalCitation · doi-reference
10.1007/bf02686090
10.1007/bf02686090 · ExternalCitation · doi-reference
10.1007/s00125-008-1053-5
10.1007/s00125-008-1053-5 · ExternalCitation · doi-reference
10.1007/s00125-015-3844-9
10.1007/s00125-015-3844-9 · ExternalCitation · doi-reference
10.1007/s11739-023-03329-1
10.1007/s11739-023-03329-1 · ExternalCitation · doi-reference
10.1016/0016-5085(81)90503-5
10.1016/0016-5085(81)90503-5 · ExternalCitation · doi-reference
10.1016/j.azn.2025.09.001
10.1016/j.azn.2025.09.001 · ExternalCitation · doi-reference
Precision Sensing by Two Opposing Gradient Sensors: How Does Escherichia coli Find its Preferred pH Level?
10.1016/j.bpj.2013.04.054 · ExternalCitation · doi-reference
10.1016/j.cell.2019.08.003
10.1016/j.cell.2019.08.003 · ExternalCitation · doi-reference
10.1016/j.celrep.2025.116919
10.1016/j.celrep.2025.116919 · ExternalCitation · doi-reference
10.1016/j.chom.2017.03.010
10.1016/j.chom.2017.03.010 · ExternalCitation · doi-reference
NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells
10.1016/j.freeradbiomed.2015.07.154 · ExternalCitation · doi-reference
10.1016/j.immuni.2021.12.013
10.1016/j.immuni.2021.12.013 · ExternalCitation · doi-reference
10.1016/j.jada.2008.01.022
10.1016/j.jada.2008.01.022 · ExternalCitation · doi-reference
Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans
10.1016/j.jcmgh.2017.04.001 · ExternalCitation · doi-reference
Regulatory Networks in Helicobacter pylori: The Roles of Two-Component Systems and CsrA in Stress Adaptation
10.1016/j.jmii.2025.06.009 · ExternalCitation · doi-reference
10.1016/j.lanmic.2026.101389
10.1016/j.lanmic.2026.101389 · ExternalCitation · doi-reference
10.1016/j.mib.2011.11.002
10.1016/j.mib.2011.11.002 · ExternalCitation · doi-reference
10.1016/j.micres.2018.11.001
10.1016/j.micres.2018.11.001 · ExternalCitation · doi-reference
10.1016/j.molmed.2019.11.006
10.1016/j.molmed.2019.11.006 · ExternalCitation · doi-reference
10.1016/j.molmet.2023.101805
10.1016/j.molmet.2023.101805 · ExternalCitation · doi-reference
Bacterial chemotaxis: the five sensors of a bacterium
10.1016/s0960-9822(98)00098-0 · ExternalCitation · doi-reference
Unique Features of Metformin: A Combined Experimental, Theoretical, and Simulation Study of Its Structure, Dynamics, and Interaction Energetics with DNA Grooves
10.1021/acs.jpcb.7b11928 · ExternalCitation · doi-reference
10.1038/msb4100050
10.1038/msb4100050 · ExternalCitation · doi-reference
10.1038/nature25979
10.1038/nature25979 · ExternalCitation · doi-reference
10.1038/nm.4345
10.1038/nm.4345 · ExternalCitation · doi-reference
10.1038/nmeth.2019
10.1038/nmeth.2019 · ExternalCitation · doi-reference
10.1038/nrgastro.2013.35
10.1038/nrgastro.2013.35 · ExternalCitation · doi-reference
10.1038/nrm1524
10.1038/nrm1524 · ExternalCitation · doi-reference
10.1038/s41467-019-13538-y
10.1038/s41467-019-13538-y · ExternalCitation · doi-reference
10.1038/s41522-026-00946-4
10.1038/s41522-026-00946-4 · ExternalCitation · doi-reference
10.1038/s41586-020-2269-x
10.1038/s41586-020-2269-x · ExternalCitation · doi-reference
10.1038/s41586-021-04177-9
10.1038/s41586-021-04177-9 · ExternalCitation · doi-reference
10.1038/s41587-023-01688-w
10.1038/s41587-023-01688-w · ExternalCitation · doi-reference
10.1038/s41591-022-01688-4
10.1038/s41591-022-01688-4 · ExternalCitation · doi-reference
10.1038/s41594-020-0497-2
10.1038/s41594-020-0497-2 · ExternalCitation · doi-reference
10.1038/s42003-021-02190-2
10.1038/s42003-021-02190-2 · ExternalCitation · doi-reference
10.1038/sj.emboj.7601610
10.1038/sj.emboj.7601610 · ExternalCitation · doi-reference
10.1038/srep40878
10.1038/srep40878 · ExternalCitation · doi-reference
10.1063/1.4982820
10.1063/1.4982820 · ExternalCitation · doi-reference
10.1073/pnas.0407076101
10.1073/pnas.0407076101 · ExternalCitation · doi-reference
10.1073/pnas.0803124105
10.1073/pnas.0803124105 · ExternalCitation · doi-reference
10.1073/pnas.120163297
10.1073/pnas.120163297 · ExternalCitation · doi-reference
10.1073/pnas.2209936120
10.1073/pnas.2209936120 · ExternalCitation · doi-reference
10.1073/pnas.94.20.10487
10.1073/pnas.94.20.10487 · ExternalCitation · doi-reference
10.1073/pnas.94.20.10541
10.1073/pnas.94.20.10541 · ExternalCitation · doi-reference
10.1080/17474124.2017.1343143
10.1080/17474124.2017.1343143 · ExternalCitation · doi-reference
10.1080/19490976.2024.2405547
10.1080/19490976.2024.2405547 · ExternalCitation · doi-reference
10.1080/19490976.2025.2587964
10.1080/19490976.2025.2587964 · ExternalCitation · doi-reference
10.1084/jem.20181635
10.1084/jem.20181635 · ExternalCitation · doi-reference
10.1093/femsre/fuab038
10.1093/femsre/fuab038 · ExternalCitation · doi-reference
10.1098/rsif.2025.0857
10.1098/rsif.2025.0857 · ExternalCitation · doi-reference
10.1103/physrevlett.101.038102
10.1103/physrevlett.101.038102 · ExternalCitation · doi-reference
10.1103/physrevlett.128.248101
10.1103/physrevlett.128.248101 · ExternalCitation · doi-reference
Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation
10.1111/j.1464-5491.2006.01858.x · ExternalCitation · doi-reference
10.1126/science.1179721
10.1126/science.1179721 · ExternalCitation · doi-reference
10.1128/aem.01357-14
10.1128/aem.01357-14 · ExternalCitation · doi-reference
10.1128/iai.70.1.1-4.2002
10.1128/iai.70.1.1-4.2002 · ExternalCitation · doi-reference
10.1128/jb.165.1.34-40.1986
10.1128/jb.165.1.34-40.1986 · ExternalCitation · doi-reference
10.1128/jb.188.10.3487-3493.2006
10.1128/jb.188.10.3487-3493.2006 · ExternalCitation · doi-reference
10.1136/gutjnl-2021-325753
10.1136/gutjnl-2021-325753 · ExternalCitation · doi-reference
10.1146/annurev-med-042320-021020
10.1146/annurev-med-042320-021020 · ExternalCitation · doi-reference
10.1186/s12866-022-02629-4
10.1186/s12866-022-02629-4 · ExternalCitation · doi-reference
10.1186/s13075-024-03293-x
10.1186/s13075-024-03293-x · ExternalCitation · doi-reference
Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition
10.1371/journal.ppat.1014012 · ExternalCitation · doi-reference
10.15252/emmm.201404169
10.15252/emmm.201404169 · ExternalCitation · doi-reference
10.1529/biophysj.107.108811
10.1529/biophysj.107.108811 · ExternalCitation · doi-reference
TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity
10.2147/jir.s407521 · ExternalCitation · doi-reference
10.2337/dc16-1324
10.2337/dc16-1324 · ExternalCitation · doi-reference
10.2337/dc18-s002
10.2337/dc18-s002 · ExternalCitation · doi-reference
10.2337/dc20-2257
10.2337/dc20-2257 · ExternalCitation · doi-reference
Accumulation of metformin by tissues of the normal and diabetic mouse
10.3109/00498259409043220 · ExternalCitation · doi-reference
10.3389/fcimb.2013.00115
10.3389/fcimb.2013.00115 · ExternalCitation · doi-reference
10.3389/fendo.2023.1232143
10.3389/fendo.2023.1232143 · ExternalCitation · doi-reference
10.3389/fimmu.2022.953196
10.3389/fimmu.2022.953196 · ExternalCitation · doi-reference
10.3389/fmed.2025.1484656
10.3389/fmed.2025.1484656 · ExternalCitation · doi-reference
10.3389/fmicb.2021.792406
10.3389/fmicb.2021.792406 · ExternalCitation · doi-reference
10.3389/fphar.2021.726707
10.3389/fphar.2021.726707 · ExternalCitation · doi-reference
The Role of the Bacterial Flagellum in Adhesion and Virulence
10.3390/biology2041242 · ExternalCitation · doi-reference
The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling
10.3390/cells13181590 · ExternalCitation · doi-reference
10.3390/ijms22031156
10.3390/ijms22031156 · ExternalCitation · doi-reference
Deciphering Bacterial Chemorepulsion: The Complex Response of Microbes to Environmental Stimuli
10.3390/microorganisms12081706 · ExternalCitation · doi-reference
10.3390/ph14020122
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Repurposing metformin as a quorum sensing inhibitor in Pseudomonas aeruginosa
10.4314/ahs.v17i3.24 · ExternalCitation · doi-reference
10.48550/arxiv.2603.20764
10.48550/arxiv.2603.20764 · ExternalCitation · doi-reference
10.7554/elife.65088
10.7554/elife.65088 · ExternalCitation · doi-reference
10.7554/elife.77266
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