Research graph
References from Newly identified COPD GWAS protein interactors reveal a potential disease network module. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis
10.1016/s2213-2600(21)00511-7 · 2022 · External reference
10.1056/nejmra1900475
10.1056/nejmra1900475 · External reference
10.1146/annurev-physiol-021317-121224
10.1146/annurev-physiol-021317-121224 · External reference
10.1038/ng.3752
10.1038/ng.3752 · External reference
10.1371/journal.pgen.1000421
10.1371/journal.pgen.1000421 · External reference
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
10.1016/s2213-2600(14)70002-5 · 2014 · External reference
10.1164/rccm.201501-0148oc
10.1164/rccm.201501-0148oc · External reference
10.1093/hmg/ddr569
10.1093/hmg/ddr569 · External reference
10.1164/rccm.2018020337oc
10.1164/rccm.2018020337oc · External reference
10.1038/nm.4021
10.1038/nm.4021 · External reference
10.1371/journal.pone.0118979
10.1371/journal.pone.0118979 · External reference
10.1016/j.matbio.2015.05.003
10.1016/j.matbio.2015.05.003 · External reference
10.1371/journal.pgen.1008229
10.1371/journal.pgen.1008229 · External reference
CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
10.1126/sciadv.abo6566 · 2022 · External reference
10.1038/415171a
10.1038/415171a · External reference
10.1073/pnas.100448997
10.1073/pnas.100448997 · External reference
10.1182/blood.2021013531
10.1182/blood.2021013531 · External reference
10.7554/elife.42720
10.7554/elife.42720 · External reference
10.1126/science.277.5334.2002
10.1126/science.277.5334.2002 · External reference
10.1016/0092-8674(92)90391-o
10.1016/0092-8674(92)90391-o · External reference
10.1073/pnas.1602342113
10.1073/pnas.1602342113 · External reference
10.1172/jci.insight.144575
10.1172/jci.insight.144575 · External reference
10.1038/nrg2918
10.1038/nrg2918 · External reference
10.1126/science.1257601
10.1126/science.1257601 · External reference
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
10.1016/j.xgen.2022.100250 · 2023 · External reference
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
10.1016/j.isci.2023.106701 · 2023 · External reference
10.1038/srep44232
10.1038/srep44232 · External reference
HHIP protein interactions in lung cells provide insight into COPD pathogenesis
10.1093/hmg/ddaf016 · 2025 · External reference
10.5281/zenodo.14604608
10.5281/zenodo.14604608 · External reference
Unresolved reference
External reference
10.1016/j.jprot.2013.10.023
10.1016/j.jprot.2013.10.023 · External reference
10.1038/nmeth.2557
10.1038/nmeth.2557 · External reference
10.1038/s41588-018-0342-2
10.1038/s41588-018-0342-2 · External reference
10.1038/s41588-023-01314-0
10.1038/s41588-023-01314-0 · External reference
10.1152/ajplung.00543.2017
10.1152/ajplung.00543.2017 · External reference
THBS1 mediates hypoxia driven EndMT in pulmonary hypertension
10.1002/pul2.70019 · 2024 · External reference
10.1073/pnas.1005574107
10.1073/pnas.1005574107 · External reference
10.1074/jbc.c800225200
10.1074/jbc.c800225200 · External reference
10.1164/rccm.201501-0137pp
10.1164/rccm.201501-0137pp · External reference
10.1007/s00441-005-0069-0
10.1007/s00441-005-0069-0 · External reference
10.1155/2010/917108
10.1155/2010/917108 · External reference
10.1007/s004410051217
10.1007/s004410051217 · External reference
Alveolar epithelial type II cells and their microenvironment in the caveolin-1-deficient mouse
10.1002/ar.21543 · 2012 · External reference
RAGE mediates β-catenin stabilization via activation of the Src/p-Cav-1 axis in a chemical-induced asthma model
10.1016/j.toxlet.2018.09.010 · 2018 · External reference
Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model
10.3389/fnmol.2024.1362581 · 2024 · External reference
10.1038/s41588-025-02480-z
10.1038/s41588-025-02480-z · External reference
Transglutaminase-2: Nature’s glue in lung fibrosis?
10.1165/rcmb.2021-0209ed · 2021 · External reference
10.1165/rcmb.2016-0379oc
10.1165/rcmb.2016-0379oc · External reference
10.1165/rcmb.2013-0092oc
10.1165/rcmb.2013-0092oc · External reference
10.1152/ajplung.00021.2016
10.1152/ajplung.00021.2016 · External reference
10.1371/journal.pone.0013390
10.1371/journal.pone.0013390 · External reference
10.1038/onc.2011.429
10.1038/onc.2011.429 · External reference
HHIP’s dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
10.1073/pnas.2424377123 · 2026 · External reference
Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease
10.3109/01902140903349562 · 2010 · External reference
10.1016/j.intimp.2013.09.003
10.1016/j.intimp.2013.09.003 · External reference
Association of plasma heat shock protein 70 with disease severity, smoking and lung function of patients with chronic obstructive pulmonary disease
10.3390/jcm9103097 · 2020 · External reference
10.1093/nar/gkw985
10.1093/nar/gkw985 · External reference
10.1093/nar/gkab1048
10.1093/nar/gkab1048 · External reference
10.1038/s41586-020-2188-x
10.1038/s41586-020-2188-x · External reference
10.1002/pro.3978
10.1002/pro.3978 · External reference
10.1093/nar/gkad1025
10.1093/nar/gkad1025 · External reference
10.1038/nmeth.2289
10.1038/nmeth.2289 · External reference
Unresolved reference
External reference
10.1093/nar/gkac1000
10.1093/nar/gkac1000 · External reference
Unresolved reference
External reference
10.1093/nar/gkv007
10.1093/nar/gkv007 · External reference
Alveolar epithelial type II cells and their microenvironment in the caveolin-1-deficient mouse
10.1002/ar.21543 · ExternalCitation · doi-reference
10.1002/pro.3978
10.1002/pro.3978 · ExternalCitation · doi-reference
THBS1 mediates hypoxia driven EndMT in pulmonary hypertension
10.1002/pul2.70019 · ExternalCitation · doi-reference
10.1007/s00441-005-0069-0
10.1007/s00441-005-0069-0 · ExternalCitation · doi-reference
10.1007/s004410051217
10.1007/s004410051217 · ExternalCitation · doi-reference
10.1016/0092-8674(92)90391-o
10.1016/0092-8674(92)90391-o · ExternalCitation · doi-reference
10.1016/j.intimp.2013.09.003
10.1016/j.intimp.2013.09.003 · ExternalCitation · doi-reference
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
10.1016/j.isci.2023.106701 · ExternalCitation · doi-reference
10.1016/j.jprot.2013.10.023
10.1016/j.jprot.2013.10.023 · ExternalCitation · doi-reference
10.1016/j.matbio.2015.05.003
10.1016/j.matbio.2015.05.003 · ExternalCitation · doi-reference
RAGE mediates β-catenin stabilization via activation of the Src/p-Cav-1 axis in a chemical-induced asthma model
10.1016/j.toxlet.2018.09.010 · ExternalCitation · doi-reference
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
10.1016/j.xgen.2022.100250 · ExternalCitation · doi-reference
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
10.1016/s2213-2600(14)70002-5 · ExternalCitation · doi-reference
Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis
10.1016/s2213-2600(21)00511-7 · ExternalCitation · doi-reference
10.1038/415171a
10.1038/415171a · ExternalCitation · doi-reference
10.1038/ng.3752
10.1038/ng.3752 · ExternalCitation · doi-reference
10.1038/nm.4021
10.1038/nm.4021 · ExternalCitation · doi-reference
10.1038/nmeth.2289
10.1038/nmeth.2289 · ExternalCitation · doi-reference
10.1038/nmeth.2557
10.1038/nmeth.2557 · ExternalCitation · doi-reference
10.1038/nrg2918
10.1038/nrg2918 · ExternalCitation · doi-reference
10.1038/onc.2011.429
10.1038/onc.2011.429 · ExternalCitation · doi-reference
10.1038/s41586-020-2188-x
10.1038/s41586-020-2188-x · ExternalCitation · doi-reference
10.1038/s41588-018-0342-2
10.1038/s41588-018-0342-2 · ExternalCitation · doi-reference
10.1038/s41588-023-01314-0
10.1038/s41588-023-01314-0 · ExternalCitation · doi-reference
10.1038/s41588-025-02480-z
10.1038/s41588-025-02480-z · ExternalCitation · doi-reference
10.1038/srep44232
10.1038/srep44232 · ExternalCitation · doi-reference
10.1056/nejmra1900475
10.1056/nejmra1900475 · ExternalCitation · doi-reference
10.1073/pnas.100448997
10.1073/pnas.100448997 · ExternalCitation · doi-reference
10.1073/pnas.1005574107
10.1073/pnas.1005574107 · ExternalCitation · doi-reference
10.1073/pnas.1602342113
10.1073/pnas.1602342113 · ExternalCitation · doi-reference
HHIP’s dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility
10.1073/pnas.2424377123 · ExternalCitation · doi-reference
10.1074/jbc.c800225200
10.1074/jbc.c800225200 · ExternalCitation · doi-reference
HHIP protein interactions in lung cells provide insight into COPD pathogenesis
10.1093/hmg/ddaf016 · ExternalCitation · doi-reference
10.1093/hmg/ddr569
10.1093/hmg/ddr569 · ExternalCitation · doi-reference
10.1093/nar/gkab1048
10.1093/nar/gkab1048 · ExternalCitation · doi-reference
10.1093/nar/gkac1000
10.1093/nar/gkac1000 · ExternalCitation · doi-reference
10.1093/nar/gkad1025
10.1093/nar/gkad1025 · ExternalCitation · doi-reference
10.1093/nar/gkv007
10.1093/nar/gkv007 · ExternalCitation · doi-reference
10.1093/nar/gkw985
10.1093/nar/gkw985 · ExternalCitation · doi-reference
CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
10.1126/sciadv.abo6566 · ExternalCitation · doi-reference
10.1126/science.1257601
10.1126/science.1257601 · ExternalCitation · doi-reference
10.1126/science.277.5334.2002
10.1126/science.277.5334.2002 · ExternalCitation · doi-reference
10.1146/annurev-physiol-021317-121224
10.1146/annurev-physiol-021317-121224 · ExternalCitation · doi-reference
10.1152/ajplung.00021.2016
10.1152/ajplung.00021.2016 · ExternalCitation · doi-reference
10.1152/ajplung.00543.2017
10.1152/ajplung.00543.2017 · ExternalCitation · doi-reference
10.1155/2010/917108
10.1155/2010/917108 · ExternalCitation · doi-reference
10.1164/rccm.201501-0137pp
10.1164/rccm.201501-0137pp · ExternalCitation · doi-reference
10.1164/rccm.201501-0148oc
10.1164/rccm.201501-0148oc · ExternalCitation · doi-reference
10.1164/rccm.2018020337oc
10.1164/rccm.2018020337oc · ExternalCitation · doi-reference
10.1165/rcmb.2013-0092oc
10.1165/rcmb.2013-0092oc · ExternalCitation · doi-reference
10.1165/rcmb.2016-0379oc
10.1165/rcmb.2016-0379oc · ExternalCitation · doi-reference
Transglutaminase-2: Nature’s glue in lung fibrosis?
10.1165/rcmb.2021-0209ed · ExternalCitation · doi-reference
10.1172/jci.insight.144575
10.1172/jci.insight.144575 · ExternalCitation · doi-reference
10.1182/blood.2021013531
10.1182/blood.2021013531 · ExternalCitation · doi-reference
10.1371/journal.pgen.1000421
10.1371/journal.pgen.1000421 · ExternalCitation · doi-reference
10.1371/journal.pgen.1008229
10.1371/journal.pgen.1008229 · ExternalCitation · doi-reference
10.1371/journal.pone.0013390
10.1371/journal.pone.0013390 · ExternalCitation · doi-reference
10.1371/journal.pone.0118979
10.1371/journal.pone.0118979 · ExternalCitation · doi-reference
Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease
10.3109/01902140903349562 · ExternalCitation · doi-reference
Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model
10.3389/fnmol.2024.1362581 · ExternalCitation · doi-reference
Association of plasma heat shock protein 70 with disease severity, smoking and lung function of patients with chronic obstructive pulmonary disease
10.3390/jcm9103097 · ExternalCitation · doi-reference
10.5281/zenodo.14604608
10.5281/zenodo.14604608 · ExternalCitation · doi-reference
10.7554/elife.42720
10.7554/elife.42720 · ExternalCitation · doi-reference
