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References from Multimodal evidence for impaired glymphatic brain clearance as a mediator of “inflammaging” in schizophrenia – integrating insights from in vivo neuroimaging, omics, and post-mortem single nucleus-RNA-Seq data. Local targets link to admitted publications; unresolved targets remain external evidence.
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Accelerated aging in schizophrenia patients: the potential role of oxidative stress
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Differences in Blood Leukocyte Subpopulations in Schizophrenia: A Systematic Review and Meta-Analysis
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A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone
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Increased inflammasome protein expression identified in microglia from postmortem brains with schizophrenia
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Longitudinal changes in DTI-ALPS and choroid plexus volume relative to CSF biomarkers during lecanemab treatment in mild cognitive impairment: A pilot study
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Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
10.1002/advs.202503576 · 2025 · External reference
A Microfluidic Model of AQP4 Polarization Dynamics and Fluid Transport in the Healthy and Inflamed Human Brain: The First Step Towards Glymphatics-on-a-Chip
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Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease
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10.3389/fpsyt.2017.00221 · 2017 · External reference
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Role of aquaporin-4 polarization in extracellular solute clearance
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Paeoniflorin regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in oxidative stressed melanocytes
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DNA methylation GrimAge strongly predicts lifespan and healthspan
2019 · External reference
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Distinct Phenotypes of Inflammation Associated Macrophages and Microglia in the Prefrontal Cortex Schizophrenia Compared to Controls
10.3389/fnins.2022.858989 · 2022 · External reference
Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation
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Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis
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Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?
10.1038/s41380-024-02539-z · 2024 · External reference
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Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome
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Elevated Proinflammatory Markers in 22q11.2 Deletion Syndrome Are Associated With Psychosis and Cognitive Deficits
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Neutrophils to lymphocytes ratio and psychosis in 22q11.2 deletion syndrome - Clinical and scientific implications
10.1016/j.schres.2021.03.023 · 2021 · External reference
Developmental Alterations in the Diffusion Tensor Imaging Analysis Along the Perivascular Space Index Suggest Possible Glymphatic-Related Mechanisms Underlying Excitation/Inhibition Imbalance and Psychosis Vulnerability in 22q11.2 Deletion Syndrome
10.1016/j.bpsgos.2026.100713 · 2026 · External reference
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Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A
10.1186/s13287-023-03284-w · 2023 · External reference
Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes
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2025 · External reference
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