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References from Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer’s disease neurons. Local targets link to admitted publications; unresolved targets remain external evidence.
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility
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10.1038/s43587-022-00290-0 · External reference
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease
10.1073/pnas.1310249110 · 2013 · External reference
Analyzing alternative splicing in Alzheimer’s disease postmortem brain: a cell-level perspective
10.3389/fnmol.2023.1237874 · 2023 · External reference
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10.1093/bib/bbaa438 · External reference
NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C
2025 · External reference
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10.1038/s41580-018-0081-3 · External reference
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10.1038/s41580-021-00441-y · External reference
10.1016/j.tibs.2017.11.004
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Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux
10.1007/s13311-021-01079-6 · 2021 · External reference
10.1038/ncomms1255
10.1038/ncomms1255 · External reference
10.1093/brain/aws013
10.1093/brain/aws013 · External reference
10.3389/fncel.2018.00169
10.3389/fncel.2018.00169 · External reference
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
2021 · External reference
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
10.1016/j.stem.2015.09.001 · 2015 · External reference
10.1016/j.stem.2022.04.018
10.1016/j.stem.2022.04.018 · External reference
10.7554/elife.18648
10.7554/elife.18648 · External reference
Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes
10.1038/s41593-018-0075-7 · 2018 · External reference
Neural cell state shifts and fate loss in ageing and age-related diseases
10.1038/s41582-023-00815-0 · 2023 · External reference
10.1016/j.stem.2022.11.010
10.1016/j.stem.2022.11.010 · External reference
10.1126/science.adl2992
10.1126/science.adl2992 · External reference
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10.64898/2026.04.13.716801 · External reference
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10.64898/2026.07.27.740588 · External reference
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease
10.1016/j.cmet.2022.07.014 · 2022 · External reference
Direct Conversion of Human Fibroblasts to Induced Neurons
10.1007/978-1-0716-1601-7_6 · 2021 · External reference
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
10.1016/j.celrep.2018.04.105 · 2018 · External reference
Unresolved reference
External reference
10.1126/science.aal3321
10.1126/science.aal3321 · External reference
POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
10.1093/nar/gkab702 · 2022 · External reference
rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data
2014 · External reference
10.1126/sciadv.abq5072
10.1126/sciadv.abq5072 · External reference
Disruption of a RAC1-centred network is associated with Alzheimer’s disease pathology and causes age-dependent neurodegeneration
10.1093/hmg/ddz320 · 2020 · External reference
GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS
10.1016/j.jbc.2023.104698 · 2023 · External reference
Matrix compliance regulates Rac1b localization
2012 · External reference
A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells
10.1016/j.chembiol.2025.01.002 · 2025 · External reference
10.1126/science.adl2992
10.1126/science.adl2992 · External reference
High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. Buratti E, editor
10.1371/journal.pone.0195771 · 2018 · External reference
Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration
10.1007/s12035-020-02258-w · 2021 · External reference
10.1242/dmm.048993
10.1242/dmm.048993 · External reference
Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution
2023 · External reference
Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
10.1038/s41467-019-09352-1 · 2019 · External reference
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility
10.1038/s41588-018-0238-1 · 2018 · External reference
Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer’s Disease
10.1371/journal.pone.0016266 · 2011 · External reference
Analyzing alternative splicing in Alzheimer’s disease postmortem brain: a cell-level perspective
10.3389/fnmol.2023.1237874 · 2023 · External reference
Unresolved reference
External reference
RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer’s disease brain
2026 · External reference
Unresolved reference
External reference
Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
10.1016/j.celrep.2019.08.104 · 2019 · External reference
10.1101/2025.07.11.664476
10.1101/2025.07.11.664476 · External reference
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS
10.1093/hmg/ddaa159 · 2020 · External reference
10.1128/mcb.00052-19
10.1128/mcb.00052-19 · External reference
An acetylation switch controls TDP-43 function and aggregation propensity
2015 · External reference
Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma
10.1038/s41388-019-0764-z · 2019 · External reference
Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response
2023 · External reference
10.1101/2024.09.04.611121
10.1101/2024.09.04.611121 · External reference
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin
10.1038/emboj.2010.333 · 2011 · External reference
TDP-43 post-translational modifications in health and disease
10.1080/14728222.2018.1439923 · 2018 · External reference
Tau acetylation at K280 regulates tau phosphorylation
10.1080/00207454.2022.2081165 · 2023 · External reference
Acetylation of tau inhibits its degradation and contributes to tauopathy
10.1016/j.neuron.2010.08.044 · 2010 · External reference
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition
10.1016/j.neuron.2025.03.028 · 2025 · External reference
High-Throughput Metabolomics: Isocratic and Gradient Mass Spectrometry-Based Methods
10.1007/978-1-4939-9236-2_2 · 2019 · External reference
Vireo: Bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference
10.1186/s13059-019-1865-2 · 2019 · External reference
Cellsnp-lite: an efficient tool for genotyping single cells
10.1093/bioinformatics/btab358 · 2021 · External reference
10.1038/nbt.4096
10.1038/nbt.4096 · External reference
10.1186/s13059-014-0550-8
10.1186/s13059-014-0550-8 · External reference
